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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CLTC-IGFBP7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CLTC-IGFBP7
FusionPDB ID: 17393
FusionGDB2.0 ID: 17393
HgeneTgene
Gene symbol

CLTC

IGFBP7

Gene ID

1213

3490

Gene nameclathrin heavy chaininsulin like growth factor binding protein 7
SynonymsCHC|CHC17|CLH-17|CLTCL2|Hc|MRD56AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF
Cytomap

17q23.1

4q12

Type of geneprotein-codingprotein-coding
Descriptionclathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2insulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factor
Modification date2020031320200313
UniProtAcc

P53675

Q16270

Ensembl transtripts involved in fusion geneENST idsENST00000269122, ENST00000393043, 
ENST00000579456, ENST00000579815, 
ENST00000512512, ENST00000295666, 
ENST00000537922, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 40 X 17=183609 X 8 X 4=288
# samples 849
** MAII scorelog2(84/18360*10)=-4.45003292063505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CLTC [Title/Abstract] AND IGFBP7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CLTC(57697534)-IGFBP7(57899477), # samples:1
Anticipated loss of major functional domain due to fusion event.CLTC-IGFBP7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLTC-IGFBP7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLTC

GO:1900126

negative regulation of hyaluronan biosynthetic process

24251095

TgeneIGFBP7

GO:0007155

cell adhesion

8117260


check buttonFusion gene breakpoints across CLTC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IGFBP7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer61NCLTCchr17

57697534

+IGFBP7chr4

57899477

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393043CLTCchr1757697534+ENST00000295666IGFBP7chr457899477-112431651435159
ENST00000393043CLTCchr1757697534+ENST00000537922IGFBP7chr457899477-94831651435159
ENST00000269122CLTCchr1757697534+ENST00000295666IGFBP7chr457899477-112431651435159
ENST00000269122CLTCchr1757697534+ENST00000537922IGFBP7chr457899477-94831651435159
ENST00000579456CLTCchr1757697534+ENST00000295666IGFBP7chr457899477-10502424400147
ENST00000579456CLTCchr1757697534+ENST00000537922IGFBP7chr457899477-8742424400147

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393043ENST00000295666CLTCchr1757697534+IGFBP7chr457899477-0.069838410.93016154
ENST00000393043ENST00000537922CLTCchr1757697534+IGFBP7chr457899477-0.0653511660.9346489
ENST00000269122ENST00000295666CLTCchr1757697534+IGFBP7chr457899477-0.069838410.93016154
ENST00000269122ENST00000537922CLTCchr1757697534+IGFBP7chr457899477-0.0653511660.9346489
ENST00000579456ENST00000295666CLTCchr1757697534+IGFBP7chr457899477-0.0944486560.9055513
ENST00000579456ENST00000537922CLTCchr1757697534+IGFBP7chr457899477-0.0363676470.9636323

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>17393_17393_1_CLTC-IGFBP7_CLTC_chr17_57697534_ENST00000269122_IGFBP7_chr4_57899477_ENST00000295666_length(amino acids)=159AA_BP=1
MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP

--------------------------------------------------------------

>17393_17393_2_CLTC-IGFBP7_CLTC_chr17_57697534_ENST00000269122_IGFBP7_chr4_57899477_ENST00000537922_length(amino acids)=159AA_BP=1
MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP

--------------------------------------------------------------

>17393_17393_3_CLTC-IGFBP7_CLTC_chr17_57697534_ENST00000393043_IGFBP7_chr4_57899477_ENST00000295666_length(amino acids)=159AA_BP=1
MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP

--------------------------------------------------------------

>17393_17393_4_CLTC-IGFBP7_CLTC_chr17_57697534_ENST00000393043_IGFBP7_chr4_57899477_ENST00000537922_length(amino acids)=159AA_BP=1
MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP

--------------------------------------------------------------

>17393_17393_5_CLTC-IGFBP7_CLTC_chr17_57697534_ENST00000579456_IGFBP7_chr4_57899477_ENST00000295666_length(amino acids)=147AA_BP=1
MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP

--------------------------------------------------------------

>17393_17393_6_CLTC-IGFBP7_CLTC_chr17_57697534_ENST00000579456_IGFBP7_chr4_57899477_ENST00000537922_length(amino acids)=147AA_BP=1
MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57697534/chr4:57899477)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLTC

P53675

IGFBP7

Q16270

FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.FUNCTION: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. {ECO:0000269|PubMed:8117260, ECO:0000269|PubMed:8939990}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132108_14914.01676.0RegionNote=WD40-like repeat 3
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+1321213_152214.01676.0RegionInvolved in binding clathrin light chain
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132150_19514.01676.0RegionNote=WD40-like repeat 4
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+1321550_167514.01676.0RegionTrimerization
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132196_25714.01676.0RegionNote=WD40-like repeat 5
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+13224_6714.01676.0RegionNote=WD40-like repeat 1
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132258_30114.01676.0RegionNote=WD40-like repeat 6
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+1322_47914.01676.0RegionNote=Globular terminal domain
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132302_33014.01676.0RegionNote=WD40-like repeat 7
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132449_46514.01676.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132480_52314.01676.0RegionNote=Flexible linker
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132524_167514.01676.0RegionNote=Heavy chain arm
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132524_63414.01676.0RegionNote=Distal segment
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132639_167514.01676.0RegionNote=Proximal segment
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+13268_10714.01676.0RegionNote=WD40-like repeat 2
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131108_14914.01640.0RegionNote=WD40-like repeat 3
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+1311213_152214.01640.0RegionInvolved in binding clathrin light chain
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131150_19514.01640.0RegionNote=WD40-like repeat 4
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+1311550_167514.01640.0RegionTrimerization
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131196_25714.01640.0RegionNote=WD40-like repeat 5
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+13124_6714.01640.0RegionNote=WD40-like repeat 1
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131258_30114.01640.0RegionNote=WD40-like repeat 6
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+1312_47914.01640.0RegionNote=Globular terminal domain
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131302_33014.01640.0RegionNote=WD40-like repeat 7
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131449_46514.01640.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131480_52314.01640.0RegionNote=Flexible linker
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131524_167514.01640.0RegionNote=Heavy chain arm
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131524_63414.01640.0RegionNote=Distal segment
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131639_167514.01640.0RegionNote=Proximal segment
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+13168_10714.01640.0RegionNote=WD40-like repeat 2
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+1321128_126914.01676.0RepeatCHCR 5
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+1321274_142014.01676.0RepeatCHCR 6
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+1321423_156614.01676.0RepeatCHCR 7
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132537_68314.01676.0RepeatCHCR 1
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132686_82814.01676.0RepeatCHCR 2
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132833_97214.01676.0RepeatCHCR 3
HgeneCLTCchr17:57697534chr4:57899477ENST00000269122+132979_112414.01676.0RepeatCHCR 4
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+1311128_126914.01640.0RepeatCHCR 5
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+1311274_142014.01640.0RepeatCHCR 6
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+1311423_156614.01640.0RepeatCHCR 7
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131537_68314.01640.0RepeatCHCR 1
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131686_82814.01640.0RepeatCHCR 2
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131833_97214.01640.0RepeatCHCR 3
HgeneCLTCchr17:57697534chr4:57899477ENST00000393043+131979_112414.01640.0RepeatCHCR 4
TgeneIGFBP7chr17:57697534chr4:57899477ENST0000029566615105_158195.0283.0DomainKazal-like
TgeneIGFBP7chr17:57697534chr4:57899477ENST0000029566615160_264195.0283.0DomainNote=Ig-like C2-type
TgeneIGFBP7chr17:57697534chr4:57899477ENST000002956661528_106195.0283.0DomainIGFBP N-terminal
TgeneIGFBP7chr17:57697534chr4:57899477ENST0000053792214105_158195.0280.0DomainKazal-like
TgeneIGFBP7chr17:57697534chr4:57899477ENST0000053792214160_264195.0280.0DomainNote=Ig-like C2-type
TgeneIGFBP7chr17:57697534chr4:57899477ENST000005379221428_106195.0280.0DomainIGFBP N-terminal


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
CLTCHGS, MCC, IKBKE, TFE3, SNX5, TOM1, SNX9, DNAJC6, ARMCX3, C10orf88, EPN1, EHD1, GGA1, GGA2, GGA3, KIT, AMPH, CLINT1, TNK2, LDLRAP1, HIP1, AP1B1, AP2A2, AP3B2, MAP3K10, PICALM, EPN2, Epn1, VCL, Arrb2, STAMBP, STAMBPL1, STAM, MAP1LC3A, SNCA, PRKACA, WNK1, Mapk13, HDAC5, SPG20, RICTOR, Erh, Cd2ap, Pttg1, EBNA-LP, PCM1, NDRG1, PPP1CA, ITSN1, ARRB1, SIRT7, SH3KBP1, DYRK1A, SNAP91, AP2B1, BIN1, AP1G1, RAC1, TOM1L1, TOM1L2, ISG15, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, XRCC6, HERC1, ATG16L1, SYNJ1, LRRK2, Nfe2l2, AKT1, GRB2, SHC1, AP2M1, MYO6, SRC, FYN, Htt, DNAJA3, RPSA, ESR1, PAXIP1, PPP1CC, SMURF1, ARRB2, ERBB2, FN1, VCAM1, Fcho2, DAB2, UBL4A, ITGA4, MYBL2, SVIL, PAN2, NPM1, PTAFR, ATP4A, EP300, QARS, YWHAQ, FBXO6, RPA1, RPA2, RPA3, ERG, EPHA2, LGR4, Fbxl16, STAU1, TP53, HUWE1, FBXW11, GJB5, NXF1, ADRB2, AVPR2, CUL7, OBSL1, CCDC8, EED, ZFYVE9, OCRL, ATR, SCYL2, HTR6, HNRNPA1, UNK, ATP1A1, ATP1A2, ATP1A3, ATP5C1, CCDC47, CCT3, CCT6A, BLOC1S1, CAD, CANX, CCT6B, CISD1, CLTA, CYC1, DHX38, EHD2, FASTKD2, HSP90B1, IPO5, MTCH2, NDUFB9, NDUFS1, NLRP1, RAB5B, RANBP2, RANBP6, SLC25A3, SSR3, TECR, TOMM22, UQCRC2, VDAC1, VDAC2, VDAC3, ZMPSTE24, DDOST, EIF6, COX2, PHB, PHB2, PPP2R1A, PPP2R1B, RPN1, TMCO1, TUFM, UQCRQ, NTRK1, OFD1, CEP97, CNTRL, FBF1, NPHP1, DCTN1, POC5, POC1B, PPME1, ABCA2, PARP4, AP2A1, ATP6V1B2, ATP6V0A1, CAV1, CLTB, CAPZA2, DBN1, FLNA, GAK, MYH9, DNAJC7, IQGAP1, PDLIM7, SEC16A, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, ARX, MYO18A, CSNK1A1, CSNK1E, STOM, EPS15, HSPA1A, HSPA4, NDUFA9, CHMP1A, PIK3C2A, PRKAR2A, SEC13, SOAT1, CLTCL1, SORBS2, PKP4, USO1, NUMB, TNK1, RAB11A, HIP1R, ATP6V0D1, XPR1, SEC24C, KIAA0430, IST1, HELZ, MVP, TROAP, SEC24B, RBM14, SEC23A, VTI1B, TRAFD1, PKP3, AAK1, BTBD3, TNRC6B, EDC4, DSTYK, PTPN23, NECAP1, TNRC6A, EHD4, EGFL7, ATP6V1D, PTRH2, PLEKHA5, CPVL, BMP2K, DCP1A, ERBB2IP, CHMP1B, KIDINS220, MTUS1, DENND1A, CRTC3, CPSF7, EDC3, CCDC115, FAM83A, REPS1, STON2, FCHO2, CHMP4B, MITD1, CRTC2, FAM83B, FAM83H, SLC35B2, Actb, Myh9, Myo1c, Ppp1cb, Tpm1, Coro1c, Cul3, Spast, Tmod3, Dctn3, Uso1, Lima1, Samm50, Calml3, Myh10, Strn3, Smap1, Ptpn23, Nhsl1, Sec24c, Flnb, IKBKB, MAP3K7, MCM2, AP3D1, U2AF2, CDC73, ZNF746, ARF6, CYLD, LASP1, BRCA1, TES, MTF1, BRD1, CFTR, ZNF598, PDGFRB, FBXO7, TMPO, PTCH1, HSPA8, MAP2K1, PIK3CA, APOE, BMPR1A, JUP, UQCRB, UBE2M, RAD18, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, LARP7, RNF4, TNF, SPDL1, RIOK1, PRKCZ, HEXIM1, MEPCE, RUNX1, RNF123, PPT1, HERC2, UBE3A, AGR2, RECQL4, SMAP1, MYC, CDK9, Prkaa1, Prkab1, CDK5RAP2, GRWD1, KRT17, KIAA1429, PLEKHA2, RC3H2, ACTC1, TET2, NR2C2, UCHL3, PRDM16, MECOM, AGRN, BMH1, BMH2, ATXN3, TCF7L2, STX2, GSK3B, ABCC6, BIRC3, LMBR1L, WWP2, Hsp22, TRIM28, GJA1, TEX101, ARIH2, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, Clta, PXN, RALBP1, PTCHD3, C18orf54, ANKRD55, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF14, ORF3a, ORF6, ORF7a, ORF7b, ABCC2, CDCA5, ACO1, OPTN, NEK4, LRRC31, DUX4, CIT, AURKB, ECT2, KIF14, KIF20A, MAD2L2, KIF23, PRC1, PRNP, CHCHD1, HAX1, MFN2, SLC25A46, LDLR, SUMO2, PRKCB, Rnf183, AIMP2, BRD4, NINL, AFTPH, NUPR1, EPHA3, CIC, Apc2, RBM39, LGALS9, RIN3, EIF3H, DNAJA1, HSPA1L, HSPA2, HSPA6, BAG5, AR, UFL1, DDRGK1, CD3EAP, LAMTOR1, POLR2C, TRIM37, HTRA4, DRD2, ADRBK1, WDR5, PAGE4, NUDCD2, BGLT3, EDEM1, BAG2, DTX3, BTF3, IGF1R, NEDD4, FBXW7, TFRC, IFITM1, BSG, IFITM3, TMPRSS11B, CLEC4E, nsp15, ORF10, FGD5, MAP1LC3B, NBR1, CALCOCO2, SQSTM1, TOLLIP, Chrna4, SIRT6, PER2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CLTCall structure
IGFBP7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CLTC-IGFBP7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CLTC-IGFBP7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLTCC4518356MiT family translocation renal cell carcinoma2ORPHANET
HgeneCLTCC4693389MENTAL RETARDATION, AUTOSOMAL DOMINANT 562GENOMICS_ENGLAND;UNIPROT
HgeneCLTCC0079744Diffuse Large B-Cell Lymphoma1CTD_human
HgeneCLTCC0334121Inflammatory Myofibroblastic Tumor1ORPHANET