UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CREBBP-GOLGA6L2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CREBBP-GOLGA6L2
	FusionPDB ID: 19363
	FusionGDB2.0 ID: 19363
		Hgene	Tgene
	Gene symbol	CREBBP	GOLGA6L2
	Gene ID	1387	283685
	Gene name	CREB binding protein	golgin A6 family like 2
	Synonyms	CBP\|KAT3A\|MKHK1\|RSTS\|RSTS1	CT105
	Cytomap	16p13.3	15q11.2
	Type of gene	protein-coding	protein-coding
	Description	CREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBP	golgin subfamily A member 6-like protein 2cancer/testis antigen 105golgi autoantigen, golgin subfamily a, 6-like 2
	Modification date	20200329	20200313
	UniProtAcc	Q92793	Q8N9W4
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262367, ENST00000382070,	ENST00000312015, ENST00000345070, ENST00000567107,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	43 X 38 X 17=27778	2 X 2 X 2=8
	# samples	61	2
	** MAII score	log2(61/27778*10)=-5.50898967694577 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: CREBBP [Title/Abstract] AND GOLGA6L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CREBBP(3900298)-GOLGA6L2(23690585), # samples:2
Anticipated loss of major functional domain due to fusion event.	CREBBP-GOLGA6L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-GOLGA6L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CREBBP	GO:0000122	negative regulation of transcription by RNA polymerase II	21539536
Hgene	CREBBP	GO:0006355	regulation of transcription, DNA-templated	12169688
Hgene	CREBBP	GO:0006473	protein acetylation	15273251\|24207024\|24939902\|28790157\|30540930
Hgene	CREBBP	GO:0016573	histone acetylation	11742995
Hgene	CREBBP	GO:0018076	N-terminal peptidyl-lysine acetylation	12435739
Hgene	CREBBP	GO:0034644	cellular response to UV	24939902
Hgene	CREBBP	GO:0045893	positive regulation of transcription, DNA-templated	11742995
Hgene	CREBBP	GO:1990258	histone glutamine methylation	30540930

Fusion gene breakpoints across CREBBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GOLGA6L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-KT-A7W1-01A	CREBBP	chr16	3900298	-	GOLGA6L2	chr15	23690585	-
ChimerDB4	LGG	TCGA-KT-A7W1	CREBBP	chr16	3900298	-	GOLGA6L2	chr15	23690585	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262367	CREBBP	chr16	3900298	-	ENST00000567107	GOLGA6L2	chr15	23690585	-	4501	1608	606	4253	1215
ENST00000382070	CREBBP	chr16	3900298	-	ENST00000567107	GOLGA6L2	chr15	23690585	-	3895	1002	0	3647	1215

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262367	ENST00000567107	CREBBP	chr16	3900298	-	GOLGA6L2	chr15	23690585	-	0.014071875	0.9859282
ENST00000382070	ENST00000567107	CREBBP	chr16	3900298	-	GOLGA6L2	chr15	23690585	-	0.020314362	0.9796856

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19363_19363_1_CREBBP-GOLGA6L2_CREBBP_chr16_3900298_ENST00000262367_GOLGA6L2_chr15_23690585_ENST00000567107_length(amino acids)=1215AA_BP=566
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFTDYRQWNIAGVGTRATDTKKKKINN
GTNPETTTSEGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALS
QAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL
RLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR
EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR
EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE
KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDVETGGEAAGAGEADVGAGGEDAGSGAEDVGPGGEDVGAGREAAGEGGENA
GAEEDVAAGGEDAGGEEDAGAGEEDMGPGGEDARGGEDAGAGEEDAGGGGDDAGAGGEDAGAGREDAGAGGEDVGAGREDAGAGGEDVGA
GGEDVGAGRRRCGSSRGCRNRRRSCGNTRRCRSRRSGAEDVGPEGEDVGAGREAAGEGGENAGAEDVAAGGEDAGEEEDAGGEDAGAARE
DAGAGGDDVGAGREDAGAGGEDVGAGGEDAGAGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDVGPGGEDVGAGG

--------------------------------------------------------------

>19363_19363_2_CREBBP-GOLGA6L2_CREBBP_chr16_3900298_ENST00000382070_GOLGA6L2_chr15_23690585_ENST00000567107_length(amino acids)=1215AA_BP=566
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFTDYRQWNIAGVGTRATDTKKKKINN
GTNPETTTSEGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALS
QAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL
RLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR
EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR
EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE
KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDVETGGEAAGAGEADVGAGGEDAGSGAEDVGPGGEDVGAGREAAGEGGENA
GAEEDVAAGGEDAGGEEDAGAGEEDMGPGGEDARGGEDAGAGEEDAGGGGDDAGAGGEDAGAGREDAGAGGEDVGAGREDAGAGGEDVGA
GGEDVGAGRRRCGSSRGCRNRRRSCGNTRRCRSRRSGAEDVGPEGEDVGAGREAAGEGGENAGAEDVAAGGEDAGEEEDAGGEDAGAARE
DAGAGGDDVGAGREDAGAGGEDVGAGGEDAGAGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDVGPGGEDVGAGG

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:3900298/chr15:23690585)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CREBBP Q92793	GOLGA6L2 Q8N9W4
FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269\|PubMed:10490106, ECO:0000269\|PubMed:11154691, ECO:0000269\|PubMed:12738767, ECO:0000269\|PubMed:12929931, ECO:0000269\|PubMed:14645221, ECO:0000269\|PubMed:24207024, ECO:0000269\|PubMed:24616510, ECO:0000269\|PubMed:24939902, ECO:0000269\|PubMed:25514493, ECO:0000269\|PubMed:28790157, ECO:0000269\|PubMed:30540930, ECO:0000269\|PubMed:9707565}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GOLGA6L2

chr16:3900298

chr15:23690585

ENST00000312015

192_526

28.0

651.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1061_1064

266.0

2443.0

Compositional bias

Note=Poly-Glu

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1199_1487

266.0

2443.0

Compositional bias

Note=Cys/His-rich

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1555_1562

266.0

2443.0

Compositional bias

Note=Poly-Glu

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1943_1948

266.0

2443.0

Compositional bias

Note=Poly-Pro

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1967_1970

266.0

2443.0

Compositional bias

Note=Poly-Gln

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

2081_2085

266.0

2443.0

Compositional bias

Note=Poly-Gln

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

2199_2216

266.0

2443.0

Compositional bias

Note=Poly-Gln

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

2245_2248

266.0

2443.0

Compositional bias

Note=Poly-Gln

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

2297_2300

266.0

2443.0

Compositional bias

Note=Poly-Gln

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1061_1064

266.0

2405.0

Compositional bias

Note=Poly-Glu

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1199_1487

266.0

2405.0

Compositional bias

Note=Cys/His-rich

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1555_1562

266.0

2405.0

Compositional bias

Note=Poly-Glu

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1943_1948

266.0

2405.0

Compositional bias

Note=Poly-Pro

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1967_1970

266.0

2405.0

Compositional bias

Note=Poly-Gln

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

2081_2085

266.0

2405.0

Compositional bias

Note=Poly-Gln

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

2199_2216

266.0

2405.0

Compositional bias

Note=Poly-Gln

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

2245_2248

266.0

2405.0

Compositional bias

Note=Poly-Gln

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

2297_2300

266.0

2405.0

Compositional bias

Note=Poly-Gln

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1103_1175

266.0

2443.0

Domain

Bromo

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1323_1700

266.0

2443.0

Domain

CBP/p300-type HAT

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

587_666

266.0

2443.0

Domain

KIX

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1103_1175

266.0

2405.0

Domain

Bromo

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1323_1700

266.0

2405.0

Domain

CBP/p300-type HAT

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

587_666

266.0

2405.0

Domain

KIX

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1434_1436

266.0

2443.0

Region

Acetyl-CoA binding

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1446_1447

266.0

2443.0

Region

Acetyl-CoA binding

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1434_1436

266.0

2405.0

Region

Acetyl-CoA binding

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1446_1447

266.0

2405.0

Region

Acetyl-CoA binding

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1701_1744

266.0

2443.0

Zinc finger

ZZ-type

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

1765_1846

266.0

2443.0

Zinc finger

TAZ-type 2

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000262367

347_433

266.0

2443.0

Zinc finger

TAZ-type 1

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1701_1744

266.0

2405.0

Zinc finger

ZZ-type

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

1765_1846

266.0

2405.0

Zinc finger

TAZ-type 2

Hgene

CREBBP

chr16:3900298

chr15:23690585

ENST00000382070

347_433

266.0

2405.0

Zinc finger

TAZ-type 1

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1936_CREBBP_3900298_GOLGA6L2_23690585_ranked_0.pdb	CREBBP	3900298	3900298	ENST00000567107	GOLGA6L2	chr15	23690585	-	MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFTDYRQWNIAGVGTRATDTKKKKINN GTNPETTTSEGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNLALS QAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL RLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDVETGGEAAGAGEADVGAGGEDAGSGAEDVGPGGEDVGAGREAAGEGGENA GAEEDVAAGGEDAGGEEDAGAGEEDMGPGGEDARGGEDAGAGEEDAGGGGDDAGAGGEDAGAGREDAGAGGEDVGAGREDAGAGGEDVGA GGEDVGAGRRRCGSSRGCRNRRRSCGNTRRCRSRRSGAEDVGPEGEDVGAGREAAGEGGENAGAEDVAAGGEDAGEEEDAGGEDAGAARE DAGAGGDDVGAGREDAGAGGEDVGAGGEDAGAGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDVGPGGEDVGAGG	1215

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CREBBP_pLDDT.png

GOLGA6L2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

CREBBP

EGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, tat, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, K8, MTDH, MEIS1, LDLR, vIRF-1, vIRF-3, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, Ctnnb1, Cebpb, EID3, POU2F3, Spi1, Nfic, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, HCVgp1, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, HHV8GK18_gp81, Ar, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, E7, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, E6, SUMO1, NFATC1, CPSF4, USP7, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25, HNRNPL, DUX4, HLF, EGLN3, FGF2, TH, FBXL19, USP14, BBC3, RBBP5, GATA3, BYRF1, TP53BP1, KIAA1429, ATF7IP, ATRX, CASP8AP2, CBX4, CHAF1A, CHD3, EIF3D, GATAD2A, HIPK3, HMGXB4, FBXO38, PIAS2, PPP1R8, PPP2R2A, PTPRF, RNF111, RPL3, RPL35, SETDB1, SP100, TOPORS, UIMC1, ZCCHC7, ZMYM2, ZNF451, ZNF106, HIPK1, PIAS1, FAF1, KISS1, ZHX1, ZMYM5, ZNFX1, WDR77, PPP1CC, BRIP1, CCAR2, HSPB1, MAPT, PNKP, PPP1CA, POLR1E, DDX3X, TSPYL2, PYCR1, TRIM24, SMG7, AFP, BRD4, KDM2B, ACSS1, ACTB, ANKS1A, ANKS1B, ANXA7, APP, BAG5, TUBB, CNTRL, CEP290, CHRDL1, CLASP2, EEF1A1, EEF2, EIF4G2, FUS, GAA, GPR161, GRIA3, GSTO2, HEXA, HIVEP1, HIVEP2, HMG20A, HUWE1, IQGAP1, KDM6B, KDM2A, CAMSAP2, EPG5, KIF5A, MAP1B, MYO1E, OGT, PAPPA, PAX6, PHLDA1, RAD50, RBM24, RBM5, RFK, RNF7, RPS20, EXOC5, SEMA3B, SEPT3, SLC1A4, SNAPC5, SNRNP200, SOS2, SPTAN1, SYT1, TIAL1, TIAM1, TP53BP2, KDM6A, VAT1L, WAS, YTHDF2, BCAT2, CDC25A, TERF2IP, TGM1, BAG2, GMEB2, HIST1H2AB, LATS1, RXRA, NEUROD1, CIITA, FOXH1, T, ERG, ETV4, FEV, FOXI1, FOXQ1, GATA2, HNF1B, KLF15, LHX3, NFIA, NFIB, PAX7, PAX8, SOX9, SP7, TAL1, TEAD1, TLX1, SNAI2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CREBBP
GOLGA6L2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CREBBP	chr16:3900298	chr15:23690585	ENST00000262367	-	2	31	1162_1180	266.0	2443.0	ASF1A
Hgene	CREBBP	chr16:3900298	chr15:23690585	ENST00000382070	-	2	30	1162_1180	266.0	2405.0	ASF1A
Hgene	CREBBP	chr16:3900298	chr15:23690585	ENST00000262367	-	2	31	1433_1435	266.0	2443.0	histone
Hgene	CREBBP	chr16:3900298	chr15:23690585	ENST00000382070	-	2	30	1433_1435	266.0	2405.0	histone
Hgene	CREBBP	chr16:3900298	chr15:23690585	ENST00000262367	-	2	31	1124_1170	266.0	2443.0	histone
Hgene	CREBBP	chr16:3900298	chr15:23690585	ENST00000382070	-	2	30	1124_1170	266.0	2405.0	histone
Hgene	CREBBP	chr16:3900298	chr15:23690585	ENST00000262367	-	2	31	227_410	266.0	2443.0	SRCAP
Hgene	CREBBP	chr16:3900298	chr15:23690585	ENST00000382070	-	2	30	227_410	266.0	2405.0	SRCAP
Hgene	CREBBP	chr16:3900298	chr15:23690585	ENST00000262367	-	2	31	1460_1891	266.0	2443.0	TRERF1
Hgene	CREBBP	chr16:3900298	chr15:23690585	ENST00000382070	-	2	30	1460_1891	266.0	2405.0	TRERF1

Top

Related Drugs to CREBBP-GOLGA6L2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CREBBP-GOLGA6L2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CREBBP	C4551859	RUBINSTEIN-TAYBI SYNDROME 1	12	CLINGEN;GENOMICS_ENGLAND;UNIPROT
Hgene	CREBBP	C0035934	Rubinstein-Taybi Syndrome	6	CLINGEN;CTD_human
Hgene	CREBBP	C0033578	Prostatic Neoplasms	2	CTD_human
Hgene	CREBBP	C0376358	Malignant neoplasm of prostate	2	CTD_human
Hgene	CREBBP	C4511003	Acute myeloid leukemia with t(8;16)(p11;p13) translocation	2	ORPHANET
Hgene	CREBBP	C0005684	Malignant neoplasm of urinary bladder	1	CTD_human
Hgene	CREBBP	C0005695	Bladder Neoplasm	1	CTD_human
Hgene	CREBBP	C0007137	Squamous cell carcinoma	1	CTD_human
Hgene	CREBBP	C0007138	Carcinoma, Transitional Cell	1	CTD_human
Hgene	CREBBP	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
Hgene	CREBBP	C0011573	Endogenous depression	1	PSYGENET
Hgene	CREBBP	C0024301	Lymphoma, Follicular	1	CTD_human
Hgene	CREBBP	C0036920	Sezary Syndrome	1	CTD_human
Hgene	CREBBP	C0079745	Lymphoma, Large-Cell, Follicular	1	CTD_human
Hgene	CREBBP	C0079758	Lymphoma, Mixed-Cell, Follicular	1	CTD_human
Hgene	CREBBP	C0079765	Lymphoma, Small Cleaved-Cell, Follicular	1	CTD_human
Hgene	CREBBP	C0149925	Small cell carcinoma of lung	1	CTD_human
Hgene	CREBBP	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Hgene	CREBBP	C0279626	Squamous cell carcinoma of esophagus	1	CTD_human
Hgene	CREBBP	C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
Hgene	CREBBP	C1862941	Amyotrophic Lateral Sclerosis, Sporadic	1	CTD_human
Hgene	CREBBP	C1956130	Lymphoma, Follicular, Grade 1	1	CTD_human
Hgene	CREBBP	C1956131	Lymphoma, Follicular, Grade 3	1	CTD_human
Hgene	CREBBP	C1956132	Lymphoma, Follicular, Grade 2	1	CTD_human
Hgene	CREBBP	C4551993	Amyotrophic Lateral Sclerosis, Familial	1	CTD_human