| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Fusion Protein:CPEB4-NRCAM |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CPEB4-NRCAM | FusionPDB ID: 18965 | FusionGDB2.0 ID: 18965 | Hgene | Tgene | Gene symbol | CPEB4 | NRCAM | Gene ID | 80315 | 4897 |
| Gene name | cytoplasmic polyadenylation element binding protein 4 | neuronal cell adhesion molecule | |
| Synonyms | CPE-BP4|hCPEB-4 | - | |
| Cytomap | 5q35.2 | 7q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytoplasmic polyadenylation element-binding protein 4CPE-binding protein 4 | neuronal cell adhesion moleculeNgCAM-related cell adhesion moleculeneuronal surface protein Bravo | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q17RY0 | Q92823 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000265085, ENST00000522336, ENST00000334035, ENST00000517880, ENST00000519467, ENST00000519835, ENST00000520867, | ENST00000522550, ENST00000351718, ENST00000379022, ENST00000379024, ENST00000379028, ENST00000413765, ENST00000425651, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 4 X 3 X 4=48 | 7 X 5 X 5=175 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: CPEB4 [Title/Abstract] AND NRCAM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CPEB4(173359503)-NRCAM(107800937), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CPEB4-NRCAM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CPEB4-NRCAM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CPEB4-NRCAM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CPEB4-NRCAM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NRCAM | GO:0045162 | clustering of voltage-gated sodium channels | 14602817 |
| Fusion gene breakpoints across CPEB4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across NRCAM (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-14-1823-01A | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - |
Top |
Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000265085 | CPEB4 | chr5 | 173359503 | + | ENST00000379028 | NRCAM | chr7 | 107800937 | - | 5434 | 2712 | 1454 | 3160 | 568 |
| ENST00000265085 | CPEB4 | chr5 | 173359503 | + | ENST00000413765 | NRCAM | chr7 | 107800937 | - | 5434 | 2712 | 1454 | 3160 | 568 |
| ENST00000265085 | CPEB4 | chr5 | 173359503 | + | ENST00000351718 | NRCAM | chr7 | 107800937 | - | 5409 | 2712 | 1454 | 3160 | 568 |
| ENST00000265085 | CPEB4 | chr5 | 173359503 | + | ENST00000379024 | NRCAM | chr7 | 107800937 | - | 4954 | 2712 | 1454 | 3160 | 568 |
| ENST00000265085 | CPEB4 | chr5 | 173359503 | + | ENST00000379022 | NRCAM | chr7 | 107800937 | - | 2957 | 2712 | 1454 | 2956 | 501 |
| ENST00000265085 | CPEB4 | chr5 | 173359503 | + | ENST00000425651 | NRCAM | chr7 | 107800937 | - | 3161 | 2712 | 1454 | 3160 | 569 |
| ENST00000522336 | CPEB4 | chr5 | 173359503 | + | ENST00000379028 | NRCAM | chr7 | 107800937 | - | 2988 | 266 | 115 | 714 | 199 |
| ENST00000522336 | CPEB4 | chr5 | 173359503 | + | ENST00000413765 | NRCAM | chr7 | 107800937 | - | 2988 | 266 | 115 | 714 | 199 |
| ENST00000522336 | CPEB4 | chr5 | 173359503 | + | ENST00000351718 | NRCAM | chr7 | 107800937 | - | 2963 | 266 | 115 | 714 | 199 |
| ENST00000522336 | CPEB4 | chr5 | 173359503 | + | ENST00000379024 | NRCAM | chr7 | 107800937 | - | 2508 | 266 | 115 | 714 | 199 |
| ENST00000522336 | CPEB4 | chr5 | 173359503 | + | ENST00000379022 | NRCAM | chr7 | 107800937 | - | 511 | 266 | 115 | 510 | 132 |
| ENST00000522336 | CPEB4 | chr5 | 173359503 | + | ENST00000425651 | NRCAM | chr7 | 107800937 | - | 715 | 266 | 115 | 714 | 200 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000265085 | ENST00000379028 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.001363733 | 0.9986363 |
| ENST00000265085 | ENST00000413765 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.001363733 | 0.9986363 |
| ENST00000265085 | ENST00000351718 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.001435671 | 0.9985643 |
| ENST00000265085 | ENST00000379024 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.00203356 | 0.9979665 |
| ENST00000265085 | ENST00000379022 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.008873552 | 0.9911265 |
| ENST00000265085 | ENST00000425651 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.003641706 | 0.99635834 |
| ENST00000522336 | ENST00000379028 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.000523509 | 0.9994765 |
| ENST00000522336 | ENST00000413765 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.000523509 | 0.9994765 |
| ENST00000522336 | ENST00000351718 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.000560638 | 0.9994393 |
| ENST00000522336 | ENST00000379024 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.000580543 | 0.99941945 |
| ENST00000522336 | ENST00000379022 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.01333938 | 0.9866606 |
| ENST00000522336 | ENST00000425651 | CPEB4 | chr5 | 173359503 | + | NRCAM | chr7 | 107800937 | - | 0.001619075 | 0.9983809 |
Top |
Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >18965_18965_1_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000265085_NRCAM_chr7_107800937_ENST00000351718_length(amino acids)=568AA_BP=419 MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDP LEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSS TIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQ LPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSW MEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLI VCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQY -------------------------------------------------------------- >18965_18965_2_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000265085_NRCAM_chr7_107800937_ENST00000379022_length(amino acids)=501AA_BP=419 MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDP LEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSS TIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQ LPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSW MEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLI -------------------------------------------------------------- >18965_18965_3_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000265085_NRCAM_chr7_107800937_ENST00000379024_length(amino acids)=568AA_BP=419 MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDP LEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSS TIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQ LPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSW MEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLI VCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQY -------------------------------------------------------------- >18965_18965_4_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000265085_NRCAM_chr7_107800937_ENST00000379028_length(amino acids)=568AA_BP=419 MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDP LEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSS TIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQ LPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSW MEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLI VCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQY -------------------------------------------------------------- >18965_18965_5_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000265085_NRCAM_chr7_107800937_ENST00000413765_length(amino acids)=568AA_BP=419 MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDP LEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSS TIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQ LPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSW MEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLI VCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQY -------------------------------------------------------------- >18965_18965_6_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000265085_NRCAM_chr7_107800937_ENST00000425651_length(amino acids)=569AA_BP=419 MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDP LEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSS TIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQ LPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSW MEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLI VCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQY -------------------------------------------------------------- >18965_18965_7_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000522336_NRCAM_chr7_107800937_ENST00000351718_length(amino acids)=199AA_BP=50 MKKSKEDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKG GKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPA -------------------------------------------------------------- >18965_18965_8_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000522336_NRCAM_chr7_107800937_ENST00000379022_length(amino acids)=132AA_BP=50 MKKSKEDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKG -------------------------------------------------------------- >18965_18965_9_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000522336_NRCAM_chr7_107800937_ENST00000379024_length(amino acids)=199AA_BP=50 MKKSKEDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKG GKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPA -------------------------------------------------------------- >18965_18965_10_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000522336_NRCAM_chr7_107800937_ENST00000379028_length(amino acids)=199AA_BP=50 MKKSKEDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKG GKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPA -------------------------------------------------------------- >18965_18965_11_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000522336_NRCAM_chr7_107800937_ENST00000413765_length(amino acids)=199AA_BP=50 MKKSKEDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKG GKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPA -------------------------------------------------------------- >18965_18965_12_CPEB4-NRCAM_CPEB4_chr5_173359503_ENST00000522336_NRCAM_chr7_107800937_ENST00000425651_length(amino acids)=200AA_BP=50 MKKSKEDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKG GKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPA -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:173359503/chr7:107800937) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CPEB4 | NRCAM |
| FUNCTION: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). {ECO:0000250|UniProtKB:Q7TN98, ECO:0000269|PubMed:22138752, ECO:0000269|PubMed:24990967, ECO:0000269|PubMed:26398195, ECO:0000269|PubMed:27857118}. | FUNCTION: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q810U4}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000265085 | + | 3 | 10 | 232_246 | 419.3333333333333 | 730.0 | Compositional bias | Note=His-rich |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000265085 | + | 3 | 10 | 302_311 | 419.3333333333333 | 730.0 | Compositional bias | Note=Poly-Gly |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000265085 | + | 3 | 10 | 1_375 | 419.3333333333333 | 730.0 | Region | Low complexity region |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 1064_1156 | 1034.3333333333333 | 1184.0 | Domain | Fibronectin type-III 5 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 1064_1156 | 1043.3333333333333 | 1193.0 | Domain | Fibronectin type-III 5 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 1191_1304 | 1034.3333333333333 | 1184.0 | Topological domain | Cytoplasmic | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 1191_1304 | 1043.3333333333333 | 1193.0 | Topological domain | Cytoplasmic | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 1191_1304 | 1155.3333333333333 | 1305.0 | Topological domain | Cytoplasmic | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 1191_1304 | 1155.3333333333333 | 1305.0 | Topological domain | Cytoplasmic | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 1168_1190 | 1034.3333333333333 | 1184.0 | Transmembrane | Helical | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 1168_1190 | 1043.3333333333333 | 1193.0 | Transmembrane | Helical | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 1168_1190 | 1155.3333333333333 | 1305.0 | Transmembrane | Helical | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 1168_1190 | 1155.3333333333333 | 1305.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000334035 | + | 1 | 9 | 232_246 | 0 | 713.0 | Compositional bias | Note=His-rich |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000334035 | + | 1 | 9 | 302_311 | 0 | 713.0 | Compositional bias | Note=Poly-Gly |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000517880 | + | 1 | 8 | 232_246 | 0 | 323.0 | Compositional bias | Note=His-rich |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000517880 | + | 1 | 8 | 302_311 | 0 | 323.0 | Compositional bias | Note=Poly-Gly |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000265085 | + | 3 | 10 | 472_563 | 419.3333333333333 | 730.0 | Domain | RRM 1 |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000265085 | + | 3 | 10 | 580_662 | 419.3333333333333 | 730.0 | Domain | RRM 2 |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000334035 | + | 1 | 9 | 472_563 | 0 | 713.0 | Domain | RRM 1 |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000334035 | + | 1 | 9 | 580_662 | 0 | 713.0 | Domain | RRM 2 |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000517880 | + | 1 | 8 | 472_563 | 0 | 323.0 | Domain | RRM 1 |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000517880 | + | 1 | 8 | 580_662 | 0 | 323.0 | Domain | RRM 2 |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000265085 | + | 3 | 10 | 541_543 | 419.3333333333333 | 730.0 | Region | RNA-binding |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000334035 | + | 1 | 9 | 1_375 | 0 | 713.0 | Region | Low complexity region |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000334035 | + | 1 | 9 | 541_543 | 0 | 713.0 | Region | RNA-binding |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000517880 | + | 1 | 8 | 1_375 | 0 | 323.0 | Region | Low complexity region |
| Hgene | CPEB4 | chr5:173359503 | chr7:107800937 | ENST00000517880 | + | 1 | 8 | 541_543 | 0 | 323.0 | Region | RNA-binding |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 141_235 | 1034.3333333333333 | 1184.0 | Domain | Note=Ig-like 2 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 267_356 | 1034.3333333333333 | 1184.0 | Domain | Note=Ig-like 3 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 361_448 | 1034.3333333333333 | 1184.0 | Domain | Note=Ig-like 4 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 454_541 | 1034.3333333333333 | 1184.0 | Domain | Note=Ig-like 5 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 46_134 | 1034.3333333333333 | 1184.0 | Domain | Note=Ig-like 1 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 545_632 | 1034.3333333333333 | 1184.0 | Domain | Note=Ig-like 6 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 649_744 | 1034.3333333333333 | 1184.0 | Domain | Fibronectin type-III 1 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 746_843 | 1034.3333333333333 | 1184.0 | Domain | Fibronectin type-III 2 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 848_950 | 1034.3333333333333 | 1184.0 | Domain | Fibronectin type-III 3 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 954_1051 | 1034.3333333333333 | 1184.0 | Domain | Fibronectin type-III 4 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 141_235 | 1043.3333333333333 | 1193.0 | Domain | Note=Ig-like 2 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 267_356 | 1043.3333333333333 | 1193.0 | Domain | Note=Ig-like 3 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 361_448 | 1043.3333333333333 | 1193.0 | Domain | Note=Ig-like 4 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 454_541 | 1043.3333333333333 | 1193.0 | Domain | Note=Ig-like 5 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 46_134 | 1043.3333333333333 | 1193.0 | Domain | Note=Ig-like 1 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 545_632 | 1043.3333333333333 | 1193.0 | Domain | Note=Ig-like 6 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 649_744 | 1043.3333333333333 | 1193.0 | Domain | Fibronectin type-III 1 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 746_843 | 1043.3333333333333 | 1193.0 | Domain | Fibronectin type-III 2 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 848_950 | 1043.3333333333333 | 1193.0 | Domain | Fibronectin type-III 3 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 954_1051 | 1043.3333333333333 | 1193.0 | Domain | Fibronectin type-III 4 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 1064_1156 | 1155.3333333333333 | 1305.0 | Domain | Fibronectin type-III 5 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 141_235 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 2 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 267_356 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 3 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 361_448 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 4 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 454_541 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 5 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 46_134 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 1 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 545_632 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 6 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 649_744 | 1155.3333333333333 | 1305.0 | Domain | Fibronectin type-III 1 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 746_843 | 1155.3333333333333 | 1305.0 | Domain | Fibronectin type-III 2 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 848_950 | 1155.3333333333333 | 1305.0 | Domain | Fibronectin type-III 3 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 954_1051 | 1155.3333333333333 | 1305.0 | Domain | Fibronectin type-III 4 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 1064_1156 | 1155.3333333333333 | 1305.0 | Domain | Fibronectin type-III 5 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 141_235 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 2 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 267_356 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 3 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 361_448 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 4 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 454_541 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 5 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 46_134 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 1 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 545_632 | 1155.3333333333333 | 1305.0 | Domain | Note=Ig-like 6 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 649_744 | 1155.3333333333333 | 1305.0 | Domain | Fibronectin type-III 1 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 746_843 | 1155.3333333333333 | 1305.0 | Domain | Fibronectin type-III 2 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 848_950 | 1155.3333333333333 | 1305.0 | Domain | Fibronectin type-III 3 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 954_1051 | 1155.3333333333333 | 1305.0 | Domain | Fibronectin type-III 4 | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000351718 | 24 | 28 | 25_1167 | 1034.3333333333333 | 1184.0 | Topological domain | Extracellular | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379024 | 26 | 30 | 25_1167 | 1043.3333333333333 | 1193.0 | Topological domain | Extracellular | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000379028 | 29 | 33 | 25_1167 | 1155.3333333333333 | 1305.0 | Topological domain | Extracellular | |
| Tgene | NRCAM | chr5:173359503 | chr7:107800937 | ENST00000425651 | 26 | 30 | 25_1167 | 1155.3333333333333 | 1305.0 | Topological domain | Extracellular |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| CPEB4 | |
| NRCAM |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to CPEB4-NRCAM |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to CPEB4-NRCAM |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies