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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CPSF6-EZH2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CPSF6-EZH2
	FusionPDB ID: 19155
	FusionGDB2.0 ID: 19155
		Hgene	Tgene
	Gene symbol	CPSF6	EZH2
	Gene ID	11052	2146
	Gene name	cleavage and polyadenylation specific factor 6	enhancer of zeste 2 polycomb repressive complex 2 subunit
	Synonyms	CFIM\|CFIM68\|CFIM72\|HPBRII-4\|HPBRII-7	ENX-1\|ENX1\|EZH2b\|KMT6\|KMT6A\|WVS\|WVS2
	Cytomap	12q15	7q36.1
	Type of gene	protein-coding	protein-coding
	Description	cleavage and polyadenylation specificity factor subunit 6CPSF 68 kDa subunitcleavage and polyadenylation specific factor 6, 68kDacleavage and polyadenylation specificity factor 68 kDa subunitcleavage factor Im complex 68 kDa subunitpre-mRNA cleavage	histone-lysine N-methyltransferase EZH2enhancer of zeste homolog 2lysine N-methyltransferase 6
	Modification date	20200313	20200329
	UniProtAcc	Q16630	Q15910
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000266679, ENST00000435070, ENST00000456847, ENST00000551516, ENST00000550987,	ENST00000320356, ENST00000350995, ENST00000460911, ENST00000476773, ENST00000478654, ENST00000483967, ENST00000541220, ENST00000536783,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	69 X 12 X 19=15732	10 X 7 X 5=350
	# samples	71	9
	** MAII score	log2(71/15732*10)=-4.46973925655087 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/350*10)=-1.95935801550265 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CPSF6 [Title/Abstract] AND EZH2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CPSF6(69656342)-EZH2(148512638), # samples:1
Anticipated loss of major functional domain due to fusion event.	CPSF6-EZH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CPSF6-EZH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CPSF6-EZH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CPSF6-EZH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CPSF6	GO:0006397	mRNA processing	14690600
Hgene	CPSF6	GO:0051262	protein tetramerization	20695905
Hgene	CPSF6	GO:0051290	protein heterotetramerization	23187700
Hgene	CPSF6	GO:1990120	messenger ribonucleoprotein complex assembly	29276085
Tgene	EZH2	GO:0000122	negative regulation of transcription by RNA polymerase II	20154697
Tgene	EZH2	GO:0010718	positive regulation of epithelial to mesenchymal transition	20154697
Tgene	EZH2	GO:0043406	positive regulation of MAP kinase activity	20154697
Tgene	EZH2	GO:0043547	positive regulation of GTPase activity	20154697
Tgene	EZH2	GO:0045814	negative regulation of gene expression, epigenetic	20154697
Tgene	EZH2	GO:0070734	histone H3-K27 methylation	24474760
Tgene	EZH2	GO:0071902	positive regulation of protein serine/threonine kinase activity	20154697

Fusion gene breakpoints across CPSF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EZH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CR-6467	CPSF6	chr12	69656342	+	EZH2	chr7	148512638	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000551516	CPSF6	chr12	69656342	+	ENST00000478654	EZH2	chr7	148512638	-	1059	172	5	796	263
ENST00000551516	CPSF6	chr12	69656342	+	ENST00000460911	EZH2	chr7	148512638	-	1184	172	5	922	305
ENST00000551516	CPSF6	chr12	69656342	+	ENST00000350995	EZH2	chr7	148512638	-	1184	172	5	922	305
ENST00000551516	CPSF6	chr12	69656342	+	ENST00000320356	EZH2	chr7	148512638	-	1184	172	5	922	305
ENST00000551516	CPSF6	chr12	69656342	+	ENST00000541220	EZH2	chr7	148512638	-	1058	172	5	796	263
ENST00000551516	CPSF6	chr12	69656342	+	ENST00000476773	EZH2	chr7	148512638	-	961	172	5	796	263
ENST00000551516	CPSF6	chr12	69656342	+	ENST00000483967	EZH2	chr7	148512638	-	1044	172	5	922	305

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000551516	ENST00000478654	CPSF6	chr12	69656342	+	EZH2	chr7	148512638	-	0.004534836	0.9954652
ENST00000551516	ENST00000460911	CPSF6	chr12	69656342	+	EZH2	chr7	148512638	-	0.002138256	0.9978618
ENST00000551516	ENST00000350995	CPSF6	chr12	69656342	+	EZH2	chr7	148512638	-	0.002138256	0.9978618
ENST00000551516	ENST00000320356	CPSF6	chr12	69656342	+	EZH2	chr7	148512638	-	0.002138256	0.9978618
ENST00000551516	ENST00000541220	CPSF6	chr12	69656342	+	EZH2	chr7	148512638	-	0.004560874	0.9954391
ENST00000551516	ENST00000476773	CPSF6	chr12	69656342	+	EZH2	chr7	148512638	-	0.00589475	0.9941052
ENST00000551516	ENST00000483967	CPSF6	chr12	69656342	+	EZH2	chr7	148512638	-	0.003241127	0.9967589

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19155_19155_1_CPSF6-EZH2_CPSF6_chr12_69656342_ENST00000551516_EZH2_chr7_148512638_ENST00000320356_length(amino acids)=305AA_BP=55
MADGVDHIDIYADVGEEFNQEAEYEREAENERGTGIVTETVTESVTESANIVIVRRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCD
SSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDV
AGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIF

--------------------------------------------------------------

>19155_19155_2_CPSF6-EZH2_CPSF6_chr12_69656342_ENST00000551516_EZH2_chr7_148512638_ENST00000350995_length(amino acids)=305AA_BP=55
MADGVDHIDIYADVGEEFNQEAEYEREAENERGTGIVTETVTESVTESANIVIVRRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCD
SSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDV
AGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIF

--------------------------------------------------------------

>19155_19155_3_CPSF6-EZH2_CPSF6_chr12_69656342_ENST00000551516_EZH2_chr7_148512638_ENST00000460911_length(amino acids)=305AA_BP=55
MADGVDHIDIYADVGEEFNQEAEYEREAENERGTGIVTETVTESVTESANIVIVRRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCD
SSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDV
AGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIF

--------------------------------------------------------------

>19155_19155_4_CPSF6-EZH2_CPSF6_chr12_69656342_ENST00000551516_EZH2_chr7_148512638_ENST00000476773_length(amino acids)=263AA_BP=55
MADGVDHIDIYADVGEEFNQEAEYEREAENERGTGIVTETVTESVTESANIVIVRRLWAAHCRKIQLKKGQNRFPGCRCKAQCNTKQCPC
YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMC

--------------------------------------------------------------

>19155_19155_5_CPSF6-EZH2_CPSF6_chr12_69656342_ENST00000551516_EZH2_chr7_148512638_ENST00000478654_length(amino acids)=263AA_BP=55
MADGVDHIDIYADVGEEFNQEAEYEREAENERGTGIVTETVTESVTESANIVIVRRLWAAHCRKIQLKKGQNRFPGCRCKAQCNTKQCPC
YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMC

--------------------------------------------------------------

>19155_19155_6_CPSF6-EZH2_CPSF6_chr12_69656342_ENST00000551516_EZH2_chr7_148512638_ENST00000483967_length(amino acids)=305AA_BP=55
MADGVDHIDIYADVGEEFNQEAEYEREAENERGTGIVTETVTESVTESANIVIVRRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCD
SSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDV
AGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIF

--------------------------------------------------------------

>19155_19155_7_CPSF6-EZH2_CPSF6_chr12_69656342_ENST00000551516_EZH2_chr7_148512638_ENST00000541220_length(amino acids)=263AA_BP=55
MADGVDHIDIYADVGEEFNQEAEYEREAENERGTGIVTETVTESVTESANIVIVRRLWAAHCRKIQLKKGQNRFPGCRCKAQCNTKQCPC
YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMC

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69656342/chr7:148512638)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CPSF6 Q16630	EZH2 Q15910
FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269\|PubMed:14690600, ECO:0000269\|PubMed:15169763, ECO:0000269\|PubMed:19864460, ECO:0000269\|PubMed:20695905, ECO:0000269\|PubMed:21295486, ECO:0000269\|PubMed:23187700, ECO:0000269\|PubMed:29276085, ECO:0000269\|PubMed:8626397, ECO:0000269\|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269\|PubMed:24130490}.	FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. {ECO:0000269\|PubMed:14532106, ECO:0000269\|PubMed:15225548, ECO:0000269\|PubMed:15231737, ECO:0000269\|PubMed:15385962, ECO:0000269\|PubMed:16179254, ECO:0000269\|PubMed:16357870, ECO:0000269\|PubMed:16618801, ECO:0000269\|PubMed:16717091, ECO:0000269\|PubMed:16936726, ECO:0000269\|PubMed:17210787, ECO:0000269\|PubMed:17344414, ECO:0000269\|PubMed:18285464, ECO:0000269\|PubMed:19026781, ECO:0000269\|PubMed:20935635, ECO:0000269\|PubMed:22323599, ECO:0000269\|PubMed:23063525, ECO:0000269\|PubMed:24474760, ECO:0000269\|PubMed:30923826}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000266679

208_398

590.0

701.3333333333334

Compositional bias

Note=Pro-rich

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000266679

490_551

590.0

701.3333333333334

Compositional bias

Note=Arg-rich

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000435070

208_398

553.0

2111.0

Compositional bias

Note=Pro-rich

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000435070

490_551

553.0

2111.0

Compositional bias

Note=Arg-rich

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000266679

202_206

590.0

701.3333333333334

Motif

GAR

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000435070

202_206

553.0

2111.0

Motif

GAR

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000266679

358_551

590.0

701.3333333333334

Region

(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000266679

404_551

590.0

701.3333333333334

Region

Sufficient for nuclear speckle localization

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000266679

405_551

590.0

701.3333333333334

Region

Necessary for RNA-binding

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000266679

510_551

590.0

701.3333333333334

Region

Sufficient for nuclear targeting

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000266679

81_161

590.0

701.3333333333334

Region

Necessary for nuclear paraspeckles localization

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000435070

358_551

553.0

2111.0

Region

(Microbial infection) Binds to HIV-1 capsid protein p24 (CA)

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000435070

404_551

553.0

2111.0

Region

Sufficient for nuclear speckle localization

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000435070

405_551

553.0

2111.0

Region

Necessary for RNA-binding

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000435070

510_551

553.0

2111.0

Region

Sufficient for nuclear targeting

Hgene

CPSF6

chr12:69656342

chr7:148512638

ENST00000435070

81_161

553.0

2111.0

Region

Necessary for nuclear paraspeckles localization

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000320356

523_605

501.6666666666667

752.0

Compositional bias

Note=Cys-rich

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000350995

523_605

457.6666666666667

708.0

Compositional bias

Note=Cys-rich

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000460911

523_605

496.6666666666667

747.0

Compositional bias

Note=Cys-rich

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000476773

523_605

487.6666666666667

696.0

Compositional bias

Note=Cys-rich

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000478654

523_605

487.6666666666667

696.0

Compositional bias

Note=Cys-rich

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000483967

523_605

487.6666666666667

738.0

Compositional bias

Note=Cys-rich

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000541220

523_605

487.6666666666667

696.0

Compositional bias

Note=Cys-rich

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000320356

503_605

501.6666666666667

752.0

Domain

CXC

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000320356

612_727

501.6666666666667

752.0

Domain

SET

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000350995

503_605

457.6666666666667

708.0

Domain

CXC

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000350995

612_727

457.6666666666667

708.0

Domain

SET

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000460911

503_605

496.6666666666667

747.0

Domain

CXC

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000460911

612_727

496.6666666666667

747.0

Domain

SET

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000476773

503_605

487.6666666666667

696.0

Domain

CXC

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000476773

612_727

487.6666666666667

696.0

Domain

SET

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000478654

503_605

487.6666666666667

696.0

Domain

CXC

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000478654

612_727

487.6666666666667

696.0

Domain

SET

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000483967

503_605

487.6666666666667

738.0

Domain

CXC

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000483967

612_727

487.6666666666667

738.0

Domain

SET

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000541220

503_605

487.6666666666667

696.0

Domain

CXC

Tgene

EZH2

chr12:69656342

chr7:148512638

ENST00000541220

612_727

487.6666666666667

696.0

Domain

SET

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CPSF6
EZH2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000320356		11	20	329_522	501.6666666666667	752.0	CDYL
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000350995		10	19	329_522	457.6666666666667	708.0	CDYL
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000460911		11	20	329_522	496.6666666666667	747.0	CDYL
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000476773		11	19	329_522	487.6666666666667	696.0	CDYL
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000478654		12	20	329_522	487.6666666666667	696.0	CDYL
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000483967		11	20	329_522	487.6666666666667	738.0	CDYL
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000541220		11	19	329_522	487.6666666666667	696.0	CDYL
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000320356		11	20	1_340	501.6666666666667	752.0	DNMT1%2C DNMT3A and DNMT3B
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000350995		10	19	1_340	457.6666666666667	708.0	DNMT1%2C DNMT3A and DNMT3B
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000460911		11	20	1_340	496.6666666666667	747.0	DNMT1%2C DNMT3A and DNMT3B
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000476773		11	19	1_340	487.6666666666667	696.0	DNMT1%2C DNMT3A and DNMT3B
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000478654		12	20	1_340	487.6666666666667	696.0	DNMT1%2C DNMT3A and DNMT3B
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000483967		11	20	1_340	487.6666666666667	738.0	DNMT1%2C DNMT3A and DNMT3B
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000541220		11	19	1_340	487.6666666666667	696.0	DNMT1%2C DNMT3A and DNMT3B
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000320356		11	20	39_68	501.6666666666667	752.0	EED
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000350995		10	19	39_68	457.6666666666667	708.0	EED
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000460911		11	20	39_68	496.6666666666667	747.0	EED
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000476773		11	19	39_68	487.6666666666667	696.0	EED
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000478654		12	20	39_68	487.6666666666667	696.0	EED
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000483967		11	20	39_68	487.6666666666667	738.0	EED
Tgene	EZH2	chr12:69656342	chr7:148512638	ENST00000541220		11	19	39_68	487.6666666666667	696.0	EED

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Related Drugs to CPSF6-EZH2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CPSF6-EZH2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source