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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CREBBP-ADCY9

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CREBBP-ADCY9
FusionPDB ID: 19349
FusionGDB2.0 ID: 19349
HgeneTgene
Gene symbol

CREBBP

ADCY9

Gene ID

1387

115

Gene nameCREB binding proteinadenylate cyclase 9
SynonymsCBP|KAT3A|MKHK1|RSTS|RSTS1AC9|ACIX
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionCREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBPadenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyase
Modification date2020032920200313
UniProtAcc

Q92793

O60503

Ensembl transtripts involved in fusion geneENST idsENST00000262367, ENST00000382070, 
ENST00000571889, ENST00000294016, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score43 X 38 X 17=277788 X 7 X 6=336
# samples 619
** MAII scorelog2(61/27778*10)=-5.50898967694577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CREBBP [Title/Abstract] AND ADCY9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ADCY9(4163751)-CREBBP(3901010), # samples:2
CREBBP(3929833)-ADCY9(4016967), # samples:2
Anticipated loss of major functional domain due to fusion event.ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

HgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

HgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

HgeneCREBBP

GO:0016573

histone acetylation

11742995

HgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

HgeneCREBBP

GO:0034644

cellular response to UV

24939902

HgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

HgeneCREBBP

GO:1990258

histone glutamine methylation

30540930

TgeneADCY9

GO:0006171

cAMP biosynthetic process

9628827|10987815

TgeneADCY9

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

9628827


check buttonFusion gene breakpoints across CREBBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADCY9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-UY-A9PB-01ACREBBPchr16

3929833

-ADCY9chr16

4016967

-
ChimerDB4ESCATCGA-L5-A43M-01ACREBBPchr16

3929833

-ADCY9chr16

4043511

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262367CREBBPchr163929833-ENST00000294016ADCY9chr164043511-61978958143072752
ENST00000382070CREBBPchr163929833-ENST00000294016ADCY9chr164043511-55912892082466752

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262367ENST00000294016CREBBPchr163929833-ADCY9chr164043511-0.00178650.9982135
ENST00000382070ENST00000294016CREBBPchr163929833-ADCY9chr164043511-0.0014755050.9985245

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19349_19349_1_CREBBP-ADCY9_CREBBP_chr16_3929833_ENST00000262367_ADCY9_chr16_4043511_ENST00000294016_length(amino acids)=752AA_BP=27
MRTCWTDRPTPKEPNSARPVSRRMTAQTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTS
LCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFA
SPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAI
LVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERN
PCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYS
KNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEF
AKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNV
KGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEER

--------------------------------------------------------------

>19349_19349_2_CREBBP-ADCY9_CREBBP_chr16_3929833_ENST00000382070_ADCY9_chr16_4043511_ENST00000294016_length(amino acids)=752AA_BP=27
MRTCWTDRPTPKEPNSARPVSRRMTAQTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTS
LCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFA
SPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCIGAI
LVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERN
PCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYS
KNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEF
AKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNV
KGKGQMKTYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEER

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:4163751/chr16:3901010)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREBBP

Q92793

ADCY9

O60503

FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.FUNCTION: Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADCY9chr16:3929833chr16:4016967ENST000002940169111058_1198956.66666666666661354.0DomainGuanylate cyclase 2
TgeneADCY9chr16:3929833chr16:4043511ENST000002940162111058_1198628.01354.0DomainGuanylate cyclase 2
TgeneADCY9chr16:3929833chr16:4016967ENST000002940169111185_1187956.66666666666661354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST000002940169111192_1196956.66666666666661354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST000002940162111185_1187628.01354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST000002940162111192_1196628.01354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911997_1353956.66666666666661354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211808_818628.01354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211840_867628.01354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211889_891628.01354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211913_920628.01354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211942_975628.01354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211997_1353628.01354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911976_996956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211787_807628.01354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211819_839628.01354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211868_888628.01354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211892_912628.01354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211921_941628.01354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211976_996628.01354.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311061_106428.3333333333333322443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311199_148728.3333333333333322443.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311555_156228.3333333333333322443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311943_194828.3333333333333322443.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311967_197028.3333333333333322443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312081_208528.3333333333333322443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312199_221628.3333333333333322443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312245_224828.3333333333333322443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312297_230028.3333333333333322443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301061_106428.3333333333333322405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301199_148728.3333333333333322405.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301555_156228.3333333333333322405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301943_194828.3333333333333322405.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301967_197028.3333333333333322405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302081_208528.3333333333333322405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302199_221628.3333333333333322405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302245_224828.3333333333333322405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302297_230028.3333333333333322405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311061_106428.3333333333333322443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311199_148728.3333333333333322443.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311555_156228.3333333333333322443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311943_194828.3333333333333322443.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311967_197028.3333333333333322443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312081_208528.3333333333333322443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312199_221628.3333333333333322443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312245_224828.3333333333333322443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312297_230028.3333333333333322443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301061_106428.3333333333333322405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301199_148728.3333333333333322405.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301555_156228.3333333333333322405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301943_194828.3333333333333322405.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301967_197028.3333333333333322405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302081_208528.3333333333333322405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302199_221628.3333333333333322405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302245_224828.3333333333333322405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302297_230028.3333333333333322405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311103_117528.3333333333333322443.0DomainBromo
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311323_170028.3333333333333322443.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-131587_66628.3333333333333322443.0DomainKIX
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301103_117528.3333333333333322405.0DomainBromo
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301323_170028.3333333333333322405.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-130587_66628.3333333333333322405.0DomainKIX
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311103_117528.3333333333333322443.0DomainBromo
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311323_170028.3333333333333322443.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-131587_66628.3333333333333322443.0DomainKIX
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301103_117528.3333333333333322405.0DomainBromo
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301323_170028.3333333333333322405.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-130587_66628.3333333333333322405.0DomainKIX
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311434_143628.3333333333333322443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311446_144728.3333333333333322443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301434_143628.3333333333333322405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301446_144728.3333333333333322405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311434_143628.3333333333333322443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311446_144728.3333333333333322443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301434_143628.3333333333333322405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301446_144728.3333333333333322405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311701_174428.3333333333333322443.0Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311765_184628.3333333333333322443.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-131347_43328.3333333333333322443.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301701_174428.3333333333333322405.0Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301765_184628.3333333333333322405.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-130347_43328.3333333333333322405.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311701_174428.3333333333333322443.0Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311765_184628.3333333333333322443.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-131347_43328.3333333333333322443.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301701_174428.3333333333333322405.0Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301765_184628.3333333333333322405.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-130347_43328.3333333333333322405.0Zinc fingerTAZ-type 1
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911394_521956.66666666666661354.0DomainGuanylate cyclase 1
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211394_521628.01354.0DomainGuanylate cyclase 1
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911399_404956.66666666666661354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911441_443956.66666666666661354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211399_404628.01354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211441_443628.01354.0Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911139_141956.66666666666661354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911163_171956.66666666666661354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911193_215956.66666666666661354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST000002940169111_117956.66666666666661354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911236_241956.66666666666661354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911260_280956.66666666666661354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911302_786956.66666666666661354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911808_818956.66666666666661354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911840_867956.66666666666661354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911889_891956.66666666666661354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911913_920956.66666666666661354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911942_975956.66666666666661354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211139_141628.01354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211163_171628.01354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211193_215628.01354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST000002940162111_117628.01354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211236_241628.01354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211260_280628.01354.0Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211302_786628.01354.0Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911118_138956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911142_162956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911172_192956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911216_235956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911242_259956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911281_301956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911787_807956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911819_839956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911868_888956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911892_912956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016911921_941956.66666666666661354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211118_138628.01354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211142_162628.01354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211172_192628.01354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211216_235628.01354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211242_259628.01354.0TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016211281_301628.01354.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
CREBBPEGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, tat, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, K8, MTDH, MEIS1, LDLR, vIRF-1, vIRF-3, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, Ctnnb1, Cebpb, EID3, POU2F3, Spi1, Nfic, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, HCVgp1, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, HHV8GK18_gp81, Ar, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, E7, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, E6, SUMO1, NFATC1, CPSF4, USP7, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25, HNRNPL, DUX4, HLF, EGLN3, FGF2, TH, FBXL19, USP14, BBC3, RBBP5, GATA3, BYRF1, TP53BP1, KIAA1429, ATF7IP, ATRX, CASP8AP2, CBX4, CHAF1A, CHD3, EIF3D, GATAD2A, HIPK3, HMGXB4, FBXO38, PIAS2, PPP1R8, PPP2R2A, PTPRF, RNF111, RPL3, RPL35, SETDB1, SP100, TOPORS, UIMC1, ZCCHC7, ZMYM2, ZNF451, ZNF106, HIPK1, PIAS1, FAF1, KISS1, ZHX1, ZMYM5, ZNFX1, WDR77, PPP1CC, BRIP1, CCAR2, HSPB1, MAPT, PNKP, PPP1CA, POLR1E, DDX3X, TSPYL2, PYCR1, TRIM24, SMG7, AFP, BRD4, KDM2B, ACSS1, ACTB, ANKS1A, ANKS1B, ANXA7, APP, BAG5, TUBB, CNTRL, CEP290, CHRDL1, CLASP2, EEF1A1, EEF2, EIF4G2, FUS, GAA, GPR161, GRIA3, GSTO2, HEXA, HIVEP1, HIVEP2, HMG20A, HUWE1, IQGAP1, KDM6B, KDM2A, CAMSAP2, EPG5, KIF5A, MAP1B, MYO1E, OGT, PAPPA, PAX6, PHLDA1, RAD50, RBM24, RBM5, RFK, RNF7, RPS20, EXOC5, SEMA3B, SEPT3, SLC1A4, SNAPC5, SNRNP200, SOS2, SPTAN1, SYT1, TIAL1, TIAM1, TP53BP2, KDM6A, VAT1L, WAS, YTHDF2, BCAT2, CDC25A, TERF2IP, TGM1, BAG2, GMEB2, HIST1H2AB, LATS1, RXRA, NEUROD1, CIITA, FOXH1, T, ERG, ETV4, FEV, FOXI1, FOXQ1, GATA2, HNF1B, KLF15, LHX3, NFIA, NFIB, PAX7, PAX8, SOX9, SP7, TAL1, TEAD1, TLX1, SNAI2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CREBBPall structure
ADCY9


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311162_118028.3333333333333322443.0ASF1A
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301162_118028.3333333333333322405.0ASF1A
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311162_118028.3333333333333322443.0ASF1A
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301162_118028.3333333333333322405.0ASF1A
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311433_143528.3333333333333322443.0histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301433_143528.3333333333333322405.0histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311433_143528.3333333333333322443.0histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301433_143528.3333333333333322405.0histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311124_117028.3333333333333322443.0histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301124_117028.3333333333333322405.0histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311124_117028.3333333333333322443.0histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301124_117028.3333333333333322405.0histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-131227_41028.3333333333333322443.0SRCAP
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-130227_41028.3333333333333322405.0SRCAP
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-131227_41028.3333333333333322443.0SRCAP
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-130227_41028.3333333333333322405.0SRCAP
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311460_189128.3333333333333322443.0TRERF1
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301460_189128.3333333333333322405.0TRERF1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311460_189128.3333333333333322443.0TRERF1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301460_189128.3333333333333322405.0TRERF1


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Related Drugs to CREBBP-ADCY9


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CREBBP-ADCY9


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCREBBPC4551859RUBINSTEIN-TAYBI SYNDROME 112CLINGEN;GENOMICS_ENGLAND;UNIPROT
HgeneCREBBPC0035934Rubinstein-Taybi Syndrome6CLINGEN;CTD_human
HgeneCREBBPC0033578Prostatic Neoplasms2CTD_human
HgeneCREBBPC0376358Malignant neoplasm of prostate2CTD_human
HgeneCREBBPC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
HgeneCREBBPC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneCREBBPC0005695Bladder Neoplasm1CTD_human
HgeneCREBBPC0007137Squamous cell carcinoma1CTD_human
HgeneCREBBPC0007138Carcinoma, Transitional Cell1CTD_human
HgeneCREBBPC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneCREBBPC0011573Endogenous depression1PSYGENET
HgeneCREBBPC0024301Lymphoma, Follicular1CTD_human
HgeneCREBBPC0036920Sezary Syndrome1CTD_human
HgeneCREBBPC0079745Lymphoma, Large-Cell, Follicular1CTD_human
HgeneCREBBPC0079758Lymphoma, Mixed-Cell, Follicular1CTD_human
HgeneCREBBPC0079765Lymphoma, Small Cleaved-Cell, Follicular1CTD_human
HgeneCREBBPC0149925Small cell carcinoma of lung1CTD_human
HgeneCREBBPC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneCREBBPC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneCREBBPC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneCREBBPC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgeneCREBBPC1956130Lymphoma, Follicular, Grade 11CTD_human
HgeneCREBBPC1956131Lymphoma, Follicular, Grade 31CTD_human
HgeneCREBBPC1956132Lymphoma, Follicular, Grade 21CTD_human
HgeneCREBBPC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human