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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CHST11-ATP1B4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CHST11-ATP1B4
	FusionPDB ID: 16677
	FusionGDB2.0 ID: 16677
		Hgene	Tgene
	Gene symbol	CHST11	ATP1B4
	Gene ID	50515	23439
	Gene name	carbohydrate sulfotransferase 11	ATPase Na+/K+ transporting family member beta 4
	Synonyms	C4ST\|C4ST-1\|C4ST1\|HSA269537\|OCBMD	-
	Cytomap	12q23.3	Xq24
	Type of gene	protein-coding	protein-coding
	Description	carbohydrate sulfotransferase 11C4S-1IgH/CHST11 fusioncarbohydrate (chondroitin 4) sulfotransferase 11chondroitin 4-O-sulfotransferase 1	protein ATP1B4ATPase, Na+/K+ transporting, beta 4 polypeptideBetaMNa,K-ATPase beta m-subunitX,K-ATPase beta-m subunitx/potassium-transporting ATPase subunit beta-m
	Modification date	20200313	20200313
	UniProtAcc	Q9NPF2	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000303694, ENST00000546689, ENST00000547956, ENST00000549260, ENST00000550711,	ENST00000218008, ENST00000361319, ENST00000539306,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 8 X 6=624	1 X 1 X 1=1
	# samples	15	1
	** MAII score	log2(15/624*10)=-2.05658352836637 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: CHST11 [Title/Abstract] AND ATP1B4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CHST11(104995769)-ATP1B4(119500380), # samples:3
Anticipated loss of major functional domain due to fusion event.	CHST11-ATP1B4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CHST11-ATP1B4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CHST11	GO:0030206	chondroitin sulfate biosynthetic process	11056388
Tgene	ATP1B4	GO:0006355	regulation of transcription, DNA-templated	17592128
Tgene	ATP1B4	GO:0015672	monovalent inorganic cation transport	17592128

Fusion gene breakpoints across CHST11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP1B4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LAML	TCGA-AB-2920-03B	CHST11	chr12	104995769	-	ATP1B4	chrX	119500380	+
ChimerDB4	LAML	TCGA-AB-2920-03B	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+
ChimerDB4	LAML	TCGA-AB-2920_631WGAAXX_2	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000547956	CHST11	chr12	104995769	+	ENST00000361319	ATP1B4	chrX	119500380	+	4586	850	814	1848	344
ENST00000547956	CHST11	chr12	104995769	+	ENST00000218008	ATP1B4	chrX	119500380	+	4598	850	814	1860	348
ENST00000547956	CHST11	chr12	104995769	+	ENST00000539306	ATP1B4	chrX	119500380	+	1757	850	814	1731	305
ENST00000549260	CHST11	chr12	104995769	+	ENST00000361319	ATP1B4	chrX	119500380	+	4366	630	12	1628	538
ENST00000549260	CHST11	chr12	104995769	+	ENST00000218008	ATP1B4	chrX	119500380	+	4378	630	12	1640	542
ENST00000549260	CHST11	chr12	104995769	+	ENST00000539306	ATP1B4	chrX	119500380	+	1537	630	12	1511	499
ENST00000303694	CHST11	chr12	104995769	+	ENST00000361319	ATP1B4	chrX	119500380	+	4379	643	10	1641	543
ENST00000303694	CHST11	chr12	104995769	+	ENST00000218008	ATP1B4	chrX	119500380	+	4391	643	10	1653	547
ENST00000303694	CHST11	chr12	104995769	+	ENST00000539306	ATP1B4	chrX	119500380	+	1550	643	10	1524	504
ENST00000546689	CHST11	chr12	104995769	+	ENST00000361319	ATP1B4	chrX	119500380	+	4406	670	862	1668	268
ENST00000546689	CHST11	chr12	104995769	+	ENST00000218008	ATP1B4	chrX	119500380	+	4418	670	862	1680	272
ENST00000546689	CHST11	chr12	104995769	+	ENST00000539306	ATP1B4	chrX	119500380	+	1577	670	862	1551	229

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000547956	ENST00000361319	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.000691541	0.99930847
ENST00000547956	ENST00000218008	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.000980924	0.999019
ENST00000547956	ENST00000539306	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.002688045	0.99731195
ENST00000549260	ENST00000361319	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.000682491	0.9993175
ENST00000549260	ENST00000218008	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.000831695	0.9991683
ENST00000549260	ENST00000539306	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.002419059	0.9975809
ENST00000303694	ENST00000361319	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.001037806	0.99896216
ENST00000303694	ENST00000218008	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.000969989	0.99903
ENST00000303694	ENST00000539306	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.002457876	0.99754214
ENST00000546689	ENST00000361319	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.000648333	0.9993517
ENST00000546689	ENST00000218008	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.000917755	0.9990822
ENST00000546689	ENST00000539306	CHST11	chr12	104995769	+	ATP1B4	chrX	119500380	+	0.002376371	0.9976236

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>16677_16677_1_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000303694_ATP1B4_chrX_119500380_ENST00000218008_length(amino acids)=547AA_BP=210
MERNEVAFGEKGEGPSDSHSGQRSGSGGGTTITARTPAARPATRQRRPPAGSEEAAERRGGGAGARSQRVHASQHFQTNSGTFHTPARAG
GSESGREATPILPLSLAQLCPAPPGLRSARRGPCSCAPGALPGHPGPRSQDKAMKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSML
HPVMRRNPFGVDICCRKGSRSPLQELYNPIQDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGN
AWWQKLQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVS
EPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPE
LGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVI

--------------------------------------------------------------

>16677_16677_2_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000303694_ATP1B4_chrX_119500380_ENST00000361319_length(amino acids)=543AA_BP=210
MERNEVAFGEKGEGPSDSHSGQRSGSGGGTTITARTPAARPATRQRRPPAGSEEAAERRGGGAGARSQRVHASQHFQTNSGTFHTPARAG
GSESGREATPILPLSLAQLCPAPPGLRSARRGPCSCAPGALPGHPGPRSQDKAMKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSML
HPVMRRNPFGVDICCRKGSRSPLQELYNPIQDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGN
AWWQKLQIMSEYLWDPERRMFLARTGLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDT
WQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDP
VKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVIFTLN

--------------------------------------------------------------

>16677_16677_3_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000303694_ATP1B4_chrX_119500380_ENST00000539306_length(amino acids)=504AA_BP=210
MERNEVAFGEKGEGPSDSHSGQRSGSGGGTTITARTPAARPATRQRRPPAGSEEAAERRGGGAGARSQRVHASQHFQTNSGTFHTPARAG
GSESGREATPILPLSLAQLCPAPPGLRSARRGPCSCAPGALPGHPGPRSQDKAMKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSML
HPVMRRNPFGVDICCRKGSRSPLQELYNPIQDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGN
AWWQKLQIMSEYLWDPERRMFLARTGQSWRVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNE
DEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLT

--------------------------------------------------------------

>16677_16677_4_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000546689_ATP1B4_chrX_119500380_ENST00000218008_length(amino acids)=272AA_BP=
MQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTW
QHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPV
KVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVIFTLNI

--------------------------------------------------------------

>16677_16677_5_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000546689_ATP1B4_chrX_119500380_ENST00000361319_length(amino acids)=268AA_BP=
MQIMSEYLWDPERRMFLARTGLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYV
ISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSC

--------------------------------------------------------------

>16677_16677_6_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000546689_ATP1B4_chrX_119500380_ENST00000539306_length(amino acids)=229AA_BP=
MQIMSEYLWDPERRMFLARTGQSWRVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKK
ACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYT

--------------------------------------------------------------

>16677_16677_7_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000547956_ATP1B4_chrX_119500380_ENST00000218008_length(amino acids)=348AA_BP=2
MRLTVSSSSNGTDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGNAWWQKLQIMSEYLWDPERR
MFLARTGQSWSLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGY
NDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDI

--------------------------------------------------------------

>16677_16677_8_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000547956_ATP1B4_chrX_119500380_ENST00000361319_length(amino acids)=344AA_BP=2
MRLTVSSSSNGTDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGNAWWQKLQIMSEYLWDPERR
MFLARTGLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSL
QEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSIS

--------------------------------------------------------------

>16677_16677_9_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000547956_ATP1B4_chrX_119500380_ENST00000539306_length(amino acids)=305AA_BP=2
MRLTVSSSSNGTDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGNAWWQKLQIMSEYLWDPERR
MFLARTGQSWRVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSG
LEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKN

--------------------------------------------------------------

>16677_16677_10_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000549260_ATP1B4_chrX_119500380_ENST00000218008_length(amino acids)=542AA_BP=205
MERNEVAFGEKGEGPSDSHSGQRSGSGGGTTITARTPAARPATRQRRPPAGSEEAAERRGGGAGARSQRVHASQHFQTNSGTFHTPARAG
GSESGREATPILPLSLAQLCPAPPGLRSARRGPCSCAPGALPGHPGPRSQDKAMKPALLEVMRMNRICRMVLATCLGSFILVIFYFQIMR
RNPFGVDICCRKGSRSPLQELYNPIQDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGNAWWQK
LQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTW
QHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPV
KVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVIFTLNI

--------------------------------------------------------------

>16677_16677_11_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000549260_ATP1B4_chrX_119500380_ENST00000361319_length(amino acids)=538AA_BP=205
MERNEVAFGEKGEGPSDSHSGQRSGSGGGTTITARTPAARPATRQRRPPAGSEEAAERRGGGAGARSQRVHASQHFQTNSGTFHTPARAG
GSESGREATPILPLSLAQLCPAPPGLRSARRGPCSCAPGALPGHPGPRSQDKAMKPALLEVMRMNRICRMVLATCLGSFILVIFYFQIMR
RNPFGVDICCRKGSRSPLQELYNPIQDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGNAWWQK
LQIMSEYLWDPERRMFLARTGLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYV
ISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSC

--------------------------------------------------------------

>16677_16677_12_CHST11-ATP1B4_CHST11_chr12_104995769_ENST00000549260_ATP1B4_chrX_119500380_ENST00000539306_length(amino acids)=499AA_BP=205
MERNEVAFGEKGEGPSDSHSGQRSGSGGGTTITARTPAARPATRQRRPPAGSEEAAERRGGGAGARSQRVHASQHFQTNSGTFHTPARAG
GSESGREATPILPLSLAQLCPAPPGLRSARRGPCSCAPGALPGHPGPRSQDKAMKPALLEVMRMNRICRMVLATCLGSFILVIFYFQIMR
RNPFGVDICCRKGSRSPLQELYNPIQDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGNAWWQK
LQIMSEYLWDPERRMFLARTGQSWRVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKK
ACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYT

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:104995769/chrX:119500380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHST11 Q9NPF2	.
FUNCTION: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHST11

chr12:104995769

chrX:119500380

ENST00000303694

1_16

68.0

353.0

Topological domain

Cytoplasmic

Hgene

CHST11

chr12:104995769

chrX:119500380

ENST00000549260

1_16

63.0

348.0

Topological domain

Cytoplasmic

Hgene

CHST11

chr12:104995769

chrX:119500380

ENST00000303694

17_37

68.0

353.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

CHST11

chr12:104995769

chrX:119500380

ENST00000549260

17_37

63.0

348.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ATP1B4

chr12:104995769

chrX:119500380

ENST00000218008

35_72

21.0

358.0

Compositional bias

Note=Glu-rich

Tgene

ATP1B4

chr12:104995769

chrX:119500380

ENST00000361319

35_72

21.0

354.0

Compositional bias

Note=Glu-rich

Tgene

ATP1B4

chr12:104995769

chrX:119500380

ENST00000218008

132_357

21.0

358.0

Topological domain

Perinuclear space

Tgene

ATP1B4

chr12:104995769

chrX:119500380

ENST00000361319

132_357

21.0

354.0

Topological domain

Perinuclear space

Tgene

ATP1B4

chr12:104995769

chrX:119500380

ENST00000218008

111_131

21.0

358.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ATP1B4

chr12:104995769

chrX:119500380

ENST00000361319

111_131

21.0

354.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHST11

chr12:104995769

chrX:119500380

ENST00000303694

124_130

68.0

353.0

Nucleotide binding

PAPS

Hgene

CHST11

chr12:104995769

chrX:119500380

ENST00000303694

186_194

68.0

353.0

Nucleotide binding

PAPS

Hgene

CHST11

chr12:104995769

chrX:119500380

ENST00000549260

124_130

63.0

348.0

Nucleotide binding

PAPS

Hgene

CHST11

chr12:104995769

chrX:119500380

ENST00000549260

186_194

63.0

348.0

Nucleotide binding

PAPS

Hgene

CHST11

chr12:104995769

chrX:119500380

ENST00000303694

38_352

68.0

353.0

Topological domain

Lumenal

Hgene

CHST11

chr12:104995769

chrX:119500380

ENST00000549260

38_352

63.0

348.0

Topological domain

Lumenal

Tgene

ATP1B4

chr12:104995769

chrX:119500380

ENST00000218008

1_110

21.0

358.0

Topological domain

Nuclear

Tgene

ATP1B4

chr12:104995769

chrX:119500380

ENST00000361319

1_110

21.0

354.0

Topological domain

Nuclear

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1170_CHST11_104995769_ATP1B4_119500380_1170_CHST11_104995769_ATP1B4_119500380_ranked_0.pdb	CHST11	104995769	104995769	ENST00000539306	ATP1B4	chrX	119500380	+	MERNEVAFGEKGEGPSDSHSGQRSGSGGGTTITARTPAARPATRQRRPPAGSEEAAERRGGGAGARSQRVHASQHFQTNSGTFHTPARAG GSESGREATPILPLSLAQLCPAPPGLRSARRGPCSCAPGALPGHPGPRSQDKAMKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSML HPVMRRNPFGVDICCRKGSRSPLQELYNPIQDDPDEANQNYLADEEEEAEEEARVTVVPKSEEEEEEEEKEEEEEEEKEEEEGQGQPTGN AWWQKLQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFYASLAAVITLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVS EPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPE LGDPVKVSCKVQRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVI	547

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CHST11_pLDDT.png

ATP1B4_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CHST11
ATP1B4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CHST11-ATP1B4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CHST11-ATP1B4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source