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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CHD9-CDH11

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CHD9-CDH11
FusionPDB ID: 16402
FusionGDB2.0 ID: 16402
HgeneTgene
Gene symbol

CHD9

CDH11

Gene ID

80205

1009

Gene namechromodomain helicase DNA binding protein 9cadherin 11
SynonymsAD013|CHD-9|CReMM|KISH2|PRIC320CAD11|CDHOB|ESWS|OB|OSF-4
Cytomap

16q12.2

16q21

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 9ATP-dependent helicase CHD9PPAR-alpha-interacting complex protein 320 kDaPPAR{gamma}-interacting cofactor 320 kDachromatin remodeling factor CHROM1chromatin-related mesenchymal modulatorciprofibrate bound pcadherin-11cadherin 11, type 2, OB-cadherin (osteoblast)
Modification date2020032020200313
UniProtAcc

Q3L8U1

P55287

Ensembl transtripts involved in fusion geneENST idsENST00000398510, ENST00000447540, 
ENST00000564845, ENST00000566029, 
ENST00000564582, 		ENST00000566827, 
ENST00000569624, ENST00000268603, 
ENST00000394156, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 9 X 6=7025 X 5 X 4=100
# samples 135
** MAII scorelog2(13/702*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CHD9 [Title/Abstract] AND CDH11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CHD9(53191453)-CDH11(65032759), # samples:1
Anticipated loss of major functional domain due to fusion event.CHD9-CDH11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD9-CDH11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD9-CDH11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CHD9-CDH11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CHD9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDH11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-HZ-A4BKCHD9chr16

53191453

+CDH11chr16

65032759

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000447540CHD9chr1653191453+ENST00000394156CDH11chr1665032759-7853166120935141101
ENST00000447540CHD9chr1653191453+ENST00000268603CDH11chr1665032759-7674166120938231204
ENST00000566029CHD9chr1653191453+ENST00000394156CDH11chr1665032759-7853166120935141101
ENST00000566029CHD9chr1653191453+ENST00000268603CDH11chr1665032759-7674166120938231204
ENST00000564845CHD9chr1653191453+ENST00000394156CDH11chr1665032759-7946175430236071101
ENST00000564845CHD9chr1653191453+ENST00000268603CDH11chr1665032759-7767175430239161204
ENST00000398510CHD9chr1653191453+ENST00000394156CDH11chr1665032759-773115398733921101
ENST00000398510CHD9chr1653191453+ENST00000268603CDH11chr1665032759-755215398737011204

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000447540ENST00000394156CHD9chr1653191453+CDH11chr1665032759-0.0001789380.9998211
ENST00000447540ENST00000268603CHD9chr1653191453+CDH11chr1665032759-0.0003360670.99966395
ENST00000566029ENST00000394156CHD9chr1653191453+CDH11chr1665032759-0.0001789380.9998211
ENST00000566029ENST00000268603CHD9chr1653191453+CDH11chr1665032759-0.0003360670.99966395
ENST00000564845ENST00000394156CHD9chr1653191453+CDH11chr1665032759-0.0001954560.99980456
ENST00000564845ENST00000268603CHD9chr1653191453+CDH11chr1665032759-0.0003681450.9996319
ENST00000398510ENST00000394156CHD9chr1653191453+CDH11chr1665032759-0.0001553790.99984455
ENST00000398510ENST00000268603CHD9chr1653191453+CDH11chr1665032759-0.0002913950.9997086

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>16402_16402_1_CHD9-CDH11_CHD9_chr16_53191453_ENST00000398510_CDH11_chr16_65032759_ENST00000268603_length(amino acids)=1204AA_BP=483
MTDPMMDFFDDANLFGETLEGLSDDAFVQPGPVSLVDELNLGAEFEPLHIDSLNHVQGTPTHQKMTDFEQLNQFDSIKFHHVNQSFGSPA
EHVLSPHSQFNCSPIHPQNQPNGLFPDVSDGSPMWGHQTATTISNQNGSPFHQQGHSHSMHQNKSFVAHHDFALFQANEQQTQCTSLRSQ
QNRNNLNPGQNSLSQSKNFMNVSGPHRVNVNHPPQMTNASNSQQSISMQQFSQTSNPSAHFHKCSSHQEGNFNGPSPNMTSCSVSNSQQF
SSHYSFSSNHISPNSLLQSSAVLASNHTNQTLSDFTGSNSFSPHRGIKQESTQHILNPNTSLNSNNFQILHSSHPQGNYSNSKLSPVHMN
FPDPVDSGTQMGHFNDHVETNGFSSLEENLLHQVESQTEPFTGLDPEDLLQEGLLPHFDESTFGQDNSSHILDHDLDRQFTSHLVTRPSD
MAQTQLQSQARSWHSSFSNHQHLHDRNHLCLQRQLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD
RDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALP
NMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDG
MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVV
GRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPY
EGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPM
SSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEED
TEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESAT

--------------------------------------------------------------

>16402_16402_2_CHD9-CDH11_CHD9_chr16_53191453_ENST00000398510_CDH11_chr16_65032759_ENST00000394156_length(amino acids)=1101AA_BP=483
MTDPMMDFFDDANLFGETLEGLSDDAFVQPGPVSLVDELNLGAEFEPLHIDSLNHVQGTPTHQKMTDFEQLNQFDSIKFHHVNQSFGSPA
EHVLSPHSQFNCSPIHPQNQPNGLFPDVSDGSPMWGHQTATTISNQNGSPFHQQGHSHSMHQNKSFVAHHDFALFQANEQQTQCTSLRSQ
QNRNNLNPGQNSLSQSKNFMNVSGPHRVNVNHPPQMTNASNSQQSISMQQFSQTSNPSAHFHKCSSHQEGNFNGPSPNMTSCSVSNSQQF
SSHYSFSSNHISPNSLLQSSAVLASNHTNQTLSDFTGSNSFSPHRGIKQESTQHILNPNTSLNSNNFQILHSSHPQGNYSNSKLSPVHMN
FPDPVDSGTQMGHFNDHVETNGFSSLEENLLHQVESQTEPFTGLDPEDLLQEGLLPHFDESTFGQDNSSHILDHDLDRQFTSHLVTRPSD
MAQTQLQSQARSWHSSFSNHQHLHDRNHLCLQRQLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD
RDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALP
NMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDG
MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVV
GRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPY
EGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPM
SSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGV

--------------------------------------------------------------

>16402_16402_3_CHD9-CDH11_CHD9_chr16_53191453_ENST00000447540_CDH11_chr16_65032759_ENST00000268603_length(amino acids)=1204AA_BP=483
MTDPMMDFFDDANLFGETLEGLSDDAFVQPGPVSLVDELNLGAEFEPLHIDSLNHVQGTPTHQKMTDFEQLNQFDSIKFHHVNQSFGSPA
EHVLSPHSQFNCSPIHPQNQPNGLFPDVSDGSPMWGHQTATTISNQNGSPFHQQGHSHSMHQNKSFVAHHDFALFQANEQQTQCTSLRSQ
QNRNNLNPGQNSLSQSKNFMNVSGPHRVNVNHPPQMTNASNSQQSISMQQFSQTSNPSAHFHKCSSHQEGNFNGPSPNMTSCSVSNSQQF
SSHYSFSSNHISPNSLLQSSAVLASNHTNQTLSDFTGSNSFSPHRGIKQESTQHILNPNTSLNSNNFQILHSSHPQGNYSNSKLSPVHMN
FPDPVDSGTQMGHFNDHVETNGFSSLEENLLHQVESQTEPFTGLDPEDLLQEGLLPHFDESTFGQDNSSHILDHDLDRQFTSHLVTRPSD
MAQTQLQSQARSWHSSFSNHQHLHDRNHLCLQRQLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD
RDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALP
NMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDG
MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVV
GRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPY
EGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPM
SSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEED
TEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESAT

--------------------------------------------------------------

>16402_16402_4_CHD9-CDH11_CHD9_chr16_53191453_ENST00000447540_CDH11_chr16_65032759_ENST00000394156_length(amino acids)=1101AA_BP=483
MTDPMMDFFDDANLFGETLEGLSDDAFVQPGPVSLVDELNLGAEFEPLHIDSLNHVQGTPTHQKMTDFEQLNQFDSIKFHHVNQSFGSPA
EHVLSPHSQFNCSPIHPQNQPNGLFPDVSDGSPMWGHQTATTISNQNGSPFHQQGHSHSMHQNKSFVAHHDFALFQANEQQTQCTSLRSQ
QNRNNLNPGQNSLSQSKNFMNVSGPHRVNVNHPPQMTNASNSQQSISMQQFSQTSNPSAHFHKCSSHQEGNFNGPSPNMTSCSVSNSQQF
SSHYSFSSNHISPNSLLQSSAVLASNHTNQTLSDFTGSNSFSPHRGIKQESTQHILNPNTSLNSNNFQILHSSHPQGNYSNSKLSPVHMN
FPDPVDSGTQMGHFNDHVETNGFSSLEENLLHQVESQTEPFTGLDPEDLLQEGLLPHFDESTFGQDNSSHILDHDLDRQFTSHLVTRPSD
MAQTQLQSQARSWHSSFSNHQHLHDRNHLCLQRQLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD
RDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALP
NMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDG
MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVV
GRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPY
EGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPM
SSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGV

--------------------------------------------------------------

>16402_16402_5_CHD9-CDH11_CHD9_chr16_53191453_ENST00000564845_CDH11_chr16_65032759_ENST00000268603_length(amino acids)=1204AA_BP=483
MTDPMMDFFDDANLFGETLEGLSDDAFVQPGPVSLVDELNLGAEFEPLHIDSLNHVQGTPTHQKMTDFEQLNQFDSIKFHHVNQSFGSPA
EHVLSPHSQFNCSPIHPQNQPNGLFPDVSDGSPMWGHQTATTISNQNGSPFHQQGHSHSMHQNKSFVAHHDFALFQANEQQTQCTSLRSQ
QNRNNLNPGQNSLSQSKNFMNVSGPHRVNVNHPPQMTNASNSQQSISMQQFSQTSNPSAHFHKCSSHQEGNFNGPSPNMTSCSVSNSQQF
SSHYSFSSNHISPNSLLQSSAVLASNHTNQTLSDFTGSNSFSPHRGIKQESTQHILNPNTSLNSNNFQILHSSHPQGNYSNSKLSPVHMN
FPDPVDSGTQMGHFNDHVETNGFSSLEENLLHQVESQTEPFTGLDPEDLLQEGLLPHFDESTFGQDNSSHILDHDLDRQFTSHLVTRPSD
MAQTQLQSQARSWHSSFSNHQHLHDRNHLCLQRQLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD
RDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALP
NMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDG
MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVV
GRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPY
EGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPM
SSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEED
TEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESAT

--------------------------------------------------------------

>16402_16402_6_CHD9-CDH11_CHD9_chr16_53191453_ENST00000564845_CDH11_chr16_65032759_ENST00000394156_length(amino acids)=1101AA_BP=483
MTDPMMDFFDDANLFGETLEGLSDDAFVQPGPVSLVDELNLGAEFEPLHIDSLNHVQGTPTHQKMTDFEQLNQFDSIKFHHVNQSFGSPA
EHVLSPHSQFNCSPIHPQNQPNGLFPDVSDGSPMWGHQTATTISNQNGSPFHQQGHSHSMHQNKSFVAHHDFALFQANEQQTQCTSLRSQ
QNRNNLNPGQNSLSQSKNFMNVSGPHRVNVNHPPQMTNASNSQQSISMQQFSQTSNPSAHFHKCSSHQEGNFNGPSPNMTSCSVSNSQQF
SSHYSFSSNHISPNSLLQSSAVLASNHTNQTLSDFTGSNSFSPHRGIKQESTQHILNPNTSLNSNNFQILHSSHPQGNYSNSKLSPVHMN
FPDPVDSGTQMGHFNDHVETNGFSSLEENLLHQVESQTEPFTGLDPEDLLQEGLLPHFDESTFGQDNSSHILDHDLDRQFTSHLVTRPSD
MAQTQLQSQARSWHSSFSNHQHLHDRNHLCLQRQLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD
RDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALP
NMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDG
MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVV
GRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPY
EGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPM
SSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGV

--------------------------------------------------------------

>16402_16402_7_CHD9-CDH11_CHD9_chr16_53191453_ENST00000566029_CDH11_chr16_65032759_ENST00000268603_length(amino acids)=1204AA_BP=483
MTDPMMDFFDDANLFGETLEGLSDDAFVQPGPVSLVDELNLGAEFEPLHIDSLNHVQGTPTHQKMTDFEQLNQFDSIKFHHVNQSFGSPA
EHVLSPHSQFNCSPIHPQNQPNGLFPDVSDGSPMWGHQTATTISNQNGSPFHQQGHSHSMHQNKSFVAHHDFALFQANEQQTQCTSLRSQ
QNRNNLNPGQNSLSQSKNFMNVSGPHRVNVNHPPQMTNASNSQQSISMQQFSQTSNPSAHFHKCSSHQEGNFNGPSPNMTSCSVSNSQQF
SSHYSFSSNHISPNSLLQSSAVLASNHTNQTLSDFTGSNSFSPHRGIKQESTQHILNPNTSLNSNNFQILHSSHPQGNYSNSKLSPVHMN
FPDPVDSGTQMGHFNDHVETNGFSSLEENLLHQVESQTEPFTGLDPEDLLQEGLLPHFDESTFGQDNSSHILDHDLDRQFTSHLVTRPSD
MAQTQLQSQARSWHSSFSNHQHLHDRNHLCLQRQLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD
RDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALP
NMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDG
MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVV
GRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPY
EGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPM
SSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEED
TEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESAT

--------------------------------------------------------------

>16402_16402_8_CHD9-CDH11_CHD9_chr16_53191453_ENST00000566029_CDH11_chr16_65032759_ENST00000394156_length(amino acids)=1101AA_BP=483
MTDPMMDFFDDANLFGETLEGLSDDAFVQPGPVSLVDELNLGAEFEPLHIDSLNHVQGTPTHQKMTDFEQLNQFDSIKFHHVNQSFGSPA
EHVLSPHSQFNCSPIHPQNQPNGLFPDVSDGSPMWGHQTATTISNQNGSPFHQQGHSHSMHQNKSFVAHHDFALFQANEQQTQCTSLRSQ
QNRNNLNPGQNSLSQSKNFMNVSGPHRVNVNHPPQMTNASNSQQSISMQQFSQTSNPSAHFHKCSSHQEGNFNGPSPNMTSCSVSNSQQF
SSHYSFSSNHISPNSLLQSSAVLASNHTNQTLSDFTGSNSFSPHRGIKQESTQHILNPNTSLNSNNFQILHSSHPQGNYSNSKLSPVHMN
FPDPVDSGTQMGHFNDHVETNGFSSLEENLLHQVESQTEPFTGLDPEDLLQEGLLPHFDESTFGQDNSSHILDHDLDRQFTSHLVTRPSD
MAQTQLQSQARSWHSSFSNHQHLHDRNHLCLQRQLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVD
RDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALP
NMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDG
MESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVV
GRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPY
EGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPM
SSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:53191453/chr16:65032759)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHD9

Q3L8U1

CDH11

P55287

FUNCTION: Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+138220_312484.02898.0Compositional biasNote=Ser-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+239220_312484.02883.0Compositional biasNote=Ser-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+239220_312484.02882.0Compositional biasNote=Ser-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+239220_312484.02882.0Compositional biasNote=Ser-rich
TgeneCDH11chr16:53191453chr16:65032759ENST00000268603213160_26876.0797.0DomainCadherin 2
TgeneCDH11chr16:53191453chr16:65032759ENST00000268603213269_38376.0797.0DomainCadherin 3
TgeneCDH11chr16:53191453chr16:65032759ENST00000268603213384_48676.0797.0DomainCadherin 4
TgeneCDH11chr16:53191453chr16:65032759ENST00000268603213487_61276.0797.0DomainCadherin 5
TgeneCDH11chr16:53191453chr16:65032759ENST00000394156214160_26876.0694.0DomainCadherin 2
TgeneCDH11chr16:53191453chr16:65032759ENST00000394156214269_38376.0694.0DomainCadherin 3
TgeneCDH11chr16:53191453chr16:65032759ENST00000394156214384_48676.0694.0DomainCadherin 4
TgeneCDH11chr16:53191453chr16:65032759ENST00000394156214487_61276.0694.0DomainCadherin 5
TgeneCDH11chr16:53191453chr16:65032759ENST00000268603213641_79676.0797.0Topological domainCytoplasmic
TgeneCDH11chr16:53191453chr16:65032759ENST00000394156214641_79676.0694.0Topological domainCytoplasmic
TgeneCDH11chr16:53191453chr16:65032759ENST00000268603213618_64076.0797.0TransmembraneHelical
TgeneCDH11chr16:53191453chr16:65032759ENST00000394156214618_64076.0694.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1382128_2198484.02898.0Compositional biasNote=Ser-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1382639_2650484.02898.0Compositional biasNote=Poly-Ala
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1382785_2788484.02898.0Compositional biasNote=Poly-Ala
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1382878_2888484.02898.0Compositional biasNote=Poly-Ser
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+138562_666484.02898.0Compositional biasNote=Lys-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2392128_2198484.02883.0Compositional biasNote=Ser-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2392639_2650484.02883.0Compositional biasNote=Poly-Ala
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2392785_2788484.02883.0Compositional biasNote=Poly-Ala
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2392878_2888484.02883.0Compositional biasNote=Poly-Ser
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+239562_666484.02883.0Compositional biasNote=Lys-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2392128_2198484.02882.0Compositional biasNote=Ser-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2392639_2650484.02882.0Compositional biasNote=Poly-Ala
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2392785_2788484.02882.0Compositional biasNote=Poly-Ala
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2392878_2888484.02882.0Compositional biasNote=Poly-Ser
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+239562_666484.02882.0Compositional biasNote=Lys-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2392128_2198484.02882.0Compositional biasNote=Ser-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2392639_2650484.02882.0Compositional biasNote=Poly-Ala
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2392785_2788484.02882.0Compositional biasNote=Poly-Ala
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2392878_2888484.02882.0Compositional biasNote=Poly-Ser
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+239562_666484.02882.0Compositional biasNote=Lys-rich
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1381186_1337484.02898.0DomainHelicase C-terminal
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+138690_761484.02898.0DomainChromo 1
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+138773_839484.02898.0DomainChromo 2
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+138872_1046484.02898.0DomainHelicase ATP-binding
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2391186_1337484.02883.0DomainHelicase C-terminal
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+239690_761484.02883.0DomainChromo 1
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+239773_839484.02883.0DomainChromo 2
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+239872_1046484.02883.0DomainHelicase ATP-binding
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2391186_1337484.02882.0DomainHelicase C-terminal
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+239690_761484.02882.0DomainChromo 1
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+239773_839484.02882.0DomainChromo 2
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+239872_1046484.02882.0DomainHelicase ATP-binding
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2391186_1337484.02882.0DomainHelicase C-terminal
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+239690_761484.02882.0DomainChromo 1
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+239773_839484.02882.0DomainChromo 2
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+239872_1046484.02882.0DomainHelicase ATP-binding
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1381036_1040484.02898.0MotifNote=LXXLL motif 2
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1382031_2035484.02898.0MotifNote=LXXLL motif 3
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1382721_2725484.02898.0MotifNote=LXXLL motif 4
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1382793_2798484.02898.0MotifNote=LXXLL motif 5
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+138868_872484.02898.0MotifNote=LXXLL motif 1
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+138997_1000484.02898.0MotifNote=DEAH box
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2391036_1040484.02883.0MotifNote=LXXLL motif 2
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2392031_2035484.02883.0MotifNote=LXXLL motif 3
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2392721_2725484.02883.0MotifNote=LXXLL motif 4
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2392793_2798484.02883.0MotifNote=LXXLL motif 5
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+239868_872484.02883.0MotifNote=LXXLL motif 1
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+239997_1000484.02883.0MotifNote=DEAH box
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2391036_1040484.02882.0MotifNote=LXXLL motif 2
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2392031_2035484.02882.0MotifNote=LXXLL motif 3
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2392721_2725484.02882.0MotifNote=LXXLL motif 4
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2392793_2798484.02882.0MotifNote=LXXLL motif 5
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+239868_872484.02882.0MotifNote=LXXLL motif 1
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+239997_1000484.02882.0MotifNote=DEAH box
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2391036_1040484.02882.0MotifNote=LXXLL motif 2
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2392031_2035484.02882.0MotifNote=LXXLL motif 3
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2392721_2725484.02882.0MotifNote=LXXLL motif 4
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2392793_2798484.02882.0MotifNote=LXXLL motif 5
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+239868_872484.02882.0MotifNote=LXXLL motif 1
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+239997_1000484.02882.0MotifNote=DEAH box
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+138885_892484.02898.0Nucleotide bindingATP
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+239885_892484.02883.0Nucleotide bindingATP
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+239885_892484.02882.0Nucleotide bindingATP
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+239885_892484.02882.0Nucleotide bindingATP
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1382332_2481484.02898.0RegionNote=Binds A/T-rich DNA
HgeneCHD9chr16:53191453chr16:65032759ENST00000398510+1382429_2436484.02898.0RegionNote=A.T hook-like
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2392332_2481484.02883.0RegionNote=Binds A/T-rich DNA
HgeneCHD9chr16:53191453chr16:65032759ENST00000447540+2392429_2436484.02883.0RegionNote=A.T hook-like
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2392332_2481484.02882.0RegionNote=Binds A/T-rich DNA
HgeneCHD9chr16:53191453chr16:65032759ENST00000564845+2392429_2436484.02882.0RegionNote=A.T hook-like
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2392332_2481484.02882.0RegionNote=Binds A/T-rich DNA
HgeneCHD9chr16:53191453chr16:65032759ENST00000566029+2392429_2436484.02882.0RegionNote=A.T hook-like
TgeneCDH11chr16:53191453chr16:65032759ENST0000026860321354_15976.0797.0DomainCadherin 1
TgeneCDH11chr16:53191453chr16:65032759ENST0000039415621454_15976.0694.0DomainCadherin 1
TgeneCDH11chr16:53191453chr16:65032759ENST0000026860321354_61776.0797.0Topological domainExtracellular
TgeneCDH11chr16:53191453chr16:65032759ENST0000039415621454_61776.0694.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CHD9
CDH11


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CHD9-CDH11


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CHD9-CDH11


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource