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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CHD3-RAD51C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CHD3-RAD51C
FusionPDB ID: 16320
FusionGDB2.0 ID: 16320
HgeneTgene
Gene symbol

CHD3

RAD51C

Gene ID

1107

5889

Gene namechromodomain helicase DNA binding protein 3RAD51 paralog C
SynonymsMi-2a|Mi2-ALPHA|SNIBCPS|ZFHBROVCA3|FANCO|R51H3|RAD51L2
Cytomap

17p13.1

17q22

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 3ATP-dependent helicase CHD3CHD-3hZFHmi-2 autoantigen 240 kDa proteinzinc finger helicasezinc-finger helicase (Snf2-like)DNA repair protein RAD51 homolog 3RAD51-like protein 2yeast RAD51 homolog 3
Modification date2020031320200313
UniProtAcc

Q12873

.
Ensembl transtripts involved in fusion geneENST idsENST00000330494, ENST00000358181, 
ENST00000380358, ENST00000570758, 
ENST00000421782, ENST00000487921, 
ENST00000337432, ENST00000583539, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 2=7212 X 11 X 4=528
# samples 715
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/528*10)=-1.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CHD3 [Title/Abstract] AND RAD51C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CHD3(7797253)-RAD51C(56787220), # samples:3
Anticipated loss of major functional domain due to fusion event.CHD3-RAD51C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD3-RAD51C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD3-RAD51C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD3-RAD51C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHD3

GO:0007051

spindle organization

17626165

HgeneCHD3

GO:0007098

centrosome cycle

17626165

TgeneRAD51C

GO:0006281

DNA repair

19451272

TgeneRAD51C

GO:0006310

DNA recombination

19451272


check buttonFusion gene breakpoints across CHD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAD51C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5KY-01ACHD3chr17

7797253

-RAD51Cchr17

56787220

+
ChimerDB4ACCTCGA-OR-A5KY-01ACHD3chr17

7797253

+RAD51Cchr17

56787220

+
ChimerDB4ACCTCGA-OR-A5KYCHD3chr17

7797253

+RAD51Cchr17

56787219

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380358CHD3chr177797253+ENST00000583539RAD51Cchr1756787220+1645110211437478
ENST00000380358CHD3chr177797253+ENST00000337432RAD51Cchr1756787220+1648110211527508
ENST00000358181CHD3chr177797253+ENST00000583539RAD51Cchr1756787220+167711342101469419
ENST00000358181CHD3chr177797253+ENST00000337432RAD51Cchr1756787220+168011342101559449
ENST00000330494CHD3chr177797253+ENST00000583539RAD51Cchr1756787220+161710741501409419
ENST00000330494CHD3chr177797253+ENST00000337432RAD51Cchr1756787220+162010741501499449
ENST00000380358CHD3chr177797253+ENST00000583539RAD51Cchr1756787219+1645110211437478
ENST00000380358CHD3chr177797253+ENST00000337432RAD51Cchr1756787219+1648110211527508
ENST00000358181CHD3chr177797253+ENST00000583539RAD51Cchr1756787219+167711342101469419
ENST00000358181CHD3chr177797253+ENST00000337432RAD51Cchr1756787219+168011342101559449
ENST00000330494CHD3chr177797253+ENST00000583539RAD51Cchr1756787219+161710741501409419
ENST00000330494CHD3chr177797253+ENST00000337432RAD51Cchr1756787219+162010741501499449

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380358ENST00000583539CHD3chr177797253+RAD51Cchr1756787220+0.008773410.9912266
ENST00000380358ENST00000337432CHD3chr177797253+RAD51Cchr1756787220+0.0075248230.9924752
ENST00000358181ENST00000583539CHD3chr177797253+RAD51Cchr1756787220+0.003291310.99670863
ENST00000358181ENST00000337432CHD3chr177797253+RAD51Cchr1756787220+0.0033653410.99663466
ENST00000330494ENST00000583539CHD3chr177797253+RAD51Cchr1756787220+0.0038359590.9961641
ENST00000330494ENST00000337432CHD3chr177797253+RAD51Cchr1756787220+0.0039718720.9960282
ENST00000380358ENST00000583539CHD3chr177797253+RAD51Cchr1756787219+0.008773410.9912266
ENST00000380358ENST00000337432CHD3chr177797253+RAD51Cchr1756787219+0.0075248230.9924752
ENST00000358181ENST00000583539CHD3chr177797253+RAD51Cchr1756787219+0.003291310.99670863
ENST00000358181ENST00000337432CHD3chr177797253+RAD51Cchr1756787219+0.0033653410.99663466
ENST00000330494ENST00000583539CHD3chr177797253+RAD51Cchr1756787219+0.0038359590.9961641
ENST00000330494ENST00000337432CHD3chr177797253+RAD51Cchr1756787219+0.0039718720.9960282

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>16320_16320_1_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000330494_RAD51C_chr17_56787219_ENST00000337432_length(amino acids)=449AA_BP=301
MKAADTVILWARSKNDQLRISFPPGLCWGDRMPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSES
GGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI
PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKR
RSKSPRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMT

--------------------------------------------------------------

>16320_16320_2_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000330494_RAD51C_chr17_56787219_ENST00000583539_length(amino acids)=419AA_BP=301
MKAADTVILWARSKNDQLRISFPPGLCWGDRMPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSES
GGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI
PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKR
RSKSPRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMT

--------------------------------------------------------------

>16320_16320_3_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000330494_RAD51C_chr17_56787220_ENST00000337432_length(amino acids)=449AA_BP=301
MKAADTVILWARSKNDQLRISFPPGLCWGDRMPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSES
GGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI
PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKR
RSKSPRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMT

--------------------------------------------------------------

>16320_16320_4_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000330494_RAD51C_chr17_56787220_ENST00000583539_length(amino acids)=419AA_BP=301
MKAADTVILWARSKNDQLRISFPPGLCWGDRMPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSES
GGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI
PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKR
RSKSPRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMT

--------------------------------------------------------------

>16320_16320_5_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000358181_RAD51C_chr17_56787219_ENST00000337432_length(amino acids)=449AA_BP=301
MKAADTVILWARSKNDQLRISFPPGLCWGDRMPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSES
GGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI
PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKR
RSKSPRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMT

--------------------------------------------------------------

>16320_16320_6_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000358181_RAD51C_chr17_56787219_ENST00000583539_length(amino acids)=419AA_BP=301
MKAADTVILWARSKNDQLRISFPPGLCWGDRMPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSES
GGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI
PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKR
RSKSPRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMT

--------------------------------------------------------------

>16320_16320_7_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000358181_RAD51C_chr17_56787220_ENST00000337432_length(amino acids)=449AA_BP=301
MKAADTVILWARSKNDQLRISFPPGLCWGDRMPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSES
GGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI
PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKR
RSKSPRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMT

--------------------------------------------------------------

>16320_16320_8_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000358181_RAD51C_chr17_56787220_ENST00000583539_length(amino acids)=419AA_BP=301
MKAADTVILWARSKNDQLRISFPPGLCWGDRMPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSES
GGSEYGTGPGRKRRRKHREKKEKKTKRRKKGEGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI
PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKR
RSKSPRVPDGRKKLRGKKMAPLKIKLGLLGGKRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMT

--------------------------------------------------------------

>16320_16320_9_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000380358_RAD51C_chr17_56787219_ENST00000337432_length(amino acids)=508AA_BP=7
MASPLRDEEEEEEEMVVSEEEEEEEEEGDEEEEEEVEAADEDDEEDDDEGVLGRGPGHDRGRDRHSPPGCHLFPPPPPPPPPLPPPPPPP
PPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSESGGSEYGTGPGRKRRRKHREKKEKKTKRRKKG
EGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFSANNPFKGSAAAVAA
AAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKRRSKSPRVPDGRKKLRGKKMAPLKIKLGLLGG
KRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWD

--------------------------------------------------------------

>16320_16320_10_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000380358_RAD51C_chr17_56787219_ENST00000583539_length(amino acids)=478AA_BP=7
MASPLRDEEEEEEEMVVSEEEEEEEEEGDEEEEEEVEAADEDDEEDDDEGVLGRGPGHDRGRDRHSPPGCHLFPPPPPPPPPLPPPPPPP
PPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSESGGSEYGTGPGRKRRRKHREKKEKKTKRRKKG
EGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFSANNPFKGSAAAVAA
AAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKRRSKSPRVPDGRKKLRGKKMAPLKIKLGLLGG
KRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWD

--------------------------------------------------------------

>16320_16320_11_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000380358_RAD51C_chr17_56787220_ENST00000337432_length(amino acids)=508AA_BP=7
MASPLRDEEEEEEEMVVSEEEEEEEEEGDEEEEEEVEAADEDDEEDDDEGVLGRGPGHDRGRDRHSPPGCHLFPPPPPPPPPLPPPPPPP
PPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSESGGSEYGTGPGRKRRRKHREKKEKKTKRRKKG
EGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFSANNPFKGSAAAVAA
AAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKRRSKSPRVPDGRKKLRGKKMAPLKIKLGLLGG
KRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWD

--------------------------------------------------------------

>16320_16320_12_CHD3-RAD51C_CHD3_chr17_7797253_ENST00000380358_RAD51C_chr17_56787220_ENST00000583539_length(amino acids)=478AA_BP=7
MASPLRDEEEEEEEMVVSEEEEEEEEEGDEEEEEEVEAADEDDEEDDDEGVLGRGPGHDRGRDRHSPPGCHLFPPPPPPPPPLPPPPPPP
PPDKDDIRLLPSALGVKKRKRGPKKQKENKPGKPRKRKKRDSEEEFGSERDEYREKSESGGSEYGTGPGRKRRRKHREKKEKKTKRRKKG
EGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFSANNPFKGSAAAVAA
AAAAAAAAVAEQVSAAVSSATPIAPSGPPALPPPPAADIQPPPIRRAKTKEGKGPGHKRRSKSPRVPDGRKKLRGKKMAPLKIKLGLLGG
KRKKGGSVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:7797253/chr17:56787220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHD3

Q12873

.
FUNCTION: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones (PubMed:9804427, PubMed:30397230). Involved in transcriptional repressiobn as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:27068747, ECO:0000269|PubMed:30397230, ECO:0000269|PubMed:9804427}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640206_221308.02001.0Compositional biasNote=Poly-Ala
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640243_246308.02001.0Compositional biasNote=Poly-Pro
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639206_221308.01967.0Compositional biasNote=Poly-Ala
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639243_246308.01967.0Compositional biasNote=Poly-Pro
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640206_221367.02060.0Compositional biasNote=Poly-Ala
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640243_246367.02060.0Compositional biasNote=Poly-Pro
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640355_358367.02060.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640206_221308.02001.0Compositional biasNote=Poly-Ala
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640243_246308.02001.0Compositional biasNote=Poly-Pro
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639206_221308.01967.0Compositional biasNote=Poly-Ala
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639243_246308.01967.0Compositional biasNote=Poly-Pro
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640206_221367.02060.0Compositional biasNote=Poly-Ala
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640243_246367.02060.0Compositional biasNote=Poly-Pro
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640355_358367.02060.0Compositional biasNote=Poly-Lys
TgeneRAD51Cchr17:7797253chr17:56787219ENST0000033743239366_370235.0377.0MotifNuclear localization signal
TgeneRAD51Cchr17:7797253chr17:56787219ENST0000042178202366_3700136.0MotifNuclear localization signal
TgeneRAD51Cchr17:7797253chr17:56787220ENST0000033743239366_370235.0377.0MotifNuclear localization signal
TgeneRAD51Cchr17:7797253chr17:56787220ENST0000042178202366_3700136.0MotifNuclear localization signal
TgeneRAD51Cchr17:7797253chr17:56787219ENST0000042178202125_1320136.0Nucleotide bindingATP
TgeneRAD51Cchr17:7797253chr17:56787220ENST0000042178202125_1320136.0Nucleotide bindingATP
TgeneRAD51Cchr17:7797253chr17:56787219ENST00000421782021_1260136.0RegionNote=Required for Holliday junction resolution activity
TgeneRAD51Cchr17:7797253chr17:56787220ENST00000421782021_1260136.0RegionNote=Required for Holliday junction resolution activity

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640355_358308.02001.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640434_446308.02001.0Compositional biasNote=Poly-Glu
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640697_703308.02001.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639355_358308.01967.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639434_446308.01967.0Compositional biasNote=Poly-Glu
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639697_703308.01967.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640434_446367.02060.0Compositional biasNote=Poly-Glu
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640697_703367.02060.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640355_358308.02001.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640434_446308.02001.0Compositional biasNote=Poly-Glu
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640697_703308.02001.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639355_358308.01967.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639434_446308.01967.0Compositional biasNote=Poly-Glu
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639697_703308.01967.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640434_446367.02060.0Compositional biasNote=Poly-Glu
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640697_703367.02060.0Compositional biasNote=Poly-Lys
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+6401064_1229308.02001.0DomainHelicase C-terminal
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640494_594308.02001.0DomainChromo 1
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640631_673308.02001.0DomainChromo 2
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640748_932308.02001.0DomainHelicase ATP-binding
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+6391064_1229308.01967.0DomainHelicase C-terminal
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639494_594308.01967.0DomainChromo 1
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639631_673308.01967.0DomainChromo 2
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639748_932308.01967.0DomainHelicase ATP-binding
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+6401064_1229367.02060.0DomainHelicase C-terminal
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640494_594367.02060.0DomainChromo 1
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640631_673367.02060.0DomainChromo 2
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640748_932367.02060.0DomainHelicase ATP-binding
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+6401064_1229308.02001.0DomainHelicase C-terminal
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640494_594308.02001.0DomainChromo 1
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640631_673308.02001.0DomainChromo 2
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640748_932308.02001.0DomainHelicase ATP-binding
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+6391064_1229308.01967.0DomainHelicase C-terminal
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639494_594308.01967.0DomainChromo 1
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639631_673308.01967.0DomainChromo 2
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639748_932308.01967.0DomainHelicase ATP-binding
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+6401064_1229367.02060.0DomainHelicase C-terminal
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640494_594367.02060.0DomainChromo 1
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640631_673367.02060.0DomainChromo 2
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640748_932367.02060.0DomainHelicase ATP-binding
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640883_886308.02001.0MotifNote=DEAH box
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639883_886308.01967.0MotifNote=DEAH box
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640883_886367.02060.0MotifNote=DEAH box
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640883_886308.02001.0MotifNote=DEAH box
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639883_886308.01967.0MotifNote=DEAH box
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640883_886367.02060.0MotifNote=DEAH box
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640761_768308.02001.0Nucleotide bindingATP
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639761_768308.01967.0Nucleotide bindingATP
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640761_768367.02060.0Nucleotide bindingATP
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640761_768308.02001.0Nucleotide bindingATP
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639761_768308.01967.0Nucleotide bindingATP
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640761_768367.02060.0Nucleotide bindingATP
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640379_426308.02001.0Zinc fingerPHD-type 1
HgeneCHD3chr17:7797253chr17:56787219ENST00000330494+640456_503308.02001.0Zinc fingerPHD-type 2
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639379_426308.01967.0Zinc fingerPHD-type 1
HgeneCHD3chr17:7797253chr17:56787219ENST00000358181+639456_503308.01967.0Zinc fingerPHD-type 2
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640379_426367.02060.0Zinc fingerPHD-type 1
HgeneCHD3chr17:7797253chr17:56787219ENST00000380358+640456_503367.02060.0Zinc fingerPHD-type 2
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640379_426308.02001.0Zinc fingerPHD-type 1
HgeneCHD3chr17:7797253chr17:56787220ENST00000330494+640456_503308.02001.0Zinc fingerPHD-type 2
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639379_426308.01967.0Zinc fingerPHD-type 1
HgeneCHD3chr17:7797253chr17:56787220ENST00000358181+639456_503308.01967.0Zinc fingerPHD-type 2
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640379_426367.02060.0Zinc fingerPHD-type 1
HgeneCHD3chr17:7797253chr17:56787220ENST00000380358+640456_503367.02060.0Zinc fingerPHD-type 2
TgeneRAD51Cchr17:7797253chr17:56787219ENST0000033743239125_132235.0377.0Nucleotide bindingATP
TgeneRAD51Cchr17:7797253chr17:56787220ENST0000033743239125_132235.0377.0Nucleotide bindingATP
TgeneRAD51Cchr17:7797253chr17:56787219ENST00000337432391_126235.0377.0RegionNote=Required for Holliday junction resolution activity
TgeneRAD51Cchr17:7797253chr17:56787220ENST00000337432391_126235.0377.0RegionNote=Required for Holliday junction resolution activity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CHD3
RAD51C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRAD51Cchr17:7797253chr17:56787219ENST000003374323979_136235.0377.0RAD51B%2C RAD51D and XRCC3
TgeneRAD51Cchr17:7797253chr17:56787220ENST000003374323979_136235.0377.0RAD51B%2C RAD51D and XRCC3


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Related Drugs to CHD3-RAD51C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CHD3-RAD51C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource