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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:COL6A2-MYH9

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: COL6A2-MYH9
FusionPDB ID: 18436
FusionGDB2.0 ID: 18436
HgeneTgene
Gene symbol

COL6A2

MYH9

Gene ID

1292

4627

Gene namecollagen type VI alpha 2 chainmyosin heavy chain 9
SynonymsBTHLM1|PP3610|UCMD1BDPLT6|DFNA17|EPSTS|FTNS|MATINS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCA
Cytomap

21q22.3

22q12.3

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-2(VI) chaincollagen VI, alpha-2 polypeptidecollagen, type VI, alpha 2epididymis secretory sperm binding proteinhuman mRNA for collagen VI alpha-2 C-terminal globular domainmyosin-9cellular myosin heavy chain, type Amyosin, heavy chain 9, non-musclenon-muscle myosin heavy chain 9non-muscle myosin heavy chain Anon-muscle myosin heavy chain IIanon-muscle myosin heavy polypeptide 9nonmuscle myosin heavy chain II-A
Modification date2020032820200315
UniProtAcc

P12110

P35579

Ensembl transtripts involved in fusion geneENST idsENST00000300527, ENST00000310645, 
ENST00000357838, ENST00000397763, 
ENST00000409416, ENST00000460886, 
ENST00000401701, ENST00000475726, 
ENST00000216181, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 9 X 8=93644 X 46 X 15=30360
# samples 1356
** MAII scorelog2(13/936*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(56/30360*10)=-5.76060115335786
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: COL6A2 [Title/Abstract] AND MYH9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)COL6A2(47542072)-MYH9(36695088), # samples:1
Anticipated loss of major functional domain due to fusion event.COL6A2-MYH9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COL6A2-MYH9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
COL6A2-MYH9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
COL6A2-MYH9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMYH9

GO:0001525

angiogenesis

16403913

TgeneMYH9

GO:0001778

plasma membrane repair

27325790

TgeneMYH9

GO:0006509

membrane protein ectodomain proteolysis

16186248

TgeneMYH9

GO:0030048

actin filament-based movement

12237319|15845534

TgeneMYH9

GO:0031032

actomyosin structure organization

24072716


check buttonFusion gene breakpoints across COL6A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYH9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-HD-7831-01ACOL6A2chr21

47542072

+MYH9chr22

36695088

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000300527COL6A2chr2147542072+ENST00000216181MYH9chr2236695088-597016761745821521
ENST00000310645COL6A2chr2147542072+ENST00000216181MYH9chr2236695088-594816548245601492
ENST00000357838COL6A2chr2147542072+ENST00000216181MYH9chr2236695088-594816548245601492
ENST00000409416COL6A2chr2147542072+ENST00000216181MYH9chr2236695088-59291635045411513
ENST00000397763COL6A2chr2147542072+ENST00000216181MYH9chr2236695088-589315992745051492

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000300527ENST00000216181COL6A2chr2147542072+MYH9chr2236695088-0.017313420.98268664
ENST00000310645ENST00000216181COL6A2chr2147542072+MYH9chr2236695088-0.0171760820.98282397
ENST00000357838ENST00000216181COL6A2chr2147542072+MYH9chr2236695088-0.0171760820.98282397
ENST00000409416ENST00000216181COL6A2chr2147542072+MYH9chr2236695088-0.0170055680.98299444
ENST00000397763ENST00000216181COL6A2chr2147542072+MYH9chr2236695088-0.0168358590.98316413

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>18436_18436_1_COL6A2-MYH9_COL6A2_chr21_47542072_ENST00000300527_MYH9_chr22_36695088_ENST00000216181_length(amino acids)=1521AA_BP=369
MLLTRRPRLGPSGAEPPRDQDFRATGAAKMLQGTCSVLLLWGILGAIQAQQQEVISPDTTERNNNCPEKTDCPIHVYFVLDTSESVTMQS
PTDILLFHMKQFVPQFISQLQNEFYLDQVALSWRYGGLHFSDQVEVFSPPGSDRASFIKNLQGISSFRRGTFTDCALANMTEQIRQDRSK
GTVHFAVVITDGHVTGSPCGGIKLQAERAREEGIRLFAVAPNQNLKEQGLRDIASTPHELYRNDYATMLPDSTEIDQDTINRIIKVMKHE
AYGECYKVSCLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDG
QKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKG
EPGRRGDPGTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPG
RPGFSYPGPRGAPEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA
QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ
ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK
VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKN
SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL
DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS
VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV
AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA
QQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKE
LKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQL

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>18436_18436_2_COL6A2-MYH9_COL6A2_chr21_47542072_ENST00000310645_MYH9_chr22_36695088_ENST00000216181_length(amino acids)=1492AA_BP=340
MLQGTCSVLLLWGILGAIQAQQQEVISPDTTERNNNCPEKTDCPIHVYFVLDTSESVTMQSPTDILLFHMKQFVPQFISQLQNEFYLDQV
ALSWRYGGLHFSDQVEVFSPPGSDRASFIKNLQGISSFRRGTFTDCALANMTEQIRQDRSKGTVHFAVVITDGHVTGSPCGGIKLQAERA
REEGIRLFAVAPNQNLKEQGLRDIASTPHELYRNDYATMLPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPGPSGPKGYRGQKGAK
GNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEA
GSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPE
GPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGAPEKKLLEDRIAEFTTNL
TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ
KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ
EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKL
QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD
MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA
KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL
QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK
QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE
ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQ
LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETAD

--------------------------------------------------------------

>18436_18436_3_COL6A2-MYH9_COL6A2_chr21_47542072_ENST00000357838_MYH9_chr22_36695088_ENST00000216181_length(amino acids)=1492AA_BP=340
MLQGTCSVLLLWGILGAIQAQQQEVISPDTTERNNNCPEKTDCPIHVYFVLDTSESVTMQSPTDILLFHMKQFVPQFISQLQNEFYLDQV
ALSWRYGGLHFSDQVEVFSPPGSDRASFIKNLQGISSFRRGTFTDCALANMTEQIRQDRSKGTVHFAVVITDGHVTGSPCGGIKLQAERA
REEGIRLFAVAPNQNLKEQGLRDIASTPHELYRNDYATMLPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPGPSGPKGYRGQKGAK
GNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEA
GSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPE
GPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGAPEKKLLEDRIAEFTTNL
TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ
KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ
EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKL
QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD
MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA
KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL
QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK
QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE
ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQ
LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETAD

--------------------------------------------------------------

>18436_18436_4_COL6A2-MYH9_COL6A2_chr21_47542072_ENST00000397763_MYH9_chr22_36695088_ENST00000216181_length(amino acids)=1492AA_BP=340
MLQGTCSVLLLWGILGAIQAQQQEVISPDTTERNNNCPEKTDCPIHVYFVLDTSESVTMQSPTDILLFHMKQFVPQFISQLQNEFYLDQV
ALSWRYGGLHFSDQVEVFSPPGSDRASFIKNLQGISSFRRGTFTDCALANMTEQIRQDRSKGTVHFAVVITDGHVTGSPCGGIKLQAERA
REEGIRLFAVAPNQNLKEQGLRDIASTPHELYRNDYATMLPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPGPSGPKGYRGQKGAK
GNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEA
GSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDPGTKGSPGSDGPKGEKGDPGPE
GPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGAPEKKLLEDRIAEFTTNL
TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ
KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ
EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKL
QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD
MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA
KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL
QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK
QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE
ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQ
LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETAD

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>18436_18436_5_COL6A2-MYH9_COL6A2_chr21_47542072_ENST00000409416_MYH9_chr22_36695088_ENST00000216181_length(amino acids)=1513AA_BP=361
LGVSERPPPLLQDFRATGAAKMLQGTCSVLLLWGILGAIQAQQQEVISPDTTERNNNCPEKTDCPIHVYFVLDTSESVTMQSPTDILLFH
MKQFVPQFISQLQNEFYLDQVALSWRYGGLHFSDQVEVFSPPGSDRASFIKNLQGISSFRRGTFTDCALANMTEQIRQDRSKGTVHFAVV
ITDGHVTGSPCGGIKLQAERAREEGIRLFAVAPNQNLKEQGLRDIASTPHELYRNDYATMLPDSTEIDQDTINRIIKVMKHEAYGECYKV
SCLEIPGPSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRI
GPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSGAPGSPGVKGAKGGPGPRGPKGEPGRRGDP
GTKGSPGSDGPKGEKGDPGPEGPRGLAGEVGNKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPG
PRGAPEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ
LAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ
EVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL
QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE
EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSAC
NLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK
RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM
DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA
DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEM
EGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:47542072/chr22:36695088)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL6A2

P12110

MYH9

P35579

FUNCTION: Collagen VI acts as a cell-binding protein.FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Promotes also cell motility together with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250|UniProtKB:Q8VDD5, ECO:0000269|PubMed:16707441, ECO:0000269|PubMed:20052411}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+192846_234524.01020.0DomainVWFA 1
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+192846_234524.0829.0DomainVWFA 1
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+192846_234524.0919.0DomainVWFA 1
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+182746_234524.0919.0DomainVWFA 1
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+182746_234524.0829.0DomainVWFA 1
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+1928366_368524.01020.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+1928426_428524.01020.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+1928489_491524.01020.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+1928498_500524.01020.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+1928366_368524.0829.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+1928426_428524.0829.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+1928489_491524.0829.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+1928498_500524.0829.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+1928366_368524.0919.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+1928426_428524.0919.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+1928489_491524.0919.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+1928498_500524.0919.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+1827366_368524.0919.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+1827426_428524.0919.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+1827489_491524.0919.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+1827498_500524.0919.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+1827366_368524.0829.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+1827426_428524.0829.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+1827489_491524.0829.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+1827498_500524.0829.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+192821_256524.01020.0RegionNote=Nonhelical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+192821_256524.0829.0RegionNote=Nonhelical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+192821_256524.0919.0RegionNote=Nonhelical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+182721_256524.0919.0RegionNote=Nonhelical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+182721_256524.0829.0RegionNote=Nonhelical region

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+1928615_805524.01020.0DomainVWFA 2
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+1928833_1014524.01020.0DomainVWFA 3
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+1928615_805524.0829.0DomainVWFA 2
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+1928833_1014524.0829.0DomainVWFA 3
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+1928615_805524.0919.0DomainVWFA 2
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+1928833_1014524.0919.0DomainVWFA 3
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+1827615_805524.0919.0DomainVWFA 2
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+1827833_1014524.0919.0DomainVWFA 3
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+1827615_805524.0829.0DomainVWFA 2
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+1827833_1014524.0829.0DomainVWFA 3
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+1928539_541524.01020.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+1928539_541524.0829.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+1928539_541524.0919.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+1827539_541524.0919.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+1827539_541524.0829.0MotifCell attachment site
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+1928257_590524.01020.0RegionNote=Triple-helical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000300527+1928591_1019524.01020.0RegionNote=Nonhelical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+1928257_590524.0829.0RegionNote=Triple-helical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000310645+1928591_1019524.0829.0RegionNote=Nonhelical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+1928257_590524.0919.0RegionNote=Triple-helical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000357838+1928591_1019524.0919.0RegionNote=Nonhelical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+1827257_590524.0919.0RegionNote=Triple-helical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000397763+1827591_1019524.0919.0RegionNote=Nonhelical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+1827257_590524.0829.0RegionNote=Triple-helical region
HgeneCOL6A2chr21:47542072chr22:36695088ENST00000409416+1827591_1019524.0829.0RegionNote=Nonhelical region
TgeneMYH9chr21:47542072chr22:36695088ENST000002161812241837_1926992.01961.0Coiled coilOntology_term=ECO:0000255
TgeneMYH9chr21:47542072chr22:36695088ENST00000216181224127_77992.01961.0DomainMyosin N-terminal SH3-like
TgeneMYH9chr21:47542072chr22:36695088ENST000002161812241779_808992.01961.0DomainIQ
TgeneMYH9chr21:47542072chr22:36695088ENST00000216181224181_776992.01961.0DomainMyosin motor
TgeneMYH9chr21:47542072chr22:36695088ENST000002161812241174_181992.01961.0Nucleotide bindingATP
TgeneMYH9chr21:47542072chr22:36695088ENST000002161812241654_676992.01961.0RegionNote=Actin-binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
COL6A2
MYH9


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to COL6A2-MYH9


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to COL6A2-MYH9


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource