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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:COL1A1-PDGFB

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: COL1A1-PDGFB
	FusionPDB ID: 18143
	FusionGDB2.0 ID: 18143
		Hgene	Tgene
	Gene symbol	COL1A1	PDGFB
	Gene ID	1277	5155
	Gene name	collagen type I alpha 1 chain	platelet derived growth factor subunit B
	Synonyms	CAFYD\|EDSARTH1\|EDSC\|OI1\|OI2\|OI3\|OI4	IBGC5\|PDGF-2\|PDGF2\|SIS\|SSV\|c-sis
	Cytomap	17q21.33	22q13.1
	Type of gene	protein-coding	protein-coding
	Description	collagen alpha-1(I) chainalpha-1 type I collagenalpha1(I) procollagencollagen alpha 1 chain type Icollagen alpha-1(I) chain preproproteincollagen of skin, tendon and bone, alpha-1 chaincollagen, type I, alpha 1pro-alpha-1 collagen type 1type I pro	platelet-derived growth factor subunit BPDGF subunit BPDGF, B chainbecaplerminepididymis secretory sperm binding proteinplatelet-derived growth factor 2platelet-derived growth factor B chainplatelet-derived growth factor beta polypeptide (simian sa
	Modification date	20200322	20200313
	UniProtAcc	P02452	P01127
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000225964,	ENST00000331163, ENST00000381551,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	56 X 95 X 16=85120	1 X 10 X 3=30
	# samples	86	19
	** MAII score	log2(86/85120*10)=-6.62901768079909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/30*10)=2.66296501272243 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: COL1A1 [Title/Abstract] AND PDGFB [Title/Abstract] AND fusion [Title/Abstract] Uterine and vaginal sarcomas resembling fibrosarcoma: a clinicopathological and molecular analysis of 13 cases showing common NTRK-rearrangements and the description of a COL1A1-PDGFB fusion novel to uterine neoplasms (pmid: 30877273)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	COL1A1(48264844)-PDGFB(39631879), # samples:3
Anticipated loss of major functional domain due to fusion event.	COL1A1-PDGFB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. COL1A1-PDGFB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. COL1A1-PDGFB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. COL1A1-PDGFB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	COL1A1	GO:0010718	positive regulation of epithelial to mesenchymal transition	20018240
Hgene	COL1A1	GO:0030335	positive regulation of cell migration	20018240
Hgene	COL1A1	GO:0034504	protein localization to nucleus	20018240
Hgene	COL1A1	GO:0045893	positive regulation of transcription, DNA-templated	20018240
Hgene	COL1A1	GO:0090263	positive regulation of canonical Wnt signaling pathway	20018240
Tgene	PDGFB	GO:0001938	positive regulation of endothelial cell proliferation	9685360
Tgene	PDGFB	GO:0002548	monocyte chemotaxis	17991872
Tgene	PDGFB	GO:0006468	protein phosphorylation	17942966
Tgene	PDGFB	GO:0008284	positive regulation of cell proliferation	2439522\|2836953\|7073684
Tgene	PDGFB	GO:0009611	response to wounding	2538439
Tgene	PDGFB	GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	2538439
Tgene	PDGFB	GO:0010544	negative regulation of platelet activation	2538439
Tgene	PDGFB	GO:0010628	positive regulation of gene expression	23554459\|24008408
Tgene	PDGFB	GO:0010629	negative regulation of gene expression	23554459\|25089138
Tgene	PDGFB	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	10734101\|11788434\|17942966
Tgene	PDGFB	GO:0014911	positive regulation of smooth muscle cell migration	9409235
Tgene	PDGFB	GO:0018105	peptidyl-serine phosphorylation	16530387
Tgene	PDGFB	GO:0018108	peptidyl-tyrosine phosphorylation	10734101\|16530387
Tgene	PDGFB	GO:0030335	positive regulation of cell migration	11788434\|21245381
Tgene	PDGFB	GO:0031954	positive regulation of protein autophosphorylation	12070119\|16530387
Tgene	PDGFB	GO:0032091	negative regulation of protein binding	22619279
Tgene	PDGFB	GO:0032147	activation of protein kinase activity	16530387
Tgene	PDGFB	GO:0032148	activation of protein kinase B activity	16530387
Tgene	PDGFB	GO:0035655	interleukin-18-mediated signaling pathway	21321938
Tgene	PDGFB	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	19019919
Tgene	PDGFB	GO:0043406	positive regulation of MAP kinase activity	9685360\|11788434\|16530387\|17942966
Tgene	PDGFB	GO:0043536	positive regulation of blood vessel endothelial cell migration	9685360
Tgene	PDGFB	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	16530387
Tgene	PDGFB	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	16530387
Tgene	PDGFB	GO:0045840	positive regulation of mitotic nuclear division	10644978\|10734101\|17942966
Tgene	PDGFB	GO:0045892	negative regulation of transcription, DNA-templated	16530387\|25089138
Tgene	PDGFB	GO:0045893	positive regulation of transcription, DNA-templated	16530387\|17324121
Tgene	PDGFB	GO:0048008	platelet-derived growth factor receptor signaling pathway	2439522\|2536956\|2836953\|19088079\|21245381\|23554459
Tgene	PDGFB	GO:0048146	positive regulation of fibroblast proliferation	2439522\|10644978\|17324121
Tgene	PDGFB	GO:0048661	positive regulation of smooth muscle cell proliferation	21321938
Tgene	PDGFB	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	21245381
Tgene	PDGFB	GO:0050921	positive regulation of chemotaxis	9409235\|19019919
Tgene	PDGFB	GO:0060326	cell chemotaxis	16014047\|17991872\|21245381
Tgene	PDGFB	GO:0061098	positive regulation of protein tyrosine kinase activity	16530387
Tgene	PDGFB	GO:0070374	positive regulation of ERK1 and ERK2 cascade	11788434\|16530387\|17942966
Tgene	PDGFB	GO:0071363	cellular response to growth factor stimulus	21245381
Tgene	PDGFB	GO:0072126	positive regulation of glomerular mesangial cell proliferation	11788434\|16014047
Tgene	PDGFB	GO:0090280	positive regulation of calcium ion import	19019919
Tgene	PDGFB	GO:1900127	positive regulation of hyaluronan biosynthetic process	17324121
Tgene	PDGFB	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	26493107
Tgene	PDGFB	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	19088079
Tgene	PDGFB	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	12070119\|19088079\|23554459
Tgene	PDGFB	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	12070119\|19088079\|23554459
Tgene	PDGFB	GO:1905064	negative regulation of vascular smooth muscle cell differentiation	19088079
Tgene	PDGFB	GO:1905176	positive regulation of vascular smooth muscle cell dedifferentiation	19088079
Tgene	PDGFB	GO:2000379	positive regulation of reactive oxygen species metabolic process	19019919
Tgene	PDGFB	GO:2000573	positive regulation of DNA biosynthetic process	10644978\|10734101\|11788434\|12070119\|16530387\|17942966\|19019919
Tgene	PDGFB	GO:2000591	positive regulation of metanephric mesenchymal cell migration	10734101

Fusion gene breakpoints across COL1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PDGFB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	dermatofibrosarcoma	X98708	COL1A1	chr17	48270408		PDGFB	chr22	39631819
ChimerKB3	.	.	COL1A1	chr17	48265322	-	PDGFB	chr22	39631818	-
ChimerKB3	.	.	COL1A1	chr17	48267067	-	PDGFB	chr22	39631818	-
ChimerKB3	.	.	COL1A1	chr17	48267219	-	PDGFB	chr22	39631879	-
ChimerKB3	.	.	COL1A1	chr17	48267939	-	PDGFB	chr22	39631818	-
ChimerKB3	.	.	COL1A1	chr17	48268762	-	PDGFB	chr22	39631818	-
ChimerKB3	.	.	COL1A1	chr17	48269835	-	PDGFB	chr22	39631879	-
ChimerKB3	.	.	COL1A1	chr17	48270383	-	PDGFB	chr22	39631818	-
ChimerKB3	.	.	COL1A1	chr17	48270408	-	PDGFB	chr22	39631818	-
ChimerKB3	.	.	COL1A1	chr17	48271303	-	PDGFB	chr22	39631879	-
ChimerKB3	.	.	COL1A1	chr17	48271969	-	PDGFB	chr22	39631818	-
ChimerKB3	.	.	COL1A1	chr17	48275856	-	PDGFB	chr22	39631818	-
ChimerKB3	.	.	COL1A1	chr17	48277126	-	PDGFB	chr22	39631818	-
ChiTaRS5.0	N/A	X98707	COL1A1	chr17	48269835	-	PDGFB	chr22	39631882	-
ChiTaRS5.0	N/A	X98708	COL1A1	chr17	48269835	-	PDGFB	chr22	39631882	-
ChiTaRS5.0	N/A	X98709	COL1A1	chr17	48275309	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	X98710	COL1A1	chr17	48274370	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	Y08643	COL1A1	chr17	48264844	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	Y15913	COL1A1	chr17	48267361	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	Y15914	COL1A1	chr17	48264844	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	Y15915	COL1A1	chr17	48265236	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	Y15916	COL1A1	chr17	48268177	-	PDGFB	chr22	39631881	-
ChiTaRS5.0	N/A	Y15917	COL1A1	chr17	48271303	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	Y15918	COL1A1	chr17	48268743	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	Y15919	COL1A1	chr17	48267039	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	Y15920	COL1A1	chr17	48264844	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	Y15921	COL1A1	chr17	48275521	-	PDGFB	chr22	39631879	-
ChiTaRS5.0	N/A	Y16341	COL1A1	chr17	48267292	-	PDGFB	chr22	39634607	-
ChiTaRS5.0	N/A	Y16342	COL1A1	chr17	48264629	-	PDGFB	chr22	39637293	-
ChiTaRS5.0	N/A	Y16343	COL1A1	chr17	48264968	-	PDGFB	chr22	39634676	-
ChiTaRS5.0	N/A	Y16344	COL1A1	chr17	48268160	-	PDGFB	chr22	39633272	-
ChiTaRS5.0	N/A	Y16345	COL1A1	chr17	48271270	-	PDGFB	chr22	39633820	-
ChiTaRS5.0	N/A	Y16346	COL1A1	chr17	48266737	-	PDGFB	chr22	39631879	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000225964	COL1A1	chr17	48267219	-	ENST00000331163	PDGFB	chr22	39631879	-	5378	2732	119	3394	1091
ENST00000225964	COL1A1	chr17	48267219	-	ENST00000381551	PDGFB	chr22	39631879	-	3802	2732	119	3394	1091
ENST00000225964	COL1A1	chr17	48269835	-	ENST00000331163	PDGFB	chr22	39631879	-	4748	2102	119	2764	881
ENST00000225964	COL1A1	chr17	48269835	-	ENST00000381551	PDGFB	chr22	39631879	-	3172	2102	119	2764	881
ENST00000225964	COL1A1	chr17	48271303	-	ENST00000331163	PDGFB	chr22	39631879	-	4532	1886	119	2548	809
ENST00000225964	COL1A1	chr17	48271303	-	ENST00000381551	PDGFB	chr22	39631879	-	2956	1886	119	2548	809
ENST00000225964	COL1A1	chr17	48269835	-	ENST00000331163	PDGFB	chr22	39631882	-	4748	2102	119	2764	881
ENST00000225964	COL1A1	chr17	48269835	-	ENST00000381551	PDGFB	chr22	39631882	-	3172	2102	119	2764	881
ENST00000225964	COL1A1	chr17	48275309	-	ENST00000331163	PDGFB	chr22	39631879	-	3407	761	119	1423	434
ENST00000225964	COL1A1	chr17	48275309	-	ENST00000381551	PDGFB	chr22	39631879	-	1831	761	119	1423	434
ENST00000225964	COL1A1	chr17	48274370	-	ENST00000331163	PDGFB	chr22	39631879	-	3569	923	119	1585	488
ENST00000225964	COL1A1	chr17	48274370	-	ENST00000381551	PDGFB	chr22	39631879	-	1993	923	119	1585	488
ENST00000225964	COL1A1	chr17	48264844	-	ENST00000331163	PDGFB	chr22	39631879	-	6188	3542	119	4204	1361
ENST00000225964	COL1A1	chr17	48264844	-	ENST00000381551	PDGFB	chr22	39631879	-	4612	3542	119	4204	1361
ENST00000225964	COL1A1	chr17	48267361	-	ENST00000331163	PDGFB	chr22	39631879	-	5324	2678	119	3340	1073
ENST00000225964	COL1A1	chr17	48267361	-	ENST00000381551	PDGFB	chr22	39631879	-	3748	2678	119	3340	1073
ENST00000225964	COL1A1	chr17	48265236	-	ENST00000331163	PDGFB	chr22	39631879	-	6134	3488	119	4150	1343
ENST00000225964	COL1A1	chr17	48265236	-	ENST00000381551	PDGFB	chr22	39631879	-	4558	3488	119	4150	1343
ENST00000225964	COL1A1	chr17	48268177	-	ENST00000331163	PDGFB	chr22	39631881	-	5108	2462	119	3124	1001
ENST00000225964	COL1A1	chr17	48268177	-	ENST00000381551	PDGFB	chr22	39631881	-	3532	2462	119	3124	1001
ENST00000225964	COL1A1	chr17	48271303	-	ENST00000331163	PDGFB	chr22	39631879	-	4532	1886	119	2548	809
ENST00000225964	COL1A1	chr17	48271303	-	ENST00000381551	PDGFB	chr22	39631879	-	2956	1886	119	2548	809
ENST00000225964	COL1A1	chr17	48268743	-	ENST00000331163	PDGFB	chr22	39631879	-	5000	2354	119	3016	965
ENST00000225964	COL1A1	chr17	48268743	-	ENST00000381551	PDGFB	chr22	39631879	-	3424	2354	119	3016	965
ENST00000225964	COL1A1	chr17	48267039	-	ENST00000331163	PDGFB	chr22	39631879	-	5432	2786	119	3448	1109
ENST00000225964	COL1A1	chr17	48267039	-	ENST00000381551	PDGFB	chr22	39631879	-	3856	2786	119	3448	1109
ENST00000225964	COL1A1	chr17	48275521	-	ENST00000331163	PDGFB	chr22	39631879	-	3353	707	119	1369	416
ENST00000225964	COL1A1	chr17	48275521	-	ENST00000381551	PDGFB	chr22	39631879	-	1777	707	119	1369	416
ENST00000225964	COL1A1	chr17	48266737	-	ENST00000331163	PDGFB	chr22	39631879	-	5594	2948	119	3610	1163
ENST00000225964	COL1A1	chr17	48266737	-	ENST00000381551	PDGFB	chr22	39631879	-	4018	2948	119	3610	1163

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000225964	ENST00000331163	COL1A1	chr17	48269835	-	PDGFB	chr22	39631882	-	0.002141219	0.9978588
ENST00000225964	ENST00000381551	COL1A1	chr17	48269835	-	PDGFB	chr22	39631882	-	0.003351837	0.99664813
ENST00000225964	ENST00000331163	COL1A1	chr17	48275309	-	PDGFB	chr22	39631879	-	0.009959897	0.9900401
ENST00000225964	ENST00000381551	COL1A1	chr17	48275309	-	PDGFB	chr22	39631879	-	0.025250075	0.9747499
ENST00000225964	ENST00000331163	COL1A1	chr17	48274370	-	PDGFB	chr22	39631879	-	0.01067736	0.9893226
ENST00000225964	ENST00000381551	COL1A1	chr17	48274370	-	PDGFB	chr22	39631879	-	0.02234934	0.97765064
ENST00000225964	ENST00000331163	COL1A1	chr17	48264844	-	PDGFB	chr22	39631879	-	0.004073801	0.99592626
ENST00000225964	ENST00000381551	COL1A1	chr17	48264844	-	PDGFB	chr22	39631879	-	0.00638637	0.99361366
ENST00000225964	ENST00000331163	COL1A1	chr17	48267361	-	PDGFB	chr22	39631879	-	0.00265705	0.997343
ENST00000225964	ENST00000381551	COL1A1	chr17	48267361	-	PDGFB	chr22	39631879	-	0.004178506	0.9958215
ENST00000225964	ENST00000331163	COL1A1	chr17	48265236	-	PDGFB	chr22	39631879	-	0.004898867	0.99510115
ENST00000225964	ENST00000381551	COL1A1	chr17	48265236	-	PDGFB	chr22	39631879	-	0.00787097	0.9921291
ENST00000225964	ENST00000331163	COL1A1	chr17	48268177	-	PDGFB	chr22	39631881	-	0.001056772	0.99894327
ENST00000225964	ENST00000381551	COL1A1	chr17	48268177	-	PDGFB	chr22	39631881	-	0.001554361	0.9984457
ENST00000225964	ENST00000331163	COL1A1	chr17	48271303	-	PDGFB	chr22	39631879	-	0.003387332	0.9966126
ENST00000225964	ENST00000381551	COL1A1	chr17	48271303	-	PDGFB	chr22	39631879	-	0.005438311	0.99456173
ENST00000225964	ENST00000331163	COL1A1	chr17	48268743	-	PDGFB	chr22	39631879	-	0.001135006	0.998865
ENST00000225964	ENST00000381551	COL1A1	chr17	48268743	-	PDGFB	chr22	39631879	-	0.001693391	0.99830663
ENST00000225964	ENST00000331163	COL1A1	chr17	48267039	-	PDGFB	chr22	39631879	-	0.002389302	0.9976107
ENST00000225964	ENST00000381551	COL1A1	chr17	48267039	-	PDGFB	chr22	39631879	-	0.003670894	0.9963291
ENST00000225964	ENST00000331163	COL1A1	chr17	48275521	-	PDGFB	chr22	39631879	-	0.007655529	0.99234444
ENST00000225964	ENST00000381551	COL1A1	chr17	48275521	-	PDGFB	chr22	39631879	-	0.020852799	0.97914726
ENST00000225964	ENST00000331163	COL1A1	chr17	48266737	-	PDGFB	chr22	39631879	-	0.004539065	0.9954609
ENST00000225964	ENST00000381551	COL1A1	chr17	48266737	-	PDGFB	chr22	39631879	-	0.007530405	0.9924696

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>18143_18143_1_COL1A1-PDGFB_COL1A1_chr17_48264844_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=1361AA_BP=369
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGP
AGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGA
SGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPTGPVGP
VGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGDPIPEELYEMLSDHSIRSFDDLQRLLHG
DPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQ
CRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTH

--------------------------------------------------------------

>18143_18143_2_COL1A1-PDGFB_COL1A1_chr17_48264844_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=1361AA_BP=369
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGP
AGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGA
SGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPTGPVGP
VGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGDPIPEELYEMLSDHSIRSFDDLQRLLHG
DPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQ
CRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTH

--------------------------------------------------------------

>18143_18143_3_COL1A1-PDGFB_COL1A1_chr17_48265236_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=1343AA_BP=369
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGP
AGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGA
SGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPTGPVGP
VGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSH
SGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEI

--------------------------------------------------------------

>18143_18143_4_COL1A1-PDGFB_COL1A1_chr17_48265236_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=1343AA_BP=369
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGP
AGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGA
SGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPTGPVGP
VGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSH
SGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEI

--------------------------------------------------------------

>18143_18143_5_COL1A1-PDGFB_COL1A1_chr17_48266737_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=1163AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGP
AGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSH
SGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEI

--------------------------------------------------------------

>18143_18143_6_COL1A1-PDGFB_COL1A1_chr17_48266737_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=1163AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGP
AGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSH
SGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEI

--------------------------------------------------------------

>18143_18143_7_COL1A1-PDGFB_COL1A1_chr17_48267039_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=1109AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGDPIPEELYEM
LSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWP
PCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRT

--------------------------------------------------------------

>18143_18143_8_COL1A1-PDGFB_COL1A1_chr17_48267039_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=1109AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGDPIPEELYEM
LSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWP
PCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRT

--------------------------------------------------------------

>18143_18143_9_COL1A1-PDGFB_COL1A1_chr17_48267219_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=1091AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGDPIPEELYEMLSDHSIRSFDDLQRLLHG
DPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQ
CRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTH

--------------------------------------------------------------

>18143_18143_10_COL1A1-PDGFB_COL1A1_chr17_48267219_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=1091AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGDPIPEELYEMLSDHSIRSFDDLQRLLHG
DPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQ
CRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTH

--------------------------------------------------------------

>18143_18143_11_COL1A1-PDGFB_COL1A1_chr17_48267361_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=1073AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSH
SGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEI

--------------------------------------------------------------

>18143_18143_12_COL1A1-PDGFB_COL1A1_chr17_48267361_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=1073AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGP
AGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSH
SGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEI

--------------------------------------------------------------

>18143_18143_13_COL1A1-PDGFB_COL1A1_chr17_48268177_ENST00000225964_PDGFB_chr22_39631881_ENST00000331163_length(amino acids)=1001AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGDPIPEELYEMLSDHSIRSFDDLQRLLHG
DPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQ
CRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTH

--------------------------------------------------------------

>18143_18143_14_COL1A1-PDGFB_COL1A1_chr17_48268177_ENST00000225964_PDGFB_chr22_39631881_ENST00000381551_length(amino acids)=1001AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGDPIPEELYEMLSDHSIRSFDDLQRLLHG
DPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQ
CRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTH

--------------------------------------------------------------

>18143_18143_15_COL1A1-PDGFB_COL1A1_chr17_48268743_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=965AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSL
TIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHL

--------------------------------------------------------------

>18143_18143_16_COL1A1-PDGFB_COL1A1_chr17_48268743_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=965AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSL
TIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHL

--------------------------------------------------------------

>18143_18143_17_COL1A1-PDGFB_COL1A1_chr17_48269835_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=881AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGR
RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATV

--------------------------------------------------------------

>18143_18143_18_COL1A1-PDGFB_COL1A1_chr17_48269835_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=881AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGR
RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATV

--------------------------------------------------------------

>18143_18143_19_COL1A1-PDGFB_COL1A1_chr17_48269835_ENST00000225964_PDGFB_chr22_39631882_ENST00000331163_length(amino acids)=881AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGR
RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATV

--------------------------------------------------------------

>18143_18143_20_COL1A1-PDGFB_COL1A1_chr17_48269835_ENST00000225964_PDGFB_chr22_39631882_ENST00000381551_length(amino acids)=881AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGE
RGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGR
RSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATV

--------------------------------------------------------------

>18143_18143_21_COL1A1-PDGFB_COL1A1_chr17_48271303_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=809AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDL
NMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQ

--------------------------------------------------------------

>18143_18143_22_COL1A1-PDGFB_COL1A1_chr17_48271303_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=809AA_BP=275
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGF
SGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE
PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDL
NMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQ

--------------------------------------------------------------

>18143_18143_23_COL1A1-PDGFB_COL1A1_chr17_48274370_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=488AA_BP=140
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGD
PIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDR
TNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKT

--------------------------------------------------------------

>18143_18143_24_COL1A1-PDGFB_COL1A1_chr17_48274370_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=488AA_BP=140
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGD
PIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDR
TNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKT

--------------------------------------------------------------

>18143_18143_25_COL1A1-PDGFB_COL1A1_chr17_48275309_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=434AA_BP=140
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLA
RGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKK

--------------------------------------------------------------

>18143_18143_26_COL1A1-PDGFB_COL1A1_chr17_48275309_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=434AA_BP=140
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLA
RGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKK

--------------------------------------------------------------

>18143_18143_27_COL1A1-PDGFB_COL1A1_chr17_48275521_ENST00000225964_PDGFB_chr22_39631879_ENST00000331163_length(amino acids)=416AA_BP=184
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIA
ECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAA

--------------------------------------------------------------

>18143_18143_28_COL1A1-PDGFB_COL1A1_chr17_48275521_ENST00000225964_PDGFB_chr22_39631879_ENST00000381551_length(amino acids)=416AA_BP=184
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGE
CCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIA
ECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAA

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:48264844/chr22:39631879)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
COL1A1 P02452	PDGFB P01127
FUNCTION: Type I collagen is a member of group I collagen (fibrillar forming collagen).	FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250\|UniProtKB:P31240, ECO:0000269\|PubMed:26599395}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

COL1A1

chr17:48264844

chr22:39631879

ENST00000225964

38_96

1141.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48265236

chr22:39631879

ENST00000225964

38_96

1123.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48266737

chr22:39631879

ENST00000225964

38_96

943.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48267039

chr22:39631879

ENST00000225964

38_96

889.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48267361

chr22:39631879

ENST00000225964

38_96

853.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48268177

chr22:39631881

ENST00000225964

38_96

781.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48268743

chr22:39631879

ENST00000225964

38_96

745.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48269835

chr22:39631882

ENST00000225964

38_96

661.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48271303

chr22:39631879

ENST00000225964

38_96

589.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48274370

chr22:39631879

ENST00000225964

38_96

268.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48275309

chr22:39631879

ENST00000225964

38_96

214.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48275521

chr22:39631879

ENST00000225964

38_96

196.0

1465.0

Domain

VWFC

Hgene

COL1A1

chr17:48264844

chr22:39631879

ENST00000225964

1093_1095

1141.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48264844

chr22:39631879

ENST00000225964

745_747

1141.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48265236

chr22:39631879

ENST00000225964

1093_1095

1123.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48265236

chr22:39631879

ENST00000225964

745_747

1123.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48266737

chr22:39631879

ENST00000225964

745_747

943.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48267039

chr22:39631879

ENST00000225964

745_747

889.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48267361

chr22:39631879

ENST00000225964

745_747

853.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48268177

chr22:39631881

ENST00000225964

745_747

781.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48268743

chr22:39631879

ENST00000225964

745_747

745.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48264844

chr22:39631879

ENST00000225964

162_178

1141.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48265236

chr22:39631879

ENST00000225964

162_178

1123.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48266737

chr22:39631879

ENST00000225964

162_178

943.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48267039

chr22:39631879

ENST00000225964

162_178

889.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48267361

chr22:39631879

ENST00000225964

162_178

853.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48268177

chr22:39631881

ENST00000225964

162_178

781.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48268743

chr22:39631879

ENST00000225964

162_178

745.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48269835

chr22:39631882

ENST00000225964

162_178

661.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48271303

chr22:39631879

ENST00000225964

162_178

589.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48274370

chr22:39631879

ENST00000225964

162_178

268.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48275309

chr22:39631879

ENST00000225964

162_178

214.0

1465.0

Region

Note=Nonhelical region (N-terminal)

Hgene

COL1A1

chr17:48275521

chr22:39631879

ENST00000225964

162_178

196.0

1465.0

Region

Note=Nonhelical region (N-terminal)

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

COL1A1

chr17:48264844

chr22:39631879

ENST00000225964

1229_1464

1141.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48265236

chr22:39631879

ENST00000225964

1229_1464

1123.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48266737

chr22:39631879

ENST00000225964

1229_1464

943.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48267039

chr22:39631879

ENST00000225964

1229_1464

889.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48267361

chr22:39631879

ENST00000225964

1229_1464

853.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48268177

chr22:39631881

ENST00000225964

1229_1464

781.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48268743

chr22:39631879

ENST00000225964

1229_1464

745.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48269835

chr22:39631882

ENST00000225964

1229_1464

661.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48271303

chr22:39631879

ENST00000225964

1229_1464

589.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48274370

chr22:39631879

ENST00000225964

1229_1464

268.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48275309

chr22:39631879

ENST00000225964

1229_1464

214.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48275521

chr22:39631879

ENST00000225964

1229_1464

196.0

1465.0

Domain

Fibrillar collagen NC1

Hgene

COL1A1

chr17:48266737

chr22:39631879

ENST00000225964

1093_1095

943.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48267039

chr22:39631879

ENST00000225964

1093_1095

889.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48267361

chr22:39631879

ENST00000225964

1093_1095

853.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48268177

chr22:39631881

ENST00000225964

1093_1095

781.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48268743

chr22:39631879

ENST00000225964

1093_1095

745.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48269835

chr22:39631882

ENST00000225964

1093_1095

661.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48269835

chr22:39631882

ENST00000225964

745_747

661.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48271303

chr22:39631879

ENST00000225964

1093_1095

589.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48271303

chr22:39631879

ENST00000225964

745_747

589.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48274370

chr22:39631879

ENST00000225964

1093_1095

268.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48274370

chr22:39631879

ENST00000225964

745_747

268.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48275309

chr22:39631879

ENST00000225964

1093_1095

214.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48275309

chr22:39631879

ENST00000225964

745_747

214.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48275521

chr22:39631879

ENST00000225964

1093_1095

196.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48275521

chr22:39631879

ENST00000225964

745_747

196.0

1465.0

Motif

Cell attachment site

Hgene

COL1A1

chr17:48264844

chr22:39631879

ENST00000225964

1193_1218

1141.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48264844

chr22:39631879

ENST00000225964

179_1192

1141.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48265236

chr22:39631879

ENST00000225964

1193_1218

1123.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48265236

chr22:39631879

ENST00000225964

179_1192

1123.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48266737

chr22:39631879

ENST00000225964

1193_1218

943.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48266737

chr22:39631879

ENST00000225964

179_1192

943.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48267039

chr22:39631879

ENST00000225964

1193_1218

889.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48267039

chr22:39631879

ENST00000225964

179_1192

889.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48267361

chr22:39631879

ENST00000225964

1193_1218

853.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48267361

chr22:39631879

ENST00000225964

179_1192

853.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48268177

chr22:39631881

ENST00000225964

1193_1218

781.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48268177

chr22:39631881

ENST00000225964

179_1192

781.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48268743

chr22:39631879

ENST00000225964

1193_1218

745.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48268743

chr22:39631879

ENST00000225964

179_1192

745.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48269835

chr22:39631882

ENST00000225964

1193_1218

661.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48269835

chr22:39631882

ENST00000225964

179_1192

661.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48271303

chr22:39631879

ENST00000225964

1193_1218

589.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48271303

chr22:39631879

ENST00000225964

179_1192

589.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48274370

chr22:39631879

ENST00000225964

1193_1218

268.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48274370

chr22:39631879

ENST00000225964

179_1192

268.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48275309

chr22:39631879

ENST00000225964

1193_1218

214.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48275309

chr22:39631879

ENST00000225964

179_1192

214.0

1465.0

Region

Note=Triple-helical region

Hgene

COL1A1

chr17:48275521

chr22:39631879

ENST00000225964

1193_1218

196.0

1465.0

Region

Note=Nonhelical region (C-terminal)

Hgene

COL1A1

chr17:48275521

chr22:39631879

ENST00000225964

179_1192

196.0

1465.0

Region

Note=Triple-helical region

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (655) >>>655.pdbFusion protein BP residue: 275 CIF file (655) >>>655.cif	COL1A1	chr17	48271303	-	PDGFB	chr22	39631879	-	MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDR DVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSE SPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPP GPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQG FQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQ GARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQ MGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVG AKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGAN GAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADG VAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPD GKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGDPIPEELYEM LSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRS LGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSG CCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCET VAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDK	809
3D view using mol* of 655 (AA BP:275)


PDB file (696) >>>696.pdbFusion protein BP residue: 275 CIF file (696) >>>696.cif	COL1A1	chr17	48269835	-	PDGFB	chr22	39631879	-	MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDR DVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSE SPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPP GPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQG FQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQ GARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQ MGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVG AKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGAN GAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADG VAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPD GKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGV PGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAG PPGEAGKPGEQGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAEL DLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRL IDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVR KKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTI	881
3D view using mol* of 696 (AA BP:275)


PDB file (797) >>>797.pdbFusion protein BP residue: 275 CIF file (797) >>>797.cif	COL1A1	chr17	48267219	-	PDGFB	chr22	39631879	-	MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDR DVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSE SPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPP GPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQG FQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQ GARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQ MGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVG AKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGAN GAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGE PGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADG VAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPD GKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGV PGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAG PPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGAN GAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGP KGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPG DRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPP GPIGNVGAPGAKGARGSAGPPGDPIPEELYEMLSDHSIRSFDDLQRLLHG DPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTR TEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRP VQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQR	1091
3D view using mol* of 797 (AA BP:275)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

COL1A1_pLDDT.png

PDGFB_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

COL1A1_PDGFB_655_pLDDT.png (AA BP:275)

COL1A1_PDGFB_655_pLDDT_and_active_sites.png (AA BP:275)

COL1A1_PDGFB_655_violinplot.png (AA BP:275)

COL1A1_PDGFB_696_pLDDT.png (AA BP:275)

COL1A1_PDGFB_696_pLDDT_and_active_sites.png (AA BP:275)

COL1A1_PDGFB_696_violinplot.png (AA BP:275)

COL1A1_PDGFB_797_pLDDT.png (AA BP:275)

COL1A1_PDGFB_797_pLDDT_and_active_sites.png (AA BP:275)

COL1A1_PDGFB_797_violinplot.png (AA BP:275)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

COL1A1_PDGFB_655.png

COL1A1_PDGFB_696.png

COL1A1_PDGFB_797.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
655	0.851	70	0.771	157.437	0.628	0.654	0.868	0.124	1.25	0.099	1.138	Chain A: 602,603,604,605,606,607,662,664,665,701,7 02,703,707,747,748,750
696	0.99	105	0.96	260.337	0.607	0.683	0.846	0.207	1.193	0.174	1.046	Chain A: 667,670,671,674,675,676,677,678,679,733,7 34,736,737,773,774,775,776,778,779,819,820,821,822 ,823,824,825
797	0.993	100	0.981	285.033	0.62	0.688	0.887	0.371	1.14	0.325	1.144	Chain A: 105,877,880,881,883,884,885,886,887,888,8 89,943,944,946,947,948,983,984,985,986,988,989,102 9,1030,1031,1032,1033,1034,1035

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
655	ZINC000003830944	DB01362	Iohexol	-7.9223	-7.9223
655	ZINC000003830945	DB01362	Iohexol	-6.85958	-6.85958
655	ZINC000000039089	DB00668	Epinephrine	-6.72347	-6.73487
655	ZINC000004228257	DB00360	Sapropterin	-6.63356	-6.65326
655	ZINC000003861768	DB00928	Azacitidine	-6.1405	-6.5597
655	ZINC000001547851	DB11868	Etiracetam	-6.5378	-6.5378
655	ZINC000000005878	DB02701	Nicotinamide	-6.47586	-6.47586
655	ZINC000001995484	DB01610	Valganciclovir	-6.21937	-6.43267
655	ZINC000000896731	DB00744	Zileuton	-6.38877	-6.40737
655	ZINC000018043251	DB00277	Theophylline	-6.36682	-6.39932
655	ZINC000000004724	DB00776	Oxcarbazepine	-6.38004	-6.38004
655	ZINC000013597823	DB00900	Didanosine	-6.24894	-6.33154
655	ZINC000000000850	DB00744	Zileuton	-6.31251	-6.33111
655	ZINC000000002005	DB00339	Pyrazinamide	-6.32092	-6.32092
655	ZINC000003831139	DB00745	Modafinil	-6.31473	-6.31473
655	ZINC000016929327	DB01262	Decitabine	-5.85146	-6.27086
655	ZINC000001530803	DB00949	Felbamate	-6.24275	-6.24275
655	ZINC000000156792	DB01193	Acebutolol	-6.23024	-6.23194
655	ZINC000003806262	DB00552	Pentostatin	-6.15061	-6.18021
655	ZINC000001543916	DB01610	Valganciclovir	-5.95062	-6.16392

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000000039089	DB00668	Epinephrine	Small molecule	CNC[C@H](O)C1=CC(O)=C(O)C=C1	Approved\|Vet_approved
ZINC000003861768	DB00928	Azacitidine	Small molecule	NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	Approved\|Investigational
ZINC000000005878	DB02701	Nicotinamide	Small molecule	NC(=O)C1=CC=CN=C1	Approved\|Investigational
ZINC000000896731	DB00744	Zileuton	Small molecule	CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1	Approved\|Investigational\|Withdrawn
ZINC000018043251	DB00277	Theophylline	Small molecule	CN1C2=C(NC=N2)C(=O)N(C)C1=O	Approved
ZINC000000004724	DB00776	Oxcarbazepine	Small molecule	NC(=O)N1C2=CC=CC=C2CC(=O)C2=C1C=CC=C2	Approved
ZINC000013597823	DB00900	Didanosine	Small molecule	OC[C@@H]1CC[C@@H](O1)N1C=NC2=C1NC=NC2=O	Approved
ZINC000000002005	DB00339	Pyrazinamide	Small molecule	NC(=O)C1=NC=CN=C1	Approved\|Investigational
ZINC000003831139	DB00745	Modafinil	Small molecule	NC(=O)CS(=O)C(C1=CC=CC=C1)C1=CC=CC=C1	Approved\|Investigational
ZINC000016929327	DB01262	Decitabine	Small molecule	NC1=NC(=O)N(C=N1)[C@H]1C[C@H](O)[C@@H](CO)O1	Approved\|Investigational
ZINC000001530803	DB00949	Felbamate	Small molecule	NC(=O)OCC(COC(N)=O)C1=CC=CC=C1	Approved
ZINC000003806262	DB00552	Pentostatin	Small molecule	OC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2=C1N=CNC[C@H]2O	Approved\|Investigational
ZINC000001543916	DB01610	Valganciclovir	Small molecule	CC(C)[C@H](N)C(=O)OCC(CO)OCN1C=NC2=C1NC(N)=NC2=O	Approved\|Investigational

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000003830944	821.143	3.746	800.499	332.755	343.824	9.483	114.436	1490.981	8	18.2	9.701	1	0	3	1
ZINC000003830945	821.143	6.563	790.789	299.687	371.476	8.079	111.546	1486.416	8	18.2	9.45	1	0	3	1
ZINC000000039089	183.207	0.987	415.609	139.04	163.719	112.85	0	664.117	4	4.7	9.006	2	56.402	0	0
ZINC000000039089	183.207	1.06	412.1	135.076	165.027	111.996	0	658.643	4	4.7	9.004	2	56.186	0	0
ZINC000004228257	241.249	7.058	447.535	159.775	268.536	19.223	0	742.971	7	8.9	7.522	2	29.427	1	0
ZINC000004228257	241.249	10.846	445.922	159.81	267.196	18.915	0	744.462	7	8.9	7.661	2	29.813	1	0
ZINC000003861768	244.207	7.104	434.888	110.158	287.613	37.117	0	717.082	5	10.8	9.386	2	36.489	0	1
ZINC000003861768	244.207	8.996	434.766	110.132	287.569	37.065	0	716.913	5	10.8	9.305	2	36.496	0	1
ZINC000003861768	244.207	6.643	431.183	93.993	304.895	32.294	0	718.65	5	11.8	9.707	2	31.372	0	1
ZINC000001547851	170.211	3.554	386.861	254.133	132.728	0	0	627.872	2	5.5	9.606	2	59.075	0	0
ZINC000000005878	122.126	6.802	305.217	0	139.794	165.422	0	456.272	2	4	10.075	2	72.907	0	0
ZINC000001995484	354.365	9.631	568.054	246.752	278.137	43.166	0	1064.885	6	11.9	8.542	1	5.895	2	1
ZINC000001995484	354.365	11.53	614.893	262.115	314.103	38.675	0	1087.654	6	11.9	8.454	1	0	2	1
ZINC000000896731	236.288	3.773	444.598	84.301	131.134	195.105	34.058	746.481	3	3.7	8.644	3	78.18	0	0
ZINC000000896731	236.288	5.297	450.816	85.528	135.414	201.881	27.993	746.812	3	3.7	8.57	3	76.556	0	0
ZINC000018043251	180.166	5.101	367.499	156.069	142.576	68.855	0	583.234	1	5	9.081	2	74.149	0	0
ZINC000018043251	180.166	3.85	368.83	158.437	132.211	78.182	0	584.316	1	5	9.211	3	76.332	0	0
ZINC000000004724	252.272	4.767	462.659	34.19	134.85	293.619	0	794.353	2	4	9.343	3	77.848	0	0
ZINC000013597823	236.23	9.641	435.158	159.57	170.601	104.987	0	727.856	2	8.4	8.967	3	66.618	0	0
ZINC000013597823	236.23	8.965	441.067	165.063	181.173	94.831	0	736.527	2	8.4	8.782	3	64.561	0	0
ZINC000000000850	236.288	5.297	457.642	85.783	137.035	198.523	36.3	755.015	3	3.7	8.91	3	75.351	0	0
ZINC000000000850	236.288	5.297	450.837	85.532	135.419	201.893	27.994	746.839	3	3.7	8.57	3	76.555	0	0
ZINC000000002005	123.114	5.397	301.507	0	160.969	140.538	0	446.636	2	5	9.967	2	67.429	0	0
ZINC000003831139	273.349	6.076	507.007	36.263	124.732	330.045	15.967	873.138	1	5.5	9.061	2	55.123	0	1
ZINC000016929327	228.207	6.404	419.717	123.692	262.101	33.925	0	692.115	4	9.1	9.544	2	43.043	0	0
ZINC000016929327	228.207	7.988	419.927	123.411	262.443	34.072	0	692.279	4	9.1	9.468	2	42.982	0	0
ZINC000016929327	228.207	5.889	424.346	123.621	268.443	32.282	0	698.619	4	10.1	9.722	2	41.319	0	0
ZINC000001530803	238.243	5.857	509.127	63.732	267.198	178.197	0	822.851	4	5	9.776	2	54.633	0	0
ZINC000000156792	336.43	6.59	723.464	502.446	130.413	90.604	0	1234.445	3	8.45	8.879	3	75.564	0	0
ZINC000003806262	268.272	1.452	502.362	225.071	237.129	40.162	0	835.803	4	9.8	8.337	2	51.848	0	0
ZINC000003806262	268.272	1.378	469.669	223.737	214.902	31.03	0	809.617	4	9.8	8.34	2	56.164	0	0
ZINC000001543916	354.365	10.833	656.576	282.226	307.955	66.396	0	1129.771	6	11.9	8.359	1	0.466	2	1
ZINC000001543916	354.365	8.84	635.736	259.299	319.155	57.282	0	1114.93	6	11.9	8.318	1	0	2	1

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000003830944	CC(=O)N(C[C@@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@H](O)CO)c1I	0.042332243	0.211666342
ZINC000003830945	CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@@H](O)CO)c1I	0.042332243	0.211666342
ZINC000000039089	CNC[C@H](O)c1ccc(O)c(O)c1	0.191748276	0.25662051
ZINC000004228257	C[C@H](O)[C@@H](O)[C@@H]1CNc2nc(N)[nH]c(=O)c2N1	0.031410569	0.318425003
ZINC000003861768	Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1	0.068057161	0.388956815
ZINC000001547851	CC[C@@H](C(N)=O)N1CCCC1=O	0.157335861	0.410047131
ZINC000000005878	NC(=O)c1cccnc1	0.501167101	0.494207739
ZINC000001995484	CC(C)[C@H](N)C(=O)OC[C@H](CO)OCn1cnc2c(=O)[nH]c(N)nc21	0.066223161	0.39718523
ZINC000000896731	C[C@H](c1cc2ccccc2s1)N(O)C(N)=O	0.136335882	0.223511692
ZINC000018043251	Cn1c(=O)c2[nH]cnc2n(C)c1=O	0.213615465	0.321876059
ZINC000000004724	NC(=O)N1c2ccccc2CC(=O)c2ccccc21	0.314026736	0.439183728
ZINC000013597823	O=c1[nH]cnc2c1ncn2[C@H]1CC[C@@H](CO)O1	0.073459482	0.448698447
ZINC000000000850	C[C@@H](c1cc2ccccc2s1)N(O)C(N)=O	0.136335882	0.223511692
ZINC000000002005	N=C(O)c1cnccn1	0.163558036	0.672419783
ZINC000003831139	NC(=O)C[S@](=O)C(c1ccccc1)c1ccccc1	0.191569261	0.489801219
ZINC000016929327	Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1	0.071131781	0.402029462
ZINC000001530803	NC(=O)OCC(COC(N)=O)c1ccccc1	0.263072531	0.486745085
ZINC000000156792	CCCC(=O)Nc1ccc(OC[C@@H](O)CNC(C)C)c(C(C)=O)c1	0.208401203	0.251834481
ZINC000003806262	OC[C@H]1O[C@@H](n2cnc3c2N=CNC[C@H]3O)C[C@@H]1O	0.024236647	0.504660299
ZINC000001543916	CC(C)[C@H](N)C(=O)OC[C@@H](CO)OCn1cnc2c(=O)[nH]c(N)nc21	0.066223161	0.39718523

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

COL1A1

IGFBP3, TXN, ITGA2, ITGB1, NID1, Nid1, NID2, SPARC, PRELP, PKD1, VWF, THBS1, MMP2, COL7A1, MATN2, MAG, ELAVL1, ATP13A2, C12orf57, RNH1, BARD1, BRCA1, UBC, CAPN1, COL1A1, COL1A2, PDGFA, PDGFB, GIPC2, UBXN11, DNM3, CD200R1, TMTC4, ERAL1, CAMKMT, TMEM180, OTUB1, EGFR, COLGALT2, P4HA2, PLOD1, LIN9, TIMM44, RASGEF1B, TLE3, YAF2, LPAR1, CYLD, MCPH1, HEXIM1, PPP1CC, KEAP1, PINK1, CDC42, NMRAL1, PAX3, NTPCR, FOXO1, IGLC1, DDX58, YIPF1, LAIR2, LAT, KIAA1191, SLC25A40, CTNND1, FOXD3, CHMP3, ZNF645, CD247, RANBP6, TRIM41, TNFRSF10D, KIR3DS1, SMDT1, PPIA, PEG10, TMEM44, RNF144A, VCP, TESPA1, ABHD14A, TADA1, ST3GAL3, KLF15, BGN, TGM2, COL18A1, NLRP7,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
COL1A1
PDGFB

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to COL1A1-PDGFB

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to COL1A1-PDGFB

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
COL1A1	PDGFB	Dermatofibrosarcoma Protuberans Invasive Breast Carcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	COL1A1	C0268358	Osteogenesis imperfecta, dominant perinatal lethal	38	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	COL1A1	C0268362	Osteogenesis imperfecta type III (disorder)	17	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	COL1A1	C0023931	Lobstein Disease	15	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	COL1A1	C0268363	Osteogenesis imperfecta type IV (disorder)	12	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	COL1A1	C0023890	Liver Cirrhosis	4	CTD_human
Hgene	COL1A1	C0239946	Fibrosis, Liver	4	CTD_human
Hgene	COL1A1	C4551623	EHLERS-DANLOS SYNDROME, ARTHROCHALASIA TYPE, 1	4	CTD_human;GENOMICS_ENGLAND
Hgene	COL1A1	C4552122	EHLERS-DANLOS SYNDROME, CLASSIC TYPE, 1	4	GENOMICS_ENGLAND;UNIPROT
Hgene	COL1A1	C0020497	Cortical Congenital Hyperostosis	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	COL1A1	C0023893	Liver Cirrhosis, Experimental	3	CTD_human
Hgene	COL1A1	C0268345	EHLERS-DANLOS SYNDROME, ARTHROCHALASIA TYPE	2	ORPHANET
Hgene	COL1A1	C0000786	Spontaneous abortion	1	CTD_human
Hgene	COL1A1	C0000822	Abortion, Tubal	1	CTD_human
Hgene	COL1A1	C0002949	Aneurysm, Dissecting	1	CTD_human
Hgene	COL1A1	C0003504	Aortic Valve Insufficiency	1	CTD_human
Hgene	COL1A1	C0004364	Autoimmune Diseases	1	CTD_human
Hgene	COL1A1	C0005398	Cholestasis, Extrahepatic	1	CTD_human
Hgene	COL1A1	C0005779	Blood Coagulation Disorders	1	GENOMICS_ENGLAND
Hgene	COL1A1	C0006663	Calcinosis	1	CTD_human
Hgene	COL1A1	C0008311	Cholangitis	1	CTD_human
Hgene	COL1A1	C0013720	Ehlers-Danlos Syndrome	1	GENOMICS_ENGLAND
Hgene	COL1A1	C0016059	Fibrosis	1	CTD_human
Hgene	COL1A1	C0018824	Heart valve disease	1	CTD_human
Hgene	COL1A1	C0020538	Hypertensive disease	1	CTD_human
Hgene	COL1A1	C0022548	Keloid	1	CTD_human
Hgene	COL1A1	C0027719	Nephrosclerosis	1	CTD_human
Hgene	COL1A1	C0027726	Nephrotic Syndrome	1	CTD_human
Hgene	COL1A1	C0029172	Oral Submucous Fibrosis	1	CTD_human
Hgene	COL1A1	C0029434	Osteogenesis Imperfecta	1	CTD_human;GENOMICS_ENGLAND
Hgene	COL1A1	C0149721	Left Ventricular Hypertrophy	1	CTD_human
Hgene	COL1A1	C0220679	Ehlers-Danlos Syndrome, Autosomal Dominant, Type Unspecified	1	ORPHANET
Hgene	COL1A1	C0263628	Tumoral calcinosis	1	CTD_human
Hgene	COL1A1	C0340643	Dissection of aorta	1	CTD_human
Hgene	COL1A1	C0521174	Microcalcification	1	CTD_human
Hgene	COL1A1	C1458140	Bleeding tendency	1	GENOMICS_ENGLAND
Hgene	COL1A1	C1619692	Nephrogenic Fibrosing Dermopathy	1	CTD_human
Hgene	COL1A1	C1623038	Cirrhosis	1	CTD_human
Hgene	COL1A1	C1846545	Autoimmune Lymphoproliferative Syndrome Type 2B	1	GENOMICS_ENGLAND
Hgene	COL1A1	C3830362	Early Pregnancy Loss	1	CTD_human
Hgene	COL1A1	C4277533	Dissection, Blood Vessel	1	CTD_human
Hgene	COL1A1	C4552766	Miscarriage	1	CTD_human
Tgene	PDGFB	C3809645	BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 5	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	PDGFB	C0393590	Fahr's syndrome (disorder)	3	GENOMICS_ENGLAND;ORPHANET
Tgene	PDGFB	C0004782	Basal Ganglia Diseases	1	CTD_human
Tgene	PDGFB	C0006663	Calcinosis	1	CTD_human
Tgene	PDGFB	C0015371	Extrapyramidal Disorders	1	CTD_human
Tgene	PDGFB	C0016059	Fibrosis	1	CTD_human
Tgene	PDGFB	C0017566	Gingival Hyperplasia	1	CTD_human
Tgene	PDGFB	C0025286	Meningioma	1	ORPHANET
Tgene	PDGFB	C0034069	Pulmonary Fibrosis	1	CTD_human
Tgene	PDGFB	C0035309	Retinal Diseases	1	CTD_human
Tgene	PDGFB	C0040028	Thrombocythemia, Essential	1	CTD_human
Tgene	PDGFB	C0263628	Tumoral calcinosis	1	CTD_human
Tgene	PDGFB	C0521174	Microcalcification	1	CTD_human
Tgene	PDGFB	C0750951	Lenticulostriate Disorders	1	CTD_human
Tgene	PDGFB	C1623038	Cirrhosis	1	CTD_human
Tgene	PDGFB	C2239176	Liver carcinoma	1	CTD_human
Tgene	PDGFB	C3489628	Thrombocytosis, Autosomal Dominant	1	CTD_human
Tgene	PDGFB	C4551624	Idiopathic basal ganglia calcification 1	1	CTD_human
Tgene	PDGFB	C4721507	Alveolitis, Fibrosing	1	CTD_human