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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CP-SOX5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CP-SOX5
	FusionPDB ID: 19208
	FusionGDB2.0 ID: 19208
		Hgene	Tgene
	Gene symbol	CP	SOX5
	Gene ID	1356	6660
	Gene name	ceruloplasmin	SRY-box transcription factor 5
	Synonyms	CP-2	L-SOX5\|L-SOX5B\|L-SOX5F\|LAMSHF
	Cytomap	3q24-q25.1	12p12.1
	Type of gene	protein-coding	protein-coding
	Description	ceruloplasminceruloplasmin (ferroxidase)	transcription factor SOX-5SRY (sex determining region Y)-box 5SRY-box 5
	Modification date	20200320	20200313
	UniProtAcc	Q8N436	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264613, ENST00000462336,	ENST00000396007, ENST00000441133, ENST00000536850, ENST00000541847, ENST00000545921, ENST00000309359, ENST00000381381, ENST00000451604, ENST00000537393, ENST00000541536, ENST00000546136,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 5 X 5=150	16 X 19 X 9=2736
	# samples	7	18
	** MAII score	log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/2736*10)=-3.92599941855622 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CP [Title/Abstract] AND SOX5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CP(148939434)-SOX5(23999127), # samples:7
Anticipated loss of major functional domain due to fusion event.	CP-SOX5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CP-SOX5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CP-SOX5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CP-SOX5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SOX5	GO:0032332	positive regulation of chondrocyte differentiation	21401405
Tgene	SOX5	GO:0061036	positive regulation of cartilage development	21401405
Tgene	SOX5	GO:0071560	cellular response to transforming growth factor beta stimulus	21401405
Tgene	SOX5	GO:2000741	positive regulation of mesenchymal stem cell differentiation	21401405

Fusion gene breakpoints across CP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SOX5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A7-A3J0-01A	CP	chr3	148939434	-	SOX5	chr12	23999127	-
ChimerDB4	BRCA	TCGA-BH-A18V-01A	CP	chr3	148939434	-	SOX5	chr12	23999127	-
ChimerDB4	BRCA	TCGA-BH-A18V-06A	CP	chr3	148939434	-	SOX5	chr12	23999127	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264613	CP	chr3	148939434	-	ENST00000546136	SOX5	chr12	23999127	-	7144	409	430	2430	666
ENST00000264613	CP	chr3	148939434	-	ENST00000381381	SOX5	chr12	23999127	-	4028	409	430	2106	558
ENST00000264613	CP	chr3	148939434	-	ENST00000309359	SOX5	chr12	23999127	-	4352	409	430	2430	666
ENST00000264613	CP	chr3	148939434	-	ENST00000451604	SOX5	chr12	23999127	-	4298	409	430	2430	666
ENST00000264613	CP	chr3	148939434	-	ENST00000537393	SOX5	chr12	23999127	-	2967	409	430	2430	666
ENST00000264613	CP	chr3	148939434	-	ENST00000541536	SOX5	chr12	23999127	-	2539	409	430	2106	558

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264613	ENST00000546136	CP	chr3	148939434	-	SOX5	chr12	23999127	-	0.000263607	0.99973637
ENST00000264613	ENST00000381381	CP	chr3	148939434	-	SOX5	chr12	23999127	-	0.001717636	0.99828243
ENST00000264613	ENST00000309359	CP	chr3	148939434	-	SOX5	chr12	23999127	-	0.002064442	0.99793553
ENST00000264613	ENST00000451604	CP	chr3	148939434	-	SOX5	chr12	23999127	-	0.002236089	0.9977639
ENST00000264613	ENST00000537393	CP	chr3	148939434	-	SOX5	chr12	23999127	-	0.005969766	0.99403024
ENST00000264613	ENST00000541536	CP	chr3	148939434	-	SOX5	chr12	23999127	-	0.006420135	0.99357986

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19208_19208_1_CP-SOX5_CP_chr3_148939434_ENST00000264613_SOX5_chr12_23999127_ENST00000309359_length(amino acids)=666AA_BP=
MSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGE
IKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPP
LMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGA
AVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVT
KAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESR
GRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDG
KKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQ

--------------------------------------------------------------

>19208_19208_2_CP-SOX5_CP_chr3_148939434_ENST00000264613_SOX5_chr12_23999127_ENST00000381381_length(amino acids)=558AA_BP=
MSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGE
IKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPP
LMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGA
AVSPTSIHTDKSTNSPPPKSKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMV
WAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQE
MRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDD

--------------------------------------------------------------

>19208_19208_3_CP-SOX5_CP_chr3_148939434_ENST00000264613_SOX5_chr12_23999127_ENST00000451604_length(amino acids)=666AA_BP=
MSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGE
IKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPP
LMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGA
AVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVT
KAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESR
GRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDG
KKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQ

--------------------------------------------------------------

>19208_19208_4_CP-SOX5_CP_chr3_148939434_ENST00000264613_SOX5_chr12_23999127_ENST00000537393_length(amino acids)=666AA_BP=
MSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGE
IKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPP
LMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGA
AVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVT
KAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESR
GRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDG
KKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQ

--------------------------------------------------------------

>19208_19208_5_CP-SOX5_CP_chr3_148939434_ENST00000264613_SOX5_chr12_23999127_ENST00000541536_length(amino acids)=558AA_BP=
MSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGE
IKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPP
LMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGA
AVSPTSIHTDKSTNSPPPKSKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMV
WAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQE
MRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDD

--------------------------------------------------------------

>19208_19208_6_CP-SOX5_CP_chr3_148939434_ENST00000264613_SOX5_chr12_23999127_ENST00000546136_length(amino acids)=666AA_BP=
MSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGE
IKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPP
LMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGA
AVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVT
KAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESR
GRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDG
KKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:148939434/chr12:23999127)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CP Q8N436	.
FUNCTION: May be involved in cell-cell interactions.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000309359

193_274

77.0

751.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000309359

448_515

77.0

751.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000381381

193_274

77.0

643.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000381381

448_515

77.0

643.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000396007

193_274

378.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000396007

448_515

378.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000451604

193_274

90.0

764.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000451604

448_515

90.0

764.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000541536

193_274

77.0

643.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000541536

448_515

77.0

643.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000545921

193_274

80.0

754.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000545921

448_515

80.0

754.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000546136

193_274

77.0

751.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000546136

448_515

77.0

751.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000309359

556_624

77.0

751.0

DNA binding

HMG box

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000381381

556_624

77.0

643.0

DNA binding

HMG box

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000396007

556_624

378.0

DNA binding

HMG box

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000451604

556_624

90.0

764.0

DNA binding

HMG box

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000541536

556_624

77.0

643.0

DNA binding

HMG box

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000545921

556_624

80.0

754.0

DNA binding

HMG box

Tgene

SOX5

chr3:148939434

chr12:23999127

ENST00000546136

556_624

77.0

751.0

DNA binding

HMG box

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

chr3:148939434

chr12:23999127

ENST00000264613

209_357

48.666666666666664

1066.0

Domain

Note=Plastocyanin-like 2

Hgene

chr3:148939434

chr12:23999127

ENST00000264613

20_200

48.666666666666664

1066.0

Domain

Note=Plastocyanin-like 1

Hgene

chr3:148939434

chr12:23999127

ENST00000264613

20_357

48.666666666666664

1066.0

Domain

Note=F5/8 type A 1

Hgene

chr3:148939434

chr12:23999127

ENST00000264613

370_560

48.666666666666664

1066.0

Domain

Note=Plastocyanin-like 3

Hgene

chr3:148939434

chr12:23999127

ENST00000264613

370_718

48.666666666666664

1066.0

Domain

Note=F5/8 type A 2

Hgene

chr3:148939434

chr12:23999127

ENST00000264613

570_718

48.666666666666664

1066.0

Domain

Note=Plastocyanin-like 4

Hgene

chr3:148939434

chr12:23999127

ENST00000264613

730_1061

48.666666666666664

1066.0

Domain

Note=F5/8 type A 3

Hgene

chr3:148939434

chr12:23999127

ENST00000264613

730_900

48.666666666666664

1066.0

Domain

Note=Plastocyanin-like 5

Hgene

chr3:148939434

chr12:23999127

ENST00000264613

908_1061

48.666666666666664

1066.0

Domain

Note=Plastocyanin-like 6

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CP_pLDDT.png

SOX5_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CP
SOX5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CP-SOX5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CP-SOX5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source