UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:COX10-INPP5K

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: COX10-INPP5K
	FusionPDB ID: 18753
	FusionGDB2.0 ID: 18753
		Hgene	Tgene
	Gene symbol	COX10	INPP5K
	Gene ID	1352	51763
	Gene name	cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10	inositol polyphosphate-5-phosphatase K
	Synonyms	-	MDCCAID\|PPS\|SKIP
	Cytomap	17p12	17p13.3
	Type of gene	protein-coding	protein-coding
	Description	protoheme IX farnesyltransferase, mitochondrialCOX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferaseCOX10, heme A:farnesyltransferase cytochrome c oxidase assembly factorcytochrome c oxidase assembly homolog 10cytochrome c	inositol polyphosphate 5-phosphatase Kphosphatidylinositol-3,4,5-trisphosphate 5-phosphatasephosphatidylinositol-4,5-bisphosphate 5-phosphataseskeletal muscle and kidney-enriched inositol phosphatase
	Modification date	20200313	20200327
	UniProtAcc	Q12887	Q9BT40
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000261643, ENST00000536205, ENST00000537334, ENST00000429152,	ENST00000320345, ENST00000397335, ENST00000406424, ENST00000421807, ENST00000542125,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 2 X 2=8	4 X 4 X 4=64
	# samples	2	5
	** MAII score	log2(2/8*10)=1.32192809488736	log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: COX10 [Title/Abstract] AND INPP5K [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	COX10(14063264)-INPP5K(1401416), # samples:1
Anticipated loss of major functional domain due to fusion event.	COX10-INPP5K seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. COX10-INPP5K seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. COX10-INPP5K seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. COX10-INPP5K seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	INPP5K	GO:0006469	negative regulation of protein kinase activity	12556481
Tgene	INPP5K	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	12556481
Tgene	INPP5K	GO:0010829	negative regulation of glucose transmembrane transport	12556481
Tgene	INPP5K	GO:0016311	dephosphorylation	21712384
Tgene	INPP5K	GO:0032869	cellular response to insulin stimulus	12556481
Tgene	INPP5K	GO:0033137	negative regulation of peptidyl-serine phosphorylation	12556481
Tgene	INPP5K	GO:0043407	negative regulation of MAP kinase activity	12556481
Tgene	INPP5K	GO:0043922	negative regulation by host of viral transcription	18774950
Tgene	INPP5K	GO:0045719	negative regulation of glycogen biosynthetic process	12556481
Tgene	INPP5K	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	18774950
Tgene	INPP5K	GO:0046627	negative regulation of insulin receptor signaling pathway	12556481
Tgene	INPP5K	GO:0046855	inositol phosphate dephosphorylation	12536145
Tgene	INPP5K	GO:0046856	phosphatidylinositol dephosphorylation	12536145\|12556481
Tgene	INPP5K	GO:0051497	negative regulation of stress fiber assembly	12556481
Tgene	INPP5K	GO:0051898	negative regulation of protein kinase B signaling	12556481
Tgene	INPP5K	GO:0051926	negative regulation of calcium ion transport	12556481
Tgene	INPP5K	GO:0071356	cellular response to tumor necrosis factor	21712384
Tgene	INPP5K	GO:0071364	cellular response to epidermal growth factor stimulus	21712384
Tgene	INPP5K	GO:0090315	negative regulation of protein targeting to membrane	12556481
Tgene	INPP5K	GO:0097178	ruffle assembly	12556481

Fusion gene breakpoints across COX10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across INPP5K (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CHOL	TCGA-W5-AA31-01A	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261643	COX10	chr17	14063264	-	ENST00000421807	INPP5K	chr17	1401416	-	2595	772	77	1342	421
ENST00000261643	COX10	chr17	14063264	-	ENST00000406424	INPP5K	chr17	1401416	-	2557	772	77	1342	421
ENST00000261643	COX10	chr17	14063264	-	ENST00000320345	INPP5K	chr17	1401416	-	2409	772	77	1342	421
ENST00000261643	COX10	chr17	14063264	-	ENST00000397335	INPP5K	chr17	1401416	-	1599	772	77	1342	421
ENST00000261643	COX10	chr17	14063264	-	ENST00000542125	INPP5K	chr17	1401416	-	1536	772	77	1342	421
ENST00000536205	COX10	chr17	14063264	-	ENST00000421807	INPP5K	chr17	1401416	-	2395	572	453	1142	229
ENST00000536205	COX10	chr17	14063264	-	ENST00000406424	INPP5K	chr17	1401416	-	2357	572	453	1142	229
ENST00000536205	COX10	chr17	14063264	-	ENST00000320345	INPP5K	chr17	1401416	-	2209	572	453	1142	229
ENST00000536205	COX10	chr17	14063264	-	ENST00000397335	INPP5K	chr17	1401416	-	1399	572	453	1142	229
ENST00000536205	COX10	chr17	14063264	-	ENST00000542125	INPP5K	chr17	1401416	-	1336	572	453	1142	229
ENST00000537334	COX10	chr17	14063264	-	ENST00000421807	INPP5K	chr17	1401416	-	2198	375	181	945	254
ENST00000537334	COX10	chr17	14063264	-	ENST00000406424	INPP5K	chr17	1401416	-	2160	375	181	945	254
ENST00000537334	COX10	chr17	14063264	-	ENST00000320345	INPP5K	chr17	1401416	-	2012	375	181	945	254
ENST00000537334	COX10	chr17	14063264	-	ENST00000397335	INPP5K	chr17	1401416	-	1202	375	181	945	254
ENST00000537334	COX10	chr17	14063264	-	ENST00000542125	INPP5K	chr17	1401416	-	1139	375	181	945	254

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261643	ENST00000421807	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.009784981	0.99021506
ENST00000261643	ENST00000406424	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.010311798	0.9896882
ENST00000261643	ENST00000320345	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.011397108	0.9886029
ENST00000261643	ENST00000397335	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.011146069	0.98885393
ENST00000261643	ENST00000542125	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.012492747	0.9875072
ENST00000536205	ENST00000421807	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.007155264	0.99284476
ENST00000536205	ENST00000406424	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.007101742	0.9928982
ENST00000536205	ENST00000320345	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.007750912	0.99224913
ENST00000536205	ENST00000397335	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.007837331	0.99216264
ENST00000536205	ENST00000542125	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.007552322	0.9924476
ENST00000537334	ENST00000421807	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.020174382	0.9798257
ENST00000537334	ENST00000406424	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.019659827	0.9803402
ENST00000537334	ENST00000320345	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.021744087	0.9782559
ENST00000537334	ENST00000397335	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.017579496	0.98242056
ENST00000537334	ENST00000542125	COX10	chr17	14063264	-	INPP5K	chr17	1401416	-	0.017093968	0.9829061

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>18753_18753_1_COX10-INPP5K_COX10_chr17_14063264_ENST00000261643_INPP5K_chr17_1401416_ENST00000320345_length(amino acids)=421AA_BP=231
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSG
QAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALA
PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSL
RGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKV

--------------------------------------------------------------

>18753_18753_2_COX10-INPP5K_COX10_chr17_14063264_ENST00000261643_INPP5K_chr17_1401416_ENST00000397335_length(amino acids)=421AA_BP=231
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSG
QAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALA
PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSL
RGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKV

--------------------------------------------------------------

>18753_18753_3_COX10-INPP5K_COX10_chr17_14063264_ENST00000261643_INPP5K_chr17_1401416_ENST00000406424_length(amino acids)=421AA_BP=231
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSG
QAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALA
PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSL
RGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKV

--------------------------------------------------------------

>18753_18753_4_COX10-INPP5K_COX10_chr17_14063264_ENST00000261643_INPP5K_chr17_1401416_ENST00000421807_length(amino acids)=421AA_BP=231
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSG
QAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALA
PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSL
RGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKV

--------------------------------------------------------------

>18753_18753_5_COX10-INPP5K_COX10_chr17_14063264_ENST00000261643_INPP5K_chr17_1401416_ENST00000542125_length(amino acids)=421AA_BP=231
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSG
QAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALA
PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSL
RGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKV

--------------------------------------------------------------

>18753_18753_6_COX10-INPP5K_COX10_chr17_14063264_ENST00000536205_INPP5K_chr17_1401416_ENST00000320345_length(amino acids)=229AA_BP=39
MICQEFWLDYPKSNSQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGIS
DHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYID

--------------------------------------------------------------

>18753_18753_7_COX10-INPP5K_COX10_chr17_14063264_ENST00000536205_INPP5K_chr17_1401416_ENST00000397335_length(amino acids)=229AA_BP=39
MICQEFWLDYPKSNSQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGIS
DHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYID

--------------------------------------------------------------

>18753_18753_8_COX10-INPP5K_COX10_chr17_14063264_ENST00000536205_INPP5K_chr17_1401416_ENST00000406424_length(amino acids)=229AA_BP=39
MICQEFWLDYPKSNSQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGIS
DHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYID

--------------------------------------------------------------

>18753_18753_9_COX10-INPP5K_COX10_chr17_14063264_ENST00000536205_INPP5K_chr17_1401416_ENST00000421807_length(amino acids)=229AA_BP=39
MICQEFWLDYPKSNSQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGIS
DHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYID

--------------------------------------------------------------

>18753_18753_10_COX10-INPP5K_COX10_chr17_14063264_ENST00000536205_INPP5K_chr17_1401416_ENST00000542125_length(amino acids)=229AA_BP=39
MICQEFWLDYPKSNSQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGIS
DHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYID

--------------------------------------------------------------

>18753_18753_11_COX10-INPP5K_COX10_chr17_14063264_ENST00000537334_INPP5K_chr17_1401416_ENST00000320345_length(amino acids)=254AA_BP=64
MVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPD
TPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVN

--------------------------------------------------------------

>18753_18753_12_COX10-INPP5K_COX10_chr17_14063264_ENST00000537334_INPP5K_chr17_1401416_ENST00000397335_length(amino acids)=254AA_BP=64
MVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPD
TPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVN

--------------------------------------------------------------

>18753_18753_13_COX10-INPP5K_COX10_chr17_14063264_ENST00000537334_INPP5K_chr17_1401416_ENST00000406424_length(amino acids)=254AA_BP=64
MVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPD
TPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVN

--------------------------------------------------------------

>18753_18753_14_COX10-INPP5K_COX10_chr17_14063264_ENST00000537334_INPP5K_chr17_1401416_ENST00000421807_length(amino acids)=254AA_BP=64
MVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPD
TPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVN

--------------------------------------------------------------

>18753_18753_15_COX10-INPP5K_COX10_chr17_14063264_ENST00000537334_INPP5K_chr17_1401416_ENST00000542125_length(amino acids)=254AA_BP=64
MVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISEKKRKPAWTDRILWRLKRQPCAGPD
TPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVN

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:14063264/chr17:1401416)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
COX10 Q12887	INPP5K Q9BT40
FUNCTION: Converts protoheme IX and farnesyl diphosphate to heme O. {ECO:0000250}.	FUNCTION: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:10753883, PubMed:16824732). Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity). {ECO:0000250\|UniProtKB:Q8C5L6, ECO:0000269\|PubMed:10753883, ECO:0000269\|PubMed:16824732, ECO:0000269\|PubMed:28190456, ECO:0000269\|PubMed:28190459}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

COX10

chr17:14063264

chr17:1401416

ENST00000261643

174_194

231.66666666666666

444.0

Transmembrane

Helical

Tgene

INPP5K

chr17:14063264

chr17:1401416

ENST00000320345

321_448

182.66666666666666

373.0

Region

Note=Required for ruffle localization

Tgene

INPP5K

chr17:14063264

chr17:1401416

ENST00000406424

321_448

182.66666666666666

373.0

Region

Note=Required for ruffle localization

Tgene

INPP5K

chr17:14063264

chr17:1401416

ENST00000421807

321_448

258.6666666666667

449.0

Region

Note=Required for ruffle localization

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

COX10

chr17:14063264

chr17:1401416

ENST00000261643

235_255

231.66666666666666

444.0

Transmembrane

Helical

Hgene

COX10

chr17:14063264

chr17:1401416

ENST00000261643

257_277

231.66666666666666

444.0

Transmembrane

Helical

Hgene

COX10

chr17:14063264

chr17:1401416

ENST00000261643

280_300

231.66666666666666

444.0

Transmembrane

Helical

Hgene

COX10

chr17:14063264

chr17:1401416

ENST00000261643

309_329

231.66666666666666

444.0

Transmembrane

Helical

Hgene

COX10

chr17:14063264

chr17:1401416

ENST00000261643

364_384

231.66666666666666

444.0

Transmembrane

Helical

Hgene

COX10

chr17:14063264

chr17:1401416

ENST00000261643

411_431

231.66666666666666

444.0

Transmembrane

Helical

Tgene

INPP5K

chr17:14063264

chr17:1401416

ENST00000320345

16_318

182.66666666666666

373.0

Region

Catalytic

Tgene

INPP5K

chr17:14063264

chr17:1401416

ENST00000406424

16_318

182.66666666666666

373.0

Region

Catalytic

Tgene

INPP5K

chr17:14063264

chr17:1401416

ENST00000421807

16_318

258.6666666666667

449.0

Region

Catalytic

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
COX10
INPP5K

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to COX10-INPP5K

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to COX10-INPP5K

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source