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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CISD1-GABRA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CISD1-GABRA1
FusionPDB ID: 16845
FusionGDB2.0 ID: 16845
HgeneTgene
Gene symbol

CISD1

GABRA1

Gene ID

55847

2554

Gene nameCDGSH iron sulfur domain 1gamma-aminobutyric acid type A receptor subunit alpha1
SynonymsC10orf70|MDS029|ZCD1|mitoNEETECA4|EIEE19|EJM|EJM5
Cytomap

10q21.1

5q34

Type of geneprotein-codingprotein-coding
DescriptionCDGSH iron-sulfur domain-containing protein 1zinc finger CDGSH-type domain 1gamma-aminobutyric acid receptor subunit alpha-1GABA(A) receptor subunit alpha-1GABA(A) receptor, alpha 1gamma-aminobutyric acid (GABA) A receptor, alpha 1gamma-aminobutyric acid type A receptor alpha1 subunit
Modification date2020031320200322
UniProtAcc

Q9NZ45

.
Ensembl transtripts involved in fusion geneENST idsENST00000333926, ENST00000488388, 
ENST00000023897, ENST00000393943, 
ENST00000420560, ENST00000428797, 
ENST00000437025, ENST00000444819, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 2=182 X 3 X 2=12
# samples 43
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CISD1 [Title/Abstract] AND GABRA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CISD1(60029064)-GABRA1(161322672), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGABRA1

GO:1902476

chloride transmembrane transport

9039914

TgeneGABRA1

GO:1904862

inhibitory synapse assembly

23909897|25489750


check buttonFusion gene breakpoints across CISD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GABRA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2782-01ACISD1chr10

60029064

-GABRA1chr5

161322672

+
ChimerDB4LUSCTCGA-66-2782-01ACISD1chr10

60029064

+GABRA1chr5

161322672

+
ChimerDB4LUSCTCGA-66-2782CISD1chr10

60029064

+GABRA1chr5

161322671

+
ChimerDB4LUSCTCGA-66-2782CISD1chr10

60029064

+GABRA1chr5

161322672

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000333926CISD1chr1060029064+ENST00000023897GABRA1chr5161322672+1006247216761181
ENST00000333926CISD1chr1060029064+ENST00000428797GABRA1chr5161322672+3309247216761181
ENST00000333926CISD1chr1060029064+ENST00000393943GABRA1chr5161322672+1006247216761181
ENST00000333926CISD1chr1060029064+ENST00000437025GABRA1chr5161322672+3294247216761181
ENST00000333926CISD1chr1060029064+ENST00000420560GABRA1chr5161322672+3299247216761181
ENST00000333926CISD1chr1060029064+ENST00000444819GABRA1chr5161322672+3299247216761181
ENST00000333926CISD1chr1060029064+ENST00000023897GABRA1chr5161322671+1006247216761181
ENST00000333926CISD1chr1060029064+ENST00000428797GABRA1chr5161322671+3309247216761181
ENST00000333926CISD1chr1060029064+ENST00000393943GABRA1chr5161322671+1006247216761181
ENST00000333926CISD1chr1060029064+ENST00000437025GABRA1chr5161322671+3294247216761181
ENST00000333926CISD1chr1060029064+ENST00000420560GABRA1chr5161322671+3299247216761181
ENST00000333926CISD1chr1060029064+ENST00000444819GABRA1chr5161322671+3299247216761181

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333926ENST00000023897CISD1chr1060029064+GABRA1chr5161322672+0.0091322630.99086773
ENST00000333926ENST00000428797CISD1chr1060029064+GABRA1chr5161322672+0.0014187590.9985813
ENST00000333926ENST00000393943CISD1chr1060029064+GABRA1chr5161322672+0.0091322630.99086773
ENST00000333926ENST00000437025CISD1chr1060029064+GABRA1chr5161322672+0.0016535740.99834645
ENST00000333926ENST00000420560CISD1chr1060029064+GABRA1chr5161322672+0.0015763650.9984237
ENST00000333926ENST00000444819CISD1chr1060029064+GABRA1chr5161322672+0.0015763650.9984237
ENST00000333926ENST00000023897CISD1chr1060029064+GABRA1chr5161322671+0.0091322630.99086773
ENST00000333926ENST00000428797CISD1chr1060029064+GABRA1chr5161322671+0.0014187590.9985813
ENST00000333926ENST00000393943CISD1chr1060029064+GABRA1chr5161322671+0.0091322630.99086773
ENST00000333926ENST00000437025CISD1chr1060029064+GABRA1chr5161322671+0.0016535740.99834645
ENST00000333926ENST00000420560CISD1chr1060029064+GABRA1chr5161322671+0.0015763650.9984237
ENST00000333926ENST00000444819CISD1chr1060029064+GABRA1chr5161322671+0.0015763650.9984237

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>16845_16845_1_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322671_ENST00000023897_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_2_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322671_ENST00000393943_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_3_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322671_ENST00000420560_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_4_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322671_ENST00000428797_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_5_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322671_ENST00000437025_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_6_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322671_ENST00000444819_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_7_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322672_ENST00000023897_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_8_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322672_ENST00000393943_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_9_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322672_ENST00000420560_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_10_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322672_ENST00000428797_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_11_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322672_ENST00000437025_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

>16845_16845_12_CISD1-GABRA1_CISD1_chr10_60029064_ENST00000333926_GABRA1_chr5_161322672_ENST00000444819_length(amino acids)=181AA_BP=1
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:60029064/chr5:161322672)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CISD1

Q9NZ45

.
FUNCTION: Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions. {ECO:0000250, ECO:0000269|PubMed:17584744, ECO:0000269|PubMed:17766440}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGABRA1chr10:60029064chr5:161322671ENST00000023897811335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322671ENST00000393943710335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322671ENST00000420560710335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322671ENST00000428797811335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322671ENST00000437025710335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322671ENST00000444819710335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322672ENST00000023897811335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322672ENST00000393943710335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322672ENST00000420560710335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322672ENST00000428797811335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322672ENST00000437025710335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322672ENST00000444819710335_421285.3333333333333457.0Topological domainCytoplasmic
TgeneGABRA1chr10:60029064chr5:161322671ENST00000023897811313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000023897811422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000393943710313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000393943710422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000420560710313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000420560710422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000428797811313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000428797811422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000437025710313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000437025710422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000444819710313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000444819710422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000023897811313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000023897811422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000393943710313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000393943710422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000420560710313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000420560710422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000428797811313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000428797811422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000437025710313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000437025710422_443285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000444819710313_334285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000444819710422_443285.3333333333333457.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCISD1chr10:60029064chr5:161322671ENST00000333926+1332_10810.333333333333334109.0Topological domainCytoplasmic
HgeneCISD1chr10:60029064chr5:161322672ENST00000333926+1332_10810.333333333333334109.0Topological domainCytoplasmic
HgeneCISD1chr10:60029064chr5:161322671ENST00000333926+1314_3110.333333333333334109.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneCISD1chr10:60029064chr5:161322672ENST00000333926+1314_3110.333333333333334109.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneGABRA1chr10:60029064chr5:161322671ENST0000002389781128_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322671ENST0000039394371028_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322671ENST0000042056071028_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322671ENST0000042879781128_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322671ENST0000043702571028_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322671ENST0000044481971028_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322672ENST0000002389781128_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322672ENST0000039394371028_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322672ENST0000042056071028_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322672ENST0000042879781128_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322672ENST0000043702571028_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322672ENST0000044481971028_251285.3333333333333457.0Topological domainExtracellular
TgeneGABRA1chr10:60029064chr5:161322671ENST00000023897811252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000023897811279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000393943710252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000393943710279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000420560710252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000420560710279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000428797811252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000428797811279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000437025710252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000437025710279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000444819710252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322671ENST00000444819710279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000023897811252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000023897811279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000393943710252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000393943710279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000420560710252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000420560710279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000428797811252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000428797811279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000437025710252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000437025710279_300285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000444819710252_273285.3333333333333457.0TransmembraneHelical
TgeneGABRA1chr10:60029064chr5:161322672ENST00000444819710279_300285.3333333333333457.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>206_CISD1_60029064_GABRA1_161322672_ranked_0.pdbCISD16002906460029064ENST00000444819GABRA1chr5161322672+
MSLTSSSSVRGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKN
NTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPH
181


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CISD1_pLDDT.png
all structure
all structure
GABRA1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CISD1
GABRA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CISD1-GABRA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CISD1-GABRA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource