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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CLASP1-ANAPC1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CLASP1-ANAPC1
	FusionPDB ID: 16929
	FusionGDB2.0 ID: 16929
		Hgene	Tgene
	Gene symbol	CLASP1	ANAPC1
	Gene ID	23332	64682
	Gene name	cytoplasmic linker associated protein 1	anaphase promoting complex subunit 1
	Synonyms	MAST1	APC1\|MCPR\|TSG24
	Cytomap	2q14.2-q14.3	2q13
	Type of gene	protein-coding	protein-coding
	Description	CLIP-associating protein 1multiple asters 1multiple asters homolog 1protein Orbit homolog 1	anaphase-promoting complex subunit 1anaphase-promoting complex 1 (meiotic checkpoint regulator)cyclosome subunit 1mitotic checkpoint regulatortestis-specific gene 24 protein
	Modification date	20200313	20200313
	UniProtAcc	Q7Z460	Q96DE5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263710, ENST00000397587, ENST00000409078, ENST00000455322, ENST00000541377, ENST00000430234, ENST00000541859, ENST00000545861,	ENST00000489177, ENST00000341068,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 6 X 5=240	6 X 6 X 4=144
	# samples	8	6
	** MAII score	log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CLASP1 [Title/Abstract] AND ANAPC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CLASP1(122363277)-ANAPC1(112608487), # samples:1
Anticipated loss of major functional domain due to fusion event.	CLASP1-ANAPC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CLASP1-ANAPC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CLASP1	GO:0051294	establishment of spindle orientation	21822276
Hgene	CLASP1	GO:0051301	cell division	21822276
Tgene	ANAPC1	GO:0070979	protein K11-linked ubiquitination	18485873

Fusion gene breakpoints across CLASP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANAPC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR315380	CLASP1	chr2	122363277	-	ANAPC1	chr2	112608487	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000409078	CLASP1	chr2	122363277	-	ENST00000341068	ANAPC1	chr2	112608487	-	6667	696	474	5015	1513
ENST00000541377	CLASP1	chr2	122363277	-	ENST00000341068	ANAPC1	chr2	112608487	-	6556	585	363	4904	1513
ENST00000455322	CLASP1	chr2	122363277	-	ENST00000341068	ANAPC1	chr2	112608487	-	6556	585	363	4904	1513
ENST00000397587	CLASP1	chr2	122363277	-	ENST00000341068	ANAPC1	chr2	112608487	-	6556	585	363	4904	1513
ENST00000263710	CLASP1	chr2	122363277	-	ENST00000341068	ANAPC1	chr2	112608487	-	6556	585	363	4904	1513

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000409078	ENST00000341068	CLASP1	chr2	122363277	-	ANAPC1	chr2	112608487	-	0.000489027	0.999511
ENST00000541377	ENST00000341068	CLASP1	chr2	122363277	-	ANAPC1	chr2	112608487	-	0.000459179	0.9995408
ENST00000455322	ENST00000341068	CLASP1	chr2	122363277	-	ANAPC1	chr2	112608487	-	0.000459179	0.9995408
ENST00000397587	ENST00000341068	CLASP1	chr2	122363277	-	ANAPC1	chr2	112608487	-	0.000459179	0.9995408
ENST00000263710	ENST00000341068	CLASP1	chr2	122363277	-	ANAPC1	chr2	112608487	-	0.000459179	0.9995408

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>16929_16929_1_CLASP1-ANAPC1_CLASP1_chr2_122363277_ENST00000263710_ANAPC1_chr2_112608487_ENST00000341068_length(amino acids)=1513AA_BP=73
MLDLDLNSTMEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVGKVFIPGLPAPSLTM
SNTMPRPSTPLDGVSTPKPLSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELSNGSMVRITIPE
IATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSET
GSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMGEGICSLVELLV
QLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYI
LGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWP
EAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMNHEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHE
FIEEKENRLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPAS
QIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTST
ELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVG
GHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILP
NSKWVDSNVPQIIRENSISLSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHN
LETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRY
HLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLSKGTQHLKSIL
SKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQ
ETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAY

--------------------------------------------------------------

>16929_16929_2_CLASP1-ANAPC1_CLASP1_chr2_122363277_ENST00000397587_ANAPC1_chr2_112608487_ENST00000341068_length(amino acids)=1513AA_BP=73
MLDLDLNSTMEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVGKVFIPGLPAPSLTM
SNTMPRPSTPLDGVSTPKPLSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELSNGSMVRITIPE
IATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSET
GSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMGEGICSLVELLV
QLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYI
LGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWP
EAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMNHEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHE
FIEEKENRLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPAS
QIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTST
ELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVG
GHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILP
NSKWVDSNVPQIIRENSISLSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHN
LETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRY
HLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLSKGTQHLKSIL
SKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQ
ETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAY

--------------------------------------------------------------

>16929_16929_3_CLASP1-ANAPC1_CLASP1_chr2_122363277_ENST00000409078_ANAPC1_chr2_112608487_ENST00000341068_length(amino acids)=1513AA_BP=73
MLDLDLNSTMEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVGKVFIPGLPAPSLTM
SNTMPRPSTPLDGVSTPKPLSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELSNGSMVRITIPE
IATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSET
GSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMGEGICSLVELLV
QLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYI
LGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWP
EAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMNHEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHE
FIEEKENRLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPAS
QIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTST
ELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVG
GHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILP
NSKWVDSNVPQIIRENSISLSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHN
LETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRY
HLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLSKGTQHLKSIL
SKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQ
ETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAY

--------------------------------------------------------------

>16929_16929_4_CLASP1-ANAPC1_CLASP1_chr2_122363277_ENST00000455322_ANAPC1_chr2_112608487_ENST00000341068_length(amino acids)=1513AA_BP=73
MLDLDLNSTMEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVGKVFIPGLPAPSLTM
SNTMPRPSTPLDGVSTPKPLSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELSNGSMVRITIPE
IATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSET
GSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMGEGICSLVELLV
QLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYI
LGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWP
EAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMNHEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHE
FIEEKENRLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPAS
QIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTST
ELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVG
GHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILP
NSKWVDSNVPQIIRENSISLSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHN
LETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRY
HLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLSKGTQHLKSIL
SKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQ
ETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAY

--------------------------------------------------------------

>16929_16929_5_CLASP1-ANAPC1_CLASP1_chr2_122363277_ENST00000541377_ANAPC1_chr2_112608487_ENST00000341068_length(amino acids)=1513AA_BP=73
MLDLDLNSTMEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVGKVFIPGLPAPSLTM
SNTMPRPSTPLDGVSTPKPLSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELSNGSMVRITIPE
IATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSET
GSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMGEGICSLVELLV
QLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYI
LGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWP
EAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMNHEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHE
FIEEKENRLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNGVAAGLKIAPAS
QIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTST
ELDVPHNVQVAAVVGIGLVYQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVPEQLYQYMVG
GHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILP
NSKWVDSNVPQIIRENSISLSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSAPNASVTGPHN
LETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRY
HLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLSKGTQHLKSIL
SKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQ
ETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAY

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:122363277/chr2:112608487)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CLASP1 Q7Z460	ANAPC1 Q96DE5
FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269\|PubMed:11290329, ECO:0000269\|PubMed:12837247, ECO:0000269\|PubMed:15631994, ECO:0000269\|PubMed:16866869, ECO:0000269\|PubMed:16914514, ECO:0000269\|PubMed:17543864}.	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269\|PubMed:20360068}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ANAPC1

chr2:122363277

chr2:112608487

ENST00000341068

1297_1325

505.0

1945.0

Repeat

Note=PC 1

Tgene

ANAPC1

chr2:122363277

chr2:112608487

ENST00000341068

1366_1404

505.0

1945.0

Repeat

Note=PC 2

Tgene

ANAPC1

chr2:122363277

chr2:112608487

ENST00000341068

1467_1501

505.0

1945.0

Repeat

Note=PC 3

Tgene

ANAPC1

chr2:122363277

chr2:112608487

ENST00000341068

1520_1552

505.0

1945.0

Repeat

Note=PC 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

1299_1330

65.0

1539.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

1299_1330

65.0

1472.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

1526_1532

65.0

1539.0

Compositional bias

Note=Poly-Ser

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

530_765

65.0

1539.0

Compositional bias

Note=Ser-rich

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

1526_1532

65.0

1472.0

Compositional bias

Note=Poly-Ser

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

530_765

65.0

1472.0

Compositional bias

Note=Ser-rich

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

1256_1538

65.0

1539.0

Region

Note=Localization to kinetochores

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

1256_1538

65.0

1472.0

Region

Note=Localization to kinetochores

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

1342_1379

65.0

1539.0

Repeat

Note=HEAT 6

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

1460_1497

65.0

1539.0

Repeat

Note=HEAT 7

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

163_200

65.0

1539.0

Repeat

Note=HEAT 2

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

405_440

65.0

1539.0

Repeat

Note=HEAT 3

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

441_477

65.0

1539.0

Repeat

Note=HEAT 4

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

87_124

65.0

1539.0

Repeat

Note=HEAT 1

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000263710

974_1011

65.0

1539.0

Repeat

Note=HEAT 5

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

1342_1379

65.0

1472.0

Repeat

Note=HEAT 6

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

1460_1497

65.0

1472.0

Repeat

Note=HEAT 7

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

163_200

65.0

1472.0

Repeat

Note=HEAT 2

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

405_440

65.0

1472.0

Repeat

Note=HEAT 3

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

441_477

65.0

1472.0

Repeat

Note=HEAT 4

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

87_124

65.0

1472.0

Repeat

Note=HEAT 1

Hgene

CLASP1

chr2:122363277

chr2:112608487

ENST00000409078

974_1011

65.0

1472.0

Repeat

Note=HEAT 5

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CLASP1
ANAPC1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CLASP1	chr2:122363277	chr2:112608487	ENST00000263710	-	2	40	662_785	65.0	1539.0	microtubules%2C MAPRE1 and MAPRE3
Hgene	CLASP1	chr2:122363277	chr2:112608487	ENST00000409078	-	2	39	662_785	65.0	1472.0	microtubules%2C MAPRE1 and MAPRE3
Hgene	CLASP1	chr2:122363277	chr2:112608487	ENST00000263710	-	2	40	1254_1538	65.0	1539.0	PHLDB2 and RSN
Hgene	CLASP1	chr2:122363277	chr2:112608487	ENST00000409078	-	2	39	1254_1538	65.0	1472.0	PHLDB2 and RSN

Top

Related Drugs to CLASP1-ANAPC1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CLASP1-ANAPC1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source