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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CEP170-RGS7

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CEP170-RGS7
	FusionPDB ID: 15804
	FusionGDB2.0 ID: 15804
		Hgene	Tgene
	Gene symbol	CEP170	RGS7
	Gene ID	9859	6000
	Gene name	centrosomal protein 170	regulator of G protein signaling 7
	Synonyms	FAM68A\|KAB\|KIAA0470	-
	Cytomap	1q43	1q43\|1q23.1
	Type of gene	protein-coding	protein-coding
	Description	centrosomal protein of 170 kDaKARP-1-binding proteinXRCC5 binding proteincentrosomal protein 170kDa	regulator of G-protein signaling 7regulator of G-protein signaling RGS7regulator of G-protein signalling 7
	Modification date	20200313	20200313
	UniProtAcc	Q9Y4F5	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000366542, ENST00000366543, ENST00000366544, ENST00000468254, ENST00000481987, ENST00000490813,	ENST00000331110, ENST00000348120, ENST00000366562, ENST00000366563, ENST00000366564, ENST00000366565, ENST00000401882, ENST00000407727, ENST00000446183,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 9 X 10=1080	13 X 11 X 8=1144
	# samples	13	14
	** MAII score	log2(13/1080*10)=-3.05444778402238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1144*10)=-3.03058831983342 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CEP170 [Title/Abstract] AND RGS7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CEP170(243385026)-RGS7(240990472), # samples:3
Anticipated loss of major functional domain due to fusion event.	CEP170-RGS7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-RGS7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-RGS7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-RGS7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RGS7	GO:0043547	positive regulation of GTPase activity	10521509

Fusion gene breakpoints across CEP170 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RGS7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-44-8119-01A	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366542	CEP170	chr1	243385026	-	ENST00000331110	RGS7	chr1	240990472	-	1103	247	52	1071	339
ENST00000366542	CEP170	chr1	243385026	-	ENST00000348120	RGS7	chr1	240990472	-	1777	247	52	1071	339
ENST00000366542	CEP170	chr1	243385026	-	ENST00000366563	RGS7	chr1	240990472	-	1777	247	52	1071	339
ENST00000366542	CEP170	chr1	243385026	-	ENST00000366564	RGS7	chr1	240990472	-	1696	247	52	1047	331
ENST00000366542	CEP170	chr1	243385026	-	ENST00000366565	RGS7	chr1	240990472	-	1750	247	52	1101	349
ENST00000366542	CEP170	chr1	243385026	-	ENST00000446183	RGS7	chr1	240990472	-	1632	247	52	1071	339
ENST00000366542	CEP170	chr1	243385026	-	ENST00000366562	RGS7	chr1	240990472	-	1048	247	52	1047	332
ENST00000366542	CEP170	chr1	243385026	-	ENST00000401882	RGS7	chr1	240990472	-	1072	247	52	1071	340
ENST00000366542	CEP170	chr1	243385026	-	ENST00000407727	RGS7	chr1	240990472	-	1126	247	52	1125	358
ENST00000366543	CEP170	chr1	243385026	-	ENST00000331110	RGS7	chr1	240990472	-	1374	518	323	1342	339
ENST00000366543	CEP170	chr1	243385026	-	ENST00000348120	RGS7	chr1	240990472	-	2048	518	323	1342	339
ENST00000366543	CEP170	chr1	243385026	-	ENST00000366563	RGS7	chr1	240990472	-	2048	518	323	1342	339
ENST00000366543	CEP170	chr1	243385026	-	ENST00000366564	RGS7	chr1	240990472	-	1967	518	323	1318	331
ENST00000366543	CEP170	chr1	243385026	-	ENST00000366565	RGS7	chr1	240990472	-	2021	518	323	1372	349
ENST00000366543	CEP170	chr1	243385026	-	ENST00000446183	RGS7	chr1	240990472	-	1903	518	323	1342	339
ENST00000366543	CEP170	chr1	243385026	-	ENST00000366562	RGS7	chr1	240990472	-	1319	518	323	1318	332
ENST00000366543	CEP170	chr1	243385026	-	ENST00000401882	RGS7	chr1	240990472	-	1343	518	323	1342	340
ENST00000366543	CEP170	chr1	243385026	-	ENST00000407727	RGS7	chr1	240990472	-	1397	518	323	1396	358
ENST00000366544	CEP170	chr1	243385026	-	ENST00000331110	RGS7	chr1	240990472	-	1374	518	323	1342	339
ENST00000366544	CEP170	chr1	243385026	-	ENST00000348120	RGS7	chr1	240990472	-	2048	518	323	1342	339
ENST00000366544	CEP170	chr1	243385026	-	ENST00000366563	RGS7	chr1	240990472	-	2048	518	323	1342	339
ENST00000366544	CEP170	chr1	243385026	-	ENST00000366564	RGS7	chr1	240990472	-	1967	518	323	1318	331
ENST00000366544	CEP170	chr1	243385026	-	ENST00000366565	RGS7	chr1	240990472	-	2021	518	323	1372	349
ENST00000366544	CEP170	chr1	243385026	-	ENST00000446183	RGS7	chr1	240990472	-	1903	518	323	1342	339
ENST00000366544	CEP170	chr1	243385026	-	ENST00000366562	RGS7	chr1	240990472	-	1319	518	323	1318	332
ENST00000366544	CEP170	chr1	243385026	-	ENST00000401882	RGS7	chr1	240990472	-	1343	518	323	1342	340
ENST00000366544	CEP170	chr1	243385026	-	ENST00000407727	RGS7	chr1	240990472	-	1397	518	323	1396	358

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366542	ENST00000331110	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.002034508	0.9979656
ENST00000366542	ENST00000348120	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.00051896	0.999481
ENST00000366542	ENST00000366563	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.00051896	0.999481
ENST00000366542	ENST00000366564	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.000474345	0.99952567
ENST00000366542	ENST00000366565	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.0004358	0.99956423
ENST00000366542	ENST00000446183	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.000838556	0.9991615
ENST00000366542	ENST00000366562	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.001575377	0.99842465
ENST00000366542	ENST00000401882	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.001905263	0.99809474
ENST00000366542	ENST00000407727	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.001608054	0.9983919
ENST00000366543	ENST00000331110	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.003018449	0.99698156
ENST00000366543	ENST00000348120	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.000742753	0.99925727
ENST00000366543	ENST00000366563	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.000742753	0.99925727
ENST00000366543	ENST00000366564	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.000668806	0.99933124
ENST00000366543	ENST00000366565	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.000626308	0.99937373
ENST00000366543	ENST00000446183	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.001126955	0.99887305
ENST00000366543	ENST00000366562	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.002436875	0.9975631
ENST00000366543	ENST00000401882	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.003068514	0.99693143
ENST00000366543	ENST00000407727	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.002598238	0.99740183
ENST00000366544	ENST00000331110	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.003018449	0.99698156
ENST00000366544	ENST00000348120	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.000742753	0.99925727
ENST00000366544	ENST00000366563	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.000742753	0.99925727
ENST00000366544	ENST00000366564	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.000668806	0.99933124
ENST00000366544	ENST00000366565	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.000626308	0.99937373
ENST00000366544	ENST00000446183	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.001126955	0.99887305
ENST00000366544	ENST00000366562	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.002436875	0.9975631
ENST00000366544	ENST00000401882	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.003068514	0.99693143
ENST00000366544	ENST00000407727	CEP170	chr1	243385026	-	RGS7	chr1	240990472	-	0.002598238	0.99740183

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15804_15804_1_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366542_RGS7_chr1_240990472_ENST00000331110_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_2_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366542_RGS7_chr1_240990472_ENST00000348120_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_3_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366542_RGS7_chr1_240990472_ENST00000366562_length(amino acids)=332AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_4_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366542_RGS7_chr1_240990472_ENST00000366563_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_5_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366542_RGS7_chr1_240990472_ENST00000366564_length(amino acids)=331AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_6_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366542_RGS7_chr1_240990472_ENST00000366565_length(amino acids)=349AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_7_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366542_RGS7_chr1_240990472_ENST00000401882_length(amino acids)=340AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_8_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366542_RGS7_chr1_240990472_ENST00000407727_length(amino acids)=358AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_9_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366542_RGS7_chr1_240990472_ENST00000446183_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_10_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366543_RGS7_chr1_240990472_ENST00000331110_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_11_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366543_RGS7_chr1_240990472_ENST00000348120_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_12_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366543_RGS7_chr1_240990472_ENST00000366562_length(amino acids)=332AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_13_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366543_RGS7_chr1_240990472_ENST00000366563_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_14_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366543_RGS7_chr1_240990472_ENST00000366564_length(amino acids)=331AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_15_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366543_RGS7_chr1_240990472_ENST00000366565_length(amino acids)=349AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_16_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366543_RGS7_chr1_240990472_ENST00000401882_length(amino acids)=340AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_17_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366543_RGS7_chr1_240990472_ENST00000407727_length(amino acids)=358AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_18_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366543_RGS7_chr1_240990472_ENST00000446183_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_19_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366544_RGS7_chr1_240990472_ENST00000331110_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_20_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366544_RGS7_chr1_240990472_ENST00000348120_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_21_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366544_RGS7_chr1_240990472_ENST00000366562_length(amino acids)=332AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_22_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366544_RGS7_chr1_240990472_ENST00000366563_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_23_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366544_RGS7_chr1_240990472_ENST00000366564_length(amino acids)=331AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_24_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366544_RGS7_chr1_240990472_ENST00000366565_length(amino acids)=349AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_25_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366544_RGS7_chr1_240990472_ENST00000401882_length(amino acids)=340AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_26_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366544_RGS7_chr1_240990472_ENST00000407727_length(amino acids)=358AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

>15804_15804_27_CEP170-RGS7_CEP170_chr1_243385026_ENST00000366544_RGS7_chr1_240990472_ENST00000446183_length(amino acids)=339AA_BP=60
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGPGCVNTTEVDIKKSSRMRNPHKTRK
SVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEA
SKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTT

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:243385026/chr1:240990472)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CEP170 Q9Y4F5	.
FUNCTION: Plays a role in microtubule organization. {ECO:0000250\|UniProtKB:Q5SW79}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000348120

255_316

150.0

626.6666666666666

Domain

Note=G protein gamma

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000348120

333_448

150.0

626.6666666666666

Domain

RGS

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366562

255_316

203.0

470.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366562

333_448

203.0

470.0

Domain

RGS

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366563

255_316

203.0

689.6666666666666

Domain

Note=G protein gamma

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366563

333_448

203.0

689.6666666666666

Domain

RGS

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366564

255_316

203.0

470.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366564

333_448

203.0

470.0

Domain

RGS

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366565

255_316

203.0

488.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366565

333_448

203.0

488.0

Domain

RGS

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000401882

255_316

150.0

425.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000401882

333_448

150.0

425.0

Domain

RGS

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000407727

255_316

203.0

496.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000407727

333_448

203.0

496.0

Domain

RGS

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366542

1467_1495

65.0

1585.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366543

1467_1495

65.0

1461.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366544

1467_1495

65.0

1487.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366542

23_73

65.0

1585.0

Domain

FHA

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366543

23_73

65.0

1461.0

Domain

FHA

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366544

23_73

65.0

1487.0

Domain

FHA

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366542

1113_1584

65.0

1585.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366542

853_1584

65.0

1585.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366543

1113_1584

65.0

1461.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366543

853_1584

65.0

1461.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366544

1113_1584

65.0

1487.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243385026

chr1:240990472

ENST00000366544

853_1584

65.0

1487.0

Region

Note=Targeting to microtubules

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000348120

37_112

150.0

626.6666666666666

Domain

DEP

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366562

37_112

203.0

470.0

Domain

DEP

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366563

37_112

203.0

689.6666666666666

Domain

DEP

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366564

37_112

203.0

470.0

Domain

DEP

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000366565

37_112

203.0

488.0

Domain

DEP

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000401882

37_112

150.0

425.0

Domain

DEP

Tgene

RGS7

chr1:243385026

chr1:240990472

ENST00000407727

37_112

203.0

496.0

Domain

DEP

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CEP170
RGS7

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CEP170	chr1:243385026	chr1:240990472	ENST00000366542	-	3	20	1015_1460	65.0	1585.0	CCDC61
Hgene	CEP170	chr1:243385026	chr1:240990472	ENST00000366543	-	3	19	1015_1460	65.0	1461.0	CCDC61
Hgene	CEP170	chr1:243385026	chr1:240990472	ENST00000366544	-	3	19	1015_1460	65.0	1487.0	CCDC61

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Related Drugs to CEP170-RGS7

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CEP170-RGS7

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source