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Fusion Protein:CNOT2-ERBB3 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CNOT2-ERBB3 | FusionPDB ID: 17732 | FusionGDB2.0 ID: 17732 | Hgene | Tgene | Gene symbol | CNOT2 | ERBB3 | Gene ID | 4848 | 2065 |
| Gene name | CCR4-NOT transcription complex subunit 2 | erb-b2 receptor tyrosine kinase 3 | |
| Synonyms | CDC36|HSPC131|IDNADFS|NOT2|NOT2H | ErbB-3|FERLK|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 | |
| Cytomap | 12q15 | 12q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2 | receptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q9NZN8 | P21860 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000229195, ENST00000418359, ENST00000548230, ENST00000551483, | ENST00000411731, ENST00000549832, ENST00000267101, ENST00000415288, ENST00000450146, ENST00000553131, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 41 X 13 X 11=5863 | 28 X 12 X 14=4704 |
| # samples | 46 | 28 | |
| ** MAII score | log2(46/5863*10)=-3.6719332904521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/4704*10)=-4.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: CNOT2 [Title/Abstract] AND ERBB3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CNOT2(70672054)-ERBB3(56493958), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | CNOT2-ERBB3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CNOT2-ERBB3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CNOT2-ERBB3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CNOT2-ERBB3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNOT2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14707134|16712523 |
| Tgene | ERBB3 | GO:0007162 | negative regulation of cell adhesion | 7556068 |
| Tgene | ERBB3 | GO:0007165 | signal transduction | 10572067 |
| Tgene | ERBB3 | GO:0009968 | negative regulation of signal transduction | 11389077 |
| Tgene | ERBB3 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
| Tgene | ERBB3 | GO:0042127 | regulation of cell proliferation | 11389077 |
| Tgene | ERBB3 | GO:0051048 | negative regulation of secretion | 10559227 |
| Fusion gene breakpoints across CNOT2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ERBB3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-06-5856-01A | CNOT2 | chr12 | 70672054 | + | ERBB3 | chr12 | 56493958 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000229195 | CNOT2 | chr12 | 70672054 | + | ENST00000267101 | ERBB3 | chr12 | 56493958 | + | 2977 | 627 | 540 | 1526 | 328 |
| ENST00000229195 | CNOT2 | chr12 | 70672054 | + | ENST00000450146 | ERBB3 | chr12 | 56493958 | + | 1846 | 627 | 540 | 1526 | 328 |
| ENST00000229195 | CNOT2 | chr12 | 70672054 | + | ENST00000415288 | ERBB3 | chr12 | 56493958 | + | 1808 | 627 | 540 | 1526 | 328 |
| ENST00000229195 | CNOT2 | chr12 | 70672054 | + | ENST00000553131 | ERBB3 | chr12 | 56493958 | + | 2278 | 627 | 540 | 1526 | 328 |
| ENST00000418359 | CNOT2 | chr12 | 70672054 | + | ENST00000267101 | ERBB3 | chr12 | 56493958 | + | 2849 | 499 | 412 | 1398 | 328 |
| ENST00000418359 | CNOT2 | chr12 | 70672054 | + | ENST00000450146 | ERBB3 | chr12 | 56493958 | + | 1718 | 499 | 412 | 1398 | 328 |
| ENST00000418359 | CNOT2 | chr12 | 70672054 | + | ENST00000415288 | ERBB3 | chr12 | 56493958 | + | 1680 | 499 | 412 | 1398 | 328 |
| ENST00000418359 | CNOT2 | chr12 | 70672054 | + | ENST00000553131 | ERBB3 | chr12 | 56493958 | + | 2150 | 499 | 412 | 1398 | 328 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000229195 | ENST00000267101 | CNOT2 | chr12 | 70672054 | + | ERBB3 | chr12 | 56493958 | + | 0.004412977 | 0.995587 |
| ENST00000229195 | ENST00000450146 | CNOT2 | chr12 | 70672054 | + | ERBB3 | chr12 | 56493958 | + | 0.008579379 | 0.9914206 |
| ENST00000229195 | ENST00000415288 | CNOT2 | chr12 | 70672054 | + | ERBB3 | chr12 | 56493958 | + | 0.008685674 | 0.99131435 |
| ENST00000229195 | ENST00000553131 | CNOT2 | chr12 | 70672054 | + | ERBB3 | chr12 | 56493958 | + | 0.007490461 | 0.9925095 |
| ENST00000418359 | ENST00000267101 | CNOT2 | chr12 | 70672054 | + | ERBB3 | chr12 | 56493958 | + | 0.004464106 | 0.99553585 |
| ENST00000418359 | ENST00000450146 | CNOT2 | chr12 | 70672054 | + | ERBB3 | chr12 | 56493958 | + | 0.009717075 | 0.9902829 |
| ENST00000418359 | ENST00000415288 | CNOT2 | chr12 | 70672054 | + | ERBB3 | chr12 | 56493958 | + | 0.00963853 | 0.99036145 |
| ENST00000418359 | ENST00000553131 | CNOT2 | chr12 | 70672054 | + | ERBB3 | chr12 | 56493958 | + | 0.007640597 | 0.99235946 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >17732_17732_1_CNOT2-ERBB3_CNOT2_chr12_70672054_ENST00000229195_ERBB3_chr12_56493958_ENST00000267101_length(amino acids)=328AA_BP=29 MIASGTVRKGHDSMVRTDGHTLSEKRNYQSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGS EAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDED EEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPA -------------------------------------------------------------- >17732_17732_2_CNOT2-ERBB3_CNOT2_chr12_70672054_ENST00000229195_ERBB3_chr12_56493958_ENST00000415288_length(amino acids)=328AA_BP=29 MIASGTVRKGHDSMVRTDGHTLSEKRNYQSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGS EAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDED EEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPA -------------------------------------------------------------- >17732_17732_3_CNOT2-ERBB3_CNOT2_chr12_70672054_ENST00000229195_ERBB3_chr12_56493958_ENST00000450146_length(amino acids)=328AA_BP=29 MIASGTVRKGHDSMVRTDGHTLSEKRNYQSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGS EAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDED EEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPA -------------------------------------------------------------- >17732_17732_4_CNOT2-ERBB3_CNOT2_chr12_70672054_ENST00000229195_ERBB3_chr12_56493958_ENST00000553131_length(amino acids)=328AA_BP=29 MIASGTVRKGHDSMVRTDGHTLSEKRNYQSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGS EAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDED EEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPA -------------------------------------------------------------- >17732_17732_5_CNOT2-ERBB3_CNOT2_chr12_70672054_ENST00000418359_ERBB3_chr12_56493958_ENST00000267101_length(amino acids)=328AA_BP=29 MIASGTVRKGHDSMVRTDGHTLSEKRNYQSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGS EAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDED EEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPA -------------------------------------------------------------- >17732_17732_6_CNOT2-ERBB3_CNOT2_chr12_70672054_ENST00000418359_ERBB3_chr12_56493958_ENST00000415288_length(amino acids)=328AA_BP=29 MIASGTVRKGHDSMVRTDGHTLSEKRNYQSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGS EAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDED EEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPA -------------------------------------------------------------- >17732_17732_7_CNOT2-ERBB3_CNOT2_chr12_70672054_ENST00000418359_ERBB3_chr12_56493958_ENST00000450146_length(amino acids)=328AA_BP=29 MIASGTVRKGHDSMVRTDGHTLSEKRNYQSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGS EAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDED EEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPA -------------------------------------------------------------- >17732_17732_8_CNOT2-ERBB3_CNOT2_chr12_70672054_ENST00000418359_ERBB3_chr12_56493958_ENST00000553131_length(amino acids)=328AA_BP=29 MIASGTVRKGHDSMVRTDGHTLSEKRNYQSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGS EAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDED EEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:70672054/chr12:56493958) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNOT2 | ERBB3 |
| FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}. | FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000411731 | 0 | 3 | 709_966 | 0 | 184.0 | Domain | Protein kinase | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000450146 | 11 | 15 | 709_966 | 400.0 | 700.0 | Domain | Protein kinase | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000411731 | 0 | 3 | 715_723 | 0 | 184.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000411731 | 0 | 3 | 788_790 | 0 | 184.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000411731 | 0 | 3 | 834_839 | 0 | 184.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000450146 | 11 | 15 | 715_723 | 400.0 | 700.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000450146 | 11 | 15 | 788_790 | 400.0 | 700.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000450146 | 11 | 15 | 834_839 | 400.0 | 700.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000411731 | 0 | 3 | 20_643 | 0 | 184.0 | Topological domain | Extracellular | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000411731 | 0 | 3 | 665_1342 | 0 | 184.0 | Topological domain | Cytoplasmic | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000450146 | 11 | 15 | 665_1342 | 400.0 | 700.0 | Topological domain | Cytoplasmic | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000411731 | 0 | 3 | 644_664 | 0 | 184.0 | Transmembrane | Helical | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000450146 | 11 | 15 | 644_664 | 400.0 | 700.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CNOT2 | chr12:70672054 | chr12:56493958 | ENST00000229195 | + | 2 | 16 | 437_540 | 16.0 | 541.0 | Region | Note=Repressor domain |
| Hgene | CNOT2 | chr12:70672054 | chr12:56493958 | ENST00000418359 | + | 3 | 17 | 437_540 | 16.0 | 541.0 | Region | Note=Repressor domain |
| Hgene | CNOT2 | chr12:70672054 | chr12:56493958 | ENST00000551483 | + | 1 | 7 | 437_540 | 0 | 192.0 | Region | Note=Repressor domain |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000267101 | 24 | 28 | 709_966 | 1043.0 | 1343.0 | Domain | Protein kinase | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000415288 | 25 | 29 | 709_966 | 984.0 | 1284.0 | Domain | Protein kinase | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000267101 | 24 | 28 | 715_723 | 1043.0 | 1343.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000267101 | 24 | 28 | 788_790 | 1043.0 | 1343.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000267101 | 24 | 28 | 834_839 | 1043.0 | 1343.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000415288 | 25 | 29 | 715_723 | 984.0 | 1284.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000415288 | 25 | 29 | 788_790 | 984.0 | 1284.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000415288 | 25 | 29 | 834_839 | 984.0 | 1284.0 | Nucleotide binding | Note=ATP | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000267101 | 24 | 28 | 20_643 | 1043.0 | 1343.0 | Topological domain | Extracellular | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000267101 | 24 | 28 | 665_1342 | 1043.0 | 1343.0 | Topological domain | Cytoplasmic | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000415288 | 25 | 29 | 20_643 | 984.0 | 1284.0 | Topological domain | Extracellular | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000415288 | 25 | 29 | 665_1342 | 984.0 | 1284.0 | Topological domain | Cytoplasmic | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000450146 | 11 | 15 | 20_643 | 400.0 | 700.0 | Topological domain | Extracellular | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000267101 | 24 | 28 | 644_664 | 1043.0 | 1343.0 | Transmembrane | Helical | |
| Tgene | ERBB3 | chr12:70672054 | chr12:56493958 | ENST00000415288 | 25 | 29 | 644_664 | 984.0 | 1284.0 | Transmembrane | Helical |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| CNOT2 | |
| ERBB3 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to CNOT2-ERBB3 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to CNOT2-ERBB3 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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