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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:COLEC11-PINX1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: COLEC11-PINX1
	FusionPDB ID: 18481
	FusionGDB2.0 ID: 18481
		Hgene	Tgene
	Gene symbol	COLEC11	PINX1
	Gene ID	78989	54984
	Gene name	collectin subfamily member 11	PIN2 (TERF1) interacting telomerase inhibitor 1
	Synonyms	3MC2\|CL-K1-I\|CL-K1-II\|CL-K1-IIa\|CL-K1-IIb\|CLK1	Gno1\|LPTL\|LPTS\|Pxr1
	Cytomap	2p25.3	8p23.1
	Type of gene	protein-coding	protein-coding
	Description	collectin-11Collectin K1collectin kidney protein 1collectin sub-family member 11	PIN2/TERF1-interacting telomerase inhibitor 167-11-3 proteinPIN2-interacting protein 1TRF1-interacting protein 1hepatocellular carcinoma-related putative tumor suppressorliver-related putative tumor suppressorpin2-interacting protein X1protein 67-1
	Modification date	20200313	20200327
	UniProtAcc	Q9BWP8	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000487365, ENST00000236693, ENST00000349077, ENST00000382062, ENST00000418971, ENST00000402794, ENST00000402922, ENST00000403096, ENST00000404205,	ENST00000314787, ENST00000426190, ENST00000519088, ENST00000520018,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 2 X 2=12	6 X 4 X 5=120
	# samples	2	6
	** MAII score	log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: COLEC11 [Title/Abstract] AND PINX1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	COLEC11(3652060)-PINX1(10692285), # samples:2
Anticipated loss of major functional domain due to fusion event.	COLEC11-PINX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. COLEC11-PINX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. COLEC11-PINX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. COLEC11-PINX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. COLEC11-PINX1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. COLEC11-PINX1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	COLEC11	GO:0006956	complement activation	23954398
Hgene	COLEC11	GO:0019730	antimicrobial humoral response	20956340
Tgene	PINX1	GO:0007004	telomere maintenance via telomerase	11701125
Tgene	PINX1	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	11701125
Tgene	PINX1	GO:0032211	negative regulation of telomere maintenance via telomerase	11701125
Tgene	PINX1	GO:0051974	negative regulation of telomerase activity	11701125
Tgene	PINX1	GO:1902570	protein localization to nucleolus	24415760
Tgene	PINX1	GO:1904744	positive regulation of telomeric DNA binding	19265708\|24415760
Tgene	PINX1	GO:1904751	positive regulation of protein localization to nucleolus	19265708

Fusion gene breakpoints across COLEC11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PINX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-X6-A8C6-01A	COLEC11	chr2	3652060	+	PINX1	chr8	10692285	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000382062	COLEC11	chr2	3652060	+	ENST00000314787	PINX1	chr8	10692285	-	1776	370	225	1337	370
ENST00000382062	COLEC11	chr2	3652060	+	ENST00000426190	PINX1	chr8	10692285	-	1697	370	225	875	216
ENST00000382062	COLEC11	chr2	3652060	+	ENST00000519088	PINX1	chr8	10692285	-	1503	370	225	875	216
ENST00000349077	COLEC11	chr2	3652060	+	ENST00000314787	PINX1	chr8	10692285	-	1639	233	88	1200	370
ENST00000349077	COLEC11	chr2	3652060	+	ENST00000426190	PINX1	chr8	10692285	-	1560	233	88	738	216
ENST00000349077	COLEC11	chr2	3652060	+	ENST00000519088	PINX1	chr8	10692285	-	1366	233	88	738	216
ENST00000418971	COLEC11	chr2	3652060	+	ENST00000314787	PINX1	chr8	10692285	-	1789	383	211	1350	379
ENST00000418971	COLEC11	chr2	3652060	+	ENST00000426190	PINX1	chr8	10692285	-	1710	383	211	888	225
ENST00000418971	COLEC11	chr2	3652060	+	ENST00000519088	PINX1	chr8	10692285	-	1516	383	211	888	225

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000382062	ENST00000314787	COLEC11	chr2	3652060	+	PINX1	chr8	10692285	-	0.001734494	0.99826556
ENST00000382062	ENST00000426190	COLEC11	chr2	3652060	+	PINX1	chr8	10692285	-	0.012711735	0.98728824
ENST00000382062	ENST00000519088	COLEC11	chr2	3652060	+	PINX1	chr8	10692285	-	0.015293216	0.9847068
ENST00000349077	ENST00000314787	COLEC11	chr2	3652060	+	PINX1	chr8	10692285	-	0.001590466	0.99840957
ENST00000349077	ENST00000426190	COLEC11	chr2	3652060	+	PINX1	chr8	10692285	-	0.009711576	0.9902884
ENST00000349077	ENST00000519088	COLEC11	chr2	3652060	+	PINX1	chr8	10692285	-	0.015500511	0.98449945
ENST00000418971	ENST00000314787	COLEC11	chr2	3652060	+	PINX1	chr8	10692285	-	0.000885666	0.99911433
ENST00000418971	ENST00000426190	COLEC11	chr2	3652060	+	PINX1	chr8	10692285	-	0.008503214	0.99149674
ENST00000418971	ENST00000519088	COLEC11	chr2	3652060	+	PINX1	chr8	10692285	-	0.012496789	0.98750323

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>18481_18481_1_COLEC11-PINX1_COLEC11_chr2_3652060_ENST00000349077_PINX1_chr8_10692285_ENST00000314787_length(amino acids)=370AA_BP=48
MPALRMRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQ
EQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSR
SKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYL
QPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEETL

--------------------------------------------------------------

>18481_18481_2_COLEC11-PINX1_COLEC11_chr2_3652060_ENST00000349077_PINX1_chr8_10692285_ENST00000426190_length(amino acids)=216AA_BP=48
MPALRMRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQ
EQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGRCQSLH

--------------------------------------------------------------

>18481_18481_3_COLEC11-PINX1_COLEC11_chr2_3652060_ENST00000349077_PINX1_chr8_10692285_ENST00000519088_length(amino acids)=216AA_BP=48
MPALRMRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQ
EQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGRCQSLH

--------------------------------------------------------------

>18481_18481_4_COLEC11-PINX1_COLEC11_chr2_3652060_ENST00000382062_PINX1_chr8_10692285_ENST00000314787_length(amino acids)=370AA_BP=48
MPALRMRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQ
EQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSR
SKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYL
QPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEETL

--------------------------------------------------------------

>18481_18481_5_COLEC11-PINX1_COLEC11_chr2_3652060_ENST00000382062_PINX1_chr8_10692285_ENST00000426190_length(amino acids)=216AA_BP=48
MPALRMRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQ
EQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGRCQSLH

--------------------------------------------------------------

>18481_18481_6_COLEC11-PINX1_COLEC11_chr2_3652060_ENST00000382062_PINX1_chr8_10692285_ENST00000519088_length(amino acids)=216AA_BP=48
MPALRMRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQ
EQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGRCQSLH

--------------------------------------------------------------

>18481_18481_7_COLEC11-PINX1_COLEC11_chr2_3652060_ENST00000418971_PINX1_chr8_10692285_ENST00000314787_length(amino acids)=379AA_BP=57
MKKQRGVGVLPALRMRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGW
SKGKGLGAQEQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKF
TKGKDLSSRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEA
TGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIA

--------------------------------------------------------------

>18481_18481_8_COLEC11-PINX1_COLEC11_chr2_3652060_ENST00000418971_PINX1_chr8_10692285_ENST00000426190_length(amino acids)=225AA_BP=57
MKKQRGVGVLPALRMRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGW
SKGKGLGAQEQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKF

--------------------------------------------------------------

>18481_18481_9_COLEC11-PINX1_COLEC11_chr2_3652060_ENST00000418971_PINX1_chr8_10692285_ENST00000519088_length(amino acids)=225AA_BP=57
MKKQRGVGVLPALRMRGNLALVGVLISLAFLSLLPSGHPQPAGDDACSVQILVPGLKGRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGW
SKGKGLGAQEQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKF

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:3652060/chr8:10692285)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
COLEC11 Q9BWP8	.
FUNCTION: Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481). {ECO:0000269\|PubMed:17179669, ECO:0000269\|PubMed:20956340, ECO:0000269\|PubMed:21258343, ECO:0000269\|PubMed:23954398, ECO:0000269\|PubMed:25912189, ECO:0000269\|PubMed:28301481, ECO:0000305\|PubMed:20956340, ECO:0000305\|PubMed:23954398}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PINX1

chr2:3652060

chr8:10692285

ENST00000314787

26_72

6.333333333333333

329.0

Domain

G-patch

Tgene

PINX1

chr2:3652060

chr8:10692285

ENST00000519088

26_72

6.333333333333333

175.0

Domain

G-patch

Tgene

PINX1

chr2:3652060

chr8:10692285

ENST00000314787

287_297

6.333333333333333

329.0

Motif

Note=TBM

Tgene

PINX1

chr2:3652060

chr8:10692285

ENST00000519088

287_297

6.333333333333333

175.0

Motif

Note=TBM

Tgene

PINX1

chr2:3652060

chr8:10692285

ENST00000314787

254_328

6.333333333333333

329.0

Region

Note=Telomerase inhibitory domain (TID)

Tgene

PINX1

chr2:3652060

chr8:10692285

ENST00000519088

254_328

6.333333333333333

175.0

Region

Note=Telomerase inhibitory domain (TID)

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000236693

114_148

14.0

269.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000349077

114_148

43.333333333333336

272.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000382062

114_148

43.333333333333336

248.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000402794

114_148

222.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000402922

114_148

222.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000403096

114_148

246.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000404205

114_148

198.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000418971

114_148

57.333333333333336

286.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000236693

149_265

14.0

269.0

Domain

C-type lectin

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000236693

65_112

14.0

269.0

Domain

Note=Collagen-like

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000349077

149_265

43.333333333333336

272.0

Domain

C-type lectin

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000349077

65_112

43.333333333333336

272.0

Domain

Note=Collagen-like

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000382062

149_265

43.333333333333336

248.0

Domain

C-type lectin

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000382062

65_112

43.333333333333336

248.0

Domain

Note=Collagen-like

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000402794

149_265

222.0

Domain

C-type lectin

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000402794

65_112

222.0

Domain

Note=Collagen-like

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000402922

149_265

222.0

Domain

C-type lectin

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000402922

65_112

222.0

Domain

Note=Collagen-like

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000403096

149_265

246.0

Domain

C-type lectin

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000403096

65_112

246.0

Domain

Note=Collagen-like

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000404205

149_265

198.0

Domain

C-type lectin

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000404205

65_112

198.0

Domain

Note=Collagen-like

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000418971

149_265

57.333333333333336

286.0

Domain

C-type lectin

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000418971

65_112

57.333333333333336

286.0

Domain

Note=Collagen-like

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000236693

252_254

14.0

269.0

Region

Carbohydrate binding

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000349077

252_254

43.333333333333336

272.0

Region

Carbohydrate binding

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000382062

252_254

43.333333333333336

248.0

Region

Carbohydrate binding

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000402794

252_254

222.0

Region

Carbohydrate binding

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000402922

252_254

222.0

Region

Carbohydrate binding

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000403096

252_254

246.0

Region

Carbohydrate binding

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000404205

252_254

198.0

Region

Carbohydrate binding

Hgene

COLEC11

chr2:3652060

chr8:10692285

ENST00000418971

252_254

57.333333333333336

286.0

Region

Carbohydrate binding

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
COLEC11
PINX1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to COLEC11-PINX1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to COLEC11-PINX1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source