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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CLTC-ALK

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CLTC-ALK
FusionPDB ID: 17381
FusionGDB2.0 ID: 17381
HgeneTgene
Gene symbol

CLTC

ALK

Gene ID

1213

238

Gene nameclathrin heavy chainALK receptor tyrosine kinase
SynonymsCHC|CHC17|CLH-17|CLTCL2|Hc|MRD56CD246|NBLST3
Cytomap

17q23.1

2p23.2-p23.1

Type of geneprotein-codingprotein-coding
Descriptionclathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase
Modification date2020031320200329
UniProtAcc

P53675

Q96BT7

Ensembl transtripts involved in fusion geneENST idsENST00000269122, ENST00000393043, 
ENST00000579456, ENST00000579815, 
ENST00000431873, ENST00000498037, 
ENST00000389048, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 40 X 17=1836056 X 74 X 20=82880
# samples 8457
** MAII scorelog2(84/18360*10)=-4.45003292063505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(57/82880*10)=-7.18391827352181
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CLTC [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.CLTC-ALK seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CLTC-ALK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CLTC-ALK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CLTC-ALK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CLTC-ALK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLTC

GO:1900126

negative regulation of hyaluronan biosynthetic process

24251095

TgeneALK

GO:0016310

phosphorylation

9174053

TgeneALK

GO:0046777

protein autophosphorylation

9174053


check buttonFusion gene breakpoints across CLTC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..CLTCchr17

57763169

+ALKchr2

29446394

-
ChimerKB3..CLTCchr17

57768072

+ALKchr2

29446394

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000269122CLTCchr1757768072+ENST00000389048ALKchr229446394-7318517727468672197
ENST00000579456CLTCchr1757768072+ENST00000389048ALKchr229446394-4055191420036041134

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>17381_17381_1_CLTC-ALK_CLTC_chr17_57768072_ENST00000269122_ALK_chr2_29446394_ENST00000389048_length(amino acids)=2197AA_BP=1634
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSV
TVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTS
AVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVE
TELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFAC
VDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLR
AAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFS
KVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKK
DSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLR
KEEEQATETQPIVYVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEG
QVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAM
LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTW
SFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGP
LVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVH
GSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVN

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>17381_17381_2_CLTC-ALK_CLTC_chr17_57768072_ENST00000579456_ALK_chr2_29446394_ENST00000389048_length(amino acids)=1134AA_BP=571
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDG
ARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMR
EHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLL
MVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAY
LFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVM
KEYLTKVDKLDASESLRKEEEQATETQPIVYVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNI
TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKS
FLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWM
PPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYC
TQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHV
NMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANM

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:/chr2:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLTC

P53675

ALK

Q96BT7

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269|PubMed:19293182, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:21285950, ECO:0000269|PubMed:31079898}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (825) >>>825.pdbFusion protein BP residue: 571
CIF file (825) >>>825.cif		CLTCchr1757768072+ALKchr229446394-
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQV
VIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMK
ARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDA
AKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDG
KEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAH
MGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVF
LYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLE
FKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSV
NESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAY
LFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKR
ECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKL
DASESLRKEEEQATETQPIVYVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVS
GMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVS
LQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACG
CQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKG
GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQ
EVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYC
TQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEER
SPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPP
SELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE
GSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGY
1134
3D view using mol* of 825 (AA BP:571)
PDB file (1110)CLTCchr1757768072+ALKchr229446394-
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQV
VIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMK
AHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAG
CQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAAS
FAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDV
FFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISG
ETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALR
MAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRR
FQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQK
IVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIV
DVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAIL
GNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEW
LVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIE
LFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRE
SNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYI
EIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVE
KRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRR
KDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADL
PNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNY
DAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAE
RCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNW
EELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQ
VGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANST
RTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELI
TMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLR
AAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVAN
VELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKP
YLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLE
KHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELA
EELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFI
QVMKEYLTKVDKLDASESLRKEEEQATETQPIVYVYRRKHQELQAMQMEL
QSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLG
HGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK
FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAM
LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGM
ARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIF
SLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR
PNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPP
LLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEG
GHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIA
KKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFR
2197


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CLTC_pLDDT.png
all structure
all structure
ALK_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CLTC_ALK_825_pLDDT.png (AA BP:571)
all structure
CLTC_ALK_825_pLDDT_and_active_sites.png (AA BP:571)
all structure
CLTC_ALK_825_violinplot.png (AA BP:571)
all structure
CLTC_ALK_1110_pLDDT_and_active_sites.png (AA BP:)
all structure
CLTC_ALK_1110_violinplot.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
CLTC_ALK_825.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
8250.98052770.9943743.9670.54810.66880.89980.50181.06440.47140.6755Chain A: 390,391,393,394,424,608,609,610,611,612,6
13,614,673,676,677,680,684,757,758,759,760,762,763
,786,787,789,790,791,792,793,794,795,796,797,798,7
99,800,801,802,803,805,806,810,814,815,816,817,818
,819,820
11101.0373411.016853.0410.5340.7530.930.4871.1520.4230.651Chain A: 26,27,28,31,32,33,34,35,41,69,70,71,72,75
,83,108,109,110,111,112,113,114,115,144,151,152,15
3,154,155,157,158,159,160,162,168,170,197,198,200,
201,202,203,260,261,262,263,264,265,266,267,268,26
9,278,302,304,305,306,307,308,309,310,313,314,315,
320

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
1110ZINC000002599970DB00983Formoterol-6.41963-8.72753
1110ZINC000001996784DB08893Mirabegron-8.39885-8.56685
1110ZINC000001999441DB04861Nebivolol-8.43526-8.45506
1110ZINC000003861768DB00928Azacitidine-8.01786-8.43706
1110ZINC000005844788DB04861Nebivolol-8.37605-8.39585
1110ZINC000003830986DB00448Lansoprazole-6.2866-8.3199
1110ZINC000005733652DB11259Diosmetin-8.25709-8.29309
1110NetarsudilDB11259-8.23666-8.24776
1110ZINC000000000416DB00598Labetalol-6.28382-8.22162
1110ZINC000000121541DB00643Mebendazole-7.5518-8.21
1110ZINC000008214402DB00308Ibutilide-8.19637-8.20747
1110ZINC000001489478DB01261Sitagliptin-8.20291-8.20571
1110ZINC000002005305DB11256Levomefolic acid-8.15567-8.17187
1110ZINC000019796080DB00450Droperidol-7.05947-8.17167
1110ZINC000084758479DB09128Brexpiprazole-7.1439-8.0852
1110ZINC000000599734DB00448Lansoprazole-8.05427-8.07377
1110ZINC000000607986DB04861Nebivolol-8.0372-8.057
1110ZINC000000000746DB00871Terbutaline-8.04092-8.05522
1110ZINC000003800475DB00374Treprostinil-8.0536-8.0536
1110ZINC000004099200DB00213Pantoprazole-7.32677-8.03367

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000001996784DB08893MirabegronSmall moleculeNC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1Approved
ZINC000003861768DB00928AzacitidineSmall moleculeNC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1OApproved|Investigational
ZINC000005733652DB11259DiosmetinSmall moleculeCOC1=C(O)C=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2OExperimental
ZINC000000121541DB00643MebendazoleSmall moleculeCOC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C1Approved|Vet_approved
ZINC000008214402DB00308IbutilideSmall moleculeCCCCCCCN(CC)CCCC(O)C1=CC=C(NS(C)(=O)=O)C=C1Approved
ZINC000001489478DB01261SitagliptinSmall moleculeN[C@@H](CC(=O)N1CCN2C(C1)=NN=C2C(F)(F)F)CC1=CC(F)=C(F)C=C1FApproved|Investigational
ZINC000002005305DB11256Levomefolic acidSmall moleculeCN1[C@@H](CNC2=CC=C(C=C2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)N=C(N)N2Approved|Investigational
ZINC000019796080DB00450DroperidolSmall moleculeFC1=CC=C(C=C1)C(=O)CCCN1CCC(=CC1)N1C(=O)NC2=CC=CC=C12Approved|Vet_approved
ZINC000084758479DB09128BrexpiprazoleSmall moleculeO=C1NC2=CC(OCCCCN3CCN(CC3)C3=C4C=CSC4=CC=C3)=CC=C2C=C1Approved|Investigational
ZINC000000599734DB00448LansoprazoleSmall moleculeCC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1Approved|Investigational
ZINC000003800475DB00374TreprostinilSmall molecule[H][C@]12C[C@@H](O)[C@H](CC[C@@H](O)CCCCC)[C@@]1([H])CC1=C(C2)C(OCC(O)=O)=CC=C1Approved|Investigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000002599970344.415.946630.817255.555164.209211.05301131.10747.28.775368.96100
ZINC000002599970344.416.639655.84259.44181.011215.38901154.47647.28.821266.12500
ZINC000001996784396.5065.759766.121167.737163.909381.05653.421313.34757.78.494375.07100
ZINC000001996784396.5065.465768.333168.285165.496381.31553.2371317.85557.78.411374.8900
ZINC000001999441405.4414.722712.226273.48884.211260.77493.7531256.14736.49.229395.14300
ZINC000001999441405.4410.513723.645269.65591.189269.03293.7681265.84436.49.27394.03900
ZINC000003861768244.2077.104434.888110.158287.61337.1170717.082510.89.386236.48901
ZINC000003861768244.2078.996434.766110.132287.56937.0650716.913510.89.305236.49601
ZINC000003861768244.2076.643431.18393.993304.89532.2940718.65511.89.707231.37201
ZINC000005844788405.4411.102724.6273.70387.795269.33993.7621272.25736.49.305394.99500
ZINC000005844788405.4413.204688.14293.00460.761240.61593.761244.95936.49.151310000
ZINC000003830986369.3615.866631.387123.39987.612281.359139.0171077.11216.58.984379.27800
ZINC000003830986369.3618.192628.369118.33587.399279.605143.031072.74316.58.997379.26100
ZINC000005733652300.2674.88528.85593.31204.424231.120896.84124.58.9373.98200
ZINC000005733652300.2676.652527.11893.294202.511231.3130894.00524.58.908374.28700
ZINC000000000416328.415.718665.292169.819199.85295.62301140.60345.459.123270.54700
ZINC000000000416328.416.318651.677168.706200.025282.94601135.81245.459.228270.41600
ZINC000000121541295.2976.562576.16198.468169.387308.3060957.18158.911383.64100
ZINC000000121541295.2972.873577.03396.773172.83307.430959.022038.668388.18700
ZINC000000121541295.29710.919575.19998.469170.072306.6580956.419158.861383.46100
ZINC000008214402384.5764.587812.188564.391124.788122.4910.5181418.04828.29.055386.05500
ZINC000008214402384.5765.54811.751563.963125.234121.9020.6511414.42728.28.927385.82300
ZINC000008214402384.5765.103805.138559.778131.852113.4660.0421406.80528.29.089284.100
ZINC000008214402384.5765.301696.882503.79593.056100.03101321.37128.29.048389.48200
ZINC000001489478407.3187.405635.836163.527132.548106.077233.6851110.874159.676379.83100
ZINC000002005305459.46111.831783.577206.681420.974155.92201372.0347.2512.257.6551021
ZINC000002005305459.46112.273767.829200.116415.916151.79601360.767.2512.257.5781021
ZINC000019796080379.4335.336690.754177.289126.948339.68946.8281214.622168.72386.62500
ZINC000019796080379.4334.227703.161188.25122.749345.33746.8251231.012168.619387.34500
ZINC000019796080379.4336.26700.949186.412123.449344.26346.8251227.254168.598387.21500
ZINC000084758479433.5677.182778.252256.64888.856381.54451.2031386.13916.258.208310001
ZINC000084758479433.5673.597780.417251.3787.519390.30851.221385.02916.258.207310001
ZINC000000599734369.3617.029628.695122.70880.977284.054140.9571073.54316.58.976380.56500
ZINC000000599734369.3616.333629.454122.38590.343278.682138.0431074.9916.58.986378.63600
ZINC000000607986405.4415.004705.664273.42884.542253.93193.7631255.21236.49.141395.02900
ZINC000000607986405.4416.242723.401276.42185.145268.0793.7641269.44636.49.103395.44200
ZINC000000000746225.2873.599496.174234.367155.26106.5470827.34444.29.067261.8700
ZINC000000000746225.2871.595496.002233.982154.54107.480824.98644.28.979261.98100
ZINC000003800475390.5192.893761.224459.71184.691116.82301354.33836.159.303281.21600
ZINC000004099200383.3698.318623.128213.24477.412222.302110.171084.47189.124376.69200
ZINC000004099200383.3698.299620.121215.6578.983216.916108.5731082.558189.183376.22100
ZINC000004099200383.3698.355619.5212.86177.163219.295110.1821080.981189.019376.60300
ZINC000004099200383.3698.428625.396215.33578.49221.055110.5161084.724189.007376.45900


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000002599970COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc10.1338630780.246482573
ZINC000001996784Nc1nc(CC(=O)Nc2ccc(CCNC[C@H](O)c3ccccc3)cc2)cs10.205681060.138337618
ZINC000001999441O[C@@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000003861768Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n10.0680571610.388956815
ZINC000005844788O[C@@H](CNC[C@@H](O)[C@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000003830986Cc1c(OCC(F)(F)F)ccnc1C[S@](=O)c1nc2ccccc2[nH]10.1205135880.361439881
ZINC000005733652COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1O0.2601990860.67867566
ZINC000000000416C[C@H](CCc1ccccc1)NC[C@@H](O)c1ccc(O)c(C(N)=O)c10.1638887930.349082082
ZINC000000121541COC(=O)/N=c1[nH]c2ccc(C(=O)c3ccccc3)cc2[nH]10.2096963420.592445172
ZINC000008214402CCCCCCCN(CC)CCC[C@@H](O)c1ccc(NS(C)(=O)=O)cc10.1877492570.20117642
ZINC000001489478N[C@@H](CC(=O)N1CCn2c(nnc2C(F)(F)F)C1)Cc1cc(F)c(F)cc1F0.105272130.27925324
ZINC000002005305CN1c2c(nc(N)[nH]c2=O)NC[C@@H]1CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc10.0734179150.401979429
ZINC000019796080O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc10.2197276360.259906112
ZINC000084758479O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]10.2500596280.126613838
ZINC000000599734Cc1c(OCC(F)(F)F)ccnc1C[S@@](=O)c1nc2ccccc2[nH]10.1205135880.361439881
ZINC000000607986O[C@@H](CNC[C@@H](O)[C@H]1CCc2cc(F)ccc2O1)[C@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000000000746CC(C)(C)NC[C@H](O)c1cc(O)cc(O)c10.1598452130.248277396
ZINC000003800475CCCCC[C@H](O)CC[C@@H]1[C@H]2Cc3cccc(OCC(=O)O)c3C[C@H]2C[C@H]1O0.056698660.165296668
ZINC000004099200COc1ccnc(C[S@](=O)c2nc3ccc(OC(F)F)cc3[nH]2)c1OC0.1146673540.321842622


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
CLTCHGS, MCC, IKBKE, TFE3, SNX5, TOM1, SNX9, DNAJC6, ARMCX3, C10orf88, EPN1, EHD1, GGA1, GGA2, GGA3, KIT, AMPH, CLINT1, TNK2, LDLRAP1, HIP1, AP1B1, AP2A2, AP3B2, MAP3K10, PICALM, EPN2, Epn1, VCL, Arrb2, STAMBP, STAMBPL1, STAM, MAP1LC3A, SNCA, PRKACA, WNK1, Mapk13, HDAC5, SPG20, RICTOR, Erh, Cd2ap, Pttg1, EBNA-LP, PCM1, NDRG1, PPP1CA, ITSN1, ARRB1, SIRT7, SH3KBP1, DYRK1A, SNAP91, AP2B1, BIN1, AP1G1, RAC1, TOM1L1, TOM1L2, ISG15, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, XRCC6, HERC1, ATG16L1, SYNJ1, LRRK2, Nfe2l2, AKT1, GRB2, SHC1, AP2M1, MYO6, SRC, FYN, Htt, DNAJA3, RPSA, ESR1, PAXIP1, PPP1CC, SMURF1, ARRB2, ERBB2, FN1, VCAM1, Fcho2, DAB2, UBL4A, ITGA4, MYBL2, SVIL, PAN2, NPM1, PTAFR, ATP4A, EP300, QARS, YWHAQ, FBXO6, RPA1, RPA2, RPA3, ERG, EPHA2, LGR4, Fbxl16, STAU1, TP53, HUWE1, FBXW11, GJB5, NXF1, ADRB2, AVPR2, CUL7, OBSL1, CCDC8, EED, ZFYVE9, OCRL, ATR, SCYL2, HTR6, HNRNPA1, UNK, ATP1A1, ATP1A2, ATP1A3, ATP5C1, CCDC47, CCT3, CCT6A, BLOC1S1, CAD, CANX, CCT6B, CISD1, CLTA, CYC1, DHX38, EHD2, FASTKD2, HSP90B1, IPO5, MTCH2, NDUFB9, NDUFS1, NLRP1, RAB5B, RANBP2, RANBP6, SLC25A3, SSR3, TECR, TOMM22, UQCRC2, VDAC1, VDAC2, VDAC3, ZMPSTE24, DDOST, EIF6, COX2, PHB, PHB2, PPP2R1A, PPP2R1B, RPN1, TMCO1, TUFM, UQCRQ, NTRK1, OFD1, CEP97, CNTRL, FBF1, NPHP1, DCTN1, POC5, POC1B, PPME1, ABCA2, PARP4, AP2A1, ATP6V1B2, ATP6V0A1, CAV1, CLTB, CAPZA2, DBN1, FLNA, GAK, MYH9, DNAJC7, IQGAP1, PDLIM7, SEC16A, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, ARX, MYO18A, CSNK1A1, CSNK1E, STOM, EPS15, HSPA1A, HSPA4, NDUFA9, CHMP1A, PIK3C2A, PRKAR2A, SEC13, SOAT1, CLTCL1, SORBS2, PKP4, USO1, NUMB, TNK1, RAB11A, HIP1R, ATP6V0D1, XPR1, SEC24C, KIAA0430, IST1, HELZ, MVP, TROAP, SEC24B, RBM14, SEC23A, VTI1B, TRAFD1, PKP3, AAK1, BTBD3, TNRC6B, EDC4, DSTYK, PTPN23, NECAP1, TNRC6A, EHD4, EGFL7, ATP6V1D, PTRH2, PLEKHA5, CPVL, BMP2K, DCP1A, ERBB2IP, CHMP1B, KIDINS220, MTUS1, DENND1A, CRTC3, CPSF7, EDC3, CCDC115, FAM83A, REPS1, STON2, FCHO2, CHMP4B, MITD1, CRTC2, FAM83B, FAM83H, SLC35B2, Actb, Myh9, Myo1c, Ppp1cb, Tpm1, Coro1c, Cul3, Spast, Tmod3, Dctn3, Uso1, Lima1, Samm50, Calml3, Myh10, Strn3, Smap1, Ptpn23, Nhsl1, Sec24c, Flnb, IKBKB, MAP3K7, MCM2, AP3D1, U2AF2, CDC73, ZNF746, ARF6, CYLD, LASP1, BRCA1, TES, MTF1, BRD1, CFTR, ZNF598, PDGFRB, FBXO7, TMPO, PTCH1, HSPA8, MAP2K1, PIK3CA, APOE, BMPR1A, JUP, UQCRB, UBE2M, RAD18, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, LARP7, RNF4, TNF, SPDL1, RIOK1, PRKCZ, HEXIM1, MEPCE, RUNX1, RNF123, PPT1, HERC2, UBE3A, AGR2, RECQL4, SMAP1, MYC, CDK9, Prkaa1, Prkab1, CDK5RAP2, GRWD1, KRT17, KIAA1429, PLEKHA2, RC3H2, ACTC1, TET2, NR2C2, UCHL3, PRDM16, MECOM, AGRN, BMH1, BMH2, ATXN3, TCF7L2, STX2, GSK3B, ABCC6, BIRC3, LMBR1L, WWP2, Hsp22, TRIM28, GJA1, TEX101, ARIH2, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, Clta, PXN, RALBP1, PTCHD3, C18orf54, ANKRD55, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF14, ORF3a, ORF6, ORF7a, ORF7b, ABCC2, CDCA5, ACO1, OPTN, NEK4, LRRC31, DUX4, CIT, AURKB, ECT2, KIF14, KIF20A, MAD2L2, KIF23, PRC1, PRNP, CHCHD1, HAX1, MFN2, SLC25A46, LDLR, SUMO2, PRKCB, Rnf183, AIMP2, BRD4, NINL, AFTPH, NUPR1, EPHA3, CIC, Apc2, RBM39, LGALS9, RIN3, EIF3H, DNAJA1, HSPA1L, HSPA2, HSPA6, BAG5, AR, UFL1, DDRGK1, CD3EAP, LAMTOR1, POLR2C, TRIM37, HTRA4, DRD2, ADRBK1, WDR5, PAGE4, NUDCD2, BGLT3, EDEM1, BAG2, DTX3, BTF3, IGF1R, NEDD4, FBXW7, TFRC, IFITM1, BSG, IFITM3, TMPRSS11B, CLEC4E, nsp15, ORF10, FGD5, MAP1LC3B, NBR1, CALCOCO2, SQSTM1, TOLLIP, Chrna4, SIRT6, PER2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CLTCall structure
ALKall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CLTC-ALK


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CLTC-ALK


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
CLTCALKLung AdenocarcinomaMyCancerGenome
CLTCALKAcute Myeloid LeukemiaMyCancerGenome
CLTCALKCancer Of Unknown PrimaryMyCancerGenome
CLTCALKDiffuse Large B-Cell LymphomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLTCC4518356MiT family translocation renal cell carcinoma2ORPHANET
HgeneCLTCC4693389MENTAL RETARDATION, AUTOSOMAL DOMINANT 562GENOMICS_ENGLAND;UNIPROT
HgeneCLTCC0079744Diffuse Large B-Cell Lymphoma1CTD_human
HgeneCLTCC0334121Inflammatory Myofibroblastic Tumor1ORPHANET
TgeneALKC0007131Non-Small Cell Lung Carcinoma28CGI;CTD_human
TgeneALKC0027819Neuroblastoma13CGI;CTD_human;ORPHANET
TgeneALKC0152013Adenocarcinoma of lung (disorder)8CGI;CTD_human
TgeneALKC2751681NEUROBLASTOMA, SUSCEPTIBILITY TO, 38CLINGEN;UNIPROT
TgeneALKC0206180Ki-1+ Anaplastic Large Cell Lymphoma6CGI;CTD_human
TgeneALKC0334121Inflammatory Myofibroblastic Tumor4CGI;CTD_human;ORPHANET
TgeneALKC0018199Granuloma, Plasma Cell3CTD_human
TgeneALKC0007621Neoplastic Cell Transformation2CTD_human
TgeneALKC0027627Neoplasm Metastasis2CTD_human
TgeneALKC0238463Papillary thyroid carcinoma2ORPHANET
TgeneALKC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneALKC0006118Brain Neoplasms1CGI;CTD_human
TgeneALKC0006142Malignant neoplasm of breast1CTD_human
TgeneALKC0007134Renal Cell Carcinoma1CTD_human
TgeneALKC0011570Mental Depression1PSYGENET
TgeneALKC0011581Depressive disorder1PSYGENET
TgeneALKC0027643Neoplasm Recurrence, Local1CTD_human
TgeneALKC0036341Schizophrenia1PSYGENET
TgeneALKC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneALKC0085269Plasma Cell Granuloma, Pulmonary1CTD_human
TgeneALKC0153633Malignant neoplasm of brain1CGI;CTD_human
TgeneALKC0278601Inflammatory Breast Carcinoma1CTD_human
TgeneALKC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneALKC0496899Benign neoplasm of brain, unspecified1CTD_human
TgeneALKC0678222Breast Carcinoma1CTD_human
TgeneALKC0750974Brain Tumor, Primary1CTD_human
TgeneALKC0750977Recurrent Brain Neoplasm1CTD_human
TgeneALKC0750979Primary malignant neoplasm of brain1CTD_human
TgeneALKC1257931Mammary Neoplasms, Human1CTD_human
TgeneALKC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneALKC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneALKC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneALKC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneALKC1332079Anaplastic Large Cell Lymphoma, ALK-Positive1ORPHANET
TgeneALKC1458155Mammary Neoplasms1CTD_human
TgeneALKC1527390Neoplasms, Intracranial1CTD_human
TgeneALKC2931189Neural crest tumor1ORPHANET
TgeneALKC3899155hereditary neuroblastoma1GENOMICS_ENGLAND
TgeneALKC4704874Mammary Carcinoma, Human1CTD_human