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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABCA1-KCNMA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCA1-KCNMA1
FusionPDB ID: 166
FusionGDB2.0 ID: 166
HgeneTgene
Gene symbol

ABCA1

KCNMA1

Gene ID

19

3778

Gene nameATP binding cassette subfamily A member 1potassium calcium-activated channel subfamily M alpha 1
SynonymsABC-1|ABC1|CERP|HDLCQTL13|HDLDT1|HPALP1|TGDBKTM|CADEDS|IEG16|KCa1.1|LIWAS|MaxiK|PNKD3|SAKCA|SLO|SLO-ALPHA|SLO1|bA205K10.1|hSlo|mSLO1
Cytomap

9q31.1

10q22.3

Type of geneprotein-codingprotein-coding
Descriptionphospholipid-transporting ATPase ABCA1ATP-binding cassette sub-family A member 1ATP-binding cassette transporter A1ATP-binding cassette, sub-family A (ABC1), member 1cholesterol efflux regulatory proteinmembrane-boundcalcium-activated potassium channel subunit alpha-1uncharacterized proteinBK channel alpha subunitBKCA alpha subunitbig potassium channel alpha subunitcalcium-activated potassium channel, subfamily M subunit alpha-1k(VCA)alphamaxi-K channel HSLOpo
Modification date2020031320200315
UniProtAcc

Q86UQ4

Q12791

Ensembl transtripts involved in fusion geneENST idsENST00000374736, ENST00000423487, 
ENST00000374733, ENST00000494467, 
ENST00000480683, ENST00000481070, 
ENST00000484507, ENST00000286627, 
ENST00000286628, ENST00000354353, 
ENST00000372440, ENST00000372443, 
ENST00000404771, ENST00000404857, 
ENST00000406533, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 9 X 9=105318 X 17 X 8=2448
# samples 1321
** MAII scorelog2(13/1053*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2448*10)=-3.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCA1 [Title/Abstract] AND KCNMA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCA1(107665894)-KCNMA1(78850268), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCA1-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA1-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA1-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA1-KCNMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCA1

GO:0007040

lysosome organization

15163665

HgeneABCA1

GO:0008203

cholesterol metabolic process

14747463

HgeneABCA1

GO:0016197

endosomal transport

14747463

HgeneABCA1

GO:0033344

cholesterol efflux

10431236|11162594|16702602|23931754

HgeneABCA1

GO:0033700

phospholipid efflux

10431236|11162594

HgeneABCA1

GO:0042632

cholesterol homeostasis

10431236

HgeneABCA1

GO:0045332

phospholipid translocation

24097981

TgeneKCNMA1

GO:0001666

response to hypoxia

15528406

TgeneKCNMA1

GO:0006813

potassium ion transport

7573516|7877450|11245614|12388065|17706472|18458941

TgeneKCNMA1

GO:0006970

response to osmotic stress

10840032|12388065

TgeneKCNMA1

GO:0030007

cellular potassium ion homeostasis

11245614

TgeneKCNMA1

GO:0034465

response to carbon monoxide

15528406

TgeneKCNMA1

GO:0042391

regulation of membrane potential

7877450|7993625

TgeneKCNMA1

GO:0045794

negative regulation of cell volume

12388065

TgeneKCNMA1

GO:0051592

response to calcium ion

12388065|18458941

TgeneKCNMA1

GO:0060073

micturition

11641143

TgeneKCNMA1

GO:0060083

smooth muscle contraction involved in micturition

11641143


check buttonFusion gene breakpoints across ABCA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNMA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADB286350ABCA1chr9

107665894

-KCNMA1chr10

78850268

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374736ABCA1chr9107665894-ENST00000404771KCNMA1chr1078850268-32474614893104871
ENST00000374736ABCA1chr9107665894-ENST00000372440KCNMA1chr1078850268-30444614892771760
ENST00000374736ABCA1chr9107665894-ENST00000372443KCNMA1chr1078850268-31284614892855788
ENST00000374736ABCA1chr9107665894-ENST00000286628KCNMA1chr1078850268-53344614892948819
ENST00000374736ABCA1chr9107665894-ENST00000286627KCNMA1chr1078850268-51604614892774761
ENST00000374736ABCA1chr9107665894-ENST00000354353KCNMA1chr1078850268-29584614892957822
ENST00000374736ABCA1chr9107665894-ENST00000404857KCNMA1chr1078850268-28984614892897802
ENST00000374736ABCA1chr9107665894-ENST00000406533KCNMA1chr1078850268-29614614892960823
ENST00000423487ABCA1chr9107665894-ENST00000404771KCNMA1chr1078850268-31493633913006871
ENST00000423487ABCA1chr9107665894-ENST00000372440KCNMA1chr1078850268-29463633912673760
ENST00000423487ABCA1chr9107665894-ENST00000372443KCNMA1chr1078850268-30303633912757788
ENST00000423487ABCA1chr9107665894-ENST00000286628KCNMA1chr1078850268-52363633912850819
ENST00000423487ABCA1chr9107665894-ENST00000286627KCNMA1chr1078850268-50623633912676761
ENST00000423487ABCA1chr9107665894-ENST00000354353KCNMA1chr1078850268-28603633912859823
ENST00000423487ABCA1chr9107665894-ENST00000404857KCNMA1chr1078850268-28003633912799803
ENST00000423487ABCA1chr9107665894-ENST00000406533KCNMA1chr1078850268-28633633912862824

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374736ENST00000404771ABCA1chr9107665894-KCNMA1chr1078850268-0.0023656980.9976343
ENST00000374736ENST00000372440ABCA1chr9107665894-KCNMA1chr1078850268-0.0041055970.99589443
ENST00000374736ENST00000372443ABCA1chr9107665894-KCNMA1chr1078850268-0.0035674720.99643254
ENST00000374736ENST00000286628ABCA1chr9107665894-KCNMA1chr1078850268-0.0008144970.9991855
ENST00000374736ENST00000286627ABCA1chr9107665894-KCNMA1chr1078850268-0.0011948550.99880517
ENST00000374736ENST00000354353ABCA1chr9107665894-KCNMA1chr1078850268-0.0033423980.9966576
ENST00000374736ENST00000404857ABCA1chr9107665894-KCNMA1chr1078850268-0.0047168780.99528307
ENST00000374736ENST00000406533ABCA1chr9107665894-KCNMA1chr1078850268-0.0034057850.99659425
ENST00000423487ENST00000404771ABCA1chr9107665894-KCNMA1chr1078850268-0.0023496640.9976503
ENST00000423487ENST00000372440ABCA1chr9107665894-KCNMA1chr1078850268-0.0039381480.99606186
ENST00000423487ENST00000372443ABCA1chr9107665894-KCNMA1chr1078850268-0.0034435930.9965564
ENST00000423487ENST00000286628ABCA1chr9107665894-KCNMA1chr1078850268-0.0007973270.99920267
ENST00000423487ENST00000286627ABCA1chr9107665894-KCNMA1chr1078850268-0.0011452360.99885476
ENST00000423487ENST00000354353ABCA1chr9107665894-KCNMA1chr1078850268-0.0032502210.99674976
ENST00000423487ENST00000404857ABCA1chr9107665894-KCNMA1chr1078850268-0.004487650.9955123
ENST00000423487ENST00000406533ABCA1chr9107665894-KCNMA1chr1078850268-0.0033775850.99662244

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>166_166_1_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000374736_KCNMA1_chr10_78850268_ENST00000286627_length(amino acids)=761AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAM
TVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVI
LSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLD
QDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLAL
LDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHS

--------------------------------------------------------------

>166_166_2_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000374736_KCNMA1_chr10_78850268_ENST00000286628_length(amino acids)=819AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRN
SPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRAS
NFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDD
SIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLM
SATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGI
YRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDK

--------------------------------------------------------------

>166_166_3_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000374736_KCNMA1_chr10_78850268_ENST00000354353_length(amino acids)=822AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRRWEEHCSLWRLESKGNVRRLNYCRGQQTFSVKVKVAARSRYSKDPFEFKKETPNSRLVTEPVEDEQPSTLSPKKKQRNGG
MRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPL
RASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQ
FDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLD
SLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLC
FGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRES

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>166_166_4_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000374736_KCNMA1_chr10_78850268_ENST00000372440_length(amino acids)=760AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAM
TVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVI
LSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLD
QDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLAL
LDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHS

--------------------------------------------------------------

>166_166_5_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000374736_KCNMA1_chr10_78850268_ENST00000372443_length(amino acids)=788AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAM
TVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVI
LSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELAKPGKLPLVS
VNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAE
ENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVP

--------------------------------------------------------------

>166_166_6_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000374736_KCNMA1_chr10_78850268_ENST00000404771_length(amino acids)=871AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRN
SPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRAS
NFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDD
SIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLM
SATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGI
YRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDK

--------------------------------------------------------------

>166_166_7_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000374736_KCNMA1_chr10_78850268_ENST00000404857_length(amino acids)=802AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILVTGWMPY
LGPRVLMTCLDIGVVCMPTDIQSTSPASIKKFKETRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIE
YLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGM
DRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLV
TGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKR

--------------------------------------------------------------

>166_166_8_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000374736_KCNMA1_chr10_78850268_ENST00000406533_length(amino acids)=823AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRGRLSILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDD
ITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNG
GMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMP
LRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSM
QFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVL
DSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNML
CFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRE

--------------------------------------------------------------

>166_166_9_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000423487_KCNMA1_chr10_78850268_ENST00000286627_length(amino acids)=761AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAM
TVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVI
LSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLD
QDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLAL
LDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHS

--------------------------------------------------------------

>166_166_10_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000423487_KCNMA1_chr10_78850268_ENST00000286628_length(amino acids)=819AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRN
SPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRAS
NFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDD
SIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLM
SATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGI
YRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDK

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>166_166_11_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000423487_KCNMA1_chr10_78850268_ENST00000354353_length(amino acids)=823AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRRWEEHCSLWRLESKGNVRRLNYCRGQQTFSVKVKVAARSRYSKDPFEFKKETPNSRLVTEPVEDEQPSTLSPKKKQRNGG
MRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPL
RASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQ
FDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLD
SLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLC
FGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRES

--------------------------------------------------------------

>166_166_12_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000423487_KCNMA1_chr10_78850268_ENST00000372440_length(amino acids)=760AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAM
TVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVI
LSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLD
QDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLAL
LDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHS

--------------------------------------------------------------

>166_166_13_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000423487_KCNMA1_chr10_78850268_ENST00000372443_length(amino acids)=788AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAM
TVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVI
LSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELAKPGKLPLVS
VNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAE
ENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVP

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>166_166_14_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000423487_KCNMA1_chr10_78850268_ENST00000404771_length(amino acids)=871AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRN
SPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRAS
NFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDD
SIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLM
SATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGI
YRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDK

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>166_166_15_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000423487_KCNMA1_chr10_78850268_ENST00000404857_length(amino acids)=803AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDP
KRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILVTGWMPY
LGPRVLMTCLDIGVVCMPTDIQSTSPASIKKFKETRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIE
YLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGM
DRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLV
TGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKR

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>166_166_16_ABCA1-KCNMA1_ABCA1_chr9_107665894_ENST00000423487_KCNMA1_chr10_78850268_ENST00000406533_length(amino acids)=824AA_BP=
MESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIM
RVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGV
SNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRGRLSILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDD
ITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNG
GMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMP
LRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSM
QFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVL
DSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNML
CFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:107665894/chr10:78850268)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCA1

Q86UQ4

KCNMA1

Q12791

FUNCTION: May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons. {ECO:0000269|PubMed:33293368}.FUNCTION: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+) (PubMed:29330545, PubMed:31152168). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). {ECO:0000269|PubMed:29330545, ECO:0000269|PubMed:31152168}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNMA1chr9:107665894chr10:78850268ENST000004806830213_200169.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr9:107665894chr10:78850268ENST000004806830239_600169.0Compositional biasNote=Poly-Ser
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000480683024_100169.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827415_558407.66666666666671179.0DomainNote=RCK N-terminal
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828415_558407.66666666666671237.0DomainNote=RCK N-terminal
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828415_558407.66666666666671220.0DomainNote=RCK N-terminal
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302415_5580169.0DomainNote=RCK N-terminal
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302336_3580169.0IntramembranePore-forming%3B Name%3DP region
TgeneKCNMA1chr9:107665894chr10:78850268ENST000002866278271003_1025407.66666666666671179.0MotifNote=Calcium bowl
TgeneKCNMA1chr9:107665894chr10:78850268ENST000002866288281003_1025407.66666666666671237.0MotifNote=Calcium bowl
TgeneKCNMA1chr9:107665894chr10:78850268ENST000004048578281003_1025407.66666666666671220.0MotifNote=Calcium bowl
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000480683021003_10250169.0MotifNote=Calcium bowl
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302352_3550169.0MotifNote=Selectivity for potassium
TgeneKCNMA1chr9:107665894chr10:78850268ENST000002866278271032_1052407.66666666666671179.0RegionNote=Segment S10
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827556_576407.66666666666671179.0RegionNote=Segment S7
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827613_633407.66666666666671179.0RegionNote=Segment S8
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827677_681407.66666666666671179.0RegionNote=Heme-binding motif
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827837_857407.66666666666671179.0RegionNote=Segment S9
TgeneKCNMA1chr9:107665894chr10:78850268ENST000002866288281032_1052407.66666666666671237.0RegionNote=Segment S10
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828556_576407.66666666666671237.0RegionNote=Segment S7
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828613_633407.66666666666671237.0RegionNote=Segment S8
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828677_681407.66666666666671237.0RegionNote=Heme-binding motif
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828837_857407.66666666666671237.0RegionNote=Segment S9
TgeneKCNMA1chr9:107665894chr10:78850268ENST000004048578281032_1052407.66666666666671220.0RegionNote=Segment S10
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828556_576407.66666666666671220.0RegionNote=Segment S7
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828613_633407.66666666666671220.0RegionNote=Segment S8
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828677_681407.66666666666671220.0RegionNote=Heme-binding motif
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828837_857407.66666666666671220.0RegionNote=Segment S9
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000480683021032_10520169.0RegionNote=Segment S10
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302556_5760169.0RegionNote=Segment S7
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302613_6330169.0RegionNote=Segment S8
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302677_6810169.0RegionNote=Heme-binding motif
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302837_8570169.0RegionNote=Segment S9
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302108_1780169.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000480683021_860169.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302200_2140169.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302236_2390169.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302261_2640169.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302286_3000169.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302322_3350169.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302359_3670169.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302389_12360169.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302179_1990169.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302215_2350169.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302240_2600169.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302265_2850169.0TransmembraneHelical%3B Name%3DSegment S4
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302301_3210169.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000048068302368_3880169.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNMA1chr9:107665894chr10:78850268ENST000004806830287_1070169.0TransmembraneHelical%3B Name%3DSegment S0

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501912_214422.02262.0DomainABC transporter 2
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-250899_113122.02262.0DomainABC transporter 1
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501946_195322.02262.0Nucleotide bindingATP 2
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-250933_94022.02262.0Nucleotide bindingATP 1
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501372_165622.02262.0Topological domainNote=Extracellular
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-25043_63922.02262.0Topological domainNote=Extracellular
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501041_105722.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501351_137122.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501657_167722.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501703_172322.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501735_175522.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501768_178822.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501802_182222.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-2501852_187222.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-25022_4222.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-250640_66022.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-250683_70322.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-250716_73622.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-250745_76522.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-250777_79722.02262.0TransmembraneHelical
HgeneABCA1chr9:107665894chr10:78850268ENST00000374736-250827_84722.02262.0TransmembraneHelical
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000028662782713_20407.66666666666671179.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000028662782739_60407.66666666666671179.0Compositional biasNote=Poly-Ser
TgeneKCNMA1chr9:107665894chr10:78850268ENST000002866278274_10407.66666666666671179.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000028662882813_20407.66666666666671237.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000028662882839_60407.66666666666671237.0Compositional biasNote=Poly-Ser
TgeneKCNMA1chr9:107665894chr10:78850268ENST000002866288284_10407.66666666666671237.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000040485782813_20407.66666666666671220.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000040485782839_60407.66666666666671220.0Compositional biasNote=Poly-Ser
TgeneKCNMA1chr9:107665894chr10:78850268ENST000004048578284_10407.66666666666671220.0Compositional biasNote=Poly-Gly
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827336_358407.66666666666671179.0IntramembranePore-forming%3B Name%3DP region
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828336_358407.66666666666671237.0IntramembranePore-forming%3B Name%3DP region
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828336_358407.66666666666671220.0IntramembranePore-forming%3B Name%3DP region
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827352_355407.66666666666671179.0MotifNote=Selectivity for potassium
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828352_355407.66666666666671237.0MotifNote=Selectivity for potassium
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828352_355407.66666666666671220.0MotifNote=Selectivity for potassium
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827108_178407.66666666666671179.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST000002866278271_86407.66666666666671179.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827200_214407.66666666666671179.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827236_239407.66666666666671179.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827261_264407.66666666666671179.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827286_300407.66666666666671179.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827322_335407.66666666666671179.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827359_367407.66666666666671179.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827389_1236407.66666666666671179.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828108_178407.66666666666671237.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST000002866288281_86407.66666666666671237.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828200_214407.66666666666671237.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828236_239407.66666666666671237.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828261_264407.66666666666671237.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828286_300407.66666666666671237.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828322_335407.66666666666671237.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828359_367407.66666666666671237.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828389_1236407.66666666666671237.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828108_178407.66666666666671220.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST000004048578281_86407.66666666666671220.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828200_214407.66666666666671220.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828236_239407.66666666666671220.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828261_264407.66666666666671220.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828286_300407.66666666666671220.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828322_335407.66666666666671220.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828359_367407.66666666666671220.0Topological domainExtracellular
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828389_1236407.66666666666671220.0Topological domainCytoplasmic
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827179_199407.66666666666671179.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827215_235407.66666666666671179.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827240_260407.66666666666671179.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827265_285407.66666666666671179.0TransmembraneHelical%3B Name%3DSegment S4
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827301_321407.66666666666671179.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286627827368_388407.66666666666671179.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000028662782787_107407.66666666666671179.0TransmembraneHelical%3B Name%3DSegment S0
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828179_199407.66666666666671237.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828215_235407.66666666666671237.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828240_260407.66666666666671237.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828265_285407.66666666666671237.0TransmembraneHelical%3B Name%3DSegment S4
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828301_321407.66666666666671237.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000286628828368_388407.66666666666671237.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000028662882887_107407.66666666666671237.0TransmembraneHelical%3B Name%3DSegment S0
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828179_199407.66666666666671220.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828215_235407.66666666666671220.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828240_260407.66666666666671220.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828265_285407.66666666666671220.0TransmembraneHelical%3B Name%3DSegment S4
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828301_321407.66666666666671220.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNMA1chr9:107665894chr10:78850268ENST00000404857828368_388407.66666666666671220.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNMA1chr9:107665894chr10:78850268ENST0000040485782887_107407.66666666666671220.0TransmembraneHelical%3B Name%3DSegment S0


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCA1
KCNMA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABCA1-KCNMA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABCA1-KCNMA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource