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Fusion Protein:ACTG1-CXCR5 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ACTG1-CXCR5 | FusionPDB ID: 1670 | FusionGDB2.0 ID: 1670 | Hgene | Tgene | Gene symbol | ACTG1 | CXCR5 | Gene ID | 71 | 643 |
| Gene name | actin gamma 1 | C-X-C motif chemokine receptor 5 | |
| Synonyms | ACT|ACTG|DFNA20|DFNA26|HEL-176 | BLR1|CD185|MDR15 | |
| Cytomap | 17q25.3 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | actin, cytoplasmic 2cytoskeletal gamma-actinepididymis luminal protein 176 | C-X-C chemokine receptor type 5Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)Burkitt lymphoma receptor 1, GTP-binding proteinCXC-R5CXCR-5MDR-15chemokine (C-X-C motif) receptor 5monocyte-derived receptor 15 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | P63261 | P32302 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000331925, ENST00000573283, ENST00000575087, ENST00000575842, | ENST00000292174, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 51 X 36 X 13=23868 | 12 X 4 X 8=384 |
| # samples | 58 | 12 | |
| ** MAII score | log2(58/23868*10)=-5.36288097153997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/384*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ACTG1 [Title/Abstract] AND CXCR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ACTG1(79476999)-CXCR5(118754475), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ACTG1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CXCR5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | DLBC | TCGA-GR-A4D9-01B | ACTG1 | chr17 | 79476999 | - | CXCR5 | chr11 | 118754475 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000331925 | ACTG1 | chr17 | 79476999 | - | ENST00000292174 | CXCR5 | chr11 | 118754475 | + | 6425 | 1994 | 135 | 1274 | 379 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000331925 | ENST00000292174 | ACTG1 | chr17 | 79476999 | - | CXCR5 | chr11 | 118754475 | + | 0.002474627 | 0.9975254 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >1670_1670_1_ACTG1-CXCR5_ACTG1_chr17_79476999_ENST00000331925_CXCR5_chr11_118754475_ENST00000292174_length(amino acids)=379AA_BP= MPVAMEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIW HHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAIL RLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSF LGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMW -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:79476999/chr11:118754475) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACTG1 | CXCR5 |
| FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. {ECO:0000305|PubMed:29581253}. | FUNCTION: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 110_124 | 17.0 | 373.0 | Topological domain | Extracellular | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 146_167 | 17.0 | 373.0 | Topological domain | Cytoplasmic | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 189_219 | 17.0 | 373.0 | Topological domain | Extracellular | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 241_259 | 17.0 | 373.0 | Topological domain | Cytoplasmic | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 281_304 | 17.0 | 373.0 | Topological domain | Extracellular | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 326_372 | 17.0 | 373.0 | Topological domain | Cytoplasmic | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 77_88 | 17.0 | 373.0 | Topological domain | Cytoplasmic | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 125_145 | 17.0 | 373.0 | Transmembrane | Helical%3B Name%3D3 | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 168_188 | 17.0 | 373.0 | Transmembrane | Helical%3B Name%3D4 | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 220_240 | 17.0 | 373.0 | Transmembrane | Helical%3B Name%3D5 | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 260_280 | 17.0 | 373.0 | Transmembrane | Helical%3B Name%3D6 | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 305_325 | 17.0 | 373.0 | Transmembrane | Helical%3B Name%3D7 | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 56_76 | 17.0 | 373.0 | Transmembrane | Helical%3B Name%3D1 | |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 89_109 | 17.0 | 373.0 | Transmembrane | Helical%3B Name%3D2 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CXCR5 | chr17:79476999 | chr11:118754475 | ENST00000292174 | -1 | 2 | 1_55 | 17.0 | 373.0 | Topological domain | Extracellular |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| ACTG1 | CFL2, CFL1, ACTG1, ACTB, DSTN, TMSB4X, FHOD1, EPS8L1, EPS8L2, FEZ1, CTNND1, ST3GAL3, SH3GL2, EIF6, PFN2, PRSS23, BCAP31, RBX1, MDK, CAP1, CAP2, RUVBL2, MEPCE, RUVBL1, gag, MORF4L1, MORF4L2, MRGBP, DMAP1, KAT5, POU5F1, UCHL5, YWHAQ, DISC1, TNIK, RPS6KA5, MAPK6, NDRG1, SP1, UBE2Q2, FBXO25, MYOC, LRRK2, APOE, PSEN2, BRCA1, LIG4, TSGA10, TRAF3IP1, GZMK, GZMA, HSP90AA1, HSP90AB1, PPP1CC, MYC, MLH1, UBL4A, ITGA4, ILF3, AICDA, WIPF1, FN1, CTTN, ADRB2, PLD1, CTBP2, GIT2, GRB2, COTL1, WASL, FBXO6, TOPBP1, CDKN2A, ACTA1, ACTBL2, BRK1, HSPA5, UBASH3B, ERRFI1, LGR4, EHHADH, CCDC22, WDYHV1, CCDC101, CCDC8, EZH2, SUZ12, EED, RNF2, BMI1, FAF2, RPS6KB2, CORO1B, CORO1C, CAD, EEF1A1, EEF1A2, NCKAP1, RAN, YARS, SFN, HSPB2, SRPK2, HIST1H3E, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, VCL, IQGAP1, PDLIM7, LIMA1, ANLN, MYO5C, MYO19, MYO18A, Actb, Flot1, Flot2, Myh9, Myo1c, Tpm1, Coro1c, Tmod3, Lima1, Tmed10, Calml3, Myh10, Flnb, TRAF2, VASP, GAN, MCM2, SHC1, ERBB3, RC3H1, Pparg, DUSP19, C17orf89, MCPH1, ACT1, AIP1, SRP1, TAE1, HDAC6, ZNF598, FGFR1, CTNNB1, KRAS, LARS, ACO2, CSNK1A1, TGFB1, PRPF8, EFTUD2, AAR2, PPP5C, CHD3, RIOK1, ESR2, H2AFZ, H3F3A, HIST1H4H, HIST2H2AC, VIM, GPD1, CERS1, HEXIM1, LARP7, CDH1, BIN1, CDK9, TLR9, RC3H2, PSMA3, FAF1, IKBKG, FADD, TANK, USP14, UCHL3, DCTN4, HOOK3, HRAS, MAPT, HIST1H4A, PSMD14, BIRC3, WWP2, HTT, PARK2, CDC37, PLEKHA4, MAGEA3, S, FANCD2, LINC01554, ZC3H18, DOK2, ELK4, MAPK7, PRKCA, PTPN12, PTPRR, RASA1, SH3BGRL, NEK4, DUX4, FASN, LDLR, SREBF2, AIMP2, BRD4, NUPR1, ORF14, Apc2, WDR76, RNF208, EIF3F, INSIG1, INSIG2, RIN3, DDX58, SPOP, ISG15, UFL1, DDRGK1, TP53, NPM1, FXR1, WDR5, BGLT3, SPRTN, BTF3, SLFN11, LHPP, CCNF, MAP1LC3B, NBR1, SQSTM1, OPTN, TOLLIP, NR3C1, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ACTG1 |  |
| CXCR5 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to ACTG1-CXCR5 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ACTG1-CXCR5 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACTG1 | C3711374 | Nonsyndromic Deafness | 18 | CLINGEN |
| Hgene | ACTG1 | C1858172 | Deafness, Autosomal Dominant 20 | 8 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | ACTG1 | C3281235 | BARAITSER-WINTER SYNDROME 2 | 4 | CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | ACTG1 | C0001787 | Osteoporosis, Age-Related | 1 | CTD_human |
| Hgene | ACTG1 | C0005745 | Blepharoptosis | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C0007097 | Carcinoma | 1 | CTD_human |
| Hgene | ACTG1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | ACTG1 | C0009363 | Congenital ocular coloboma (disorder) | 1 | CTD_human |
| Hgene | ACTG1 | C0014544 | Epilepsy | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C0024433 | Macrostomia | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | ACTG1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | ACTG1 | C0029456 | Osteoporosis | 1 | CTD_human |
| Hgene | ACTG1 | C0029459 | Osteoporosis, Senile | 1 | CTD_human |
| Hgene | ACTG1 | C0033377 | Ptosis | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
| Hgene | ACTG1 | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
| Hgene | ACTG1 | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
| Hgene | ACTG1 | C0205699 | Carcinomatosis | 1 | CTD_human |
| Hgene | ACTG1 | C0240583 | Short upturned nose | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C0265541 | Cranioschisis | 1 | CTD_human |
| Hgene | ACTG1 | C0266551 | Congenital coloboma of iris | 1 | ORPHANET |
| Hgene | ACTG1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Hgene | ACTG1 | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
| Hgene | ACTG1 | C0751406 | Post-Traumatic Osteoporosis | 1 | CTD_human |
| Hgene | ACTG1 | C0857379 | Abnormality of the pinna | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
| Hgene | ACTG1 | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
| Hgene | ACTG1 | C1384666 | hearing impairment | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C1843156 | Progressive sensorineural hearing impairment | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C1844505 | Pointed chin | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C1849340 | Long palpebral fissure | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C1855722 | Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation | 1 | ORPHANET |
| Hgene | ACTG1 | C1865014 | Long philtrum | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C1865017 | Thin upper lip vermilion | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C1868571 | Highly arched eyebrow | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C1970280 | Hearing loss begins with loss of high frequencies | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C1970281 | Audiogram shows sloping configuration | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C1970282 | Deafness, profound, by 6th decade | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C3279369 | Microphthalmia (in some patients) | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C3549665 | Deafness (in some patients) | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C3808883 | Short neck (in some patients) | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4012410 | Enlarged ventricles (in some patients) | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4229649 | Heart defect (in some patients) | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4229650 | Pterygium colli (in some patients) | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4229651 | Hypertelorism/telecanthus | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4229652 | Eye coloboma (in some patients) | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4229653 | Trigonocephaly/metopic ridge | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4231117 | Pectus (in some patients) | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4231118 | Kyphosis/scoliosis (in some patients) | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4231120 | Prominent nasal root on profile | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4231121 | Large, squared nose tip | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4231123 | Retrognathia (in some patients) | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4231124 | Prominent/full/wide cheeks | 1 | GENOMICS_ENGLAND |
| Hgene | ACTG1 | C4554007 | Uveoretinal Coloboma | 1 | CTD_human |
| Hgene | ACTG1 | C4708599 | Coloboma of choroid and retina | 1 | ORPHANET |
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