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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CHD4-FYTTD1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CHD4-FYTTD1
FusionPDB ID: 16326
FusionGDB2.0 ID: 16326
HgeneTgene
Gene symbol

CHD4

FYTTD1

Gene ID

1108

84248

Gene namechromodomain helicase DNA binding protein 4forty-two-three domain containing 1
SynonymsCHD-4|Mi-2b|Mi2-BETA|SIHIWESUIF
Cytomap

12p13.31

3q29

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 4ATP-dependent helicase CHD4Mi-2 autoantigen 218 kDa proteinUAP56-interacting factorforty-two-three domain-containing protein 1protein 40-2-3
Modification date2020031320200313
UniProtAcc

Q14839

Q96QD9

Ensembl transtripts involved in fusion geneENST idsENST00000309577, ENST00000357008, 
ENST00000544040, ENST00000544484, 
ENST00000540960, 		ENST00000492360, 
ENST00000241502, ENST00000415708, 
ENST00000424384, ENST00000428395, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 21 X 8=235210 X 10 X 6=600
# samples 2011
** MAII scorelog2(20/2352*10)=-3.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/600*10)=-2.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CHD4 [Title/Abstract] AND FYTTD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CHD4(6710814)-FYTTD1(197501020), # samples:1
Anticipated loss of major functional domain due to fusion event.CHD4-FYTTD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD4-FYTTD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD4-FYTTD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD4-FYTTD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CHD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FYTTD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-5415-01ACHD4chr12

6710814

-FYTTD1chr3

197501020

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544484CHD4chr126710814-ENST00000415708FYTTD1chr3197501020+1283695114710198
ENST00000544484CHD4chr126710814-ENST00000428395FYTTD1chr3197501020+3595695114710198
ENST00000544484CHD4chr126710814-ENST00000241502FYTTD1chr3197501020+6745695114710198
ENST00000544484CHD4chr126710814-ENST00000424384FYTTD1chr3197501020+1529695114710198
ENST00000357008CHD4chr126710814-ENST00000415708FYTTD1chr3197501020+1309721131736201
ENST00000357008CHD4chr126710814-ENST00000428395FYTTD1chr3197501020+3621721131736201
ENST00000357008CHD4chr126710814-ENST00000241502FYTTD1chr3197501020+6771721131736201
ENST00000357008CHD4chr126710814-ENST00000424384FYTTD1chr3197501020+1555721131736201
ENST00000309577CHD4chr126710814-ENST00000415708FYTTD1chr3197501020+1309721131736201
ENST00000309577CHD4chr126710814-ENST00000428395FYTTD1chr3197501020+3621721131736201
ENST00000309577CHD4chr126710814-ENST00000241502FYTTD1chr3197501020+6771721131736201
ENST00000309577CHD4chr126710814-ENST00000424384FYTTD1chr3197501020+1555721131736201
ENST00000544040CHD4chr126710814-ENST00000415708FYTTD1chr3197501020+1327739170754194
ENST00000544040CHD4chr126710814-ENST00000428395FYTTD1chr3197501020+3639739170754194
ENST00000544040CHD4chr126710814-ENST00000241502FYTTD1chr3197501020+6789739170754194
ENST00000544040CHD4chr126710814-ENST00000424384FYTTD1chr3197501020+1573739170754194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544484ENST00000415708CHD4chr126710814-FYTTD1chr3197501020+0.0020892860.9979107
ENST00000544484ENST00000428395CHD4chr126710814-FYTTD1chr3197501020+0.0003841530.9996158
ENST00000544484ENST00000241502CHD4chr126710814-FYTTD1chr3197501020+0.000385940.99961406
ENST00000544484ENST00000424384CHD4chr126710814-FYTTD1chr3197501020+0.0011036810.99889624
ENST00000357008ENST00000415708CHD4chr126710814-FYTTD1chr3197501020+0.00136880.9986312
ENST00000357008ENST00000428395CHD4chr126710814-FYTTD1chr3197501020+0.0002533420.9997466
ENST00000357008ENST00000241502CHD4chr126710814-FYTTD1chr3197501020+0.0002576410.9997423
ENST00000357008ENST00000424384CHD4chr126710814-FYTTD1chr3197501020+0.0007771260.9992229
ENST00000309577ENST00000415708CHD4chr126710814-FYTTD1chr3197501020+0.00136880.9986312
ENST00000309577ENST00000428395CHD4chr126710814-FYTTD1chr3197501020+0.0002533420.9997466
ENST00000309577ENST00000241502CHD4chr126710814-FYTTD1chr3197501020+0.0002576410.9997423
ENST00000309577ENST00000424384CHD4chr126710814-FYTTD1chr3197501020+0.0007771260.9992229
ENST00000544040ENST00000415708CHD4chr126710814-FYTTD1chr3197501020+0.0018073430.9981926
ENST00000544040ENST00000428395CHD4chr126710814-FYTTD1chr3197501020+0.0003416320.99965835
ENST00000544040ENST00000241502CHD4chr126710814-FYTTD1chr3197501020+0.0003417360.9996582
ENST00000544040ENST00000424384CHD4chr126710814-FYTTD1chr3197501020+0.0010466970.9989532

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>16326_16326_1_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000309577_FYTTD1_chr3_197501020_ENST00000241502_length(amino acids)=201AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLC
RQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSE

--------------------------------------------------------------

>16326_16326_2_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000309577_FYTTD1_chr3_197501020_ENST00000415708_length(amino acids)=201AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLC
RQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSE

--------------------------------------------------------------

>16326_16326_3_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000309577_FYTTD1_chr3_197501020_ENST00000424384_length(amino acids)=201AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLC
RQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSE

--------------------------------------------------------------

>16326_16326_4_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000309577_FYTTD1_chr3_197501020_ENST00000428395_length(amino acids)=201AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLC
RQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSE

--------------------------------------------------------------

>16326_16326_5_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000357008_FYTTD1_chr3_197501020_ENST00000241502_length(amino acids)=201AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLC
RQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSE

--------------------------------------------------------------

>16326_16326_6_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000357008_FYTTD1_chr3_197501020_ENST00000415708_length(amino acids)=201AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLC
RQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSE

--------------------------------------------------------------

>16326_16326_7_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000357008_FYTTD1_chr3_197501020_ENST00000424384_length(amino acids)=201AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLC
RQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSE

--------------------------------------------------------------

>16326_16326_8_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000357008_FYTTD1_chr3_197501020_ENST00000428395_length(amino acids)=201AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLC
RQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSE

--------------------------------------------------------------

>16326_16326_9_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000544040_FYTTD1_chr3_197501020_ENST00000241502_length(amino acids)=194AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKELGDSS
GEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLT

--------------------------------------------------------------

>16326_16326_10_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000544040_FYTTD1_chr3_197501020_ENST00000415708_length(amino acids)=194AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKELGDSS
GEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLT

--------------------------------------------------------------

>16326_16326_11_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000544040_FYTTD1_chr3_197501020_ENST00000424384_length(amino acids)=194AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKELGDSS
GEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLT

--------------------------------------------------------------

>16326_16326_12_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000544040_FYTTD1_chr3_197501020_ENST00000428395_length(amino acids)=194AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKELGDSS
GEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLT

--------------------------------------------------------------

>16326_16326_13_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000544484_FYTTD1_chr3_197501020_ENST00000241502_length(amino acids)=198AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLCRQL
GDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDY

--------------------------------------------------------------

>16326_16326_14_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000544484_FYTTD1_chr3_197501020_ENST00000415708_length(amino acids)=198AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLCRQL
GDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDY

--------------------------------------------------------------

>16326_16326_15_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000544484_FYTTD1_chr3_197501020_ENST00000424384_length(amino acids)=198AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLCRQL
GDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDY

--------------------------------------------------------------

>16326_16326_16_CHD4-FYTTD1_CHD4_chr12_6710814_ENST00000544484_FYTTD1_chr3_197501020_ENST00000428395_length(amino acids)=198AA_BP=
MGQFPGRERKGMASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPEDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQKKERMLLCRQL
GDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6710814/chr3:197501020)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHD4

Q14839

FYTTD1

Q96QD9

FUNCTION: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}.FUNCTION: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269|PubMed:19836239}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539114_119185.666666666666661941.0Compositional biasNote=Poly-Lys
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539134_138185.666666666666661941.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539139_144185.666666666666661941.0Compositional biasNote=Poly-Asp
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-53950_59185.666666666666661941.0Compositional biasNote=Poly-Lys
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-53994_98185.666666666666661941.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540114_119185.666666666666661913.0Compositional biasNote=Poly-Lys
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540134_138185.666666666666661913.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540139_144185.666666666666661913.0Compositional biasNote=Poly-Asp
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-54050_59185.666666666666661913.0Compositional biasNote=Poly-Lys
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-54094_98185.666666666666661913.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539114_119182.666666666666661938.0Compositional biasNote=Poly-Lys
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539134_138182.666666666666661938.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539139_144182.666666666666661938.0Compositional biasNote=Poly-Asp
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-53950_59182.666666666666661938.0Compositional biasNote=Poly-Lys
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-53994_98182.666666666666661938.0Compositional biasNote=Poly-Glu

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-5391052_1055185.666666666666661941.0Compositional biasNote=Poly-Leu
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-5391294_1301185.666666666666661941.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-5391665_1668185.666666666666661941.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539227_235185.666666666666661941.0Compositional biasNote=Poly-Ala
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539248_252185.666666666666661941.0Compositional biasNote=Poly-Pro
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539350_354185.666666666666661941.0Compositional biasNote=Poly-Lys
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-5401052_1055185.666666666666661913.0Compositional biasNote=Poly-Leu
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-5401294_1301185.666666666666661913.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-5401665_1668185.666666666666661913.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540227_235185.666666666666661913.0Compositional biasNote=Poly-Ala
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540248_252185.666666666666661913.0Compositional biasNote=Poly-Pro
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540350_354185.666666666666661913.0Compositional biasNote=Poly-Lys
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-5391052_1055182.666666666666661938.0Compositional biasNote=Poly-Leu
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-5391294_1301182.666666666666661938.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-5391665_1668182.666666666666661938.0Compositional biasNote=Poly-Glu
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539227_235182.666666666666661938.0Compositional biasNote=Poly-Ala
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539248_252182.666666666666661938.0Compositional biasNote=Poly-Pro
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539350_354182.666666666666661938.0Compositional biasNote=Poly-Lys
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-5391054_1203185.666666666666661941.0DomainHelicase C-terminal
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539494_594185.666666666666661941.0DomainChromo 1
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539622_697185.666666666666661941.0DomainChromo 2
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539738_922185.666666666666661941.0DomainHelicase ATP-binding
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-5401054_1203185.666666666666661913.0DomainHelicase C-terminal
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540494_594185.666666666666661913.0DomainChromo 1
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540622_697185.666666666666661913.0DomainChromo 2
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540738_922185.666666666666661913.0DomainHelicase ATP-binding
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-5391054_1203182.666666666666661938.0DomainHelicase C-terminal
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539494_594182.666666666666661938.0DomainChromo 1
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539622_697182.666666666666661938.0DomainChromo 2
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539738_922182.666666666666661938.0DomainHelicase ATP-binding
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539873_876185.666666666666661941.0MotifNote=DEAH box
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540873_876185.666666666666661913.0MotifNote=DEAH box
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539873_876182.666666666666661938.0MotifNote=DEAH box
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539751_758185.666666666666661941.0Nucleotide bindingATP
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540751_758185.666666666666661913.0Nucleotide bindingATP
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539751_758182.666666666666661938.0Nucleotide bindingATP
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539370_417185.666666666666661941.0Zinc fingerPHD-type 1
HgeneCHD4chr12:6710814chr3:197501020ENST00000309577-539449_496185.666666666666661941.0Zinc fingerPHD-type 2
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540370_417185.666666666666661913.0Zinc fingerPHD-type 1
HgeneCHD4chr12:6710814chr3:197501020ENST00000357008-540449_496185.666666666666661913.0Zinc fingerPHD-type 2
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539370_417182.666666666666661938.0Zinc fingerPHD-type 1
HgeneCHD4chr12:6710814chr3:197501020ENST00000544484-539449_496182.666666666666661938.0Zinc fingerPHD-type 2
TgeneFYTTD1chr12:6710814chr3:197501020ENST000002415024926_44198.0319.0MotifNote=UAP56-binding motif
TgeneFYTTD1chr12:6710814chr3:197501020ENST0000041570851026_44172.0293.0MotifNote=UAP56-binding motif
TgeneFYTTD1chr12:6710814chr3:197501020ENST000004243844926_44131.0252.0MotifNote=UAP56-binding motif


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CHD4
FYTTD1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CHD4-FYTTD1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CHD4-FYTTD1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource