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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CLSTN1-CTNNBIP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CLSTN1-CTNNBIP1
FusionPDB ID: 17342
FusionGDB2.0 ID: 17342
HgeneTgene
Gene symbol

CLSTN1

CTNNBIP1

Gene ID

22883

56998

Gene namecalsyntenin 1catenin beta interacting protein 1
SynonymsALC-ALPHA|CDHR12|CST-1|CSTN1|PIK3CD|XB31alpha|alcalpha1|alcalpha2ICAT
Cytomap

1p36.22

1p36.22

Type of geneprotein-codingprotein-coding
Descriptioncalsyntenin-1alcadein-alphaalzheimer-related cadherin-like proteincadherin-related family member 12non-classical cadherin XB31alphabeta-catenin-interacting protein 1beta-catenin-interacting protein ICATinhibitor of beta-catenin and Tcf-4
Modification date2020031320200313
UniProtAcc

O94985

Q9NSA3

Ensembl transtripts involved in fusion geneENST idsENST00000361311, ENST00000377288, 
ENST00000377298, ENST00000477264, 
ENST00000377256, ENST00000377258, 
ENST00000377263, ENST00000400904, 
ENST00000537447, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 15 X 7=12607 X 7 X 9=441
# samples 2013
** MAII scorelog2(20/1260*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/441*10)=-1.76226703252907
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CLSTN1 [Title/Abstract] AND CTNNBIP1 [Title/Abstract] AND fusion [Title/Abstract]

Recurrent chimeric fusion RNAs in non-cancer tissues and cells (pmid: 26837576)
Recurrent chimeric fusion RNAs in non-cancer tissues and cells (pmid: 26837576)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CTNNBIP1(9931244)-CLSTN1(9833452), # samples:6
CLSTN1(9833330)-CTNNBIP1(9910834), # samples:2
CLSTN1(9809519)-CTNNBIP1(9910834), # samples:2
Anticipated loss of major functional domain due to fusion event.CLSTN1-CTNNBIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLSTN1-CTNNBIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLSTN1-CTNNBIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLSTN1-CTNNBIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLSTN1-CTNNBIP1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CTNNBIP1-CLSTN1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCTNNBIP1

GO:0032091

negative regulation of protein binding

12408825|18287330


check buttonFusion gene breakpoints across CLSTN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CTNNBIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TU-01ACLSTN1chr1

9833329

-CTNNBIP1chr1

9910833

-
ChimerDB4BRCATCGA-AR-A0TU-01ACLSTN1chr1

9833330

-CTNNBIP1chr1

9910834

-
ChimerDB4KIRCTCGA-BP-4761-01ACLSTN1chr1

9883701

-CTNNBIP1chr1

9910834

-
ChimerDB4LUADTCGA-55-8616-01ACLSTN1chr1

9809519

-CTNNBIP1chr1

9910834

-
ChimerDB4LUADTCGA-55-8616CLSTN1chr1

9809518

-CTNNBIP1chr1

9910834

-
ChimerDB4SKCMTCGA-EE-A2MS-06ACLSTN1chr1

9883701

-CTNNBIP1chr1

9932146

-
ChiTaRS5.0N/AEC558830CLSTN1chr1

9881282

+CTNNBIP1chr1

9941492

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377298CLSTN1chr19809518-ENST00000377263CTNNBIP1chr19910834-427917785681836422
ENST00000361311CLSTN1chr19809518-ENST00000377263CTNNBIP1chr19910834-37071206261264412
ENST00000377288CLSTN1chr19809518-ENST00000377263CTNNBIP1chr19910834-427917785681836422
ENST00000377298CLSTN1chr19809519-ENST00000377263CTNNBIP1chr19910834-427917785681836422
ENST00000361311CLSTN1chr19809519-ENST00000377263CTNNBIP1chr19910834-37071206261264412
ENST00000377288CLSTN1chr19809519-ENST00000377263CTNNBIP1chr19910834-427917785681836422

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377298ENST00000377263CLSTN1chr19809518-CTNNBIP1chr19910834-0.0009227650.9990772
ENST00000361311ENST00000377263CLSTN1chr19809518-CTNNBIP1chr19910834-0.0018044240.9981956
ENST00000377288ENST00000377263CLSTN1chr19809518-CTNNBIP1chr19910834-0.0009227650.9990772
ENST00000377298ENST00000377263CLSTN1chr19809519-CTNNBIP1chr19910834-0.0009227650.9990772
ENST00000361311ENST00000377263CLSTN1chr19809519-CTNNBIP1chr19910834-0.0018044240.9981956
ENST00000377288ENST00000377263CLSTN1chr19809519-CTNNBIP1chr19910834-0.0009227650.9990772

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>17342_17342_1_CLSTN1-CTNNBIP1_CLSTN1_chr1_9809518_ENST00000361311_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=412AA_BP=31
MLPLPSARRCSEAGRAPRPERAAQRHGGGGGGSSLDPRSSPRRGAASPRPLEPRELRELRSASRAPPCRSRPGLAMLRRPAPALAPAARL
LLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEK
LDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEII
TPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEP

--------------------------------------------------------------

>17342_17342_2_CLSTN1-CTNNBIP1_CLSTN1_chr1_9809518_ENST00000377288_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=422AA_BP=31
MLPLPSARRCSEAGRAPRPERAAQRHGGGGGGSSLDPRSSPRRGAASPRPLEPRELRELRSASRAPPCRSRPGLAMLRRPAPALAPAARL
LLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKST
GEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQ
FSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFP

--------------------------------------------------------------

>17342_17342_3_CLSTN1-CTNNBIP1_CLSTN1_chr1_9809518_ENST00000377298_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=422AA_BP=31
MLPLPSARRCSEAGRAPRPERAAQRHGGGGGGSSLDPRSSPRRGAASPRPLEPRELRELRSASRAPPCRSRPGLAMLRRPAPALAPAARL
LLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKST
GEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQ
FSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFP

--------------------------------------------------------------

>17342_17342_4_CLSTN1-CTNNBIP1_CLSTN1_chr1_9809519_ENST00000361311_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=412AA_BP=31
MLPLPSARRCSEAGRAPRPERAAQRHGGGGGGSSLDPRSSPRRGAASPRPLEPRELRELRSASRAPPCRSRPGLAMLRRPAPALAPAARL
LLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEK
LDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEII
TPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEP

--------------------------------------------------------------

>17342_17342_5_CLSTN1-CTNNBIP1_CLSTN1_chr1_9809519_ENST00000377288_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=422AA_BP=31
MLPLPSARRCSEAGRAPRPERAAQRHGGGGGGSSLDPRSSPRRGAASPRPLEPRELRELRSASRAPPCRSRPGLAMLRRPAPALAPAARL
LLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKST
GEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQ
FSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFP

--------------------------------------------------------------

>17342_17342_6_CLSTN1-CTNNBIP1_CLSTN1_chr1_9809519_ENST00000377298_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=422AA_BP=31
MLPLPSARRCSEAGRAPRPERAAQRHGGGGGGSSLDPRSSPRRGAASPRPLEPRELRELRSASRAPPCRSRPGLAMLRRPAPALAPAARL
LLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKST
GEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQ
FSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:9931244/chr1:9833452)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLSTN1

O94985

CTNNBIP1

Q9NSA3

FUNCTION: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity). {ECO:0000250, ECO:0000269|PubMed:12972431}.FUNCTION: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:12408824}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000361311-618165_265318.3333333333333972.0DomainCadherin 2
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000361311-61838_164318.3333333333333972.0DomainCadherin 1
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000377298-719165_265328.3333333333333982.0DomainCadherin 2
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000377298-71938_164328.3333333333333982.0DomainCadherin 1
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000361311-618165_265318.3333333333333972.0DomainCadherin 2
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000361311-61838_164318.3333333333333972.0DomainCadherin 1
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000377298-719165_265328.3333333333333982.0DomainCadherin 2
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000377298-71938_164328.3333333333333982.0DomainCadherin 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000361311-618916_959318.3333333333333972.0Compositional biasNote=Glu-rich (highly acidic)
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000377298-719916_959328.3333333333333982.0Compositional biasNote=Glu-rich (highly acidic)
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000361311-618916_959318.3333333333333972.0Compositional biasNote=Glu-rich (highly acidic)
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000377298-719916_959328.3333333333333982.0Compositional biasNote=Glu-rich (highly acidic)
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000361311-218916_95971.33333333333333972.0Compositional biasNote=Glu-rich (highly acidic)
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000377298-219916_95971.33333333333333982.0Compositional biasNote=Glu-rich (highly acidic)
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000361311-218916_95971.33333333333333972.0Compositional biasNote=Glu-rich (highly acidic)
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000377298-219916_95971.33333333333333982.0Compositional biasNote=Glu-rich (highly acidic)
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000361311-118916_95930.333333333333332972.0Compositional biasNote=Glu-rich (highly acidic)
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000377298-119916_95930.333333333333332982.0Compositional biasNote=Glu-rich (highly acidic)
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000361311-218165_26571.33333333333333972.0DomainCadherin 2
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000361311-21838_16471.33333333333333972.0DomainCadherin 1
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000377298-219165_26571.33333333333333982.0DomainCadherin 2
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000377298-21938_16471.33333333333333982.0DomainCadherin 1
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000361311-218165_26571.33333333333333972.0DomainCadherin 2
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000361311-21838_16471.33333333333333972.0DomainCadherin 1
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000377298-219165_26571.33333333333333982.0DomainCadherin 2
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000377298-21938_16471.33333333333333982.0DomainCadherin 1
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000361311-118165_26530.333333333333332972.0DomainCadherin 2
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000361311-11838_16430.333333333333332972.0DomainCadherin 1
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000377298-119165_26530.333333333333332982.0DomainCadherin 2
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000377298-11938_16430.333333333333332982.0DomainCadherin 1
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000361311-61829_859318.3333333333333972.0Topological domainExtracellular
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000361311-618881_981318.3333333333333972.0Topological domainCytoplasmic
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000377298-71929_859328.3333333333333982.0Topological domainExtracellular
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000377298-719881_981328.3333333333333982.0Topological domainCytoplasmic
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000361311-61829_859318.3333333333333972.0Topological domainExtracellular
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000361311-618881_981318.3333333333333972.0Topological domainCytoplasmic
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000377298-71929_859328.3333333333333982.0Topological domainExtracellular
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000377298-719881_981328.3333333333333982.0Topological domainCytoplasmic
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000361311-21829_85971.33333333333333972.0Topological domainExtracellular
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000361311-218881_98171.33333333333333972.0Topological domainCytoplasmic
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000377298-21929_85971.33333333333333982.0Topological domainExtracellular
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000377298-219881_98171.33333333333333982.0Topological domainCytoplasmic
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000361311-21829_85971.33333333333333972.0Topological domainExtracellular
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000361311-218881_98171.33333333333333972.0Topological domainCytoplasmic
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000377298-21929_85971.33333333333333982.0Topological domainExtracellular
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000377298-219881_98171.33333333333333982.0Topological domainCytoplasmic
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000361311-11829_85930.333333333333332972.0Topological domainExtracellular
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000361311-118881_98130.333333333333332972.0Topological domainCytoplasmic
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000377298-11929_85930.333333333333332982.0Topological domainExtracellular
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000377298-119881_98130.333333333333332982.0Topological domainCytoplasmic
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000361311-618860_880318.3333333333333972.0TransmembraneHelical
HgeneCLSTN1chr1:9809518chr1:9910834ENST00000377298-719860_880328.3333333333333982.0TransmembraneHelical
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000361311-618860_880318.3333333333333972.0TransmembraneHelical
HgeneCLSTN1chr1:9809519chr1:9910834ENST00000377298-719860_880328.3333333333333982.0TransmembraneHelical
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000361311-218860_88071.33333333333333972.0TransmembraneHelical
HgeneCLSTN1chr1:9833329chr1:9910833ENST00000377298-219860_88071.33333333333333982.0TransmembraneHelical
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000361311-218860_88071.33333333333333972.0TransmembraneHelical
HgeneCLSTN1chr1:9833330chr1:9910834ENST00000377298-219860_88071.33333333333333982.0TransmembraneHelical
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000361311-118860_88030.333333333333332972.0TransmembraneHelical
HgeneCLSTN1chr1:9883701chr1:9910834ENST00000377298-119860_88030.333333333333332982.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CLSTN1
CTNNBIP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CLSTN1-CTNNBIP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CLSTN1-CTNNBIP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource