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Fusion Protein:CNOT6-CLTC |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CNOT6-CLTC | FusionPDB ID: 17778 | FusionGDB2.0 ID: 17778 | Hgene | Tgene | Gene symbol | CNOT6 | CLTC | Gene ID | 57472 | 1213 |
| Gene name | CCR4-NOT transcription complex subunit 6 | clathrin heavy chain | |
| Synonyms | CCR4|Ccr4a | CHC|CHC17|CLH-17|CLTCL2|Hc|MRD56 | |
| Cytomap | 5q35.3 | 17q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CCR4-NOT transcription complex subunit 6carbon catabolite repression 4 proteincarbon catabolite repressor protein 4 homologcytoplasmic deadenylase | clathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | Q96LI5 | P53675 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000261951, ENST00000393356, ENST00000502447, | ENST00000579456, ENST00000579815, ENST00000269122, ENST00000393043, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 6 X 4=144 | 18 X 18 X 8=2592 |
| # samples | 5 | 22 | |
| ** MAII score | log2(5/144*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/2592*10)=-3.55849028935997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: CNOT6 [Title/Abstract] AND CLTC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CNOT6(179991743)-CLTC(57746137), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CNOT6-CLTC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CNOT6-CLTC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CNOT6-CLTC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CNOT6-CLTC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNOT6 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 20065043 |
| Hgene | CNOT6 | GO:2000327 | positive regulation of nuclear receptor transcription coactivator activity | 18180299 |
| Tgene | CLTC | GO:1900126 | negative regulation of hyaluronan biosynthetic process | 24251095 |
| Fusion gene breakpoints across CNOT6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CLTC (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | 5373N | CNOT6 | chr5 | 179991743 | + | CLTC | chr17 | 57746137 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000261951 | CNOT6 | chr5 | 179991743 | + | ENST00000393043 | CLTC | chr17 | 57746137 | + | 3798 | 908 | 289 | 3699 | 1136 |
| ENST00000261951 | CNOT6 | chr5 | 179991743 | + | ENST00000269122 | CLTC | chr17 | 57746137 | + | 6266 | 908 | 289 | 3807 | 1172 |
| ENST00000393356 | CNOT6 | chr5 | 179991743 | + | ENST00000393043 | CLTC | chr17 | 57746137 | + | 3873 | 983 | 403 | 3774 | 1123 |
| ENST00000393356 | CNOT6 | chr5 | 179991743 | + | ENST00000269122 | CLTC | chr17 | 57746137 | + | 6341 | 983 | 403 | 3882 | 1159 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000261951 | ENST00000393043 | CNOT6 | chr5 | 179991743 | + | CLTC | chr17 | 57746137 | + | 0.001308659 | 0.9986914 |
| ENST00000261951 | ENST00000269122 | CNOT6 | chr5 | 179991743 | + | CLTC | chr17 | 57746137 | + | 0.000380579 | 0.99961936 |
| ENST00000393356 | ENST00000393043 | CNOT6 | chr5 | 179991743 | + | CLTC | chr17 | 57746137 | + | 0.001164441 | 0.9988356 |
| ENST00000393356 | ENST00000269122 | CNOT6 | chr5 | 179991743 | + | CLTC | chr17 | 57746137 | + | 0.000368846 | 0.99963117 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >17778_17778_1_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000261951_CLTC_chr17_57746137_ENST00000269122_length(amino acids)=1172AA_BP=206 MHSQGGGGGSGGGRRRTPRGMPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDI AKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGT AKRITTEQPPPRSWIMLQEPDRTRPTGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLP LIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLE ARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDP ELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEY INRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADD PSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSN FGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAH MGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVEL YYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNI SLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVL ETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGY -------------------------------------------------------------- >17778_17778_2_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000261951_CLTC_chr17_57746137_ENST00000393043_length(amino acids)=1136AA_BP=206 MHSQGGGGGSGGGRRRTPRGMPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDI AKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGT AKRITTEQPPPRSWIMLQEPDRTRPTGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLP LIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLE ARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDP ELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEY INRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADD PSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSN FGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAH MGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVEL YYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNI SLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVL -------------------------------------------------------------- >17778_17778_3_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000393356_CLTC_chr17_57746137_ENST00000269122_length(amino acids)=1159AA_BP=193 MDLLLLCMPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSS NKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRS WIMLQEPDRTRPTGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHD LVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATH NALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPY RRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIA NIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANT SGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGE YQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSK FKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKP LLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIE FRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAM -------------------------------------------------------------- >17778_17778_4_CNOT6-CLTC_CNOT6_chr5_179991743_ENST00000393356_CLTC_chr17_57746137_ENST00000393043_length(amino acids)=1123AA_BP=193 MDLLLLCMPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSS NKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRS WIMLQEPDRTRPTGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHD LVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATH NALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPY RRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIA NIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANT SGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGE YQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSK FKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKP LLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIE FRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAM -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179991743/chr17:57746137) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNOT6 | CLTC |
| FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:18377426, ECO:0000269|PubMed:21233283}. | FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CNOT6 | chr5:179991743 | chr17:57746137 | ENST00000261951 | + | 6 | 12 | 121_143 | 186.33333333333334 | 558.0 | Repeat | Note=LRR 4 |
| Hgene | CNOT6 | chr5:179991743 | chr17:57746137 | ENST00000261951 | + | 6 | 12 | 52_73 | 186.33333333333334 | 558.0 | Repeat | Note=LRR 1 |
| Hgene | CNOT6 | chr5:179991743 | chr17:57746137 | ENST00000261951 | + | 6 | 12 | 75_96 | 186.33333333333334 | 558.0 | Repeat | Note=LRR 2 |
| Hgene | CNOT6 | chr5:179991743 | chr17:57746137 | ENST00000261951 | + | 6 | 12 | 98_120 | 186.33333333333334 | 558.0 | Repeat | Note=LRR 3 |
| Hgene | CNOT6 | chr5:179991743 | chr17:57746137 | ENST00000393356 | + | 8 | 14 | 121_143 | 186.33333333333334 | 558.0 | Repeat | Note=LRR 4 |
| Hgene | CNOT6 | chr5:179991743 | chr17:57746137 | ENST00000393356 | + | 8 | 14 | 52_73 | 186.33333333333334 | 558.0 | Repeat | Note=LRR 1 |
| Hgene | CNOT6 | chr5:179991743 | chr17:57746137 | ENST00000393356 | + | 8 | 14 | 75_96 | 186.33333333333334 | 558.0 | Repeat | Note=LRR 2 |
| Hgene | CNOT6 | chr5:179991743 | chr17:57746137 | ENST00000393356 | + | 8 | 14 | 98_120 | 186.33333333333334 | 558.0 | Repeat | Note=LRR 3 |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 1213_1522 | 709.3333333333334 | 1676.0 | Region | Involved in binding clathrin light chain | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 1550_1675 | 709.3333333333334 | 1676.0 | Region | Trimerization | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 1213_1522 | 709.3333333333334 | 1640.0 | Region | Involved in binding clathrin light chain | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 1550_1675 | 709.3333333333334 | 1640.0 | Region | Trimerization | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 1128_1269 | 709.3333333333334 | 1676.0 | Repeat | CHCR 5 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 1274_1420 | 709.3333333333334 | 1676.0 | Repeat | CHCR 6 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 1423_1566 | 709.3333333333334 | 1676.0 | Repeat | CHCR 7 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 833_972 | 709.3333333333334 | 1676.0 | Repeat | CHCR 3 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 979_1124 | 709.3333333333334 | 1676.0 | Repeat | CHCR 4 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 1128_1269 | 709.3333333333334 | 1640.0 | Repeat | CHCR 5 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 1274_1420 | 709.3333333333334 | 1640.0 | Repeat | CHCR 6 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 1423_1566 | 709.3333333333334 | 1640.0 | Repeat | CHCR 7 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 833_972 | 709.3333333333334 | 1640.0 | Repeat | CHCR 3 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 979_1124 | 709.3333333333334 | 1640.0 | Repeat | CHCR 4 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CNOT6 | chr5:179991743 | chr17:57746137 | ENST00000261951 | + | 6 | 12 | 153_557 | 186.33333333333334 | 558.0 | Region | Nuclease domain |
| Hgene | CNOT6 | chr5:179991743 | chr17:57746137 | ENST00000393356 | + | 8 | 14 | 153_557 | 186.33333333333334 | 558.0 | Region | Nuclease domain |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 108_149 | 709.3333333333334 | 1676.0 | Region | Note=WD40-like repeat 3 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 150_195 | 709.3333333333334 | 1676.0 | Region | Note=WD40-like repeat 4 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 196_257 | 709.3333333333334 | 1676.0 | Region | Note=WD40-like repeat 5 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 24_67 | 709.3333333333334 | 1676.0 | Region | Note=WD40-like repeat 1 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 258_301 | 709.3333333333334 | 1676.0 | Region | Note=WD40-like repeat 6 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 2_479 | 709.3333333333334 | 1676.0 | Region | Note=Globular terminal domain | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 302_330 | 709.3333333333334 | 1676.0 | Region | Note=WD40-like repeat 7 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 449_465 | 709.3333333333334 | 1676.0 | Region | Binding site for the uncoating ATPase%2C involved in lattice disassembly | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 480_523 | 709.3333333333334 | 1676.0 | Region | Note=Flexible linker | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 524_1675 | 709.3333333333334 | 1676.0 | Region | Note=Heavy chain arm | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 524_634 | 709.3333333333334 | 1676.0 | Region | Note=Distal segment | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 639_1675 | 709.3333333333334 | 1676.0 | Region | Note=Proximal segment | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 68_107 | 709.3333333333334 | 1676.0 | Region | Note=WD40-like repeat 2 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 108_149 | 709.3333333333334 | 1640.0 | Region | Note=WD40-like repeat 3 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 150_195 | 709.3333333333334 | 1640.0 | Region | Note=WD40-like repeat 4 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 196_257 | 709.3333333333334 | 1640.0 | Region | Note=WD40-like repeat 5 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 24_67 | 709.3333333333334 | 1640.0 | Region | Note=WD40-like repeat 1 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 258_301 | 709.3333333333334 | 1640.0 | Region | Note=WD40-like repeat 6 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 2_479 | 709.3333333333334 | 1640.0 | Region | Note=Globular terminal domain | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 302_330 | 709.3333333333334 | 1640.0 | Region | Note=WD40-like repeat 7 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 449_465 | 709.3333333333334 | 1640.0 | Region | Binding site for the uncoating ATPase%2C involved in lattice disassembly | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 480_523 | 709.3333333333334 | 1640.0 | Region | Note=Flexible linker | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 524_1675 | 709.3333333333334 | 1640.0 | Region | Note=Heavy chain arm | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 524_634 | 709.3333333333334 | 1640.0 | Region | Note=Distal segment | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 639_1675 | 709.3333333333334 | 1640.0 | Region | Note=Proximal segment | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 68_107 | 709.3333333333334 | 1640.0 | Region | Note=WD40-like repeat 2 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 537_683 | 709.3333333333334 | 1676.0 | Repeat | CHCR 1 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000269122 | 12 | 32 | 686_828 | 709.3333333333334 | 1676.0 | Repeat | CHCR 2 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 537_683 | 709.3333333333334 | 1640.0 | Repeat | CHCR 1 | |
| Tgene | CLTC | chr5:179991743 | chr17:57746137 | ENST00000393043 | 12 | 31 | 686_828 | 709.3333333333334 | 1640.0 | Repeat | CHCR 2 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| CLTC | HGS, MCC, IKBKE, TFE3, SNX5, TOM1, SNX9, DNAJC6, ARMCX3, C10orf88, EPN1, EHD1, GGA1, GGA2, GGA3, KIT, AMPH, CLINT1, TNK2, LDLRAP1, HIP1, AP1B1, AP2A2, AP3B2, MAP3K10, PICALM, EPN2, Epn1, VCL, Arrb2, STAMBP, STAMBPL1, STAM, MAP1LC3A, SNCA, PRKACA, WNK1, Mapk13, HDAC5, SPG20, RICTOR, Erh, Cd2ap, Pttg1, EBNA-LP, PCM1, NDRG1, PPP1CA, ITSN1, ARRB1, SIRT7, SH3KBP1, DYRK1A, SNAP91, AP2B1, BIN1, AP1G1, RAC1, TOM1L1, TOM1L2, ISG15, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, XRCC6, HERC1, ATG16L1, SYNJ1, LRRK2, Nfe2l2, AKT1, GRB2, SHC1, AP2M1, MYO6, SRC, FYN, Htt, DNAJA3, RPSA, ESR1, PAXIP1, PPP1CC, SMURF1, ARRB2, ERBB2, FN1, VCAM1, Fcho2, DAB2, UBL4A, ITGA4, MYBL2, SVIL, PAN2, NPM1, PTAFR, ATP4A, EP300, QARS, YWHAQ, FBXO6, RPA1, RPA2, RPA3, ERG, EPHA2, LGR4, Fbxl16, STAU1, TP53, HUWE1, FBXW11, GJB5, NXF1, ADRB2, AVPR2, CUL7, OBSL1, CCDC8, EED, ZFYVE9, OCRL, ATR, SCYL2, HTR6, HNRNPA1, UNK, ATP1A1, ATP1A2, ATP1A3, ATP5C1, CCDC47, CCT3, CCT6A, BLOC1S1, CAD, CANX, CCT6B, CISD1, CLTA, CYC1, DHX38, EHD2, FASTKD2, HSP90B1, IPO5, MTCH2, NDUFB9, NDUFS1, NLRP1, RAB5B, RANBP2, RANBP6, SLC25A3, SSR3, TECR, TOMM22, UQCRC2, VDAC1, VDAC2, VDAC3, ZMPSTE24, DDOST, EIF6, COX2, PHB, PHB2, PPP2R1A, PPP2R1B, RPN1, TMCO1, TUFM, UQCRQ, NTRK1, OFD1, CEP97, CNTRL, FBF1, NPHP1, DCTN1, POC5, POC1B, PPME1, ABCA2, PARP4, AP2A1, ATP6V1B2, ATP6V0A1, CAV1, CLTB, CAPZA2, DBN1, FLNA, GAK, MYH9, DNAJC7, IQGAP1, PDLIM7, SEC16A, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, ARX, MYO18A, CSNK1A1, CSNK1E, STOM, EPS15, HSPA1A, HSPA4, NDUFA9, CHMP1A, PIK3C2A, PRKAR2A, SEC13, SOAT1, CLTCL1, SORBS2, PKP4, USO1, NUMB, TNK1, RAB11A, HIP1R, ATP6V0D1, XPR1, SEC24C, KIAA0430, IST1, HELZ, MVP, TROAP, SEC24B, RBM14, SEC23A, VTI1B, TRAFD1, PKP3, AAK1, BTBD3, TNRC6B, EDC4, DSTYK, PTPN23, NECAP1, TNRC6A, EHD4, EGFL7, ATP6V1D, PTRH2, PLEKHA5, CPVL, BMP2K, DCP1A, ERBB2IP, CHMP1B, KIDINS220, MTUS1, DENND1A, CRTC3, CPSF7, EDC3, CCDC115, FAM83A, REPS1, STON2, FCHO2, CHMP4B, MITD1, CRTC2, FAM83B, FAM83H, SLC35B2, Actb, Myh9, Myo1c, Ppp1cb, Tpm1, Coro1c, Cul3, Spast, Tmod3, Dctn3, Uso1, Lima1, Samm50, Calml3, Myh10, Strn3, Smap1, Ptpn23, Nhsl1, Sec24c, Flnb, IKBKB, MAP3K7, MCM2, AP3D1, U2AF2, CDC73, ZNF746, ARF6, CYLD, LASP1, BRCA1, TES, MTF1, BRD1, CFTR, ZNF598, PDGFRB, FBXO7, TMPO, PTCH1, HSPA8, MAP2K1, PIK3CA, APOE, BMPR1A, JUP, UQCRB, UBE2M, RAD18, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, LARP7, RNF4, TNF, SPDL1, RIOK1, PRKCZ, HEXIM1, MEPCE, RUNX1, RNF123, PPT1, HERC2, UBE3A, AGR2, RECQL4, SMAP1, MYC, CDK9, Prkaa1, Prkab1, CDK5RAP2, GRWD1, KRT17, KIAA1429, PLEKHA2, RC3H2, ACTC1, TET2, NR2C2, UCHL3, PRDM16, MECOM, AGRN, BMH1, BMH2, ATXN3, TCF7L2, STX2, GSK3B, ABCC6, BIRC3, LMBR1L, WWP2, Hsp22, TRIM28, GJA1, TEX101, ARIH2, PLEKHA4, PINK1, YAP1, TFCP2, FANCD2, Clta, PXN, RALBP1, PTCHD3, C18orf54, ANKRD55, E, M, nsp13, nsp14, nsp4, nsp5, nsp6, ORF14, ORF3a, ORF6, ORF7a, ORF7b, ABCC2, CDCA5, ACO1, OPTN, NEK4, LRRC31, DUX4, CIT, AURKB, ECT2, KIF14, KIF20A, MAD2L2, KIF23, PRC1, PRNP, CHCHD1, HAX1, MFN2, SLC25A46, LDLR, SUMO2, PRKCB, Rnf183, AIMP2, BRD4, NINL, AFTPH, NUPR1, EPHA3, CIC, Apc2, RBM39, LGALS9, RIN3, EIF3H, DNAJA1, HSPA1L, HSPA2, HSPA6, BAG5, AR, UFL1, DDRGK1, CD3EAP, LAMTOR1, POLR2C, TRIM37, HTRA4, DRD2, ADRBK1, WDR5, PAGE4, NUDCD2, BGLT3, EDEM1, BAG2, DTX3, BTF3, IGF1R, NEDD4, FBXW7, TFRC, IFITM1, BSG, IFITM3, TMPRSS11B, CLEC4E, nsp15, ORF10, FGD5, MAP1LC3B, NBR1, CALCOCO2, SQSTM1, TOLLIP, Chrna4, SIRT6, PER2, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| CNOT6 | |
| CLTC |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to CNOT6-CLTC |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to CNOT6-CLTC |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CLTC | C4518356 | MiT family translocation renal cell carcinoma | 2 | ORPHANET |
| Tgene | CLTC | C4693389 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 56 | 2 | GENOMICS_ENGLAND;UNIPROT |
| Tgene | CLTC | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
| Tgene | CLTC | C0334121 | Inflammatory Myofibroblastic Tumor | 1 | ORPHANET |
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