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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ACTN4-ACTN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ACTN4-ACTN1
FusionPDB ID: 1761
FusionGDB2.0 ID: 1761
HgeneTgene
Gene symbol

ACTN4

ACTN1

Gene ID

81

87

Gene nameactinin alpha 4actinin alpha 1
SynonymsACTININ-4|FSGS|FSGS1BDPLT15
Cytomap

19q13.2

14q24.1|14q22-q24

Type of geneprotein-codingprotein-coding
Descriptionalpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4alpha-actinin-1F-actin cross-linking proteinactinin 1 smooth musclealpha-actinin cytoskeletal isoformepididymis secretory sperm binding proteinnon-muscle alpha-actinin-1
Modification date2020032720200327
UniProtAcc

O43707

P12814

Ensembl transtripts involved in fusion geneENST idsENST00000252699, ENST00000390009, 
ENST00000424234, ENST00000497637, 
ENST00000554508, ENST00000193403, 
ENST00000376839, ENST00000394419, 
ENST00000438964, ENST00000538545, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score42 X 60 X 18=4536017 X 18 X 5=1530
# samples 7720
** MAII scorelog2(77/45360*10)=-5.88041838424733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1530*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ACTN4 [Title/Abstract] AND ACTN1 [Title/Abstract] AND fusion [Title/Abstract]

Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein-protein interaction analysis (pmid: 21246116)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ACTN4(39195660)-ACTN1(69376759), # samples:7
Anticipated loss of major functional domain due to fusion event.ACTN4-ACTN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-ACTN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-ACTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACTN4-ACTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTN4

GO:0033209

tumor necrosis factor-mediated signaling pathway

25411248

HgeneACTN4

GO:0035357

peroxisome proliferator activated receptor signaling pathway

22351778

HgeneACTN4

GO:0048384

retinoic acid receptor signaling pathway

22351778

HgeneACTN4

GO:0051272

positive regulation of cellular component movement

9508771


check buttonFusion gene breakpoints across ACTN4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACTN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer13NACTN4chr19

39195660

+ACTN1chr14

69376759

-
ChimerDB4Non-Cancer267NACTN4chr19

39215205

+ACTN1chr14

69347706

-
ChimerDB4Non-Cancer271NACTN4chr19

39215205

+ACTN1chr14

69347706

-
ChimerDB4Non-CancerTCGA-HU-A4GC-11AACTN4chr19

39195660

+ACTN1chr14

69376759

-
ChimerDB4Non-CancerTCGA-HU-A4GC-11AACTN4chr19

39215205

+ACTN1chr14

69347706

-
ChimerDB4Non-CancerTCGA-HU-A4GP-11AACTN4chr19

39195660

+ACTN1chr14

69376759

-
ChimerDB4Non-CancerTCGA-IG-A3I8-11AACTN4chr19

39195660

+ACTN1chr14

69376759

-
ChimerDB4Non-CancerTCGA-L5-A4OM-11AACTN4chr19

39195660

+ACTN1chr14

69376759

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000252699ACTN4chr1939195660+ENST00000193403ACTN1chr1469376759-3528560762811911
ENST00000252699ACTN4chr1939195660+ENST00000394419ACTN1chr1469376759-3414560762877933
ENST00000252699ACTN4chr1939195660+ENST00000438964ACTN1chr1469376759-2970560762796906
ENST00000252699ACTN4chr1939195660+ENST00000376839ACTN1chr1469376759-2873560762796906
ENST00000252699ACTN4chr1939195660+ENST00000538545ACTN1chr1469376759-2926560762925950
ENST00000252699ACTN4chr1939215205+ENST00000193403ACTN1chr1469347706-35282086762811911
ENST00000252699ACTN4chr1939215205+ENST00000394419ACTN1chr1469347706-34142086762877933
ENST00000252699ACTN4chr1939215205+ENST00000438964ACTN1chr1469347706-29702086762796906
ENST00000252699ACTN4chr1939215205+ENST00000376839ACTN1chr1469347706-28732086762796906
ENST00000252699ACTN4chr1939215205+ENST00000538545ACTN1chr1469347706-29262086762925950
ENST00000424234ACTN4chr1939215205+ENST00000193403ACTN1chr1469347706-2341899591624521
ENST00000424234ACTN4chr1939215205+ENST00000394419ACTN1chr1469347706-2227899591690543
ENST00000424234ACTN4chr1939215205+ENST00000438964ACTN1chr1469347706-1783899591609516
ENST00000424234ACTN4chr1939215205+ENST00000376839ACTN1chr1469347706-1686899591609516
ENST00000424234ACTN4chr1939215205+ENST00000538545ACTN1chr1469347706-1739899591738560
ENST00000390009ACTN4chr1939215205+ENST00000193403ACTN1chr1469347706-2803136182086692
ENST00000390009ACTN4chr1939215205+ENST00000394419ACTN1chr1469347706-2689136182152714
ENST00000390009ACTN4chr1939215205+ENST00000438964ACTN1chr1469347706-2245136182071687
ENST00000390009ACTN4chr1939215205+ENST00000376839ACTN1chr1469347706-2148136182071687
ENST00000390009ACTN4chr1939215205+ENST00000538545ACTN1chr1469347706-2201136182200731

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252699ENST00000193403ACTN4chr1939195660+ACTN1chr1469376759-0.0074339340.9925661
ENST00000252699ENST00000394419ACTN4chr1939195660+ACTN1chr1469376759-0.0074772930.99252266
ENST00000252699ENST00000438964ACTN4chr1939195660+ACTN1chr1469376759-0.0115282540.98847175
ENST00000252699ENST00000376839ACTN4chr1939195660+ACTN1chr1469376759-0.010927340.9890726
ENST00000252699ENST00000538545ACTN4chr1939195660+ACTN1chr1469376759-0.0094904460.9905096
ENST00000252699ENST00000193403ACTN4chr1939215205+ACTN1chr1469347706-0.0106936810.9893063
ENST00000252699ENST00000394419ACTN4chr1939215205+ACTN1chr1469347706-0.010840930.98915905
ENST00000252699ENST00000438964ACTN4chr1939215205+ACTN1chr1469347706-0.018215350.9817847
ENST00000252699ENST00000376839ACTN4chr1939215205+ACTN1chr1469347706-0.0176050830.9823949
ENST00000252699ENST00000538545ACTN4chr1939215205+ACTN1chr1469347706-0.0155180070.98448205
ENST00000424234ENST00000193403ACTN4chr1939215205+ACTN1chr1469347706-0.0077710260.9922289
ENST00000424234ENST00000394419ACTN4chr1939215205+ACTN1chr1469347706-0.0086882810.9913118
ENST00000424234ENST00000438964ACTN4chr1939215205+ACTN1chr1469347706-0.0093819840.99061805
ENST00000424234ENST00000376839ACTN4chr1939215205+ACTN1chr1469347706-0.0072095730.99279046
ENST00000424234ENST00000538545ACTN4chr1939215205+ACTN1chr1469347706-0.0094970320.99050295
ENST00000390009ENST00000193403ACTN4chr1939215205+ACTN1chr1469347706-0.0155684980.98443156
ENST00000390009ENST00000394419ACTN4chr1939215205+ACTN1chr1469347706-0.0139367130.9860633
ENST00000390009ENST00000438964ACTN4chr1939215205+ACTN1chr1469347706-0.0155705450.9844295
ENST00000390009ENST00000376839ACTN4chr1939215205+ACTN1chr1469347706-0.0122719060.9877281
ENST00000390009ENST00000538545ACTN4chr1939215205+ACTN1chr1469347706-0.0143399080.9856601

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1761_1761_1_ACTN4-ACTN1_ACTN4_chr19_39195660_ENST00000252699_ACTN1_chr14_69376759_ENST00000193403_length(amino acids)=911AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK
ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPF
NNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLV
PRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAE
FARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMS

--------------------------------------------------------------

>1761_1761_2_ACTN4-ACTN1_ACTN4_chr19_39195660_ENST00000252699_ACTN1_chr14_69376759_ENST00000376839_length(amino acids)=906AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK
ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPF
NNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLV
PRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIM
SIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTAL

--------------------------------------------------------------

>1761_1761_3_ACTN4-ACTN1_ACTN4_chr19_39195660_ENST00000252699_ACTN1_chr14_69376759_ENST00000394419_length(amino acids)=933AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK
ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPF
NNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLV
PRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTG
MMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEY

--------------------------------------------------------------

>1761_1761_4_ACTN4-ACTN1_ACTN4_chr19_39195660_ENST00000252699_ACTN1_chr14_69376759_ENST00000438964_length(amino acids)=906AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK
ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPF
NNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLV
PRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIM
SIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTAL

--------------------------------------------------------------

>1761_1761_5_ACTN4-ACTN1_ACTN4_chr19_39195660_ENST00000252699_ACTN1_chr14_69376759_ENST00000538545_length(amino acids)=950AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIK
ALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPF
NNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLV
PRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIM
SIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKLQEGGKMQTAHAAFTPPGFAAVSGRAALRLLDFAAFLTTLSSQNYI

--------------------------------------------------------------

>1761_1761_6_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000252699_ACTN1_chr14_69347706_ENST00000193403_length(amino acids)=911AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIK
ALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF
NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLV
PKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAE
FARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMS

--------------------------------------------------------------

>1761_1761_7_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000252699_ACTN1_chr14_69347706_ENST00000376839_length(amino acids)=906AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIK
ALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF
NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLV
PKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIM
SIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTAL

--------------------------------------------------------------

>1761_1761_8_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000252699_ACTN1_chr14_69347706_ENST00000394419_length(amino acids)=933AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIK
ALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF
NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLV
PKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTG
MMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEY

--------------------------------------------------------------

>1761_1761_9_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000252699_ACTN1_chr14_69347706_ENST00000438964_length(amino acids)=906AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIK
ALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF
NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLV
PKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIM
SIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTAL

--------------------------------------------------------------

>1761_1761_10_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000252699_ACTN1_chr14_69347706_ENST00000538545_length(amino acids)=950AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
ISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSG
AQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIK
ALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF
NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLV
PKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIM
SIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKLQEGGKMQTAHAAFTPPGFAAVSGRAALRLLDFAAFLTTLSSQNYI

--------------------------------------------------------------

>1761_1761_11_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000390009_ACTN1_chr14_69347706_ENST00000193403_length(amino acids)=692AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWI
RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEE
WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSH
NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD
ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKM
EEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDA
KGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVM

--------------------------------------------------------------

>1761_1761_12_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000390009_ACTN1_chr14_69347706_ENST00000376839_length(amino acids)=687AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWI
RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEE
WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSH
NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD
ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKM
EEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDA
KGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKI

--------------------------------------------------------------

>1761_1761_13_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000390009_ACTN1_chr14_69347706_ENST00000394419_length(amino acids)=714AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWI
RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEE
WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSH
NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD
ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKM
EEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDA
KGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVT

--------------------------------------------------------------

>1761_1761_14_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000390009_ACTN1_chr14_69347706_ENST00000438964_length(amino acids)=687AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWI
RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEE
WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSH
NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD
ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKM
EEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDA
KGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKI

--------------------------------------------------------------

>1761_1761_15_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000390009_ACTN1_chr14_69347706_ENST00000538545_length(amino acids)=731AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWI
RRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEE
WLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSH
NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD
ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKM
EEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDA
KGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKI
LAGDKLQEGGKMQTAHAAFTPPGFAAVSGRAALRLLDFAAFLTTLSSQNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSF

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>1761_1761_16_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000424234_ACTN1_chr14_69347706_ENST00000193403_length(amino acids)=521AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
HELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAH
DQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV
VGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEV
ENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETA

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>1761_1761_17_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000424234_ACTN1_chr14_69347706_ENST00000376839_length(amino acids)=516AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
HELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAH
DQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV
VGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEV
ENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTA

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>1761_1761_18_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000424234_ACTN1_chr14_69347706_ENST00000394419_length(amino acids)=543AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
HELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAH
DQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV
VGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEV
ENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIV
DPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGE

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>1761_1761_19_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000424234_ACTN1_chr14_69347706_ENST00000438964_length(amino acids)=516AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
HELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAH
DQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV
VGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEV
ENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTA

--------------------------------------------------------------

>1761_1761_20_ACTN4-ACTN1_ACTN4_chr19_39215205_ENST00000424234_ACTN1_chr14_69347706_ENST00000538545_length(amino acids)=560AA_BP=29
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEV
HELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAH
DQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV
VGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEV
ENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTA
DQVMASFKILAGDKLQEGGKMQTAHAAFTPPGFAAVSGRAALRLLDFAAFLTTLSSQNYITMDELRRELPPDQAEYCIARMAPYTGPDSV

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:39195660/chr14:69376759)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTN4

O43707

ACTN1

P12814

FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}.FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+42119_26161.33333333333334912.0Compositional biasPoly-Gly
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+162119_26670.0912.0Compositional biasPoly-Gly
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+91419_26451.0693.0Compositional biasPoly-Gly
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+42150_154161.33333333333334912.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+1621163_269670.0912.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+162150_154670.0912.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+914163_269451.0693.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+91450_154451.0693.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+42184_88161.33333333333334912.0MotifLXXLL motif
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+162184_88670.0912.0MotifLXXLL motif
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+91484_88451.0693.0MotifLXXLL motif
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+1621177_192670.0912.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+16211_269670.0912.0RegionNote=Actin-binding
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+914177_192451.0693.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+9141_269451.0693.0RegionNote=Actin-binding
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+1621293_403670.0912.0RepeatSpectrin 1
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+1621413_518670.0912.0RepeatSpectrin 2
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+1621528_639670.0912.0RepeatSpectrin 3
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+914293_403451.0693.0RepeatSpectrin 1
TgeneACTN1chr19:39195660chr14:69376759ENST00000193403321759_770142.33333333333334893.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39195660chr14:69376759ENST00000193403321800_811142.33333333333334893.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39195660chr14:69376759ENST00000394419322759_770142.33333333333334915.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39195660chr14:69376759ENST00000394419322800_811142.33333333333334915.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39195660chr14:69376759ENST00000438964321759_770142.33333333333334888.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39195660chr14:69376759ENST00000438964321800_811142.33333333333334888.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39195660chr14:69376759ENST00000538545321759_770142.33333333333334931.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39195660chr14:69376759ENST00000538545321800_811142.33333333333334931.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39215205chr14:69347706ENST000001934031521759_770651.0893.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39215205chr14:69347706ENST000001934031521800_811651.0893.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39215205chr14:69347706ENST000003944191522759_770651.0915.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39215205chr14:69347706ENST000003944191522800_811651.0915.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39215205chr14:69347706ENST000004389641521759_770651.0888.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39215205chr14:69347706ENST000004389641521800_811651.0888.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39215205chr14:69347706ENST000005385451521759_770651.0931.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39215205chr14:69347706ENST000005385451521800_811651.0931.0Calcium bindingOntology_term=ECO:0000255
TgeneACTN1chr19:39195660chr14:69376759ENST00000193403321144_250142.33333333333334893.0DomainCalponin-homology (CH) 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000193403321746_781142.33333333333334893.0DomainEF-hand 1
TgeneACTN1chr19:39195660chr14:69376759ENST00000193403321787_822142.33333333333334893.0DomainEF-hand 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000394419322144_250142.33333333333334915.0DomainCalponin-homology (CH) 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000394419322746_781142.33333333333334915.0DomainEF-hand 1
TgeneACTN1chr19:39195660chr14:69376759ENST00000394419322787_822142.33333333333334915.0DomainEF-hand 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000438964321144_250142.33333333333334888.0DomainCalponin-homology (CH) 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000438964321746_781142.33333333333334888.0DomainEF-hand 1
TgeneACTN1chr19:39195660chr14:69376759ENST00000438964321787_822142.33333333333334888.0DomainEF-hand 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000538545321144_250142.33333333333334931.0DomainCalponin-homology (CH) 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000538545321746_781142.33333333333334931.0DomainEF-hand 1
TgeneACTN1chr19:39195660chr14:69376759ENST00000538545321787_822142.33333333333334931.0DomainEF-hand 2
TgeneACTN1chr19:39215205chr14:69347706ENST000001934031521746_781651.0893.0DomainEF-hand 1
TgeneACTN1chr19:39215205chr14:69347706ENST000001934031521787_822651.0893.0DomainEF-hand 2
TgeneACTN1chr19:39215205chr14:69347706ENST000003944191522746_781651.0915.0DomainEF-hand 1
TgeneACTN1chr19:39215205chr14:69347706ENST000003944191522787_822651.0915.0DomainEF-hand 2
TgeneACTN1chr19:39215205chr14:69347706ENST000004389641521746_781651.0888.0DomainEF-hand 1
TgeneACTN1chr19:39215205chr14:69347706ENST000004389641521787_822651.0888.0DomainEF-hand 2
TgeneACTN1chr19:39215205chr14:69347706ENST000005385451521746_781651.0931.0DomainEF-hand 1
TgeneACTN1chr19:39215205chr14:69347706ENST000005385451521787_822651.0931.0DomainEF-hand 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000193403321274_384142.33333333333334893.0RepeatNote=Spectrin 1
TgeneACTN1chr19:39195660chr14:69376759ENST00000193403321394_499142.33333333333334893.0RepeatNote=Spectrin 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000193403321509_620142.33333333333334893.0RepeatNote=Spectrin 3
TgeneACTN1chr19:39195660chr14:69376759ENST00000193403321630_733142.33333333333334893.0RepeatNote=Spectrin 4
TgeneACTN1chr19:39195660chr14:69376759ENST00000394419322274_384142.33333333333334915.0RepeatNote=Spectrin 1
TgeneACTN1chr19:39195660chr14:69376759ENST00000394419322394_499142.33333333333334915.0RepeatNote=Spectrin 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000394419322509_620142.33333333333334915.0RepeatNote=Spectrin 3
TgeneACTN1chr19:39195660chr14:69376759ENST00000394419322630_733142.33333333333334915.0RepeatNote=Spectrin 4
TgeneACTN1chr19:39195660chr14:69376759ENST00000438964321274_384142.33333333333334888.0RepeatNote=Spectrin 1
TgeneACTN1chr19:39195660chr14:69376759ENST00000438964321394_499142.33333333333334888.0RepeatNote=Spectrin 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000438964321509_620142.33333333333334888.0RepeatNote=Spectrin 3
TgeneACTN1chr19:39195660chr14:69376759ENST00000438964321630_733142.33333333333334888.0RepeatNote=Spectrin 4
TgeneACTN1chr19:39195660chr14:69376759ENST00000538545321274_384142.33333333333334931.0RepeatNote=Spectrin 1
TgeneACTN1chr19:39195660chr14:69376759ENST00000538545321394_499142.33333333333334931.0RepeatNote=Spectrin 2
TgeneACTN1chr19:39195660chr14:69376759ENST00000538545321509_620142.33333333333334931.0RepeatNote=Spectrin 3
TgeneACTN1chr19:39195660chr14:69376759ENST00000538545321630_733142.33333333333334931.0RepeatNote=Spectrin 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+421778_789161.33333333333334912.0Calcium binding1
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+421819_830161.33333333333334912.0Calcium binding2
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114778_7890693.0Calcium binding1
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114819_8300693.0Calcium binding2
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+1621778_789670.0912.0Calcium binding1
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+1621819_830670.0912.0Calcium binding2
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+914778_789451.0693.0Calcium binding1
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+914819_830451.0693.0Calcium binding2
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+11419_260693.0Compositional biasPoly-Gly
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+421163_269161.33333333333334912.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+421765_800161.33333333333334912.0DomainEF-hand 1
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+421806_841161.33333333333334912.0DomainEF-hand 2
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114163_2690693.0DomainCalponin-homology (CH) 2
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+11450_1540693.0DomainCalponin-homology (CH) 1
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114765_8000693.0DomainEF-hand 1
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114806_8410693.0DomainEF-hand 2
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+1621765_800670.0912.0DomainEF-hand 1
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+1621806_841670.0912.0DomainEF-hand 2
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+914765_800451.0693.0DomainEF-hand 1
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+914806_841451.0693.0DomainEF-hand 2
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+11484_880693.0MotifLXXLL motif
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+421177_192161.33333333333334912.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+4211_269161.33333333333334912.0RegionNote=Actin-binding
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114177_1920693.0RegionPolyphosphoinositide (PIP2)-binding
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+1141_2690693.0RegionNote=Actin-binding
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+421293_403161.33333333333334912.0RepeatSpectrin 1
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+421413_518161.33333333333334912.0RepeatSpectrin 2
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+421528_639161.33333333333334912.0RepeatSpectrin 3
HgeneACTN4chr19:39195660chr14:69376759ENST00000252699+421649_752161.33333333333334912.0RepeatSpectrin 4
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114293_4030693.0RepeatSpectrin 1
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114413_5180693.0RepeatSpectrin 2
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114528_6390693.0RepeatSpectrin 3
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114649_7520693.0RepeatSpectrin 4
HgeneACTN4chr19:39215205chr14:69347706ENST00000252699+1621649_752670.0912.0RepeatSpectrin 4
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+914413_518451.0693.0RepeatSpectrin 2
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+914528_639451.0693.0RepeatSpectrin 3
HgeneACTN4chr19:39215205chr14:69347706ENST00000390009+914649_752451.0693.0RepeatSpectrin 4
TgeneACTN1chr19:39195660chr14:69376759ENST0000019340332131_135142.33333333333334893.0DomainCalponin-homology (CH) 1
TgeneACTN1chr19:39195660chr14:69376759ENST0000039441932231_135142.33333333333334915.0DomainCalponin-homology (CH) 1
TgeneACTN1chr19:39195660chr14:69376759ENST0000043896432131_135142.33333333333334888.0DomainCalponin-homology (CH) 1
TgeneACTN1chr19:39195660chr14:69376759ENST0000053854532131_135142.33333333333334931.0DomainCalponin-homology (CH) 1
TgeneACTN1chr19:39215205chr14:69347706ENST000001934031521144_250651.0893.0DomainCalponin-homology (CH) 2
TgeneACTN1chr19:39215205chr14:69347706ENST00000193403152131_135651.0893.0DomainCalponin-homology (CH) 1
TgeneACTN1chr19:39215205chr14:69347706ENST000003944191522144_250651.0915.0DomainCalponin-homology (CH) 2
TgeneACTN1chr19:39215205chr14:69347706ENST00000394419152231_135651.0915.0DomainCalponin-homology (CH) 1
TgeneACTN1chr19:39215205chr14:69347706ENST000004389641521144_250651.0888.0DomainCalponin-homology (CH) 2
TgeneACTN1chr19:39215205chr14:69347706ENST00000438964152131_135651.0888.0DomainCalponin-homology (CH) 1
TgeneACTN1chr19:39215205chr14:69347706ENST000005385451521144_250651.0931.0DomainCalponin-homology (CH) 2
TgeneACTN1chr19:39215205chr14:69347706ENST00000538545152131_135651.0931.0DomainCalponin-homology (CH) 1
TgeneACTN1chr19:39195660chr14:69376759ENST000001934033211_247142.33333333333334893.0RegionNote=Actin-binding
TgeneACTN1chr19:39195660chr14:69376759ENST000003944193221_247142.33333333333334915.0RegionNote=Actin-binding
TgeneACTN1chr19:39195660chr14:69376759ENST000004389643211_247142.33333333333334888.0RegionNote=Actin-binding
TgeneACTN1chr19:39195660chr14:69376759ENST000005385453211_247142.33333333333334931.0RegionNote=Actin-binding
TgeneACTN1chr19:39215205chr14:69347706ENST0000019340315211_247651.0893.0RegionNote=Actin-binding
TgeneACTN1chr19:39215205chr14:69347706ENST0000039441915221_247651.0915.0RegionNote=Actin-binding
TgeneACTN1chr19:39215205chr14:69347706ENST0000043896415211_247651.0888.0RegionNote=Actin-binding
TgeneACTN1chr19:39215205chr14:69347706ENST0000053854515211_247651.0931.0RegionNote=Actin-binding
TgeneACTN1chr19:39215205chr14:69347706ENST000001934031521274_384651.0893.0RepeatNote=Spectrin 1
TgeneACTN1chr19:39215205chr14:69347706ENST000001934031521394_499651.0893.0RepeatNote=Spectrin 2
TgeneACTN1chr19:39215205chr14:69347706ENST000001934031521509_620651.0893.0RepeatNote=Spectrin 3
TgeneACTN1chr19:39215205chr14:69347706ENST000001934031521630_733651.0893.0RepeatNote=Spectrin 4
TgeneACTN1chr19:39215205chr14:69347706ENST000003944191522274_384651.0915.0RepeatNote=Spectrin 1
TgeneACTN1chr19:39215205chr14:69347706ENST000003944191522394_499651.0915.0RepeatNote=Spectrin 2
TgeneACTN1chr19:39215205chr14:69347706ENST000003944191522509_620651.0915.0RepeatNote=Spectrin 3
TgeneACTN1chr19:39215205chr14:69347706ENST000003944191522630_733651.0915.0RepeatNote=Spectrin 4
TgeneACTN1chr19:39215205chr14:69347706ENST000004389641521274_384651.0888.0RepeatNote=Spectrin 1
TgeneACTN1chr19:39215205chr14:69347706ENST000004389641521394_499651.0888.0RepeatNote=Spectrin 2
TgeneACTN1chr19:39215205chr14:69347706ENST000004389641521509_620651.0888.0RepeatNote=Spectrin 3
TgeneACTN1chr19:39215205chr14:69347706ENST000004389641521630_733651.0888.0RepeatNote=Spectrin 4
TgeneACTN1chr19:39215205chr14:69347706ENST000005385451521274_384651.0931.0RepeatNote=Spectrin 1
TgeneACTN1chr19:39215205chr14:69347706ENST000005385451521394_499651.0931.0RepeatNote=Spectrin 2
TgeneACTN1chr19:39215205chr14:69347706ENST000005385451521509_620651.0931.0RepeatNote=Spectrin 3
TgeneACTN1chr19:39215205chr14:69347706ENST000005385451521630_733651.0931.0RepeatNote=Spectrin 4


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ACTN4_pLDDT.png
all structure
all structure
ACTN1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ACTN4MYOZ2, MYOZ1, PDLIM1, USP6NL, P2rx7, SLC9A3R2, COL17A1, TRIM3, MAGI1, GSN, Lrrc7, CAMK2A, CAMK2B, INO80, UBTF, STAT1, HDAC7, MEF2A, UCHL5, TJP1, ATXN7, HDAC5, VDR, ESR1, PSMA3, ELAVL1, SIRT7, SLC2A4, ISG15, COIL, SACS, HGS, UBASH3B, SHC1, NOS3, ACTN2, ACTN1, FMNL1, TRAF3IP1, FN1, VCAM1, Fcho2, CDH1, ITGA4, SVIL, CD81, IGSF8, ICAM1, TXN, RPS27, POT1, KPNA2, MAPK7, CDKN2A, VCP, SF3A3, GNB2, HUWE1, ACTN3, BMP7, ALK, CUL7, OBSL1, CCDC8, EGFR, LUZP4, RARA, HSPB1, AHNAK, ALDOA, ALDOC, IDH3A, MYH15, MYH2, MYH7B, NCAPG2, PSMA6, PSMB5, PUS7, TPM2, TSG101, CKB, CYC1, ECSIT, MCFD2, PSMB8, TPM1, TPM3, TPM4, NTRK1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, MAPRE1, SIN3B, MYEF2, LIMA1, ANLN, MYO5C, MYO19, MYO18A, Actb, Flot2, Myh9, Myo1c, Tpm1, Coro1c, Tmod3, Lima1, Ncbp2, Calml3, Myh10, Flnb, CTNNB1, MCM2, NFYA, CDC73, LCMT2, MEOX2, SORBS2, DDIAS, SSH1, act1, SLC9A1, NCL, DLD, DNM1L, PDHA1, SOD1, TRIM25, TES, CFTR, PPM1D, HDAC4, UBE2M, RAD18, PRPF8, TNIP2, RNF4, TRIM23, AGR2, ACTA1, MYC, CDK9, KIAA1429, ATG16L1, ACTC1, USP14, HDAC2, GBF1, AGRN, DYNC1LI1, BMH1, BMH2, ATXN3, BRF1, CYB5B, GBAS, HADHB, SYNJ2BP, VDAC3, RELA, PRMT5, MDP1, GRIN1, RGS9, BIRC3, SOX2, LNX1, MICALL2, C14orf119, PLEKHA4, PINK1, FANCD2, SH2D3C, SRC, TTN, NEK4, CIT, CHMP4B, CHMP4C, PTGER4, ECT2, KIF14, KIF20A, PRC1, PRNP, MKI67, HNRNPH1, NMRAL1, NUPR1, TRIM21, Apc2, RBM39, LGALS9, YWHAE, EIF3F, INSIG1, INSIG2, RIN3, CANX, GGH, ERP44, ACO2, KDM4C, AHCY, SHMT2, IDH2, SMCHD1, AR, TP53, ACTB, ANKFY1, EZR, RDX, VASP, ZYX, TRIM37, HTRA4, NUDCD2, BGLT3, BTF3, SEPT9, UBR5, LHPP, TFRC, CTSB, CTSS, DPP4, ORF3a, ORF8, NRP1, TMPRSS2, TOP3B, CTSL, FURIN, IFITM1, ANPEP, BSG, IFITM3, TMPRSS11B, CLEC4D, ACE2, TMPRSS4, CLEC4E, nsp2, ORF10, FGD5, TMEM106B, PDE4B, PER2, OTUD3, SIK2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ACTN4all structure
ACTN1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+114108_1260693.0VCL
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+11412_260693.0VCL
HgeneACTN4chr19:39195660chr14:69376759ENST00000390009+11440_610693.0VCL
TgeneACTN1chr19:39215205chr14:69347706ENST000001934031521274_733651.0893.0DDN
TgeneACTN1chr19:39215205chr14:69347706ENST000003944191522274_733651.0915.0DDN
TgeneACTN1chr19:39215205chr14:69347706ENST000004389641521274_733651.0888.0DDN
TgeneACTN1chr19:39215205chr14:69347706ENST000005385451521274_733651.0931.0DDN


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Related Drugs to ACTN4-ACTN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ACTN4-ACTN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTN4C4551527Focal segmental glomerulosclerosis 19GENOMICS_ENGLAND;UNIPROT
HgeneACTN4C0007097Carcinoma1CTD_human
HgeneACTN4C0019193Hepatitis, Toxic1CTD_human
HgeneACTN4C0024667Animal Mammary Neoplasms1CTD_human
HgeneACTN4C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneACTN4C0205696Anaplastic carcinoma1CTD_human
HgeneACTN4C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneACTN4C0205698Undifferentiated carcinoma1CTD_human
HgeneACTN4C0205699Carcinomatosis1CTD_human
HgeneACTN4C0860207Drug-Induced Liver Disease1CTD_human
HgeneACTN4C1257925Mammary Carcinoma, Animal1CTD_human
HgeneACTN4C1262760Hepatitis, Drug-Induced1CTD_human
HgeneACTN4C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
HgeneACTN4C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneACTN4C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneACTN4C4279912Chemically-Induced Liver Toxicity1CTD_human