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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CLK2-CD244

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CLK2-CD244
FusionPDB ID: 17203
FusionGDB2.0 ID: 17203
HgeneTgene
Gene symbol

CLK2

CD244

Gene ID

9894

51744

Gene nametelomere maintenance 2CD244 molecule
SynonymsCLK2|TEL2|YHFS2B4|NAIL|NKR2B4|Nmrk|SLAMF4
Cytomap

16p13.3

1q23.3

Type of geneprotein-codingprotein-coding
Descriptiontelomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homolognatural killer cell receptor 2B4CD244 molecule, natural killer cell receptor 2B4NK cell activation inducing ligand NAILNK cell activation-inducing ligandNK cell type I receptor protein 2B4SLAM family member 4h2B4signaling lymphocytic activation mol
Modification date2020031320200313
UniProtAcc

P49760

Q9BZW8

Ensembl transtripts involved in fusion geneENST idsENST00000355560, ENST00000361168, 
ENST00000368361, ENST00000536801, 
ENST00000497188, 		ENST00000481677, 
ENST00000322302, ENST00000368032, 
ENST00000368033, ENST00000368034, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 6 X 5=1503 X 2 X 3=18
# samples 64
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CLK2 [Title/Abstract] AND CD244 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CLK2(155239279)-CD244(160808839), # samples:3
Anticipated loss of major functional domain due to fusion event.CLK2-CD244 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLK2-CD244 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLK2-CD244 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLK2-CD244 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLK2-CD244 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CLK2-CD244 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CLK2-CD244 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCD244

GO:0002323

natural killer cell activation involved in immune response

11714776

TgeneCD244

GO:0060732

positive regulation of inositol phosphate biosynthetic process

8376943

TgeneCD244

GO:0071663

positive regulation of granzyme B production

11714776

TgeneCD244

GO:1902715

positive regulation of interferon-gamma secretion

11714776

TgeneCD244

GO:2000484

positive regulation of interleukin-8 secretion

8376943


check buttonFusion gene breakpoints across CLK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CD244 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A62V-01ACLK2chr1

155239279

-CD244chr1

160808839

-
ChimerDB4BRCATCGA-AC-A62VCLK2chr1

155239278

-CD244chr1

160808839

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000536801CLK2chr1155239279-ENST00000368034CD244chr1160808839-2202572105917270
ENST00000536801CLK2chr1155239279-ENST00000368033CD244chr1160808839-1179572105917270
ENST00000536801CLK2chr1155239279-ENST00000322302CD244chr1160808839-1091572105917270
ENST00000536801CLK2chr1155239279-ENST00000368032CD244chr1160808839-907572105881258
ENST00000536801CLK2chr1155239278-ENST00000368034CD244chr1160808839-2202572105917270
ENST00000536801CLK2chr1155239278-ENST00000368033CD244chr1160808839-1179572105917270
ENST00000536801CLK2chr1155239278-ENST00000322302CD244chr1160808839-1091572105917270
ENST00000536801CLK2chr1155239278-ENST00000368032CD244chr1160808839-907572105881258

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000536801ENST00000368034CLK2chr1155239279-CD244chr1160808839-0.0072367570.9927632
ENST00000536801ENST00000368033CLK2chr1155239279-CD244chr1160808839-0.0021770890.9978229
ENST00000536801ENST00000322302CLK2chr1155239279-CD244chr1160808839-0.0018468060.99815315
ENST00000536801ENST00000368032CLK2chr1155239279-CD244chr1160808839-0.0015785510.99842143
ENST00000536801ENST00000368034CLK2chr1155239278-CD244chr1160808839-0.0072367570.9927632
ENST00000536801ENST00000368033CLK2chr1155239278-CD244chr1160808839-0.0021770890.9978229
ENST00000536801ENST00000322302CLK2chr1155239278-CD244chr1160808839-0.0018468060.99815315
ENST00000536801ENST00000368032CLK2chr1155239278-CD244chr1160808839-0.0015785510.99842143

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>17203_17203_1_CLK2-CD244_CLK2_chr1_155239278_ENST00000536801_CD244_chr1_160808839_ENST00000322302_length(amino acids)=270AA_BP=154
MLCLHGAHPAYTLGLLEPSVAIRCRILEGTTPQSEAAGGVTVNTIGAESISDEEVAPGQVVVTGHDGVGERTATMSVLEAVMMIVRPTGG
CMTGDTVAATDATIIAGIGEMPTMTQTIGIPMNISGRTAVTAASAAAGGSTDGGGGAAGHLAAHLRIQILAVFGDHRDSKRTVPWHPCLL
LCVEEKEEGEAVRDQSQGIFDNLRRCQGSENQEKSRAGADFSWRGEHHLLYDPVPVFCSHVTRTCIYIIFINSAFQEVWIQEEEPQPFLQ

--------------------------------------------------------------

>17203_17203_2_CLK2-CD244_CLK2_chr1_155239278_ENST00000536801_CD244_chr1_160808839_ENST00000368032_length(amino acids)=258AA_BP=154
MLCLHGAHPAYTLGLLEPSVAIRCRILEGTTPQSEAAGGVTVNTIGAESISDEEVAPGQVVVTGHDGVGERTATMSVLEAVMMIVRPTGG
CMTGDTVAATDATIIAGIGEMPTMTQTIGIPMNISGRTAVTAASAAAGGSTDGGGGAAGHLAAHLRIQILAVFGDHRDSKRTVPWHPCLL

--------------------------------------------------------------

>17203_17203_3_CLK2-CD244_CLK2_chr1_155239278_ENST00000536801_CD244_chr1_160808839_ENST00000368033_length(amino acids)=270AA_BP=154
MLCLHGAHPAYTLGLLEPSVAIRCRILEGTTPQSEAAGGVTVNTIGAESISDEEVAPGQVVVTGHDGVGERTATMSVLEAVMMIVRPTGG
CMTGDTVAATDATIIAGIGEMPTMTQTIGIPMNISGRTAVTAASAAAGGSTDGGGGAAGHLAAHLRIQILAVFGDHRDSKRTVPWHPCLL
LCVEEKEEGEAVRDQSQGIFDNLRRCQGSENQEKSRAGADFSWRGEHHLLYDPVPVFCSHVTRTCIYIIFINSAFQEVWIQEEEPQPFLQ

--------------------------------------------------------------

>17203_17203_4_CLK2-CD244_CLK2_chr1_155239278_ENST00000536801_CD244_chr1_160808839_ENST00000368034_length(amino acids)=270AA_BP=154
MLCLHGAHPAYTLGLLEPSVAIRCRILEGTTPQSEAAGGVTVNTIGAESISDEEVAPGQVVVTGHDGVGERTATMSVLEAVMMIVRPTGG
CMTGDTVAATDATIIAGIGEMPTMTQTIGIPMNISGRTAVTAASAAAGGSTDGGGGAAGHLAAHLRIQILAVFGDHRDSKRTVPWHPCLL
LCVEEKEEGEAVRDQSQGIFDNLRRCQGSENQEKSRAGADFSWRGEHHLLYDPVPVFCSHVTRTCIYIIFINSAFQEVWIQEEEPQPFLQ

--------------------------------------------------------------

>17203_17203_5_CLK2-CD244_CLK2_chr1_155239279_ENST00000536801_CD244_chr1_160808839_ENST00000322302_length(amino acids)=270AA_BP=154
MLCLHGAHPAYTLGLLEPSVAIRCRILEGTTPQSEAAGGVTVNTIGAESISDEEVAPGQVVVTGHDGVGERTATMSVLEAVMMIVRPTGG
CMTGDTVAATDATIIAGIGEMPTMTQTIGIPMNISGRTAVTAASAAAGGSTDGGGGAAGHLAAHLRIQILAVFGDHRDSKRTVPWHPCLL
LCVEEKEEGEAVRDQSQGIFDNLRRCQGSENQEKSRAGADFSWRGEHHLLYDPVPVFCSHVTRTCIYIIFINSAFQEVWIQEEEPQPFLQ

--------------------------------------------------------------

>17203_17203_6_CLK2-CD244_CLK2_chr1_155239279_ENST00000536801_CD244_chr1_160808839_ENST00000368032_length(amino acids)=258AA_BP=154
MLCLHGAHPAYTLGLLEPSVAIRCRILEGTTPQSEAAGGVTVNTIGAESISDEEVAPGQVVVTGHDGVGERTATMSVLEAVMMIVRPTGG
CMTGDTVAATDATIIAGIGEMPTMTQTIGIPMNISGRTAVTAASAAAGGSTDGGGGAAGHLAAHLRIQILAVFGDHRDSKRTVPWHPCLL

--------------------------------------------------------------

>17203_17203_7_CLK2-CD244_CLK2_chr1_155239279_ENST00000536801_CD244_chr1_160808839_ENST00000368033_length(amino acids)=270AA_BP=154
MLCLHGAHPAYTLGLLEPSVAIRCRILEGTTPQSEAAGGVTVNTIGAESISDEEVAPGQVVVTGHDGVGERTATMSVLEAVMMIVRPTGG
CMTGDTVAATDATIIAGIGEMPTMTQTIGIPMNISGRTAVTAASAAAGGSTDGGGGAAGHLAAHLRIQILAVFGDHRDSKRTVPWHPCLL
LCVEEKEEGEAVRDQSQGIFDNLRRCQGSENQEKSRAGADFSWRGEHHLLYDPVPVFCSHVTRTCIYIIFINSAFQEVWIQEEEPQPFLQ

--------------------------------------------------------------

>17203_17203_8_CLK2-CD244_CLK2_chr1_155239279_ENST00000536801_CD244_chr1_160808839_ENST00000368034_length(amino acids)=270AA_BP=154
MLCLHGAHPAYTLGLLEPSVAIRCRILEGTTPQSEAAGGVTVNTIGAESISDEEVAPGQVVVTGHDGVGERTATMSVLEAVMMIVRPTGG
CMTGDTVAATDATIIAGIGEMPTMTQTIGIPMNISGRTAVTAASAAAGGSTDGGGGAAGHLAAHLRIQILAVFGDHRDSKRTVPWHPCLL
LCVEEKEEGEAVRDQSQGIFDNLRRCQGSENQEKSRAGADFSWRGEHHLLYDPVPVFCSHVTRTCIYIIFINSAFQEVWIQEEEPQPFLQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:155239279/chr1:160808839)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLK2

P49760

CD244

Q9BZW8

FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:28289210). {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.FUNCTION: Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). {ECO:0000250|UniProtKB:Q07763, ECO:0000269|PubMed:10359122, ECO:0000269|PubMed:10741393, ECO:0000269|PubMed:10934222, ECO:0000269|PubMed:11714776, ECO:0000269|PubMed:11917118, ECO:0000269|PubMed:8376943, ECO:0000305|PubMed:15713798}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCD244chr1:155239278chr1:160808839ENST0000032230218131_215126.33333333333333274.0DomainNote=Ig-like 2
TgeneCD244chr1:155239279chr1:160808839ENST0000032230218131_215126.33333333333333274.0DomainNote=Ig-like 2
TgeneCD244chr1:155239278chr1:160808839ENST0000032230218269_274126.33333333333333274.0MotifITSM 1
TgeneCD244chr1:155239278chr1:160808839ENST0000032230218295_300126.33333333333333274.0MotifITSM 2
TgeneCD244chr1:155239278chr1:160808839ENST0000032230218315_320126.33333333333333274.0MotifITSM 3
TgeneCD244chr1:155239278chr1:160808839ENST0000032230218340_345126.33333333333333274.0MotifITSM 4
TgeneCD244chr1:155239278chr1:160808839ENST0000036803228269_274218.33333333333334330.0MotifITSM 1
TgeneCD244chr1:155239278chr1:160808839ENST0000036803228295_300218.33333333333334330.0MotifITSM 2
TgeneCD244chr1:155239278chr1:160808839ENST0000036803228315_320218.33333333333334330.0MotifITSM 3
TgeneCD244chr1:155239278chr1:160808839ENST0000036803228340_345218.33333333333334330.0MotifITSM 4
TgeneCD244chr1:155239278chr1:160808839ENST0000036803329269_274223.33333333333334371.0MotifITSM 1
TgeneCD244chr1:155239278chr1:160808839ENST0000036803329295_300223.33333333333334371.0MotifITSM 2
TgeneCD244chr1:155239278chr1:160808839ENST0000036803329315_320223.33333333333334371.0MotifITSM 3
TgeneCD244chr1:155239278chr1:160808839ENST0000036803329340_345223.33333333333334371.0MotifITSM 4
TgeneCD244chr1:155239278chr1:160808839ENST0000036803429269_274218.33333333333334366.0MotifITSM 1
TgeneCD244chr1:155239278chr1:160808839ENST0000036803429295_300218.33333333333334366.0MotifITSM 2
TgeneCD244chr1:155239278chr1:160808839ENST0000036803429315_320218.33333333333334366.0MotifITSM 3
TgeneCD244chr1:155239278chr1:160808839ENST0000036803429340_345218.33333333333334366.0MotifITSM 4
TgeneCD244chr1:155239279chr1:160808839ENST0000032230218269_274126.33333333333333274.0MotifITSM 1
TgeneCD244chr1:155239279chr1:160808839ENST0000032230218295_300126.33333333333333274.0MotifITSM 2
TgeneCD244chr1:155239279chr1:160808839ENST0000032230218315_320126.33333333333333274.0MotifITSM 3
TgeneCD244chr1:155239279chr1:160808839ENST0000032230218340_345126.33333333333333274.0MotifITSM 4
TgeneCD244chr1:155239279chr1:160808839ENST0000036803228269_274218.33333333333334330.0MotifITSM 1
TgeneCD244chr1:155239279chr1:160808839ENST0000036803228295_300218.33333333333334330.0MotifITSM 2
TgeneCD244chr1:155239279chr1:160808839ENST0000036803228315_320218.33333333333334330.0MotifITSM 3
TgeneCD244chr1:155239279chr1:160808839ENST0000036803228340_345218.33333333333334330.0MotifITSM 4
TgeneCD244chr1:155239279chr1:160808839ENST0000036803329269_274223.33333333333334371.0MotifITSM 1
TgeneCD244chr1:155239279chr1:160808839ENST0000036803329295_300223.33333333333334371.0MotifITSM 2
TgeneCD244chr1:155239279chr1:160808839ENST0000036803329315_320223.33333333333334371.0MotifITSM 3
TgeneCD244chr1:155239279chr1:160808839ENST0000036803329340_345223.33333333333334371.0MotifITSM 4
TgeneCD244chr1:155239279chr1:160808839ENST0000036803429269_274218.33333333333334366.0MotifITSM 1
TgeneCD244chr1:155239279chr1:160808839ENST0000036803429295_300218.33333333333334366.0MotifITSM 2
TgeneCD244chr1:155239279chr1:160808839ENST0000036803429315_320218.33333333333334366.0MotifITSM 3
TgeneCD244chr1:155239279chr1:160808839ENST0000036803429340_345218.33333333333334366.0MotifITSM 4
TgeneCD244chr1:155239278chr1:160808839ENST0000032230218251_370126.33333333333333274.0Topological domainCytoplasmic
TgeneCD244chr1:155239278chr1:160808839ENST0000036803228251_370218.33333333333334330.0Topological domainCytoplasmic
TgeneCD244chr1:155239278chr1:160808839ENST0000036803329251_370223.33333333333334371.0Topological domainCytoplasmic
TgeneCD244chr1:155239278chr1:160808839ENST0000036803429251_370218.33333333333334366.0Topological domainCytoplasmic
TgeneCD244chr1:155239279chr1:160808839ENST0000032230218251_370126.33333333333333274.0Topological domainCytoplasmic
TgeneCD244chr1:155239279chr1:160808839ENST0000036803228251_370218.33333333333334330.0Topological domainCytoplasmic
TgeneCD244chr1:155239279chr1:160808839ENST0000036803329251_370223.33333333333334371.0Topological domainCytoplasmic
TgeneCD244chr1:155239279chr1:160808839ENST0000036803429251_370218.33333333333334366.0Topological domainCytoplasmic
TgeneCD244chr1:155239278chr1:160808839ENST0000032230218230_250126.33333333333333274.0TransmembraneHelical
TgeneCD244chr1:155239278chr1:160808839ENST0000036803228230_250218.33333333333334330.0TransmembraneHelical
TgeneCD244chr1:155239278chr1:160808839ENST0000036803329230_250223.33333333333334371.0TransmembraneHelical
TgeneCD244chr1:155239278chr1:160808839ENST0000036803429230_250218.33333333333334366.0TransmembraneHelical
TgeneCD244chr1:155239279chr1:160808839ENST0000032230218230_250126.33333333333333274.0TransmembraneHelical
TgeneCD244chr1:155239279chr1:160808839ENST0000036803228230_250218.33333333333334330.0TransmembraneHelical
TgeneCD244chr1:155239279chr1:160808839ENST0000036803329230_250223.33333333333334371.0TransmembraneHelical
TgeneCD244chr1:155239279chr1:160808839ENST0000036803429230_250218.33333333333334366.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLK2chr1:155239278chr1:160808839ENST00000361168-313163_479133.0499.0DomainProtein kinase
HgeneCLK2chr1:155239278chr1:160808839ENST00000368361-313163_479133.0500.0DomainProtein kinase
HgeneCLK2chr1:155239278chr1:160808839ENST00000536801-313163_479133.0500.0DomainProtein kinase
HgeneCLK2chr1:155239279chr1:160808839ENST00000361168-313163_479133.0499.0DomainProtein kinase
HgeneCLK2chr1:155239279chr1:160808839ENST00000368361-313163_479133.0500.0DomainProtein kinase
HgeneCLK2chr1:155239279chr1:160808839ENST00000536801-313163_479133.0500.0DomainProtein kinase
HgeneCLK2chr1:155239278chr1:160808839ENST00000361168-313169_177133.0499.0Nucleotide bindingATP
HgeneCLK2chr1:155239278chr1:160808839ENST00000368361-313169_177133.0500.0Nucleotide bindingATP
HgeneCLK2chr1:155239278chr1:160808839ENST00000536801-313169_177133.0500.0Nucleotide bindingATP
HgeneCLK2chr1:155239279chr1:160808839ENST00000361168-313169_177133.0499.0Nucleotide bindingATP
HgeneCLK2chr1:155239279chr1:160808839ENST00000368361-313169_177133.0500.0Nucleotide bindingATP
HgeneCLK2chr1:155239279chr1:160808839ENST00000536801-313169_177133.0500.0Nucleotide bindingATP
TgeneCD244chr1:155239278chr1:160808839ENST000003223021822_127126.33333333333333274.0DomainNote=Ig-like 1
TgeneCD244chr1:155239278chr1:160808839ENST0000036803228131_215218.33333333333334330.0DomainNote=Ig-like 2
TgeneCD244chr1:155239278chr1:160808839ENST000003680322822_127218.33333333333334330.0DomainNote=Ig-like 1
TgeneCD244chr1:155239278chr1:160808839ENST0000036803329131_215223.33333333333334371.0DomainNote=Ig-like 2
TgeneCD244chr1:155239278chr1:160808839ENST000003680332922_127223.33333333333334371.0DomainNote=Ig-like 1
TgeneCD244chr1:155239278chr1:160808839ENST0000036803429131_215218.33333333333334366.0DomainNote=Ig-like 2
TgeneCD244chr1:155239278chr1:160808839ENST000003680342922_127218.33333333333334366.0DomainNote=Ig-like 1
TgeneCD244chr1:155239279chr1:160808839ENST000003223021822_127126.33333333333333274.0DomainNote=Ig-like 1
TgeneCD244chr1:155239279chr1:160808839ENST0000036803228131_215218.33333333333334330.0DomainNote=Ig-like 2
TgeneCD244chr1:155239279chr1:160808839ENST000003680322822_127218.33333333333334330.0DomainNote=Ig-like 1
TgeneCD244chr1:155239279chr1:160808839ENST0000036803329131_215223.33333333333334371.0DomainNote=Ig-like 2
TgeneCD244chr1:155239279chr1:160808839ENST000003680332922_127223.33333333333334371.0DomainNote=Ig-like 1
TgeneCD244chr1:155239279chr1:160808839ENST0000036803429131_215218.33333333333334366.0DomainNote=Ig-like 2
TgeneCD244chr1:155239279chr1:160808839ENST000003680342922_127218.33333333333334366.0DomainNote=Ig-like 1
TgeneCD244chr1:155239278chr1:160808839ENST000003223021822_229126.33333333333333274.0Topological domainExtracellular
TgeneCD244chr1:155239278chr1:160808839ENST000003680322822_229218.33333333333334330.0Topological domainExtracellular
TgeneCD244chr1:155239278chr1:160808839ENST000003680332922_229223.33333333333334371.0Topological domainExtracellular
TgeneCD244chr1:155239278chr1:160808839ENST000003680342922_229218.33333333333334366.0Topological domainExtracellular
TgeneCD244chr1:155239279chr1:160808839ENST000003223021822_229126.33333333333333274.0Topological domainExtracellular
TgeneCD244chr1:155239279chr1:160808839ENST000003680322822_229218.33333333333334330.0Topological domainExtracellular
TgeneCD244chr1:155239279chr1:160808839ENST000003680332922_229223.33333333333334371.0Topological domainExtracellular
TgeneCD244chr1:155239279chr1:160808839ENST000003680342922_229218.33333333333334366.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CLK2
CD244


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CLK2-CD244


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CLK2-CD244


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource