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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CLTC-TFEB

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CLTC-TFEB
	FusionPDB ID: 17413
	FusionGDB2.0 ID: 17413
		Hgene	Tgene
	Gene symbol	CLTC	TFEB
	Gene ID	1213	7942
	Gene name	clathrin heavy chain	transcription factor EB
	Synonyms	CHC\|CHC17\|CLH-17\|CLTCL2\|Hc\|MRD56	ALPHATFEB\|BHLHE35\|TCFEB
	Cytomap	17q23.1	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	clathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2	transcription factor EBT-cell transcription factor EBclass E basic helix-loop-helix protein 35
	Modification date	20200313	20200329
	UniProtAcc	P53675	P19484
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000269122, ENST00000393043, ENST00000579456, ENST00000579815,	ENST00000230323, ENST00000358871, ENST00000373033, ENST00000394283, ENST00000403298, ENST00000420312,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	27 X 40 X 17=18360	6 X 5 X 6=180
	# samples	84	5
	** MAII score	log2(84/18360*10)=-4.45003292063505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/180*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CLTC [Title/Abstract] AND TFEB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CLTC	GO:1900126	negative regulation of hyaluronan biosynthetic process	24251095
Tgene	TFEB	GO:0010468	regulation of gene expression	27278822
Tgene	TFEB	GO:0045893	positive regulation of transcription, DNA-templated	27278822\|29146937
Tgene	TFEB	GO:0045944	positive regulation of transcription by RNA polymerase II	19556463

Fusion gene breakpoints across CLTC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TFEB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	CLTC	chr17	57754549	+	TFEB	chr6	41655766	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393043	CLTC	chr17	57754549	+	ENST00000230323	TFEB	chr6	41655766	-	4573	3070	274	3951	1225
ENST00000393043	CLTC	chr17	57754549	+	ENST00000358871	TFEB	chr6	41655766	-	4573	3070	274	3951	1225
ENST00000393043	CLTC	chr17	57754549	+	ENST00000420312	TFEB	chr6	41655766	-	4572	3070	274	3951	1225
ENST00000393043	CLTC	chr17	57754549	+	ENST00000403298	TFEB	chr6	41655766	-	4572	3070	274	3951	1225
ENST00000393043	CLTC	chr17	57754549	+	ENST00000373033	TFEB	chr6	41655766	-	4571	3070	274	3951	1225
ENST00000393043	CLTC	chr17	57754549	+	ENST00000394283	TFEB	chr6	41655766	-	3889	3070	274	3327	1017
ENST00000269122	CLTC	chr17	57754549	+	ENST00000230323	TFEB	chr6	41655766	-	4573	3070	274	3951	1225
ENST00000269122	CLTC	chr17	57754549	+	ENST00000358871	TFEB	chr6	41655766	-	4573	3070	274	3951	1225
ENST00000269122	CLTC	chr17	57754549	+	ENST00000420312	TFEB	chr6	41655766	-	4572	3070	274	3951	1225
ENST00000269122	CLTC	chr17	57754549	+	ENST00000403298	TFEB	chr6	41655766	-	4572	3070	274	3951	1225
ENST00000269122	CLTC	chr17	57754549	+	ENST00000373033	TFEB	chr6	41655766	-	4571	3070	274	3951	1225
ENST00000269122	CLTC	chr17	57754549	+	ENST00000394283	TFEB	chr6	41655766	-	3889	3070	274	3327	1017

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>17413_17413_1_CLTC-TFEB_CLTC_chr17_57754549_ENST00000269122_TFEB_chr6_41655766_ENST00000230323_length(amino acids)=1225AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN
LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTT
SPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGH

--------------------------------------------------------------

>17413_17413_2_CLTC-TFEB_CLTC_chr17_57754549_ENST00000269122_TFEB_chr6_41655766_ENST00000358871_length(amino acids)=1225AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN
LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTT
SPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGH

--------------------------------------------------------------

>17413_17413_3_CLTC-TFEB_CLTC_chr17_57754549_ENST00000269122_TFEB_chr6_41655766_ENST00000373033_length(amino acids)=1225AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN
LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTT
SPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGH

--------------------------------------------------------------

>17413_17413_4_CLTC-TFEB_CLTC_chr17_57754549_ENST00000269122_TFEB_chr6_41655766_ENST00000394283_length(amino acids)=1017AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN

--------------------------------------------------------------

>17413_17413_5_CLTC-TFEB_CLTC_chr17_57754549_ENST00000269122_TFEB_chr6_41655766_ENST00000403298_length(amino acids)=1225AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN
LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTT
SPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGH

--------------------------------------------------------------

>17413_17413_6_CLTC-TFEB_CLTC_chr17_57754549_ENST00000269122_TFEB_chr6_41655766_ENST00000420312_length(amino acids)=1225AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN
LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTT
SPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGH

--------------------------------------------------------------

>17413_17413_7_CLTC-TFEB_CLTC_chr17_57754549_ENST00000393043_TFEB_chr6_41655766_ENST00000230323_length(amino acids)=1225AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN
LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTT
SPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGH

--------------------------------------------------------------

>17413_17413_8_CLTC-TFEB_CLTC_chr17_57754549_ENST00000393043_TFEB_chr6_41655766_ENST00000358871_length(amino acids)=1225AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN
LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTT
SPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGH

--------------------------------------------------------------

>17413_17413_9_CLTC-TFEB_CLTC_chr17_57754549_ENST00000393043_TFEB_chr6_41655766_ENST00000373033_length(amino acids)=1225AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN
LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTT
SPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGH

--------------------------------------------------------------

>17413_17413_10_CLTC-TFEB_CLTC_chr17_57754549_ENST00000393043_TFEB_chr6_41655766_ENST00000394283_length(amino acids)=1017AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN

--------------------------------------------------------------

>17413_17413_11_CLTC-TFEB_CLTC_chr17_57754549_ENST00000393043_TFEB_chr6_41655766_ENST00000403298_length(amino acids)=1225AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN
LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTT
SPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGH

--------------------------------------------------------------

>17413_17413_12_CLTC-TFEB_CLTC_chr17_57754549_ENST00000393043_TFEB_chr6_41655766_ENST00000420312_length(amino acids)=1225AA_BP=932
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPS
RLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY
DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN
LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTT
SPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGH

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:/chr6:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CLTC P53675	TFEB P19484
FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.	FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:30120233, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22576015, PubMed:22343943, PubMed:22692423). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus or S.enterica, acting downstream of protein kinase D (PKD), probably by regulating cytokine and chemokine expression (By similarity). {ECO:0000250\|UniProtKB:Q9R210, ECO:0000269\|PubMed:1748288, ECO:0000269\|PubMed:19556463, ECO:0000269\|PubMed:2115126, ECO:0000269\|PubMed:21617040, ECO:0000269\|PubMed:22343943, ECO:0000269\|PubMed:22576015, ECO:0000269\|PubMed:22692423, ECO:0000269\|PubMed:23434374, ECO:0000269\|PubMed:27278822, ECO:0000269\|PubMed:29146937, ECO:0000269\|PubMed:30120233, ECO:0000269\|PubMed:31672913}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (758) >>>758.pdbFusion protein BP residue: 932 CIF file (758) >>>758.cif	CLTC	chr17	57754549	+	TFEB	chr6	41655766	-	MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQV VIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMK AHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAG CQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAAS FAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDV FFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISG ETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALR MAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRR FQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQK IVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIV DVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAIL GNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEW LVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIE LFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRE SNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYI EIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVE KRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVT ASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNI	1017
3D view using mol* of 758 (AA BP:932)


PDB file (863) >>>863.pdbFusion protein BP residue: 932 CIF file (863) >>>863.cif	CLTC	chr17	57754549	+	TFEB	chr6	41655766	-	MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQV VIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMK AHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAG CQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAAS FAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDV FFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISG ETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALR MAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRR FQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQK IVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIV DVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAIL GNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEW LVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIE LFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRE SNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYI EIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVE KRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYY DSRVVGKYCEKRDPHLACVAYERGQCDLELINLPLSSSHLNVYSSDPQVT ASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNI NDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENH SRRLEMTNKQLWLRIQELEMQARVHGLPTTSPSGMNMAELAQQVVKQELP SEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLS FGGREDEGPPGYPEPLAPGHGSPFPSLSKKDLDLMLLDDSLLPLASDPLL	1225
3D view using mol* of 863 (AA BP:932)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CLTC_pLDDT.png

TFEB_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CLTC_TFEB_758_pLDDT.png (AA BP:932)

CLTC_TFEB_758_pLDDT_and_active_sites.png (AA BP:932)

CLTC_TFEB_758_violinplot.png (AA BP:932)

CLTC_TFEB_863_pLDDT.png (AA BP:932)

CLTC_TFEB_863_pLDDT_and_active_sites.png (AA BP:932)

CLTC_TFEB_863_violinplot.png (AA BP:932)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

CLTC_TFEB_758.png

CLTC_TFEB_863.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
758	1.0427	230	1.0115	508.326	0.5198	0.7619	0.9638	0.5042	1.1831	0.4262	0.617	Chain A: 26,27,28,29,30,31,32,33,41,70,71,72,83,10 9,110,111,112,124,144,149,150,151,152,153,154,155, 157,166,168,170,197,198,199,260,261,262,263,264,26 5,278,302,304,305,306,307,308,320
863	1.008	498	1.04	1332.555	0.611	0.685	0.862	0.51	0.955	0.533	0.779	Chain A: 25,26,27,28,29,30,31,32,33,34,35,41,70,71 ,72,75,83,108,109,110,111,112,113,114,115,124,144, 150,151,152,153,154,155,156,157,158,159,160,166,16 7,168,170,197,198,199,200,201,202,203,204,205,206, 207,214,243,244,246,260,262,263,264,265,266,267,26 8,269,270,271,278,287,288,289,302,304,305,306,307, 308,309,310,313,320,346,349,350,353,354,355,356,36 4,367,379,382,383,385,386,387,388,389,390,393,421, 424

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
758	ZINC000043100953	DB09042	Tedizolid phosphate	-9.38514	-9.47014
758	ZINC000004474682	DB00287	Travoprost	-8.4931	-8.4931
758	ZINC000005844788	DB04861	Nebivolol	-6.42515	-8.44865
758	ZINC000003943279	DB06695	Dabigatran etexilate	-5.87994	-8.24014
758	ZINC000003861768	DB00928	Azacitidine	-7.80295	-8.22215
758	ZINC000000607986	DB04861	Nebivolol	-6.0298	-8.0533
758	ZINC000003785268	DB00938	Salmeterol	-7.92508	-7.93038
758	ZINC000005844792	DB04861	Nebivolol	-7.85435	-7.87415
758	ZINC000013585233	DB00360	Sapropterin	-5.81056	-7.83746
758	ZINC000003799072	DB00938	Salmeterol	-7.81313	-7.81843
758	ZINC000012468792	DB00654	Latanoprost	-7.67892	-7.67892
758	ZINC000004102194	DB00410	Mupirocin	-7.6581	-7.6616
758	ZINC000003927870	DB01073	Fludarabine	-6.39191	-7.54081
758	ZINC000000083315	DB00150	Tryptophan	-7.50436	-7.50436
758	ZINC000252679615	DB01219	Dantrolene	-7.39919	-7.47159
758	ZINC000007997966	DB01219	Dantrolene	-7.39919	-7.47159
758	ZINC000003830215	DB01060	Amoxicillin	-7.26453	-7.45713
758	ZINC000000002281	DB00871	Terbutaline	-7.43094	-7.44524
758	ZINC000003872277	DB01119	Diazoxide	-7.41836	-7.42616
758	ZINC000029571072	DB06636	Isavuconazonium	-6.91891	-7.42271

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000043100953	DB09042	Tedizolid phosphate	Small molecule	CN1N=NC(=N1)C1=CC=C(C=N1)C1=CC=C(C=C1F)N1C[C@H](COP(O)(O)=O)OC1=O	Approved
ZINC000004474682	DB00287	Travoprost	Small molecule	CC(C)OC(=O)CCCC=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1C=C[C@@H](O)COC1=CC=CC(=C1)C(F)(F)F	Approved
ZINC000003943279	DB06695	Dabigatran etexilate	Small molecule	CCCCCCOC(=O)N=C(N)C1=CC=C(NCC2=NC3=C(C=CC(=C3)C(=O)N(CCC(=O)OCC)C3=NC=CC=C3)N2C)C=C1	Approved
ZINC000003861768	DB00928	Azacitidine	Small molecule	NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	Approved\|Investigational
ZINC000003799072	DB00938	Salmeterol	Small molecule	OCC1=C(O)C=CC(=C1)C(O)CNCCCCCCOCCCCC1=CC=CC=C1	Approved
ZINC000012468792	DB00654	Latanoprost	Small molecule	CC(C)OC(=O)CCCC=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1	Approved\|Investigational
ZINC000004102194	DB00410	Mupirocin	Small molecule	C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@H]1CO[C@@H](CC(C)=CC(=O)OCCCCCCCCC(O)=O)[C@H](O)[C@@H]1O	Approved\|Investigational\|Vet_approved
ZINC000003927870	DB01073	Fludarabine	Small molecule	NC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O	Approved
ZINC000000083315	DB00150	Tryptophan	Small molecule	N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O	Approved\|Nutraceutical\|Withdrawn
ZINC000007997966	DB01219	Dantrolene	Small molecule	[O-][N+](=O)C1=CC=C(C=C1)C1=CC=C(O1)C=NN1CC(=O)NC1=O	Approved\|Investigational
ZINC000003830215	DB01060	Amoxicillin	Small molecule	[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=C(O)C=C1)C(O)=O	Approved\|Vet_approved
ZINC000000002281	DB00871	Terbutaline	Small molecule	CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1	Approved
ZINC000003872277	DB01119	Diazoxide	Small molecule	CC1=NS(=O)(=O)C2=C(N1)C=CC(Cl)=C2	Approved

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000043100953	450.322	8.428	720.625	174.492	308.419	199.974	37.741	1252.979	2	13	9.192	1	17.345	1	1
ZINC000043100953	450.322	8.806	708.392	174.655	291.009	204.376	38.352	1241.002	2	13	9.026	1	20.706	1	1
ZINC000004474682	500.554	7.814	798.264	377.787	163.81	139.044	117.622	1521.375	3	7.85	9.535	3	85.406	1	2
ZINC000005844788	405.441	1.102	724.6	273.703	87.795	269.339	93.762	1272.257	3	6.4	9.305	3	94.995	0	0
ZINC000005844788	405.441	3.204	688.14	293.004	60.761	240.615	93.76	1244.959	3	6.4	9.151	3	100	0	0
ZINC000003943279	627.742	4.667	1184.331	574.306	231.253	378.772	0	2103.011	2	11	8.55	1	58.304	3	1
ZINC000003943279	627.742	7.938	1170.006	572.981	237.303	359.722	0	2090.012	2	11	8.404	1	56.447	3	1
ZINC000003943279	627.742	6.121	1133.409	561.818	218.501	353.089	0	2055.355	2	11	8.475	1	59.143	3	1
ZINC000003943279	627.742	10.2	1166.266	573.103	235.814	357.349	0	2084.657	2	11	8.292	1	56.55	3	1
ZINC000003943279	627.742	9.595	1158.598	580.852	244.759	332.987	0	2079.282	2	11	8.313	1	54.32	3	1
ZINC000003943279	627.742	7.327	1178.116	572.965	232.033	373.118	0	2096.733	2	11	8.58	1	57.88	3	1
ZINC000003943279	627.742	9.958	1175.042	575.778	234.38	364.884	0	2092.735	2	11	8.327	1	57.186	3	1
ZINC000003861768	244.207	7.104	434.888	110.158	287.613	37.117	0	717.082	5	10.8	9.386	2	36.489	0	1
ZINC000003861768	244.207	8.996	434.766	110.132	287.569	37.065	0	716.913	5	10.8	9.305	2	36.496	0	1
ZINC000003861768	244.207	6.643	431.183	93.993	304.895	32.294	0	718.65	5	11.8	9.707	2	31.372	0	1
ZINC000000607986	405.441	5.004	705.664	273.428	84.542	253.931	93.763	1255.212	3	6.4	9.141	3	95.029	0	0
ZINC000000607986	405.441	6.242	723.401	276.421	85.145	268.07	93.764	1269.446	3	6.4	9.103	3	95.442	0	0
ZINC000003785268	415.572	3.517	849.197	428.88	141.859	278.458	0	1521.525	4	7.35	9.193	1	87.175	0	0
ZINC000005844792	405.441	2.88	705.095	278.739	76.814	255.781	93.761	1255.099	3	6.4	9.355	3	96.665	0	0
ZINC000005844792	405.441	2.543	700.215	280.743	73.672	252.036	93.764	1255.101	3	6.4	9.361	3	100	0	0
ZINC000013585233	241.249	7.548	455.149	158.349	273.982	22.819	0	749.387	7	8.9	7.637	2	28.323	1	0
ZINC000013585233	241.249	11.056	455.167	158.05	274.486	22.631	0	750.263	7	8.9	7.777	2	28.249	1	0
ZINC000003799072	415.572	1.007	891.483	448.736	146.571	296.176	0	1542.86	4	7.35	9.17	1	86.908	0	0
ZINC000012468792	432.599	2.028	800.281	456.672	137.125	206.485	0	1494.735	3	7.1	9.572	1	100	0	1
ZINC000004102194	500.628	5.2	958.349	669.366	278.361	10.622	0	1720.75	3	11.8	10.124	1	47.626	1	3
ZINC000003927870	365.214	10.011	558.493	73.58	358.734	76.063	50.116	953.163	6	14.1	8.598	1	0	2	1
ZINC000003927870	365.214	6.236	564.927	82.608	356.666	68.682	56.971	956.451	6	14.1	8.73	1	0	2	1
ZINC000000083315	204.228	3.132	419.183	46.221	166.648	206.314	0	687.589	4	3	8.088	2	42.506	0	1
ZINC000252679615	314.257	3.867	548.758	54.323	243.185	251.25	0	924.46	1	5	9.205	3	67.058	0	0
ZINC000252679615	314.257	2.557	527.996	64.383	238.233	225.38	0	905.494	1	5	9.686	3	67.506	0	0
ZINC000252679615	314.257	4.186	547.3	54.729	241.127	251.444	0	922.097	1	5	9.191	3	67.408	0	0
ZINC000252679615	314.257	2.845	525.884	65.15	235.939	224.795	0	902.055	1	5	9.671	3	67.875	0	0
ZINC000007997966	314.257	2.557	527.996	64.383	238.233	225.38	0	905.494	1	5	9.686	3	67.506	0	0
ZINC000007997966	314.257	2.845	525.884	65.15	235.939	224.795	0	902.055	1	5	9.671	3	67.875	0	0
ZINC000003830215	365.403	8.476	622.007	184.093	266.5	144.7	26.714	1089.545	4.25	8	9.102	1	9.167	0	1
ZINC000003830215	365.403	7.756	618.261	185.62	270.995	138.749	22.896	1092.462	4.25	8	9.277	1	8.485	0	1
ZINC000000002281	225.287	1.825	496.176	234.368	155.26	106.547	0	827.346	4	4.2	9.125	2	61.87	0	0
ZINC000000002281	225.287	1.72	496.493	234.237	154.658	107.598	0	825.348	4	4.2	8.976	2	61.962	0	0
ZINC000003872277	230.668	10.522	415.073	94.247	119.686	128.269	72.87	661.918	0	4.5	9.329	3	82.986	0	0
ZINC000003872277	230.668	11.183	413.943	93.631	118.113	129.281	72.918	659.366	1	5.5	9.406	3	83.218	0	0

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000043100953	Cn1nnc(-c2ccc(-c3ccc(N4C[C@H](COP(=O)(O)O)OC4=O)cc3F)cn2)n1	0.092845107	0.135775423
ZINC000004474682	CC(C)OC(=O)CCC/C=CC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1	0.043771914	0.166030074
ZINC000005844788	O[C@@H](CNC[C@@H](O)[C@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O1	0.055550082	0.198725964
ZINC000003943279	CCCCCCOC(=O)/N=C(N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1	0.136066223	0.265677856
ZINC000003861768	Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1	0.068057161	0.388956815
ZINC000000607986	O[C@@H](CNC[C@@H](O)[C@H]1CCc2cc(F)ccc2O1)[C@H]1CCc2cc(F)ccc2O1	0.055550082	0.198725964
ZINC000003785268	OCc1cc([C@H](O)CNCCCCCCOCCCCc2ccccc2)ccc1O	0.179069583	0.323056978
ZINC000005844792	O[C@@H](CNC[C@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O1	0.055550082	0.198725964
ZINC000013585233	C[C@H](O)[C@H](O)[C@H]1CNc2nc(N)[nH]c(=O)c2N1	0.031410569	0.318425003
ZINC000003799072	OCc1cc([C@@H](O)CNCCCCCCOCCCCc2ccccc2)ccc1O	0.179069583	0.323056978
ZINC000012468792	CC(C)OC(=O)CCC/C=CC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1	0.057567479	0.159818744
ZINC000004102194	C/C(=CC(=O)OCCCCCCCCC(=O)O)C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O	0.027172761	0.295123922
ZINC000003927870	Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]1O	0.050585445	0.380605086
ZINC000000083315	N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O	0.272359065	0.412747788
ZINC000252679615	O=C1CN(N=Cc2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(O)=N1	0.149132109	0.500589886
ZINC000007997966	O=C1CN(/N=Cc2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(O)=N1	0.149132109	0.500589886
ZINC000003830215	CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O	0.069890243	0.164328141
ZINC000000002281	CC(C)(C)NC[C@@H](O)c1cc(O)cc(O)c1	0.159845213	0.248277396
ZINC000003872277	CC1=NS(=O)(=O)c2cc(Cl)ccc2N1	0.17675056	0.347952196
ZINC000029571072	CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c1	0.025416027	0.235213823

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

CLTC

HGS, MCC, IKBKE, TFE3, SNX5, TOM1, SNX9, DNAJC6, ARMCX3, C10orf88, EPN1, EHD1, GGA1, GGA2, GGA3, KIT, AMPH, CLINT1, TNK2, LDLRAP1, HIP1, AP1B1, AP2A2, AP3B2, MAP3K10, PICALM, EPN2, Epn1, VCL, Arrb2, STAMBP, STAMBPL1, STAM, MAP1LC3A, SNCA, PRKACA, WNK1, Mapk13, HDAC5, SPG20, RICTOR, Erh, Cd2ap, Pttg1, EBNA-LP, PCM1, NDRG1, PPP1CA, ITSN1, ARRB1, SIRT7, SH3KBP1, DYRK1A, SNAP91, AP2B1, BIN1, AP1G1, RAC1, TOM1L1, TOM1L2, ISG15, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, XRCC6, HERC1, ATG16L1, SYNJ1, LRRK2, Nfe2l2, AKT1, GRB2, SHC1, AP2M1, MYO6, SRC, FYN, Htt, DNAJA3, RPSA, ESR1, PAXIP1, PPP1CC, SMURF1, ARRB2, ERBB2, FN1, VCAM1, Fcho2, DAB2, UBL4A, ITGA4, MYBL2, SVIL, PAN2, NPM1, PTAFR, ATP4A, EP300, QARS, YWHAQ, FBXO6, RPA1, RPA2, RPA3, ERG, EPHA2, LGR4, Fbxl16, STAU1, TP53, HUWE1, FBXW11, GJB5, NXF1, ADRB2, AVPR2, CUL7, OBSL1, CCDC8, EED, ZFYVE9, OCRL, ATR, SCYL2, HTR6, HNRNPA1, UNK, ATP1A1, ATP1A2, ATP1A3, ATP5C1, CCDC47, CCT3, CCT6A, BLOC1S1, CAD, CANX, CCT6B, CISD1, CLTA, CYC1, DHX38, EHD2, FASTKD2, HSP90B1, IPO5, MTCH2, NDUFB9, NDUFS1, NLRP1, RAB5B, RANBP2, RANBP6, SLC25A3, SSR3, TECR, TOMM22, UQCRC2, VDAC1, VDAC2, VDAC3, ZMPSTE24, DDOST, EIF6, COX2, PHB, PHB2, PPP2R1A, PPP2R1B, RPN1, TMCO1, TUFM, UQCRQ, NTRK1, OFD1, CEP97, CNTRL, FBF1, NPHP1, DCTN1, POC5, POC1B, PPME1, ABCA2, PARP4, AP2A1, ATP6V1B2, ATP6V0A1, CAV1, CLTB, CAPZA2, DBN1, FLNA, GAK, MYH9, DNAJC7, IQGAP1, PDLIM7, SEC16A, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, ARX, MYO18A, CSNK1A1, CSNK1E, STOM, EPS15, HSPA1A, HSPA4, NDUFA9, CHMP1A, PIK3C2A, PRKAR2A, SEC13, SOAT1, CLTCL1, SORBS2, PKP4, USO1, NUMB, TNK1, RAB11A, HIP1R, ATP6V0D1, XPR1, SEC24C, KIAA0430, IST1, HELZ, MVP, TROAP, SEC24B, RBM14, SEC23A, VTI1B, TRAFD1, PKP3, AAK1, BTBD3, TNRC6B, EDC4, DSTYK, PTPN23, NECAP1, TNRC6A, EHD4, EGFL7, ATP6V1D, PTRH2, PLEKHA5, CPVL, BMP2K, DCP1A, ERBB2IP, CHMP1B, KIDINS220, MTUS1, DENND1A, CRTC3, CPSF7, EDC3, CCDC115, FAM83A, REPS1, STON2, FCHO2, CHMP4B, MITD1, CRTC2, FAM83B, FAM83H, SLC35B2, Actb, Myh9, Myo1c, Ppp1cb, Tpm1, Coro1c, Cul3, Spast, Tmod3, Dctn3, Uso1, Lima1, Samm50, Calml3, Myh10, Strn3, Smap1, Ptpn23, Nhsl1, Sec24c, Flnb, IKBKB, MAP3K7, MCM2, AP3D1, U2AF2, CDC73, ZNF746, ARF6, CYLD, LASP1, BRCA1, TES, MTF1, BRD1, CFTR, ZNF598, PDGFRB, FBXO7, TMPO, PTCH1, HSPA8, MAP2K1, PIK3CA, APOE, BMPR1A, JUP, UQCRB, UBE2M, RAD18, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, LARP7, RNF4, TNF, SPDL1, RIOK1, PRKCZ, HEXIM1, MEPCE, RUNX1, RNF123, PPT1, HERC2, UBE3A, AGR2, RECQL4, SMAP1, MYC, CDK9, Prkaa1, Prkab1, CDK5RAP2, GRWD1, KRT17, KIAA1429, PLEKHA2, RC3H2, ACTC1, TET2, NR2C2, UCHL3, PRDM16, MECOM, AGRN, BMH1, BMH2, ATXN3, TCF7L2, STX2, GSK3B, ABCC6, BIRC3, LMBR1L, WWP2, Hsp22, TRIM28, GJA1, TEX101, ARIH2, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, Clta, PXN, RALBP1, PTCHD3, C18orf54, ANKRD55, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF14, ORF3a, ORF6, ORF7a, ORF7b, ABCC2, CDCA5, ACO1, OPTN, NEK4, LRRC31, DUX4, CIT, AURKB, ECT2, KIF14, KIF20A, MAD2L2, KIF23, PRC1, PRNP, CHCHD1, HAX1, MFN2, SLC25A46, LDLR, SUMO2, PRKCB, Rnf183, AIMP2, BRD4, NINL, AFTPH, NUPR1, EPHA3, CIC, Apc2, RBM39, LGALS9, RIN3, EIF3H, DNAJA1, HSPA1L, HSPA2, HSPA6, BAG5, AR, UFL1, DDRGK1, CD3EAP, LAMTOR1, POLR2C, TRIM37, HTRA4, DRD2, ADRBK1, WDR5, PAGE4, NUDCD2, BGLT3, EDEM1, BAG2, DTX3, BTF3, IGF1R, NEDD4, FBXW7, TFRC, IFITM1, BSG, IFITM3, TMPRSS11B, CLEC4E, nsp15, ORF10, FGD5, MAP1LC3B, NBR1, CALCOCO2, SQSTM1, TOLLIP, Chrna4, SIRT6, PER2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CLTC
TFEB

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CLTC-TFEB

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CLTC-TFEB

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CLTC	C4518356	MiT family translocation renal cell carcinoma	2	ORPHANET
Hgene	CLTC	C4693389	MENTAL RETARDATION, AUTOSOMAL DOMINANT 56	2	GENOMICS_ENGLAND;UNIPROT
Hgene	CLTC	C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human
Hgene	CLTC	C0334121	Inflammatory Myofibroblastic Tumor	1	ORPHANET
Tgene	TFEB	C4518356	MiT family translocation renal cell carcinoma	2	ORPHANET