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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CLTC-EPB41L3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CLTC-EPB41L3
	FusionPDB ID: 17389
	FusionGDB2.0 ID: 17389
		Hgene	Tgene
	Gene symbol	CLTC	EPB41L3
	Gene ID	1213	23136
	Gene name	clathrin heavy chain	erythrocyte membrane protein band 4.1 like 3
	Synonyms	CHC\|CHC17\|CLH-17\|CLTCL2\|Hc\|MRD56	4.1B\|DAL-1\|DAL1
	Cytomap	17q23.1	18p11.31
	Type of gene	protein-coding	protein-coding
	Description	clathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2	band 4.1-like protein 3differentially expressed in adenocarcinoma of the lung protein 1
	Modification date	20200313	20200320
	UniProtAcc	P53675	Q9Y2J2
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000269122, ENST00000393043, ENST00000579456, ENST00000579815,	ENST00000427684, ENST00000542146, ENST00000542652, ENST00000341928, ENST00000342933, ENST00000400111, ENST00000540638, ENST00000544123,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	27 X 40 X 17=18360	4 X 4 X 4=64
	# samples	84	4
	** MAII score	log2(84/18360*10)=-4.45003292063505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CLTC [Title/Abstract] AND EPB41L3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CLTC(57697534)-EPB41L3(5397425), # samples:1
Anticipated loss of major functional domain due to fusion event.	CLTC-EPB41L3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CLTC-EPB41L3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CLTC-EPB41L3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CLTC-EPB41L3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CLTC	GO:1900126	negative regulation of hyaluronan biosynthetic process	24251095

Fusion gene breakpoints across CLTC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EPB41L3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A0HB-01A	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393043	CLTC	chr17	57697534	+	ENST00000341928	EPB41L3	chr18	5397425	-	2209	316	274	1107	277
ENST00000393043	CLTC	chr17	57697534	+	ENST00000544123	EPB41L3	chr18	5397425	-	1407	316	274	1002	242
ENST00000393043	CLTC	chr17	57697534	+	ENST00000540638	EPB41L3	chr18	5397425	-	1500	316	274	1107	277
ENST00000393043	CLTC	chr17	57697534	+	ENST00000342933	EPB41L3	chr18	5397425	-	1108	316	274	1107	278
ENST00000393043	CLTC	chr17	57697534	+	ENST00000400111	EPB41L3	chr18	5397425	-	1108	316	274	1107	278
ENST00000269122	CLTC	chr17	57697534	+	ENST00000341928	EPB41L3	chr18	5397425	-	2209	316	274	1107	277
ENST00000269122	CLTC	chr17	57697534	+	ENST00000544123	EPB41L3	chr18	5397425	-	1407	316	274	1002	242
ENST00000269122	CLTC	chr17	57697534	+	ENST00000540638	EPB41L3	chr18	5397425	-	1500	316	274	1107	277
ENST00000269122	CLTC	chr17	57697534	+	ENST00000342933	EPB41L3	chr18	5397425	-	1108	316	274	1107	278
ENST00000269122	CLTC	chr17	57697534	+	ENST00000400111	EPB41L3	chr18	5397425	-	1108	316	274	1107	278
ENST00000579456	CLTC	chr17	57697534	+	ENST00000341928	EPB41L3	chr18	5397425	-	2135	242	200	1033	277
ENST00000579456	CLTC	chr17	57697534	+	ENST00000544123	EPB41L3	chr18	5397425	-	1333	242	200	928	242
ENST00000579456	CLTC	chr17	57697534	+	ENST00000540638	EPB41L3	chr18	5397425	-	1426	242	200	1033	277
ENST00000579456	CLTC	chr17	57697534	+	ENST00000342933	EPB41L3	chr18	5397425	-	1034	242	200	1033	278
ENST00000579456	CLTC	chr17	57697534	+	ENST00000400111	EPB41L3	chr18	5397425	-	1034	242	200	1033	278

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393043	ENST00000341928	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.001104329	0.99889565
ENST00000393043	ENST00000544123	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.003445874	0.99655414
ENST00000393043	ENST00000540638	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.002807332	0.9971927
ENST00000393043	ENST00000342933	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.004902013	0.99509794
ENST00000393043	ENST00000400111	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.004902013	0.99509794
ENST00000269122	ENST00000341928	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.001104329	0.99889565
ENST00000269122	ENST00000544123	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.003445874	0.99655414
ENST00000269122	ENST00000540638	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.002807332	0.9971927
ENST00000269122	ENST00000342933	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.004902013	0.99509794
ENST00000269122	ENST00000400111	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.004902013	0.99509794
ENST00000579456	ENST00000341928	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.001133719	0.9988663
ENST00000579456	ENST00000544123	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.003356722	0.9966433
ENST00000579456	ENST00000540638	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.003073936	0.996926
ENST00000579456	ENST00000342933	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.00521033	0.9947897
ENST00000579456	ENST00000400111	CLTC	chr17	57697534	+	EPB41L3	chr18	5397425	-	0.00521033	0.9947897

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>17389_17389_1_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000269122_EPB41L3_chr18_5397425_ENST00000341928_length(amino acids)=277AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_2_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000269122_EPB41L3_chr18_5397425_ENST00000342933_length(amino acids)=278AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_3_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000269122_EPB41L3_chr18_5397425_ENST00000400111_length(amino acids)=278AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_4_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000269122_EPB41L3_chr18_5397425_ENST00000540638_length(amino acids)=277AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_5_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000269122_EPB41L3_chr18_5397425_ENST00000544123_length(amino acids)=242AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS

--------------------------------------------------------------

>17389_17389_6_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000393043_EPB41L3_chr18_5397425_ENST00000341928_length(amino acids)=277AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_7_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000393043_EPB41L3_chr18_5397425_ENST00000342933_length(amino acids)=278AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_8_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000393043_EPB41L3_chr18_5397425_ENST00000400111_length(amino acids)=278AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_9_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000393043_EPB41L3_chr18_5397425_ENST00000540638_length(amino acids)=277AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_10_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000393043_EPB41L3_chr18_5397425_ENST00000544123_length(amino acids)=242AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS

--------------------------------------------------------------

>17389_17389_11_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000579456_EPB41L3_chr18_5397425_ENST00000341928_length(amino acids)=277AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_12_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000579456_EPB41L3_chr18_5397425_ENST00000342933_length(amino acids)=278AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_13_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000579456_EPB41L3_chr18_5397425_ENST00000400111_length(amino acids)=278AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_14_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000579456_EPB41L3_chr18_5397425_ENST00000540638_length(amino acids)=277AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS
QVDPGTDLEPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI

--------------------------------------------------------------

>17389_17389_15_CLTC-EPB41L3_CLTC_chr17_57697534_ENST00000579456_EPB41L3_chr18_5397425_ENST00000544123_length(amino acids)=242AA_BP=13
MAQILPIRFQEHLQKMETKTESSGIETEPTVHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGSVSPGGVKLEISTKEVPVVHTETKTITYESS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57697534/chr18:5397425)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CLTC P53675	EPB41L3 Q9Y2J2
FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.	FUNCTION: Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269\|PubMed:15334060, ECO:0000269\|PubMed:15737618, ECO:0000269\|PubMed:16420693, ECO:0000269\|PubMed:9892180}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000341928

861_1083

824.0

1317.3333333333333

Region

Note=C-terminal (CTD)

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000342933

861_1083

824.0

1088.0

Region

Note=C-terminal (CTD)

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000400111

861_1083

602.0

866.0

Region

Note=C-terminal (CTD)

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000540638

861_1083

602.0

846.0

Region

Note=C-terminal (CTD)

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

108_149

14.0

1676.0

Region

Note=WD40-like repeat 3

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

1213_1522

14.0

1676.0

Region

Involved in binding clathrin light chain

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

150_195

14.0

1676.0

Region

Note=WD40-like repeat 4

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

1550_1675

14.0

1676.0

Region

Trimerization

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

196_257

14.0

1676.0

Region

Note=WD40-like repeat 5

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

24_67

14.0

1676.0

Region

Note=WD40-like repeat 1

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

258_301

14.0

1676.0

Region

Note=WD40-like repeat 6

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

2_479

14.0

1676.0

Region

Note=Globular terminal domain

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

302_330

14.0

1676.0

Region

Note=WD40-like repeat 7

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

449_465

14.0

1676.0

Region

Binding site for the uncoating ATPase%2C involved in lattice disassembly

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

480_523

14.0

1676.0

Region

Note=Flexible linker

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

524_1675

14.0

1676.0

Region

Note=Heavy chain arm

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

524_634

14.0

1676.0

Region

Note=Distal segment

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

639_1675

14.0

1676.0

Region

Note=Proximal segment

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

68_107

14.0

1676.0

Region

Note=WD40-like repeat 2

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

108_149

14.0

1640.0

Region

Note=WD40-like repeat 3

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

1213_1522

14.0

1640.0

Region

Involved in binding clathrin light chain

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

150_195

14.0

1640.0

Region

Note=WD40-like repeat 4

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

1550_1675

14.0

1640.0

Region

Trimerization

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

196_257

14.0

1640.0

Region

Note=WD40-like repeat 5

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

24_67

14.0

1640.0

Region

Note=WD40-like repeat 1

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

258_301

14.0

1640.0

Region

Note=WD40-like repeat 6

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

2_479

14.0

1640.0

Region

Note=Globular terminal domain

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

302_330

14.0

1640.0

Region

Note=WD40-like repeat 7

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

449_465

14.0

1640.0

Region

Binding site for the uncoating ATPase%2C involved in lattice disassembly

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

480_523

14.0

1640.0

Region

Note=Flexible linker

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

524_1675

14.0

1640.0

Region

Note=Heavy chain arm

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

524_634

14.0

1640.0

Region

Note=Distal segment

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

639_1675

14.0

1640.0

Region

Note=Proximal segment

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

68_107

14.0

1640.0

Region

Note=WD40-like repeat 2

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

1128_1269

14.0

1676.0

Repeat

CHCR 5

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

1274_1420

14.0

1676.0

Repeat

CHCR 6

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

1423_1566

14.0

1676.0

Repeat

CHCR 7

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

537_683

14.0

1676.0

Repeat

CHCR 1

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

686_828

14.0

1676.0

Repeat

CHCR 2

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

833_972

14.0

1676.0

Repeat

CHCR 3

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000269122

979_1124

14.0

1676.0

Repeat

CHCR 4

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

1128_1269

14.0

1640.0

Repeat

CHCR 5

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

1274_1420

14.0

1640.0

Repeat

CHCR 6

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

1423_1566

14.0

1640.0

Repeat

CHCR 7

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

537_683

14.0

1640.0

Repeat

CHCR 1

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

686_828

14.0

1640.0

Repeat

CHCR 2

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

833_972

14.0

1640.0

Repeat

CHCR 3

Hgene

CLTC

chr17:57697534

chr18:5397425

ENST00000393043

979_1124

14.0

1640.0

Repeat

CHCR 4

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000341928

110_391

824.0

1317.3333333333333

Domain

FERM

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000342933

110_391

824.0

1088.0

Domain

FERM

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000400111

110_391

602.0

866.0

Domain

FERM

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000540638

110_391

602.0

846.0

Domain

FERM

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000341928

394_513

824.0

1317.3333333333333

Region

Note=Hydrophilic

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000341928

514_860

824.0

1317.3333333333333

Region

Spectrin--actin-binding

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000342933

394_513

824.0

1088.0

Region

Note=Hydrophilic

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000342933

514_860

824.0

1088.0

Region

Spectrin--actin-binding

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000400111

394_513

602.0

866.0

Region

Note=Hydrophilic

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000400111

514_860

602.0

866.0

Region

Spectrin--actin-binding

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000540638

394_513

602.0

846.0

Region

Note=Hydrophilic

Tgene

EPB41L3

chr17:57697534

chr18:5397425

ENST00000540638

514_860

602.0

846.0

Region

Spectrin--actin-binding

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

CLTC

HGS, MCC, IKBKE, TFE3, SNX5, TOM1, SNX9, DNAJC6, ARMCX3, C10orf88, EPN1, EHD1, GGA1, GGA2, GGA3, KIT, AMPH, CLINT1, TNK2, LDLRAP1, HIP1, AP1B1, AP2A2, AP3B2, MAP3K10, PICALM, EPN2, Epn1, VCL, Arrb2, STAMBP, STAMBPL1, STAM, MAP1LC3A, SNCA, PRKACA, WNK1, Mapk13, HDAC5, SPG20, RICTOR, Erh, Cd2ap, Pttg1, EBNA-LP, PCM1, NDRG1, PPP1CA, ITSN1, ARRB1, SIRT7, SH3KBP1, DYRK1A, SNAP91, AP2B1, BIN1, AP1G1, RAC1, TOM1L1, TOM1L2, ISG15, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, XRCC6, HERC1, ATG16L1, SYNJ1, LRRK2, Nfe2l2, AKT1, GRB2, SHC1, AP2M1, MYO6, SRC, FYN, Htt, DNAJA3, RPSA, ESR1, PAXIP1, PPP1CC, SMURF1, ARRB2, ERBB2, FN1, VCAM1, Fcho2, DAB2, UBL4A, ITGA4, MYBL2, SVIL, PAN2, NPM1, PTAFR, ATP4A, EP300, QARS, YWHAQ, FBXO6, RPA1, RPA2, RPA3, ERG, EPHA2, LGR4, Fbxl16, STAU1, TP53, HUWE1, FBXW11, GJB5, NXF1, ADRB2, AVPR2, CUL7, OBSL1, CCDC8, EED, ZFYVE9, OCRL, ATR, SCYL2, HTR6, HNRNPA1, UNK, ATP1A1, ATP1A2, ATP1A3, ATP5C1, CCDC47, CCT3, CCT6A, BLOC1S1, CAD, CANX, CCT6B, CISD1, CLTA, CYC1, DHX38, EHD2, FASTKD2, HSP90B1, IPO5, MTCH2, NDUFB9, NDUFS1, NLRP1, RAB5B, RANBP2, RANBP6, SLC25A3, SSR3, TECR, TOMM22, UQCRC2, VDAC1, VDAC2, VDAC3, ZMPSTE24, DDOST, EIF6, COX2, PHB, PHB2, PPP2R1A, PPP2R1B, RPN1, TMCO1, TUFM, UQCRQ, NTRK1, OFD1, CEP97, CNTRL, FBF1, NPHP1, DCTN1, POC5, POC1B, PPME1, ABCA2, PARP4, AP2A1, ATP6V1B2, ATP6V0A1, CAV1, CLTB, CAPZA2, DBN1, FLNA, GAK, MYH9, DNAJC7, IQGAP1, PDLIM7, SEC16A, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, ARX, MYO18A, CSNK1A1, CSNK1E, STOM, EPS15, HSPA1A, HSPA4, NDUFA9, CHMP1A, PIK3C2A, PRKAR2A, SEC13, SOAT1, CLTCL1, SORBS2, PKP4, USO1, NUMB, TNK1, RAB11A, HIP1R, ATP6V0D1, XPR1, SEC24C, KIAA0430, IST1, HELZ, MVP, TROAP, SEC24B, RBM14, SEC23A, VTI1B, TRAFD1, PKP3, AAK1, BTBD3, TNRC6B, EDC4, DSTYK, PTPN23, NECAP1, TNRC6A, EHD4, EGFL7, ATP6V1D, PTRH2, PLEKHA5, CPVL, BMP2K, DCP1A, ERBB2IP, CHMP1B, KIDINS220, MTUS1, DENND1A, CRTC3, CPSF7, EDC3, CCDC115, FAM83A, REPS1, STON2, FCHO2, CHMP4B, MITD1, CRTC2, FAM83B, FAM83H, SLC35B2, Actb, Myh9, Myo1c, Ppp1cb, Tpm1, Coro1c, Cul3, Spast, Tmod3, Dctn3, Uso1, Lima1, Samm50, Calml3, Myh10, Strn3, Smap1, Ptpn23, Nhsl1, Sec24c, Flnb, IKBKB, MAP3K7, MCM2, AP3D1, U2AF2, CDC73, ZNF746, ARF6, CYLD, LASP1, BRCA1, TES, MTF1, BRD1, CFTR, ZNF598, PDGFRB, FBXO7, TMPO, PTCH1, HSPA8, MAP2K1, PIK3CA, APOE, BMPR1A, JUP, UQCRB, UBE2M, RAD18, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, LARP7, RNF4, TNF, SPDL1, RIOK1, PRKCZ, HEXIM1, MEPCE, RUNX1, RNF123, PPT1, HERC2, UBE3A, AGR2, RECQL4, SMAP1, MYC, CDK9, Prkaa1, Prkab1, CDK5RAP2, GRWD1, KRT17, KIAA1429, PLEKHA2, RC3H2, ACTC1, TET2, NR2C2, UCHL3, PRDM16, MECOM, AGRN, BMH1, BMH2, ATXN3, TCF7L2, STX2, GSK3B, ABCC6, BIRC3, LMBR1L, WWP2, Hsp22, TRIM28, GJA1, TEX101, ARIH2, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, Clta, PXN, RALBP1, PTCHD3, C18orf54, ANKRD55, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF14, ORF3a, ORF6, ORF7a, ORF7b, ABCC2, CDCA5, ACO1, OPTN, NEK4, LRRC31, DUX4, CIT, AURKB, ECT2, KIF14, KIF20A, MAD2L2, KIF23, PRC1, PRNP, CHCHD1, HAX1, MFN2, SLC25A46, LDLR, SUMO2, PRKCB, Rnf183, AIMP2, BRD4, NINL, AFTPH, NUPR1, EPHA3, CIC, Apc2, RBM39, LGALS9, RIN3, EIF3H, DNAJA1, HSPA1L, HSPA2, HSPA6, BAG5, AR, UFL1, DDRGK1, CD3EAP, LAMTOR1, POLR2C, TRIM37, HTRA4, DRD2, ADRBK1, WDR5, PAGE4, NUDCD2, BGLT3, EDEM1, BAG2, DTX3, BTF3, IGF1R, NEDD4, FBXW7, TFRC, IFITM1, BSG, IFITM3, TMPRSS11B, CLEC4E, nsp15, ORF10, FGD5, MAP1LC3B, NBR1, CALCOCO2, SQSTM1, TOLLIP, Chrna4, SIRT6, PER2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CLTC
EPB41L3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CLTC-EPB41L3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CLTC-EPB41L3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CLTC	C4518356	MiT family translocation renal cell carcinoma	2	ORPHANET
Hgene	CLTC	C4693389	MENTAL RETARDATION, AUTOSOMAL DOMINANT 56	2	GENOMICS_ENGLAND;UNIPROT
Hgene	CLTC	C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human
Hgene	CLTC	C0334121	Inflammatory Myofibroblastic Tumor	1	ORPHANET