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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CRCP-ADAM22

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CRCP-ADAM22
	FusionPDB ID: 19294
	FusionGDB2.0 ID: 19294
		Hgene	Tgene
	Gene symbol	CRCP	ADAM22
	Gene ID	27297	53616
	Gene name	CGRP receptor component	ADAM metallopeptidase domain 22
	Synonyms	C17\|CGRP-RCP\|CGRPRCP\|POLR3I\|POLR3J\|RCP\|RCP9\|RPC9	ADAM 22\|EIEE61\|MDC2
	Cytomap	7q11.21	7q21.12
	Type of gene	protein-coding	protein-coding
	Description	DNA-directed RNA polymerase III subunit RPC9CGRP-receptor component proteinRNA polymerase III subunit C9calcitonin gene-related peptide-receptor component protein	disintegrin and metalloproteinase domain-containing protein 22a disintegrin and metalloproteinase domain 22metalloproteinase-disintegrin ADAM22-3metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
	Modification date	20200322	20200313
	UniProtAcc	O75575	Q9P0K1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000338592, ENST00000395326, ENST00000398684, ENST00000415001, ENST00000431089, ENST00000492264,	ENST00000476330, ENST00000265727, ENST00000315984, ENST00000398201, ENST00000398204, ENST00000398209, ENST00000439864,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 3 X 3=36	5 X 5 X 4=100
	# samples	4	6
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CRCP [Title/Abstract] AND ADAM22 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CRCP(65579957)-ADAM22(87704941), # samples:3
Anticipated loss of major functional domain due to fusion event.	CRCP-ADAM22 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CRCP-ADAM22 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CRCP	GO:0006383	transcription by RNA polymerase III	12482973

Fusion gene breakpoints across CRCP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAM22 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-C5-A7CM-01A	CRCP	chr7	65579957	-	ADAM22	chr7	87704941	+
ChimerDB4	CESC	TCGA-C5-A7CM-01A	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000395326	CRCP	chr7	65579957	+	ENST00000398204	ADAM22	chr7	87704941	+	9054	366	358	2655	765
ENST00000395326	CRCP	chr7	65579957	+	ENST00000439864	ADAM22	chr7	87704941	+	2404	366	358	1071	237
ENST00000395326	CRCP	chr7	65579957	+	ENST00000398201	ADAM22	chr7	87704941	+	2708	366	358	2622	754
ENST00000395326	CRCP	chr7	65579957	+	ENST00000265727	ADAM22	chr7	87704941	+	2855	366	358	2763	801
ENST00000395326	CRCP	chr7	65579957	+	ENST00000315984	ADAM22	chr7	87704941	+	3384	366	358	2742	794
ENST00000395326	CRCP	chr7	65579957	+	ENST00000398209	ADAM22	chr7	87704941	+	9141	366	358	2742	794
ENST00000398684	CRCP	chr7	65579957	+	ENST00000398204	ADAM22	chr7	87704941	+	8818	130	122	2419	765
ENST00000398684	CRCP	chr7	65579957	+	ENST00000439864	ADAM22	chr7	87704941	+	2168	130	122	835	237
ENST00000398684	CRCP	chr7	65579957	+	ENST00000398201	ADAM22	chr7	87704941	+	2472	130	122	2386	754
ENST00000398684	CRCP	chr7	65579957	+	ENST00000265727	ADAM22	chr7	87704941	+	2619	130	122	2527	801
ENST00000398684	CRCP	chr7	65579957	+	ENST00000315984	ADAM22	chr7	87704941	+	3148	130	122	2506	794
ENST00000398684	CRCP	chr7	65579957	+	ENST00000398209	ADAM22	chr7	87704941	+	8905	130	122	2506	794
ENST00000338592	CRCP	chr7	65579957	+	ENST00000398204	ADAM22	chr7	87704941	+	8809	121	113	2410	765
ENST00000338592	CRCP	chr7	65579957	+	ENST00000439864	ADAM22	chr7	87704941	+	2159	121	113	826	237
ENST00000338592	CRCP	chr7	65579957	+	ENST00000398201	ADAM22	chr7	87704941	+	2463	121	113	2377	754
ENST00000338592	CRCP	chr7	65579957	+	ENST00000265727	ADAM22	chr7	87704941	+	2610	121	113	2518	801
ENST00000338592	CRCP	chr7	65579957	+	ENST00000315984	ADAM22	chr7	87704941	+	3139	121	113	2497	794
ENST00000338592	CRCP	chr7	65579957	+	ENST00000398209	ADAM22	chr7	87704941	+	8896	121	113	2497	794

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000395326	ENST00000398204	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000326269	0.9996737
ENST00000395326	ENST00000439864	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000800358	0.9991997
ENST00000395326	ENST00000398201	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000601681	0.99939835
ENST00000395326	ENST00000265727	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000583826	0.99941623
ENST00000395326	ENST00000315984	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000438109	0.99956185
ENST00000395326	ENST00000398209	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000267175	0.9997328
ENST00000398684	ENST00000398204	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000321514	0.9996785
ENST00000398684	ENST00000439864	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000716582	0.9992835
ENST00000398684	ENST00000398201	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000564343	0.9994356
ENST00000398684	ENST00000265727	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.00059887	0.9994011
ENST00000398684	ENST00000315984	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000463551	0.9995365
ENST00000398684	ENST00000398209	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000262589	0.99973744
ENST00000338592	ENST00000398204	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000320589	0.99967945
ENST00000338592	ENST00000439864	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000607111	0.99939287
ENST00000338592	ENST00000398201	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000560343	0.99943966
ENST00000338592	ENST00000265727	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000599047	0.999401
ENST00000338592	ENST00000315984	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000464869	0.9995352
ENST00000338592	ENST00000398209	CRCP	chr7	65579957	+	ADAM22	chr7	87704941	+	0.000261801	0.99973816

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19294_19294_1_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000338592_ADAM22_chr7_87704941_ENST00000265727_length(amino acids)=801AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDIC

--------------------------------------------------------------

>19294_19294_2_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000338592_ADAM22_chr7_87704941_ENST00000315984_length(amino acids)=794AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYNNIFNFRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEYL

--------------------------------------------------------------

>19294_19294_3_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000338592_ADAM22_chr7_87704941_ENST00000398201_length(amino acids)=754AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDIC

--------------------------------------------------------------

>19294_19294_4_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000338592_ADAM22_chr7_87704941_ENST00000398204_length(amino acids)=765AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTETL

--------------------------------------------------------------

>19294_19294_5_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000338592_ADAM22_chr7_87704941_ENST00000398209_length(amino acids)=794AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEYL

--------------------------------------------------------------

>19294_19294_6_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000338592_ADAM22_chr7_87704941_ENST00000439864_length(amino acids)=237AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI

--------------------------------------------------------------

>19294_19294_7_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000395326_ADAM22_chr7_87704941_ENST00000265727_length(amino acids)=801AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDIC

--------------------------------------------------------------

>19294_19294_8_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000395326_ADAM22_chr7_87704941_ENST00000315984_length(amino acids)=794AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYNNIFNFRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEYL

--------------------------------------------------------------

>19294_19294_9_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000395326_ADAM22_chr7_87704941_ENST00000398201_length(amino acids)=754AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDIC

--------------------------------------------------------------

>19294_19294_10_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000395326_ADAM22_chr7_87704941_ENST00000398204_length(amino acids)=765AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTETL

--------------------------------------------------------------

>19294_19294_11_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000395326_ADAM22_chr7_87704941_ENST00000398209_length(amino acids)=794AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEYL

--------------------------------------------------------------

>19294_19294_12_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000395326_ADAM22_chr7_87704941_ENST00000439864_length(amino acids)=237AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI

--------------------------------------------------------------

>19294_19294_13_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000398684_ADAM22_chr7_87704941_ENST00000265727_length(amino acids)=801AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDIC

--------------------------------------------------------------

>19294_19294_14_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000398684_ADAM22_chr7_87704941_ENST00000315984_length(amino acids)=794AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYNNIFNFRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEYL

--------------------------------------------------------------

>19294_19294_15_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000398684_ADAM22_chr7_87704941_ENST00000398201_length(amino acids)=754AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDIC

--------------------------------------------------------------

>19294_19294_16_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000398684_ADAM22_chr7_87704941_ENST00000398204_length(amino acids)=765AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTETL

--------------------------------------------------------------

>19294_19294_17_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000398684_ADAM22_chr7_87704941_ENST00000398209_length(amino acids)=794AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI
VLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLA
HNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAE
CVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCK
YIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEED
VDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGT
NIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEYL

--------------------------------------------------------------

>19294_19294_18_CRCP-ADAM22_CRCP_chr7_65579957_ENST00000398684_ADAM22_chr7_87704941_ENST00000439864_length(amino acids)=237AA_BP=3
MEVDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEF
SLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRI

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:65579957/chr7:87704941)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CRCP O75575	ADAM22 Q9P0K1
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.; FUNCTION: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.	FUNCTION: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269\|PubMed:12589811, ECO:0000269\|PubMed:15882968, ECO:0000269\|PubMed:16385342, ECO:0000269\|PubMed:19692335}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000265727

532_678

107.66666666666667

907.0

Compositional bias

Note=Cys-rich

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398201

532_678

107.66666666666667

860.0

Compositional bias

Note=Cys-rich

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398204

532_678

107.66666666666667

871.0

Compositional bias

Note=Cys-rich

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398209

532_678

107.66666666666667

900.0

Compositional bias

Note=Cys-rich

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000265727

239_438

107.66666666666667

907.0

Domain

Peptidase M12B

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000265727

444_531

107.66666666666667

907.0

Domain

Disintegrin

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000265727

675_712

107.66666666666667

907.0

Domain

Note=EGF-like

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398201

239_438

107.66666666666667

860.0

Domain

Peptidase M12B

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398201

444_531

107.66666666666667

860.0

Domain

Disintegrin

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398201

675_712

107.66666666666667

860.0

Domain

Note=EGF-like

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398204

239_438

107.66666666666667

871.0

Domain

Peptidase M12B

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398204

444_531

107.66666666666667

871.0

Domain

Disintegrin

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398204

675_712

107.66666666666667

871.0

Domain

Note=EGF-like

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398209

239_438

107.66666666666667

900.0

Domain

Peptidase M12B

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398209

444_531

107.66666666666667

900.0

Domain

Disintegrin

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398209

675_712

107.66666666666667

900.0

Domain

Note=EGF-like

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000265727

223_736

107.66666666666667

907.0

Topological domain

Extracellular

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000265727

758_906

107.66666666666667

907.0

Topological domain

Cytoplasmic

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398201

223_736

107.66666666666667

860.0

Topological domain

Extracellular

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398201

758_906

107.66666666666667

860.0

Topological domain

Cytoplasmic

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398204

223_736

107.66666666666667

871.0

Topological domain

Extracellular

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398204

758_906

107.66666666666667

871.0

Topological domain

Cytoplasmic

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398209

223_736

107.66666666666667

900.0

Topological domain

Extracellular

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398209

758_906

107.66666666666667

900.0

Topological domain

Cytoplasmic

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000265727

737_757

107.66666666666667

907.0

Transmembrane

Helical

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398201

737_757

107.66666666666667

860.0

Transmembrane

Helical

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398204

737_757

107.66666666666667

871.0

Transmembrane

Helical

Tgene

ADAM22

chr7:65579957

chr7:87704941

ENST00000398209

737_757

107.66666666666667

900.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CRCP
ADAM22

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CRCP-ADAM22

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CRCP-ADAM22

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source