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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CLTC-CEP95

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CLTC-CEP95
FusionPDB ID: 17384
FusionGDB2.0 ID: 17384
HgeneTgene
Gene symbol

CLTC

CEP95

Gene ID

1213

90799

Gene nameclathrin heavy chaincentrosomal protein 95
SynonymsCHC|CHC17|CLH-17|CLTCL2|Hc|MRD56CCDC45
Cytomap

17q23.1

17q23.3

Type of geneprotein-codingprotein-coding
Descriptionclathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2centrosomal protein of 95 kDacentrosomal protein 95kDacoiled-coil domain containing 45coiled-coil domain-containing protein 45
Modification date2020031320200313
UniProtAcc

P53675

Q96GE4

Ensembl transtripts involved in fusion geneENST idsENST00000269122, ENST00000393043, 
ENST00000579456, ENST00000579815, 
ENST00000577476, ENST00000581056, 
ENST00000553412, ENST00000556440, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 40 X 17=183606 X 7 X 3=126
# samples 847
** MAII scorelog2(84/18360*10)=-4.45003292063505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CLTC [Title/Abstract] AND CEP95 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CLTC(57739004)-CEP95(62532720), # samples:3
Anticipated loss of major functional domain due to fusion event.CLTC-CEP95 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLTC-CEP95 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLTC-CEP95 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLTC-CEP95 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLTC

GO:1900126

negative regulation of hyaluronan biosynthetic process

24251095


check buttonFusion gene breakpoints across CLTC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP95 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-CA-5254-01ACLTCchr17

57739004

-CEP95chr17

62532720

+
ChimerDB4COADTCGA-CA-5254-01ACLTCchr17

57739004

+CEP95chr17

62532720

+
ChimerDB4COADTCGA-CA-5254CLTCchr17

57739004

+CEP95chr17

62532719

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393043CLTCchr1757739004+ENST00000556440CEP95chr1762532720+220116422742037587
ENST00000393043CLTCchr1757739004+ENST00000553412CEP95chr1762532720+220116422742037587
ENST00000269122CLTCchr1757739004+ENST00000556440CEP95chr1762532720+220116422742037587
ENST00000269122CLTCchr1757739004+ENST00000553412CEP95chr1762532720+220116422742037587
ENST00000393043CLTCchr1757739004+ENST00000556440CEP95chr1762532719+220116422742037587
ENST00000393043CLTCchr1757739004+ENST00000553412CEP95chr1762532719+220116422742037587
ENST00000269122CLTCchr1757739004+ENST00000556440CEP95chr1762532719+220116422742037587
ENST00000269122CLTCchr1757739004+ENST00000553412CEP95chr1762532719+220116422742037587

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393043ENST00000556440CLTCchr1757739004+CEP95chr1762532720+0.0015912970.99840873
ENST00000393043ENST00000553412CLTCchr1757739004+CEP95chr1762532720+0.0015912970.99840873
ENST00000269122ENST00000556440CLTCchr1757739004+CEP95chr1762532720+0.0015912970.99840873
ENST00000269122ENST00000553412CLTCchr1757739004+CEP95chr1762532720+0.0015912970.99840873
ENST00000393043ENST00000556440CLTCchr1757739004+CEP95chr1762532719+0.0015912970.99840873
ENST00000393043ENST00000553412CLTCchr1757739004+CEP95chr1762532719+0.0015912970.99840873
ENST00000269122ENST00000556440CLTCchr1757739004+CEP95chr1762532719+0.0015912970.99840873
ENST00000269122ENST00000553412CLTCchr1757739004+CEP95chr1762532719+0.0015912970.99840873

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>17384_17384_1_CLTC-CEP95_CLTC_chr17_57739004_ENST00000269122_CEP95_chr17_62532719_ENST00000553412_length(amino acids)=587AA_BP=456
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKRELRS

--------------------------------------------------------------

>17384_17384_2_CLTC-CEP95_CLTC_chr17_57739004_ENST00000269122_CEP95_chr17_62532719_ENST00000556440_length(amino acids)=587AA_BP=456
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKRELRS

--------------------------------------------------------------

>17384_17384_3_CLTC-CEP95_CLTC_chr17_57739004_ENST00000269122_CEP95_chr17_62532720_ENST00000553412_length(amino acids)=587AA_BP=456
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKRELRS

--------------------------------------------------------------

>17384_17384_4_CLTC-CEP95_CLTC_chr17_57739004_ENST00000269122_CEP95_chr17_62532720_ENST00000556440_length(amino acids)=587AA_BP=456
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKRELRS

--------------------------------------------------------------

>17384_17384_5_CLTC-CEP95_CLTC_chr17_57739004_ENST00000393043_CEP95_chr17_62532719_ENST00000553412_length(amino acids)=587AA_BP=456
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKRELRS

--------------------------------------------------------------

>17384_17384_6_CLTC-CEP95_CLTC_chr17_57739004_ENST00000393043_CEP95_chr17_62532719_ENST00000556440_length(amino acids)=587AA_BP=456
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKRELRS

--------------------------------------------------------------

>17384_17384_7_CLTC-CEP95_CLTC_chr17_57739004_ENST00000393043_CEP95_chr17_62532720_ENST00000553412_length(amino acids)=587AA_BP=456
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKRELRS

--------------------------------------------------------------

>17384_17384_8_CLTC-CEP95_CLTC_chr17_57739004_ENST00000393043_CEP95_chr17_62532720_ENST00000556440_length(amino acids)=587AA_BP=456
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKRELRS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57739004/chr17:62532720)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLTC

P53675

CEP95

Q96GE4

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832108_149456.01676.0RegionNote=WD40-like repeat 3
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832150_195456.01676.0RegionNote=WD40-like repeat 4
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832196_257456.01676.0RegionNote=WD40-like repeat 5
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+83224_67456.01676.0RegionNote=WD40-like repeat 1
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832258_301456.01676.0RegionNote=WD40-like repeat 6
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832302_330456.01676.0RegionNote=WD40-like repeat 7
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+83268_107456.01676.0RegionNote=WD40-like repeat 2
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831108_149456.01640.0RegionNote=WD40-like repeat 3
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831150_195456.01640.0RegionNote=WD40-like repeat 4
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831196_257456.01640.0RegionNote=WD40-like repeat 5
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+83124_67456.01640.0RegionNote=WD40-like repeat 1
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831258_301456.01640.0RegionNote=WD40-like repeat 6
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831302_330456.01640.0RegionNote=WD40-like repeat 7
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+83168_107456.01640.0RegionNote=WD40-like repeat 2
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832108_149456.01676.0RegionNote=WD40-like repeat 3
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832150_195456.01676.0RegionNote=WD40-like repeat 4
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832196_257456.01676.0RegionNote=WD40-like repeat 5
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+83224_67456.01676.0RegionNote=WD40-like repeat 1
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832258_301456.01676.0RegionNote=WD40-like repeat 6
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832302_330456.01676.0RegionNote=WD40-like repeat 7
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+83268_107456.01676.0RegionNote=WD40-like repeat 2
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831108_149456.01640.0RegionNote=WD40-like repeat 3
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831150_195456.01640.0RegionNote=WD40-like repeat 4
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831196_257456.01640.0RegionNote=WD40-like repeat 5
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+83124_67456.01640.0RegionNote=WD40-like repeat 1
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831258_301456.01640.0RegionNote=WD40-like repeat 6
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831302_330456.01640.0RegionNote=WD40-like repeat 7
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+83168_107456.01640.0RegionNote=WD40-like repeat 2
TgeneCEP95chr17:57739004chr17:62532719ENST000005564401620700_794690.0822.0Coiled coilOntology_term=ECO:0000255
TgeneCEP95chr17:57739004chr17:62532720ENST000005564401620700_794690.0822.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+8321213_1522456.01676.0RegionInvolved in binding clathrin light chain
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+8321550_1675456.01676.0RegionTrimerization
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+8322_479456.01676.0RegionNote=Globular terminal domain
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832449_465456.01676.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832480_523456.01676.0RegionNote=Flexible linker
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832524_1675456.01676.0RegionNote=Heavy chain arm
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832524_634456.01676.0RegionNote=Distal segment
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832639_1675456.01676.0RegionNote=Proximal segment
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+8311213_1522456.01640.0RegionInvolved in binding clathrin light chain
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+8311550_1675456.01640.0RegionTrimerization
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+8312_479456.01640.0RegionNote=Globular terminal domain
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831449_465456.01640.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831480_523456.01640.0RegionNote=Flexible linker
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831524_1675456.01640.0RegionNote=Heavy chain arm
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831524_634456.01640.0RegionNote=Distal segment
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831639_1675456.01640.0RegionNote=Proximal segment
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+8321213_1522456.01676.0RegionInvolved in binding clathrin light chain
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+8321550_1675456.01676.0RegionTrimerization
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+8322_479456.01676.0RegionNote=Globular terminal domain
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832449_465456.01676.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832480_523456.01676.0RegionNote=Flexible linker
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832524_1675456.01676.0RegionNote=Heavy chain arm
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832524_634456.01676.0RegionNote=Distal segment
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832639_1675456.01676.0RegionNote=Proximal segment
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+8311213_1522456.01640.0RegionInvolved in binding clathrin light chain
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+8311550_1675456.01640.0RegionTrimerization
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+8312_479456.01640.0RegionNote=Globular terminal domain
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831449_465456.01640.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831480_523456.01640.0RegionNote=Flexible linker
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831524_1675456.01640.0RegionNote=Heavy chain arm
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831524_634456.01640.0RegionNote=Distal segment
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831639_1675456.01640.0RegionNote=Proximal segment
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+8321128_1269456.01676.0RepeatCHCR 5
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+8321274_1420456.01676.0RepeatCHCR 6
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+8321423_1566456.01676.0RepeatCHCR 7
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832537_683456.01676.0RepeatCHCR 1
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832686_828456.01676.0RepeatCHCR 2
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832833_972456.01676.0RepeatCHCR 3
HgeneCLTCchr17:57739004chr17:62532719ENST00000269122+832979_1124456.01676.0RepeatCHCR 4
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+8311128_1269456.01640.0RepeatCHCR 5
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+8311274_1420456.01640.0RepeatCHCR 6
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+8311423_1566456.01640.0RepeatCHCR 7
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831537_683456.01640.0RepeatCHCR 1
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831686_828456.01640.0RepeatCHCR 2
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831833_972456.01640.0RepeatCHCR 3
HgeneCLTCchr17:57739004chr17:62532719ENST00000393043+831979_1124456.01640.0RepeatCHCR 4
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+8321128_1269456.01676.0RepeatCHCR 5
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+8321274_1420456.01676.0RepeatCHCR 6
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+8321423_1566456.01676.0RepeatCHCR 7
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832537_683456.01676.0RepeatCHCR 1
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832686_828456.01676.0RepeatCHCR 2
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832833_972456.01676.0RepeatCHCR 3
HgeneCLTCchr17:57739004chr17:62532720ENST00000269122+832979_1124456.01676.0RepeatCHCR 4
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+8311128_1269456.01640.0RepeatCHCR 5
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+8311274_1420456.01640.0RepeatCHCR 6
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+8311423_1566456.01640.0RepeatCHCR 7
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831537_683456.01640.0RepeatCHCR 1
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831686_828456.01640.0RepeatCHCR 2
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831833_972456.01640.0RepeatCHCR 3
HgeneCLTCchr17:57739004chr17:62532720ENST00000393043+831979_1124456.01640.0RepeatCHCR 4
TgeneCEP95chr17:57739004chr17:62532719ENST000005564401620585_632690.0822.0Coiled coilOntology_term=ECO:0000255
TgeneCEP95chr17:57739004chr17:62532720ENST000005564401620585_632690.0822.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
CLTCHGS, MCC, IKBKE, TFE3, SNX5, TOM1, SNX9, DNAJC6, ARMCX3, C10orf88, EPN1, EHD1, GGA1, GGA2, GGA3, KIT, AMPH, CLINT1, TNK2, LDLRAP1, HIP1, AP1B1, AP2A2, AP3B2, MAP3K10, PICALM, EPN2, Epn1, VCL, Arrb2, STAMBP, STAMBPL1, STAM, MAP1LC3A, SNCA, PRKACA, WNK1, Mapk13, HDAC5, SPG20, RICTOR, Erh, Cd2ap, Pttg1, EBNA-LP, PCM1, NDRG1, PPP1CA, ITSN1, ARRB1, SIRT7, SH3KBP1, DYRK1A, SNAP91, AP2B1, BIN1, AP1G1, RAC1, TOM1L1, TOM1L2, ISG15, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, XRCC6, HERC1, ATG16L1, SYNJ1, LRRK2, Nfe2l2, AKT1, GRB2, SHC1, AP2M1, MYO6, SRC, FYN, Htt, DNAJA3, RPSA, ESR1, PAXIP1, PPP1CC, SMURF1, ARRB2, ERBB2, FN1, VCAM1, Fcho2, DAB2, UBL4A, ITGA4, MYBL2, SVIL, PAN2, NPM1, PTAFR, ATP4A, EP300, QARS, YWHAQ, FBXO6, RPA1, RPA2, RPA3, ERG, EPHA2, LGR4, Fbxl16, STAU1, TP53, HUWE1, FBXW11, GJB5, NXF1, ADRB2, AVPR2, CUL7, OBSL1, CCDC8, EED, ZFYVE9, OCRL, ATR, SCYL2, HTR6, HNRNPA1, UNK, ATP1A1, ATP1A2, ATP1A3, ATP5C1, CCDC47, CCT3, CCT6A, BLOC1S1, CAD, CANX, CCT6B, CISD1, CLTA, CYC1, DHX38, EHD2, FASTKD2, HSP90B1, IPO5, MTCH2, NDUFB9, NDUFS1, NLRP1, RAB5B, RANBP2, RANBP6, SLC25A3, SSR3, TECR, TOMM22, UQCRC2, VDAC1, VDAC2, VDAC3, ZMPSTE24, DDOST, EIF6, COX2, PHB, PHB2, PPP2R1A, PPP2R1B, RPN1, TMCO1, TUFM, UQCRQ, NTRK1, OFD1, CEP97, CNTRL, FBF1, NPHP1, DCTN1, POC5, POC1B, PPME1, ABCA2, PARP4, AP2A1, ATP6V1B2, ATP6V0A1, CAV1, CLTB, CAPZA2, DBN1, FLNA, GAK, MYH9, DNAJC7, IQGAP1, PDLIM7, SEC16A, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, ARX, MYO18A, CSNK1A1, CSNK1E, STOM, EPS15, HSPA1A, HSPA4, NDUFA9, CHMP1A, PIK3C2A, PRKAR2A, SEC13, SOAT1, CLTCL1, SORBS2, PKP4, USO1, NUMB, TNK1, RAB11A, HIP1R, ATP6V0D1, XPR1, SEC24C, KIAA0430, IST1, HELZ, MVP, TROAP, SEC24B, RBM14, SEC23A, VTI1B, TRAFD1, PKP3, AAK1, BTBD3, TNRC6B, EDC4, DSTYK, PTPN23, NECAP1, TNRC6A, EHD4, EGFL7, ATP6V1D, PTRH2, PLEKHA5, CPVL, BMP2K, DCP1A, ERBB2IP, CHMP1B, KIDINS220, MTUS1, DENND1A, CRTC3, CPSF7, EDC3, CCDC115, FAM83A, REPS1, STON2, FCHO2, CHMP4B, MITD1, CRTC2, FAM83B, FAM83H, SLC35B2, Actb, Myh9, Myo1c, Ppp1cb, Tpm1, Coro1c, Cul3, Spast, Tmod3, Dctn3, Uso1, Lima1, Samm50, Calml3, Myh10, Strn3, Smap1, Ptpn23, Nhsl1, Sec24c, Flnb, IKBKB, MAP3K7, MCM2, AP3D1, U2AF2, CDC73, ZNF746, ARF6, CYLD, LASP1, BRCA1, TES, MTF1, BRD1, CFTR, ZNF598, PDGFRB, FBXO7, TMPO, PTCH1, HSPA8, MAP2K1, PIK3CA, APOE, BMPR1A, JUP, UQCRB, UBE2M, RAD18, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, LARP7, RNF4, TNF, SPDL1, RIOK1, PRKCZ, HEXIM1, MEPCE, RUNX1, RNF123, PPT1, HERC2, UBE3A, AGR2, RECQL4, SMAP1, MYC, CDK9, Prkaa1, Prkab1, CDK5RAP2, GRWD1, KRT17, KIAA1429, PLEKHA2, RC3H2, ACTC1, TET2, NR2C2, UCHL3, PRDM16, MECOM, AGRN, BMH1, BMH2, ATXN3, TCF7L2, STX2, GSK3B, ABCC6, BIRC3, LMBR1L, WWP2, Hsp22, TRIM28, GJA1, TEX101, ARIH2, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, Clta, PXN, RALBP1, PTCHD3, C18orf54, ANKRD55, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF14, ORF3a, ORF6, ORF7a, ORF7b, ABCC2, CDCA5, ACO1, OPTN, NEK4, LRRC31, DUX4, CIT, AURKB, ECT2, KIF14, KIF20A, MAD2L2, KIF23, PRC1, PRNP, CHCHD1, HAX1, MFN2, SLC25A46, LDLR, SUMO2, PRKCB, Rnf183, AIMP2, BRD4, NINL, AFTPH, NUPR1, EPHA3, CIC, Apc2, RBM39, LGALS9, RIN3, EIF3H, DNAJA1, HSPA1L, HSPA2, HSPA6, BAG5, AR, UFL1, DDRGK1, CD3EAP, LAMTOR1, POLR2C, TRIM37, HTRA4, DRD2, ADRBK1, WDR5, PAGE4, NUDCD2, BGLT3, EDEM1, BAG2, DTX3, BTF3, IGF1R, NEDD4, FBXW7, TFRC, IFITM1, BSG, IFITM3, TMPRSS11B, CLEC4E, nsp15, ORF10, FGD5, MAP1LC3B, NBR1, CALCOCO2, SQSTM1, TOLLIP, Chrna4, SIRT6, PER2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CLTCall structure
CEP95


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CLTC-CEP95


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CLTC-CEP95


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLTCC4518356MiT family translocation renal cell carcinoma2ORPHANET
HgeneCLTCC4693389MENTAL RETARDATION, AUTOSOMAL DOMINANT 562GENOMICS_ENGLAND;UNIPROT
HgeneCLTCC0079744Diffuse Large B-Cell Lymphoma1CTD_human
HgeneCLTCC0334121Inflammatory Myofibroblastic Tumor1ORPHANET