UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:COL4A1-FLNA

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: COL4A1-FLNA
FusionPDB ID: 18339
FusionGDB2.0 ID: 18339
HgeneTgene
Gene symbol

COL4A1

FLNA

Gene ID

1282

2316

Gene namecollagen type IV alpha 1 chainfilamin A
SynonymsBSVD|BSVD1|PADMAL|RATORABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVD
Cytomap

13q34

Xq28

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-1(IV) chainCOL4A1 NC1 domainarrestencollagen IV, alpha-1 polypeptidecollagen of basement membrane, alpha-1 chainfilamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinepididymis secretory sperm binding proteinfilamin A, alphafilamin-1non-muscle filamin
Modification date2020031320200313
UniProtAcc

P02462

P21333

Ensembl transtripts involved in fusion geneENST idsENST00000375820, ENST00000467182, 
ENST00000543140, 		ENST00000498491, 
ENST00000344736, ENST00000360319, 
ENST00000369850, ENST00000369856, 
ENST00000422373, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 15 X 8=156025 X 31 X 6=4650
# samples 1531
** MAII scorelog2(15/1560*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/4650*10)=-3.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: COL4A1 [Title/Abstract] AND FLNA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)COL4A1(110826247)-FLNA(153578575), # samples:1
Anticipated loss of major functional domain due to fusion event.COL4A1-FLNA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COL4A1-FLNA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COL4A1-FLNA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
COL4A1-FLNA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFLNA

GO:0016479

negative regulation of transcription by RNA polymerase I

22307607

TgeneFLNA

GO:0030334

regulation of cell migration

16291724

TgeneFLNA

GO:0031532

actin cytoskeleton reorganization

10051605

TgeneFLNA

GO:0034394

protein localization to cell surface

18322202

TgeneFLNA

GO:0043113

receptor clustering

10692483

TgeneFLNA

GO:0043433

negative regulation of DNA-binding transcription factor activity

15684392

TgeneFLNA

GO:0044319

wound healing, spreading of cells

16291724

TgeneFLNA

GO:0045184

establishment of protein localization

18322202

TgeneFLNA

GO:0051764

actin crosslink formation

10051605

TgeneFLNA

GO:0072659

protein localization to plasma membrane

24951510

TgeneFLNA

GO:0090307

mitotic spindle assembly

18548008

TgeneFLNA

GO:1901381

positive regulation of potassium ion transmembrane transport

24951510


check buttonFusion gene breakpoints across COL4A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FLNA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48J-01ACOL4A1chr13

110826247

-FLNAchrX

153578575

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375820COL4A1chr13110826247-ENST00000360319FLNAchrX153578575-473836276244141450
ENST00000375820COL4A1chr13110826247-ENST00000422373FLNAchrX153578575-473236276244141450
ENST00000375820COL4A1chr13110826247-ENST00000369850FLNAchrX153578575-461636276244141450
ENST00000375820COL4A1chr13110826247-ENST00000369856FLNAchrX153578575-460836276244141450
ENST00000375820COL4A1chr13110826247-ENST00000344736FLNAchrX153578575-448036276244141450

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375820ENST00000360319COL4A1chr13110826247-FLNAchrX153578575-0.0015399970.99846005
ENST00000375820ENST00000422373COL4A1chr13110826247-FLNAchrX153578575-0.0015394550.99846053
ENST00000375820ENST00000369850COL4A1chr13110826247-FLNAchrX153578575-0.0016754040.9983246
ENST00000375820ENST00000369856COL4A1chr13110826247-FLNAchrX153578575-0.0016681460.99833184
ENST00000375820ENST00000344736COL4A1chr13110826247-FLNAchrX153578575-0.0015796840.99842036

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>18339_18339_1_COL4A1-FLNA_COL4A1_chr13_110826247_ENST00000375820_FLNA_chrX_153578575_ENST00000344736_length(amino acids)=1450AA_BP=200
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEG
PQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPG
EILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKGDQGVSGPPGVPGQAQVQE
KGDFATKGEKGQKGEPGFQGMPGVGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGIVIGTGPL
GEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNG
IVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGL
IGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMTGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGP
AGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFPGPQGDRGFPGTPGRPGLPGEKGAVGQPGIGFPGPPGPKGV
DGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLP
GSVGSPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGE
MGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGD
PGTPGVPGKDGQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGIGIP
GLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQK
GEPGSDGIPGSAGEKGEPDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNA
GAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQH
GAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHI

--------------------------------------------------------------

>18339_18339_2_COL4A1-FLNA_COL4A1_chr13_110826247_ENST00000375820_FLNA_chrX_153578575_ENST00000360319_length(amino acids)=1450AA_BP=200
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEG
PQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPG
EILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKGDQGVSGPPGVPGQAQVQE
KGDFATKGEKGQKGEPGFQGMPGVGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGIVIGTGPL
GEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNG
IVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGL
IGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMTGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGP
AGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFPGPQGDRGFPGTPGRPGLPGEKGAVGQPGIGFPGPPGPKGV
DGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLP
GSVGSPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGE
MGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGD
PGTPGVPGKDGQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGIGIP
GLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQK
GEPGSDGIPGSAGEKGEPDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNA
GAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQH
GAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHI

--------------------------------------------------------------

>18339_18339_3_COL4A1-FLNA_COL4A1_chr13_110826247_ENST00000375820_FLNA_chrX_153578575_ENST00000369850_length(amino acids)=1450AA_BP=200
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEG
PQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPG
EILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKGDQGVSGPPGVPGQAQVQE
KGDFATKGEKGQKGEPGFQGMPGVGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGIVIGTGPL
GEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNG
IVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGL
IGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMTGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGP
AGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFPGPQGDRGFPGTPGRPGLPGEKGAVGQPGIGFPGPPGPKGV
DGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLP
GSVGSPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGE
MGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGD
PGTPGVPGKDGQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGIGIP
GLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQK
GEPGSDGIPGSAGEKGEPDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNA
GAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQH
GAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHI

--------------------------------------------------------------

>18339_18339_4_COL4A1-FLNA_COL4A1_chr13_110826247_ENST00000375820_FLNA_chrX_153578575_ENST00000369856_length(amino acids)=1450AA_BP=200
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEG
PQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPG
EILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKGDQGVSGPPGVPGQAQVQE
KGDFATKGEKGQKGEPGFQGMPGVGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGIVIGTGPL
GEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNG
IVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGL
IGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMTGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGP
AGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFPGPQGDRGFPGTPGRPGLPGEKGAVGQPGIGFPGPPGPKGV
DGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLP
GSVGSPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGE
MGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGD
PGTPGVPGKDGQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGIGIP
GLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQK
GEPGSDGIPGSAGEKGEPDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNA
GAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQH
GAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHI

--------------------------------------------------------------

>18339_18339_5_COL4A1-FLNA_COL4A1_chr13_110826247_ENST00000375820_FLNA_chrX_153578575_ENST00000422373_length(amino acids)=1450AA_BP=200
MSAAAPARRAAVPRRLGRATMGPRLSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEG
PQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPG
EILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKGDQGVSGPPGVPGQAQVQE
KGDFATKGEKGQKGEPGFQGMPGVGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGIVIGTGPL
GEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNG
IVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGL
IGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMTGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGP
AGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFPGPQGDRGFPGTPGRPGLPGEKGAVGQPGIGFPGPPGPKGV
DGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLP
GSVGSPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGE
MGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGD
PGTPGVPGKDGQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGIGIP
GLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQK
GEPGSDGIPGSAGEKGEPDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNA
GAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQH
GAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHI

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:110826247/chrX:153578575)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL4A1

P02462

FLNA

P21333

FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. {ECO:0000250|UniProtKB:P02463}.; FUNCTION: Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. {ECO:0000269|PubMed:10811134, ECO:0000269|PubMed:18775695}.FUNCTION: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941462517_25512377.33333333333352640.0RegionNote=Hinge 2
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941462517_26472377.33333333333352640.0RegionNote=Self-association site%2C tail
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043482517_25512385.33333333333352648.0RegionNote=Hinge 2
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043482517_26472385.33333333333352648.0RegionNote=Self-association site%2C tail
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342472517_25512377.33333333333352640.0RegionNote=Hinge 2
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342472517_26472377.33333333333352640.0RegionNote=Self-association site%2C tail
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941462424_25162377.33333333333352640.0RepeatNote=Filamin 23
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941462552_26462377.33333333333352640.0RepeatNote=Filamin 24
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043482424_25162385.33333333333352648.0RepeatNote=Filamin 23
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043482552_26462385.33333333333352648.0RepeatNote=Filamin 24
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342472424_25162377.33333333333352640.0RepeatNote=Filamin 23
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342472552_26462377.33333333333352640.0RepeatNote=Filamin 24

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL4A1chr13:110826247chrX:153578575ENST00000375820-40521445_16691168.33333333333331670.0DomainCollagen IV NC1
HgeneCOL4A1chr13:110826247chrX:153578575ENST00000375820-4052173_14401168.33333333333331670.0RegionNote=Triple-helical region
TgeneFLNAchr13:110826247chrX:153578575ENST000003603194146166_2692377.33333333333352640.0DomainCalponin-homology (CH) 2
TgeneFLNAchr13:110826247chrX:153578575ENST00000360319414643_1492377.33333333333352640.0DomainCalponin-homology (CH) 1
TgeneFLNAchr13:110826247chrX:153578575ENST000003698504348166_2692385.33333333333352648.0DomainCalponin-homology (CH) 2
TgeneFLNAchr13:110826247chrX:153578575ENST00000369850434843_1492385.33333333333352648.0DomainCalponin-homology (CH) 1
TgeneFLNAchr13:110826247chrX:153578575ENST000004223734247166_2692377.33333333333352640.0DomainCalponin-homology (CH) 2
TgeneFLNAchr13:110826247chrX:153578575ENST00000422373424743_1492377.33333333333352640.0DomainCalponin-homology (CH) 1
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461741_17782377.33333333333352640.0RegionNote=Hinge 1
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941462_2742377.33333333333352640.0RegionNote=Actin-binding
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481741_17782385.33333333333352648.0RegionNote=Hinge 1
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043482_2742385.33333333333352648.0RegionNote=Actin-binding
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471741_17782377.33333333333352640.0RegionNote=Hinge 1
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342472_2742377.33333333333352640.0RegionNote=Actin-binding
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461062_11542377.33333333333352640.0RepeatNote=Filamin 9
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461155_12492377.33333333333352640.0RepeatNote=Filamin 10
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461250_13492377.33333333333352640.0RepeatNote=Filamin 11
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461350_14422377.33333333333352640.0RepeatNote=Filamin 12
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461443_15392377.33333333333352640.0RepeatNote=Filamin 13
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461540_16362377.33333333333352640.0RepeatNote=Filamin 14
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461649_17402377.33333333333352640.0RepeatNote=Filamin 15
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461779_18602377.33333333333352640.0RepeatNote=Filamin 16
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461861_19502377.33333333333352640.0RepeatNote=Filamin 17
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461951_20392377.33333333333352640.0RepeatNote=Filamin 18
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941462042_21312377.33333333333352640.0RepeatNote=Filamin 19
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941462132_22302377.33333333333352640.0RepeatNote=Filamin 20
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941462233_23252377.33333333333352640.0RepeatNote=Filamin 21
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941462327_24202377.33333333333352640.0RepeatNote=Filamin 22
TgeneFLNAchr13:110826247chrX:153578575ENST000003603194146276_3742377.33333333333352640.0RepeatNote=Filamin 1
TgeneFLNAchr13:110826247chrX:153578575ENST000003603194146376_4742377.33333333333352640.0RepeatNote=Filamin 2
TgeneFLNAchr13:110826247chrX:153578575ENST000003603194146475_5702377.33333333333352640.0RepeatNote=Filamin 3
TgeneFLNAchr13:110826247chrX:153578575ENST000003603194146571_6632377.33333333333352640.0RepeatNote=Filamin 4
TgeneFLNAchr13:110826247chrX:153578575ENST000003603194146667_7632377.33333333333352640.0RepeatNote=Filamin 5
TgeneFLNAchr13:110826247chrX:153578575ENST000003603194146764_8662377.33333333333352640.0RepeatNote=Filamin 6
TgeneFLNAchr13:110826247chrX:153578575ENST000003603194146867_9652377.33333333333352640.0RepeatNote=Filamin 7
TgeneFLNAchr13:110826247chrX:153578575ENST000003603194146966_10612377.33333333333352640.0RepeatNote=Filamin 8
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481062_11542385.33333333333352648.0RepeatNote=Filamin 9
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481155_12492385.33333333333352648.0RepeatNote=Filamin 10
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481250_13492385.33333333333352648.0RepeatNote=Filamin 11
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481350_14422385.33333333333352648.0RepeatNote=Filamin 12
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481443_15392385.33333333333352648.0RepeatNote=Filamin 13
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481540_16362385.33333333333352648.0RepeatNote=Filamin 14
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481649_17402385.33333333333352648.0RepeatNote=Filamin 15
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481779_18602385.33333333333352648.0RepeatNote=Filamin 16
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481861_19502385.33333333333352648.0RepeatNote=Filamin 17
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481951_20392385.33333333333352648.0RepeatNote=Filamin 18
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043482042_21312385.33333333333352648.0RepeatNote=Filamin 19
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043482132_22302385.33333333333352648.0RepeatNote=Filamin 20
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043482233_23252385.33333333333352648.0RepeatNote=Filamin 21
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043482327_24202385.33333333333352648.0RepeatNote=Filamin 22
TgeneFLNAchr13:110826247chrX:153578575ENST000003698504348276_3742385.33333333333352648.0RepeatNote=Filamin 1
TgeneFLNAchr13:110826247chrX:153578575ENST000003698504348376_4742385.33333333333352648.0RepeatNote=Filamin 2
TgeneFLNAchr13:110826247chrX:153578575ENST000003698504348475_5702385.33333333333352648.0RepeatNote=Filamin 3
TgeneFLNAchr13:110826247chrX:153578575ENST000003698504348571_6632385.33333333333352648.0RepeatNote=Filamin 4
TgeneFLNAchr13:110826247chrX:153578575ENST000003698504348667_7632385.33333333333352648.0RepeatNote=Filamin 5
TgeneFLNAchr13:110826247chrX:153578575ENST000003698504348764_8662385.33333333333352648.0RepeatNote=Filamin 6
TgeneFLNAchr13:110826247chrX:153578575ENST000003698504348867_9652385.33333333333352648.0RepeatNote=Filamin 7
TgeneFLNAchr13:110826247chrX:153578575ENST000003698504348966_10612385.33333333333352648.0RepeatNote=Filamin 8
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471062_11542377.33333333333352640.0RepeatNote=Filamin 9
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471155_12492377.33333333333352640.0RepeatNote=Filamin 10
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471250_13492377.33333333333352640.0RepeatNote=Filamin 11
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471350_14422377.33333333333352640.0RepeatNote=Filamin 12
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471443_15392377.33333333333352640.0RepeatNote=Filamin 13
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471540_16362377.33333333333352640.0RepeatNote=Filamin 14
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471649_17402377.33333333333352640.0RepeatNote=Filamin 15
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471779_18602377.33333333333352640.0RepeatNote=Filamin 16
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471861_19502377.33333333333352640.0RepeatNote=Filamin 17
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471951_20392377.33333333333352640.0RepeatNote=Filamin 18
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342472042_21312377.33333333333352640.0RepeatNote=Filamin 19
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342472132_22302377.33333333333352640.0RepeatNote=Filamin 20
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342472233_23252377.33333333333352640.0RepeatNote=Filamin 21
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342472327_24202377.33333333333352640.0RepeatNote=Filamin 22
TgeneFLNAchr13:110826247chrX:153578575ENST000004223734247276_3742377.33333333333352640.0RepeatNote=Filamin 1
TgeneFLNAchr13:110826247chrX:153578575ENST000004223734247376_4742377.33333333333352640.0RepeatNote=Filamin 2
TgeneFLNAchr13:110826247chrX:153578575ENST000004223734247475_5702377.33333333333352640.0RepeatNote=Filamin 3
TgeneFLNAchr13:110826247chrX:153578575ENST000004223734247571_6632377.33333333333352640.0RepeatNote=Filamin 4
TgeneFLNAchr13:110826247chrX:153578575ENST000004223734247667_7632377.33333333333352640.0RepeatNote=Filamin 5
TgeneFLNAchr13:110826247chrX:153578575ENST000004223734247764_8662377.33333333333352640.0RepeatNote=Filamin 6
TgeneFLNAchr13:110826247chrX:153578575ENST000004223734247867_9652377.33333333333352640.0RepeatNote=Filamin 7
TgeneFLNAchr13:110826247chrX:153578575ENST000004223734247966_10612377.33333333333352640.0RepeatNote=Filamin 8


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
COL4A1
FLNA


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneFLNAchr13:110826247chrX:153578575ENST0000036031941461490_16072377.33333333333352640.0furin
TgeneFLNAchr13:110826247chrX:153578575ENST0000036985043481490_16072385.33333333333352648.0furin
TgeneFLNAchr13:110826247chrX:153578575ENST0000042237342471490_16072377.33333333333352640.0furin


Top

Related Drugs to COL4A1-FLNA


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to COL4A1-FLNA


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource