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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CREBBP-KMT2A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CREBBP-KMT2A
	FusionPDB ID: 19369
	FusionGDB2.0 ID: 19369
		Hgene	Tgene
	Gene symbol	CREBBP	KMT2A
	Gene ID	1387	4297
	Gene name	CREB binding protein	lysine methyltransferase 2A
	Synonyms	CBP\|KAT3A\|MKHK1\|RSTS\|RSTS1	ALL-1\|CXXC7\|HRX\|HTRX1\|MLL\|MLL1\|MLL1A\|TRX1\|WDSTS
	Cytomap	16p13.3	11q23.3
	Type of gene	protein-coding	protein-coding
	Description	CREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBP	histone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like
	Modification date	20200329	20200319
	UniProtAcc	Q92793	Q03164
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262367, ENST00000382070,	ENST00000420751, ENST00000354520, ENST00000389506, ENST00000534358,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	43 X 38 X 17=27778	31 X 72 X 3=6696
	# samples	61	79
	** MAII score	log2(61/27778*10)=-5.50898967694577 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(79/6696*10)=-3.08337496948588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CREBBP [Title/Abstract] AND KMT2A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.	CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-KMT2A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CREBBP	GO:0000122	negative regulation of transcription by RNA polymerase II	21539536
Hgene	CREBBP	GO:0006355	regulation of transcription, DNA-templated	12169688
Hgene	CREBBP	GO:0006473	protein acetylation	15273251\|24207024\|24939902\|28790157\|30540930
Hgene	CREBBP	GO:0016573	histone acetylation	11742995
Hgene	CREBBP	GO:0018076	N-terminal peptidyl-lysine acetylation	12435739
Hgene	CREBBP	GO:0034644	cellular response to UV	24939902
Hgene	CREBBP	GO:0045893	positive regulation of transcription, DNA-templated	11742995
Hgene	CREBBP	GO:1990258	histone glutamine methylation	30540930
Tgene	KMT2A	GO:0044648	histone H3-K4 dimethylation	25561738
Tgene	KMT2A	GO:0045944	positive regulation of transcription by RNA polymerase II	20861184
Tgene	KMT2A	GO:0051568	histone H3-K4 methylation	19556245
Tgene	KMT2A	GO:0065003	protein-containing complex assembly	15199122
Tgene	KMT2A	GO:0080182	histone H3-K4 trimethylation	20861184
Tgene	KMT2A	GO:0097692	histone H3-K4 monomethylation	25561738\|26324722

Fusion gene breakpoints across CREBBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KMT2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	CREBBP	chr16	3900297	-	KMT2A	chr11	118354897
ChimerKB3	.	.	CREBBP	chr16	3900297	-	KMT2A	chr11	118359328
ChimerKB3	.	.	CREBBP	chr16	3900297	-	KMT2A	chr11	118359328	+
ChimerKB4	.	.	CREBBP	chr16	3900297	-	KMT2A	chr11	118359328	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262367	CREBBP	chr16	3900297	-	ENST00000534358	KMT2A	chr11	118359328	+	13847	1608	606	9194	2862
ENST00000262367	CREBBP	chr16	3900297	-	ENST00000389506	KMT2A	chr11	118359328	+	10931	1608	606	9185	2859
ENST00000262367	CREBBP	chr16	3900297	-	ENST00000354520	KMT2A	chr11	118359328	+	11710	1608	606	9185	2859
ENST00000382070	CREBBP	chr16	3900297	-	ENST00000534358	KMT2A	chr11	118359328	+	13241	1002	0	8588	2862
ENST00000382070	CREBBP	chr16	3900297	-	ENST00000389506	KMT2A	chr11	118359328	+	10325	1002	0	8579	2859
ENST00000382070	CREBBP	chr16	3900297	-	ENST00000354520	KMT2A	chr11	118359328	+	11104	1002	0	8579	2859
ENST00000262367	CREBBP	chr16	3900297	-	ENST00000534358	KMT2A	chr11	118354897		14093	1608	606	9440	2944
ENST00000262367	CREBBP	chr16	3900297	-	ENST00000389506	KMT2A	chr11	118354897		11177	1608	606	9431	2941
ENST00000262367	CREBBP	chr16	3900297	-	ENST00000354520	KMT2A	chr11	118354897		11842	1608	606	9317	2903
ENST00000382070	CREBBP	chr16	3900297	-	ENST00000534358	KMT2A	chr11	118354897		13487	1002	0	8834	2944
ENST00000382070	CREBBP	chr16	3900297	-	ENST00000389506	KMT2A	chr11	118354897		10571	1002	0	8825	2941
ENST00000382070	CREBBP	chr16	3900297	-	ENST00000354520	KMT2A	chr11	118354897		11236	1002	0	8711	2903

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19369_19369_1_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000262367_KMT2A_chr11_118354897_ENST00000354520_length(amino acids)=2903AA_BP=334
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLNILSTLSNGNS
SKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPT
KPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEM
YEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTE
VSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNS
GMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALC
LTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVF
LDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYW
STTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIR
TPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDL
ESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYP
GIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINE
HMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVE
GSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDR
NLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTR
TVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKN
EPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGES
PESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSG
EKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKY
VPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLN
PSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRL
QTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGT
STISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMF
PQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLE
QNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGA
EAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSD
DGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARA
EVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVI
EYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKF

--------------------------------------------------------------

>19369_19369_2_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000262367_KMT2A_chr11_118354897_ENST00000389506_length(amino acids)=2941AA_BP=334
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLNILSTLSNGNS
SKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRR
CKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNF
CPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTS
HLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIK
KANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSP
TPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRG
KQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPEN
IHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSK
ESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTS
SLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEM
KQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRND
RDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEV
LTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEP
ISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFY
SSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSS
QIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTEL
LKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAE
EQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPP
CGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGV
TQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGV
QPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSS
HRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPR
LLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQL
LASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLD
KGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEE
ESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVV
FLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPM
RFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHS

--------------------------------------------------------------

>19369_19369_3_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000262367_KMT2A_chr11_118354897_ENST00000534358_length(amino acids)=2944AA_BP=334
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLNILSTLSNGNS
SKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRR
CKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNF
CPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSR
TTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQP
EIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEP
DSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAV
IRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLE
PENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTES
SSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRH
STSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSS
SEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQ
RNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFM
DEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSP
TEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDI
PFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTR
KSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYN
TELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSI
SAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHIS
SPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLP
NGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLL
IGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLN
TSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLT
NPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHV
NQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQL
PLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTV
EEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHD
AVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLP
MPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFI

--------------------------------------------------------------

>19369_19369_4_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000262367_KMT2A_chr11_118359328_ENST00000354520_length(amino acids)=2859AA_BP=334
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFVYCQVCCEPFHKFCLEENERPLEDQ
LENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA
KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTA
LLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINS
DGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPK
GPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKN
VHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKF
LNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT
SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSI
GSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHL
DGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHL
HLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL
KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQI
ESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSY
GEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSV
TATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNL
LDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSS
VSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD
ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYV
LQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNP
PSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLD
LGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG
HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHY
QLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKT
KRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESA
EPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML
GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRAT
SMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN

--------------------------------------------------------------

>19369_19369_5_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000262367_KMT2A_chr11_118359328_ENST00000389506_length(amino acids)=2859AA_BP=334
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFVYCQVCCEPFHKFCLEENERPLEDQ
LENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA
KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTA
LLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINS
DGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPK
GPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKN
VHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKF
LNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT
SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSI
GSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHL
DGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHL
HLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL
KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQI
ESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSY
GEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSV
TATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNL
LDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSS
VSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD
ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYV
LQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNP
PSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLD
LGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG
HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHY
QLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKT
KRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESA
EPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML
GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRAT
SMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN

--------------------------------------------------------------

>19369_19369_6_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000262367_KMT2A_chr11_118359328_ENST00000534358_length(amino acids)=2862AA_BP=334
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFVYCQVCCEPFHKFCLEENERPLEDQ
LENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA
KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQV
LTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAA
INSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAP
KPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGS
LKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLR
RKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAH
SPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGL
RSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKN
SHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSF
PHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEE
GNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASP
LQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGV
RSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESD
TSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSD
KNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPV
DSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQG
HMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQP
LYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNI
SNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPS
LLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSAS
VPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEAD
EHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPK
PKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQ
ESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGL
RMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSAR
RATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATM

--------------------------------------------------------------

>19369_19369_7_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000382070_KMT2A_chr11_118354897_ENST00000354520_length(amino acids)=2903AA_BP=334
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLNILSTLSNGNS
SKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPT
KPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEM
YEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTE
VSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNS
GMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALC
LTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVF
LDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYW
STTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIR
TPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDL
ESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYP
GIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINE
HMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVE
GSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDR
NLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTR
TVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKN
EPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGES
PESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSG
EKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKY
VPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLN
PSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRL
QTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGT
STISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMF
PQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLE
QNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGA
EAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSD
DGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARA
EVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVI
EYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKF

--------------------------------------------------------------

>19369_19369_8_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000382070_KMT2A_chr11_118354897_ENST00000389506_length(amino acids)=2941AA_BP=334
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLNILSTLSNGNS
SKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRR
CKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNF
CPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTS
HLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIK
KANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSP
TPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRG
KQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPEN
IHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSK
ESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTS
SLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEM
KQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRND
RDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEV
LTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEP
ISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFY
SSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSS
QIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTEL
LKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAE
EQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPP
CGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGV
TQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGV
QPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSS
HRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPR
LLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQL
LASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLD
KGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEE
ESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVV
FLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPM
RFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHS

--------------------------------------------------------------

>19369_19369_9_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000382070_KMT2A_chr11_118354897_ENST00000534358_length(amino acids)=2944AA_BP=334
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLNILSTLSNGNS
SKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRR
CKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNF
CPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSR
TTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQP
EIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEP
DSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAV
IRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLE
PENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTES
SSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRH
STSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSS
SEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQ
RNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFM
DEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSP
TEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDI
PFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTR
KSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYN
TELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSI
SAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHIS
SPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLP
NGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLL
IGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLN
TSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLT
NPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHV
NQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQL
PLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTV
EEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHD
AVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLP
MPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFI

--------------------------------------------------------------

>19369_19369_10_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000382070_KMT2A_chr11_118359328_ENST00000354520_length(amino acids)=2859AA_BP=334
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFVYCQVCCEPFHKFCLEENERPLEDQ
LENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA
KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTA
LLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINS
DGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPK
GPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKN
VHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKF
LNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT
SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSI
GSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHL
DGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHL
HLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL
KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQI
ESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSY
GEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSV
TATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNL
LDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSS
VSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD
ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYV
LQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNP
PSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLD
LGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG
HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHY
QLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKT
KRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESA
EPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML
GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRAT
SMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN

--------------------------------------------------------------

>19369_19369_11_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000382070_KMT2A_chr11_118359328_ENST00000389506_length(amino acids)=2859AA_BP=334
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFVYCQVCCEPFHKFCLEENERPLEDQ
LENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA
KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTA
LLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINS
DGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPK
GPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKN
VHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKF
LNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT
SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSI
GSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHL
DGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHL
HLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL
KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQI
ESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSY
GEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSV
TATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNL
LDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSS
VSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD
ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYV
LQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNP
PSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLD
LGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG
HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHY
QLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKT
KRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESA
EPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML
GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRAT
SMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN

--------------------------------------------------------------

>19369_19369_12_CREBBP-KMT2A_CREBBP_chr16_3900297_ENST00000382070_KMT2A_chr11_118359328_ENST00000534358_length(amino acids)=2862AA_BP=334
LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFVYCQVCCEPFHKFCLEENERPLEDQ
LENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA
KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQV
LTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAA
INSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAP
KPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGS
LKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLR
RKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAH
SPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGL
RSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKN
SHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSF
PHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEE
GNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASP
LQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGV
RSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESD
TSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSD
KNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPV
DSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQG
HMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQP
LYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNI
SNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPS
LLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSAS
VPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEAD
EHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPK
PKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQ
ESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGL
RMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSAR
RATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATM

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Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:/chr11:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CREBBP Q92793	KMT2A Q03164
FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269\|PubMed:10490106, ECO:0000269\|PubMed:11154691, ECO:0000269\|PubMed:12738767, ECO:0000269\|PubMed:12929931, ECO:0000269\|PubMed:14645221, ECO:0000269\|PubMed:24207024, ECO:0000269\|PubMed:24616510, ECO:0000269\|PubMed:24939902, ECO:0000269\|PubMed:25514493, ECO:0000269\|PubMed:28790157, ECO:0000269\|PubMed:30540930, ECO:0000269\|PubMed:9707565}.	FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

18_32

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

18_32

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1_41

266.0

2443.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

74_179

266.0

2443.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1_41

266.0

2405.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

74_179

266.0

2405.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1822_1847

1362.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2096_2118

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2146_2174

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2189_2232

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2275_2320

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2402_2418

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2419_2445

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2526_2594

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2721_2746

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2747_2784

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2785_2821

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3011_3064

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3166_3183

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3195_3222

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3230_3244

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3464_3530

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3563_3606

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1822_1847

1362.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2096_2118

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2146_2174

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2189_2232

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2275_2320

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2402_2418

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2419_2445

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2526_2594

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2721_2746

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2747_2784

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2785_2821

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3011_3064

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3166_3183

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3195_3222

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3230_3244

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3464_3530

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3563_3606

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1822_1847

1362.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2096_2118

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2146_2174

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2189_2232

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2275_2320

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2402_2418

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2419_2445

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2526_2594

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2721_2746

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2747_2784

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2785_2821

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3011_3064

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3166_3183

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3195_3222

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3230_3244

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3464_3530

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3563_3606

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1703_1748

1362.0

3932.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2018_2074

1362.0

3932.0

Domain

FYR N-terminal

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3666_3747

1362.0

3932.0

Domain

FYR C-terminal

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3829_3945

1362.0

3932.0

Domain

SET

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3953_3969

1362.0

3932.0

Domain

Post-SET

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1703_1748

1362.0

3970.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2018_2074

1362.0

3970.0

Domain

FYR N-terminal

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3666_3747

1362.0

3970.0

Domain

FYR C-terminal

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3829_3945

1362.0

3970.0

Domain

SET

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3953_3969

1362.0

3970.0

Domain

Post-SET

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1703_1748

1362.0

3973.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2018_2074

1362.0

3973.0

Domain

FYR N-terminal

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3666_3747

1362.0

3973.0

Domain

FYR C-terminal

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3829_3945

1362.0

3973.0

Domain

SET

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3953_3969

1362.0

3973.0

Domain

Post-SET

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1663_1713

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1806_1869

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2081_2133

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2145_2232

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2275_2333

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2373_2460

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2475_2618

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2647_2675

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2713_2821

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

2961_3064

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3166_3244

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3464_3608

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3620_3643

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3785_3808

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

3906_3907

1362.0

3932.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1663_1713

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1806_1869

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2081_2133

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2145_2232

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2275_2333

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2373_2460

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2475_2618

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2647_2675

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2713_2821

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

2961_3064

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3166_3244

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3464_3608

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3620_3643

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3785_3808

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

3906_3907

1362.0

3970.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1663_1713

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1806_1869

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2081_2133

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2145_2232

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2275_2333

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2373_2460

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2475_2618

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2647_2675

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2713_2821

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

2961_3064

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3166_3244

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3464_3608

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3620_3643

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3785_3808

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

3906_3907

1362.0

3973.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1431_1482

1362.0

3932.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1479_1533

1362.0

3932.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1566_1627

1362.0

3932.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1870_1910

1362.0

3932.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1931_1978

1362.0

3932.0

Zinc finger

PHD-type 4

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1431_1482

1362.0

3970.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1479_1533

1362.0

3970.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1566_1627

1362.0

3970.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1870_1910

1362.0

3970.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1931_1978

1362.0

3970.0

Zinc finger

PHD-type 4

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1431_1482

1362.0

3973.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1479_1533

1362.0

3973.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1566_1627

1362.0

3973.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1870_1910

1362.0

3973.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1931_1978

1362.0

3973.0

Zinc finger

PHD-type 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1066_1081

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1556_1571

266.0

2443.0

Compositional bias

Basic and acidic residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1588_1602

266.0

2443.0

Compositional bias

Basic residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1883_1916

266.0

2443.0

Compositional bias

Pro residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1921_1939

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1940_1954

266.0

2443.0

Compositional bias

Pro residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1977_2008

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

2112_2145

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

2160_2186

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

2193_2220

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

2239_2263

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

2294_2350

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

2351_2378

266.0

2443.0

Compositional bias

Pro residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

2395_2429

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

271_290

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

794_824

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

848_862

266.0

2443.0

Compositional bias

Pro residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

873_887

266.0

2443.0

Compositional bias

Pro residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

888_929

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

938_952

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

960_990

266.0

2443.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

998_1065

266.0

2443.0

Compositional bias

Basic and acidic residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1066_1081

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1556_1571

266.0

2405.0

Compositional bias

Basic and acidic residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1588_1602

266.0

2405.0

Compositional bias

Basic residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1883_1916

266.0

2405.0

Compositional bias

Pro residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1921_1939

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1940_1954

266.0

2405.0

Compositional bias

Pro residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1977_2008

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

2112_2145

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

2160_2186

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

2193_2220

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

2239_2263

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

2294_2350

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

2351_2378

266.0

2405.0

Compositional bias

Pro residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

2395_2429

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

271_290

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

794_824

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

848_862

266.0

2405.0

Compositional bias

Pro residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

873_887

266.0

2405.0

Compositional bias

Pro residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

888_929

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

938_952

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

960_990

266.0

2405.0

Compositional bias

Polar residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

998_1065

266.0

2405.0

Compositional bias

Basic and acidic residues

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1103_1175

266.0

2443.0

Domain

Bromo

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1323_1700

266.0

2443.0

Domain

CBP/p300-type HAT

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

587_666

266.0

2443.0

Domain

KIX

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1103_1175

266.0

2405.0

Domain

Bromo

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1323_1700

266.0

2405.0

Domain

CBP/p300-type HAT

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

587_666

266.0

2405.0

Domain

KIX

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1434_1436

266.0

2443.0

Region

Acetyl-CoA binding

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1446_1447

266.0

2443.0

Region

Acetyl-CoA binding

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1556_1615

266.0

2443.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1874_1959

266.0

2443.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1977_2028

266.0

2443.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

2112_2263

266.0

2443.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

2294_2433

266.0

2443.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

266_290

266.0

2443.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

794_1083

266.0

2443.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1434_1436

266.0

2405.0

Region

Acetyl-CoA binding

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1446_1447

266.0

2405.0

Region

Acetyl-CoA binding

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1556_1615

266.0

2405.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1874_1959

266.0

2405.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1977_2028

266.0

2405.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

2112_2263

266.0

2405.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

2294_2433

266.0

2405.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

266_290

266.0

2405.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

794_1083

266.0

2405.0

Region

Disordered

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1702_1750

266.0

2443.0

Zinc finger

ZZ-type

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

1765_1846

266.0

2443.0

Zinc finger

TAZ-type 2

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000262367

347_433

266.0

2443.0

Zinc finger

TAZ-type 1

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1702_1750

266.0

2405.0

Zinc finger

ZZ-type

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

1765_1846

266.0

2405.0

Zinc finger

TAZ-type 2

Hgene

CREBBP

chr16:3900297

chr11:118354897

ENST00000382070

347_433

266.0

2405.0

Zinc finger

TAZ-type 1

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1046_1061

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1249_1272

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1278_1302

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1303_1317

1362.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

184_203

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

204_226

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

236_253

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

325_351

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

37_58

1362.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

445_495

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

535_556

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

557_576

1362.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

713_731

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

747_780

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

798_845

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

81_103

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

846_898

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1046_1061

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1249_1272

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1278_1302

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1303_1317

1362.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

184_203

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

204_226

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

236_253

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

325_351

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

37_58

1362.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

445_495

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

535_556

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

557_576

1362.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

713_731

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

747_780

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

798_845

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

81_103

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

846_898

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1046_1061

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1249_1272

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1278_1302

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1303_1317

1362.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

184_203

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

204_226

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

236_253

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

325_351

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

37_58

1362.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

445_495

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

535_556

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

557_576

1362.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

713_731

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

747_780

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

798_845

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

81_103

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

846_898

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

169_180

1362.0

3932.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

217_227

1362.0

3932.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

301_309

1362.0

3932.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

169_180

1362.0

3970.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

217_227

1362.0

3970.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

301_309

1362.0

3970.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

169_180

1362.0

3973.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

217_227

1362.0

3973.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

301_309

1362.0

3973.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

123_134

1362.0

3932.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

147_152

1362.0

3932.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

6_25

1362.0

3932.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

123_134

1362.0

3970.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

147_152

1362.0

3970.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

6_25

1362.0

3970.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

123_134

1362.0

3973.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

147_152

1362.0

3973.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

6_25

1362.0

3973.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1038_1066

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1106_1166

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1200_1375

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

132_253

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1_108

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

301_352

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

445_585

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

713_780

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

798_949

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1038_1066

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1106_1166

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1200_1375

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

132_253

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1_108

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

301_352

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

445_585

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

713_780

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

798_949

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1038_1066

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1106_1166

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1200_1375

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

132_253

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1_108

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

301_352

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

445_585

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

713_780

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

798_949

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000354520

1147_1195

1362.0

3932.0

Zinc finger

CXXC-type

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000389506

1147_1195

1362.0

3970.0

Zinc finger

CXXC-type

Tgene

KMT2A

chr16:3900297

chr11:118354897

ENST00000534358

1147_1195

1362.0

3973.0

Zinc finger

CXXC-type

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (1215) >>>1215.pdbFusion protein BP residue: 334 CIF file (1215) >>>1215.cif	CREBBP	chr16	3900297	-	KMT2A	chr11	118359328	+	MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVR ALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGFSANDSTDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFVYCQVCCEPFHKFCL EENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECL GPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEIL SNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHL LRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEG VKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIR QMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREE NSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPE LNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEV FEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSR AKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKF LNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTD ARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKES QNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCR PLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIM SPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNT STSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKV LSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFS SKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNR SSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAK ELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPIS ASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDG SFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRS AEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCD LPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPED AGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRV HTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSM QALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSS VSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRV TITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCG SVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQIS NAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSS TPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQ HLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTT VATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPS QLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTA ATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLG TSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLA SKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPT SPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHL RTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQ VAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESI TEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLS FAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNP HGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRAT SMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAG NVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCE PNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG	2859
3D view using mol* of 1215 (AA BP:334)


PDB file (1216)	CREBBP	chr16	3900297	-	KMT2A	chr11	118359328	+	LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVR ALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGFSANDSTDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFVYCQVCCEPFHKFCL EENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECL GPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEIL SNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHL LRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEG VKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIR QMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREE NSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPE LNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEV FEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSR AKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKF LNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTD ARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKES QNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCR PLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIM SPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNT STSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKV LSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFS SKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNR SSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAK ELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPIS ASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDG SFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRS AEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCD LPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPED AGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRV HTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSM QALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSS VSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRV TITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCG SVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQIS NAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSS TPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQ HLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTT VATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPS QLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTA ATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLG TSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLA SKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPT SPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHL RTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQ VAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESI TEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLS FAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNP HGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRAT SMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAG NVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCE PNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG	2859

PDB file (1218) >>>1218.pdbFusion protein BP residue: 334 CIF file (1218) >>>1218.cif	CREBBP	chr16	3900297	-	KMT2A	chr11	118359328	+	MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVR ALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGFSANDSTDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFVYCQVCCEPFHKFCL EENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECL GPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMY EILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTT SHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLD LEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSF FIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQE REENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSRED SPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWS AEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFM CSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLR RKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWS TTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSS KESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSP GCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKL RIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLG QNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEK TKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSV SFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGM SNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEE GNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEG SAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTE PISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQ EDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRG KRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEE QCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDR PEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESS RRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNT PSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPV DSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGE KRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSP PCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPS QISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSS VSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMS HHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDL STTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINF TPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVG GTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSAS VPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFP QLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQ LLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQA SPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKV SHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQP AGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRK ESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLK QLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPP LNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSAR RATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIE YAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINH SCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPC	2862
3D view using mol* of 1218 (AA BP:334)


PDB file (1219)	CREBBP	chr16	3900297	-	KMT2A	chr11	118359328	+	LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVR ALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGFSANDSTDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKFVYCQVCCEPFHKFCL EENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECL GPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMY EILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTT SHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLD LEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSF FIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQE REENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSRED SPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWS AEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFM CSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLR RKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWS TTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSS KESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSP GCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKL RIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLG QNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEK TKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSV SFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGM SNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEE GNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEG SAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTE PISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQ EDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRG KRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEE QCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDR PEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESS RRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNT PSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPV DSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGE KRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSP PCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPS QISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSS VSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMS HHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDL STTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINF TPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVG GTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSAS VPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFP QLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQ LLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQA SPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKV SHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQP AGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRK ESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLK QLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPP LNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSAR RATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIE YAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINH SCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPC	2862

PDB file (1223) >>>1223.pdbFusion protein BP residue: 334 CIF file (1223) >>>1223.cif	CREBBP	chr16	3900297	-	KMT2A	chr11	118354897		MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVR ALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGFSANDSTDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLN ILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLEENERP LEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPT KPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKG NFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPES VAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQA AKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMD QGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVF PWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQ PPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPG IEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDG SLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVF LDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEP ENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCV YTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEI ISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAG SPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTG NTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNL QRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSS EGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALS FPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINE HMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMD EVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPR KRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPG DGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRY PRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVD GADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQ LDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEH VTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPS DKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGES PESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSIS AEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKS VASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGH GNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQT TPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVME TNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFP AATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSS GLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHP SLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGT STISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTN PRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPS TAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIH SSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSP SSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSE AHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPE VQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPK KGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNG LRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARA EVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPM PMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSI QTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSR VINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRK	2903
3D view using mol* of 1223 (AA BP:334)


PDB file (1224)	CREBBP	chr16	3900297	-	KMT2A	chr11	118354897		LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVR ALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGFSANDSTDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLN ILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLEENERP LEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPT KPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKG NFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPES VAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQA AKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMD QGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVF PWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQ PPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPG IEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDG SLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVF LDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEP ENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCV YTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEI ISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAG SPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTG NTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNL QRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSS EGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALS FPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINE HMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMD EVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPR KRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPG DGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRY PRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVD GADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQ LDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEH VTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPS DKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGES PESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSIS AEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKS VASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGH GNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQT TPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVME TNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFP AATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSS GLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHP SLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGT STISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTN PRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPS TAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIH SSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSP SSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSE AHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPE VQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPK KGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNG LRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARA EVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPM PMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSI QTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSR VINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRK	2903

PDB file (1233)	CREBBP	chr16	3900297	-	KMT2A	chr11	118354897		MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVR ALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGFSANDSTDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLN ILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPI TPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRR CKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICT KCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDD DDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERH PAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEE SIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSD DIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWE PNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPK PKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLT YGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRG KQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHR DLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTI DCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPV VEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHS QTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTV GDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVS TTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNS HLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGI PKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRND RDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQK GKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRP CNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLK MENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNT SCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMF FGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDD LYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDT SVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEP KMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTEL LKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLG EGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELP SDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLS PGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSST PGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKL IVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGG LTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNIS NPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQT RKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSS HRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTS GSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSI SNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICV LPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGP QVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASP SVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLT SGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQE SAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDG FQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVV FLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMF NFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSK EAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSK GIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVI	2941

PDB file (1234)	CREBBP	chr16	3900297	-	KMT2A	chr11	118354897		LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVR ALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGFSANDSTDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLN ILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPI TPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRR CKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICT KCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDD DDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERH PAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEE SIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSD DIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWE PNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPK PKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLT YGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRG KQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHR DLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTI DCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPV VEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHS QTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTV GDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVS TTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNS HLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGI PKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRND RDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQK GKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRP CNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLK MENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNT SCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMF FGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDD LYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDT SVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEP KMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTEL LKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLG EGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELP SDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLS PGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSST PGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKL IVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGG LTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNIS NPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQT RKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSS HRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTS GSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSI SNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICV LPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGP QVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASP SVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLT SGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQE SAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDG FQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVV FLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMF NFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSK EAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSK GIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVI	2941

PDB file (1236)	CREBBP	chr16	3900297	-	KMT2A	chr11	118354897		MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVR ALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGFSANDSTDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLN ILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPI TPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRR CKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICT KCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDD DDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCT ERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPE TEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLE FSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSR FWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIP APKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCAL CLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAV IRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQ RHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGS MTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECR PPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRP PHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEI VTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVS SVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGN KNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAY PGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQ RNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDR RQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMG QRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLT PLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSP NNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARS NMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSD EDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTE SDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHK NEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYN TELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELL NLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPL ELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPA LLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRN SSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPAT EKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPM GGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPP NISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISR LQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLN TSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSH LTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDI GSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASS ICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSA SGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRS ASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETT SLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPAN EQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISS DDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHD AVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAF DMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKK TSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYY DSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKH	2944

PDB file (1237)	CREBBP	chr16	3900297	-	KMT2A	chr11	118354897		LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVR ALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGFSANDSTDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKEKPPPVNKQENAGTLN ILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPI TPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRR CKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICT KCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDD DDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCT ERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPE TEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLE FSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSR FWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIP APKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCAL CLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAV IRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQ RHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGS MTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECR PPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRP PHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEI VTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVS SVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGN KNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAY PGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQ RNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDR RQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMG QRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLT PLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSP NNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARS NMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSD EDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTE SDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHK NEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYN TELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELL NLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPL ELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPA LLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRN SSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPAT EKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPM GGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPP NISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISR LQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLN TSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSH LTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDI GSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASS ICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSA SGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRS ASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETT SLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPAN EQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISS DDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHD AVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAF DMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKK TSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYY DSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKH	2944

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CREBBP_pLDDT.png

KMT2A_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CREBBP_KMT2A_1215_pLDDT.png (AA BP:334)

CREBBP_KMT2A_1215_pLDDT_and_active_sites.png (AA BP:334)

CREBBP_KMT2A_1215_violinplot.png (AA BP:334)

CREBBP_KMT2A_1216_pLDDT_and_active_sites.png (AA BP:)

CREBBP_KMT2A_1216_violinplot.png (AA BP:)

CREBBP_KMT2A_1218_pLDDT.png (AA BP:334)

CREBBP_KMT2A_1218_pLDDT_and_active_sites.png (AA BP:334)

CREBBP_KMT2A_1218_violinplot.png (AA BP:334)

CREBBP_KMT2A_1219_pLDDT_and_active_sites.png (AA BP:)

CREBBP_KMT2A_1219_violinplot.png (AA BP:)

CREBBP_KMT2A_1223_pLDDT.png (AA BP:334)

CREBBP_KMT2A_1223_pLDDT_and_active_sites.png (AA BP:334)

CREBBP_KMT2A_1223_violinplot.png (AA BP:334)

CREBBP_KMT2A_1224_pLDDT_and_active_sites.png (AA BP:)

CREBBP_KMT2A_1224_violinplot.png (AA BP:)

CREBBP_KMT2A_1233_pLDDT_and_active_sites.png (AA BP:)

CREBBP_KMT2A_1233_violinplot.png (AA BP:)

CREBBP_KMT2A_1234_pLDDT_and_active_sites.png (AA BP:)

CREBBP_KMT2A_1234_violinplot.png (AA BP:)

CREBBP_KMT2A_1236_pLDDT_and_active_sites.png (AA BP:)

CREBBP_KMT2A_1236_violinplot.png (AA BP:)

CREBBP_KMT2A_1237_pLDDT_and_active_sites.png (AA BP:)

CREBBP_KMT2A_1237_violinplot.png (AA BP:)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

CREBBP_KMT2A_1215.png

CREBBP_KMT2A_1218.png

CREBBP_KMT2A_1223.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
1215	1.047	304	1.097	616.714	0.585	0.702	0.873	0.905	0.811	1.116	0.74	Chain A: 179,181,182,183,184,185,186,187,188,189,1 732,1733,1734,1735,1736,1737,1738,1739,1740,1821,1 822,2667,2668,2670,2671,2673,2675,2676,2677,2679,2 713,2714,2717,2718,2721,2722,2723,2724,2736,2746,2 747,2749,2788,2789,2790,2791,2793,2794
1216	1.01	1806	1.03	5219.088	0.57	0.709	0.901	0.464	1.028	0.452	0.742	Chain A: 55,56,57,58,59,60,61,62,63,64,65,66,67,68 ,309,310,311,312,313,314,315,316,317,318,319,320,3 21,322,323,324,325,326,327,328,329,330,331,333,335 ,336,337,339,340,341,343,344,345,346,348,349,350,3 51,353,354,355,356,357,359,360,361,362,363,364,365 ,366,367,368,369,370,371,372,373,374,375,376,377,3 78,379,380,381,384,385,386,387,389,390,391,392,393 ,394,395,396,397,398,399,400,401,402,404,406,408,4 13,414,415,416,418,419,420,421,422,423,424,425,427 ,429,442,443,444,445,453,460,461,462,463,464,472,4 73,474,486,488,489,490,491,492,493,512,513,753,754 ,755,756,757,758,759,760,761,762,763,764,770,771,7 74,778,779,780,781,782,784,785,786,787,788,791,803 ,805,807,809,883,884,886,887,888,889,890,891,892,8 96,900,909,910,911,912,913,914,915,916,917,918,919 ,942,943,944,946,951,952,953,954,956,1206,1207,120 8,1209,1210,1211,1212,1213,1215,1216,1217,1218,121 9,1220,1221,1222,1223,1330,1331,1332,1333,1334,133 5,1336,1337,1338,1339,1340,1570,1571,1572,1573,157 5,1576,1577,1578,2577,2580,2581,2584,2591,2596,259 7,2598,2599,2600,2601,2602,2603,2604,2605,2606,260 8,2609,2611,2613,2614,2615,2616,2619,2620,2623,266 5,2666,2667,2668,2730,2731,2766,2767,2768,2769,277 0,2771,2773,2786,2793,2794
1218	1.064	229	1.115	568.351	0.509	0.724	0.949	1.136	0.795	1.429	0.662	Chain A: 785,786,787,788,789,790,811,812,813,814,8 15,816,818,819,822,892,893,894,895,896,897,899,900 ,901,903,904,907,911,912,913,914,915,916,1736,2619 ,2622,2623,2626,2641
1219	1.052	244	1.087	581.728	0.523	0.737	0.924	0.653	0.904	0.723	0.714	Chain A: 340,353,354,355,356,360,363,364,365,367,3 69,370,371,373,379,384,385,386,387,389,392,393,394 ,408,413,414,415,2600,2601,2602,2603
1223	0.9836	328	1.0318	960.057	0.6943	0.6225	0.7701	0.3487	0.8642	0.4035	0.894	Chain A: 201,202,203,204,205,206,207,208,212,213,2 14,215,216,217,218,219,220,221,234,235,236,237,238 ,239,240,1420,1421,1422,1423,1424,1442,1443,1444,1 445,1745,1746,1747,1748,1749,1750,1751,1752,1753,1 754,1755,1756,1757,1758,2142,2143,2144,2145,2146,2 147,2149,2150,2151,2166,2167,2234,2235,2236,2237,2 238,2239,2240,2241
1224	1.021	774	1.048	2969.351	0.598	0.71	0.905	0.703	0.975	0.721	0.823	Chain A: 370,371,372,373,374,375,377,379,381,384,3 85,387,388,389,390,392,393,394,395,398,399,410,411 ,412,413,415,793,794,795,796,797,798,799,800,801,8 02,803,804,805,815,816,818,822,823,824,825,826,828 ,829,830,832,835,849,853,926,927,928,929,930,931,9 32,933,935,938,939,940,941,943,944,945,947,948,950 ,952,953,954,955,956,958,959,960,961,962,963,976,9 77,978,986,987,988,997,998,999,1000,1562,1563,1564 ,1565,1566,1567,1568,1569,1570,1571,1572,1573,1574 ,1575,1576,1691,1692,1693,1694,1695,1696,2610,2646 ,2647,2648,2649,2652,2653,2655,2656,2657,2658,2659 ,2660,2662,2663,2664,2666,2667,2668,2669,2670,2671 ,2672,2677,2678,2680,2681,2682,2684,2685
1233	1.107	120	1.044	215.404	0.431	0.858	1.148	0.502	1.26	0.399	0.818	Chain A: 375,376,377,378,379,381,392,393,395,409,4 10,411,843,862,863,864,865,866,867,870,894,969,970 ,971,973,976,978,982,993
1234	1.039	318	1.034	914.781	0.48	0.756	1.011	0.66	1.101	0.599	0.687	Chain A: 1604,1605,1606,1607,1608,1609,2738,2739,2 740,2741,2742,2743,2744,2745,2746,2747,2748,2749,2 750,2751,2754,2755,2807,2808,2809,2810,2811,2812,2 813,2830,2851,2852,2853,2854,2855,2856,2857,2858,2 874,2875,2876,2877,2878,2879,2900,2914,2916,2917,2 918,2927,2928,2929,2930,2931,2940
1236	1.026	262	1.048	901.404	0.539	0.727	0.945	0.633	1.008	0.628	0.979	Chain A: 1908,1909,1910,2741,2742,2743,2744,2745,2 746,2747,2748,2750,2751,2752,2753,2754,2757,2810,2 811,2812,2813,2814,2815,2816,2833,2854,2855,2856,2 857,2858,2860,2872,2877,2878,2879,2880,2881,2882,2 903,2917,2919,2921,2931,2932,2933,2934,2943
1237	1.086	154	0.968	440.412	0.473	0.827	1.153	0.611	1.435	0.426	0.494	Chain A: 387,388,389,390,407,423,425,450,451,453,4 60,998,1001,1017,1018,1019,1028,2535,2536,2537,253 8,2662,2687,2688,2689,2690,2692,2693,2694,2696,269 7,2698,2699,2700,2703,2706,2717,2718,2719,2721

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
1233	ZINC000001543916	DB01610	Valganciclovir	-7.28855	-7.50185
1233	ZINC000000034157	DB06707	Levonordefrin	-7.36531	-7.38281
1233	ZINC000000001735	DB00350	Minoxidil	-7.14261	-7.14261
1233	ZINC000000004009	DB00196	Fluconazole	-7.09638	-7.09638
1233	ZINC000000039089	DB00668	Epinephrine	-7.01366	-7.02506
1233	ZINC000000057624	DB00368	Norepinephrine	-6.95512	-6.97262
1233	ZINC000000001644	DB06795	Mafenide	-6.89055	-6.92015
1233	ZINC000002568036	DB01219	Dantrolene	-6.79707	-6.86947
1233	ZINC000252679615	DB01219	Dantrolene	-6.79707	-6.86947
1233	ZINC000029571072	DB06636	Isavuconazonium	-6.28908	-6.79288
1233	ZINC000009164421	DB09050	Ceftolozane	-6.78681	-6.78841
1233	ZINC000000000507	DB00211	Midodrine	-6.60671	-6.71471
1233	ZINC000000000905	DB00488	Altretamine	-6.64452	-6.69322
1233	ZINC000001530806	DB00593	Ethosuximide	-6.69178	-6.69258
1233	Acalabrutinib	DB00593		-4.4306	-6.6529
1233	ZINC000000509440	DB00842	Oxazepam	-6.64631	-6.64631
1233	Baricitinib	DB00842		-6.6089	-6.6089
1233	ZINC000000643114	DB00808	Indapamide	-6.57251	-6.57491
1233	ZINC000002539827	DB00360	Sapropterin	-6.52209	-6.54179
1233	ZINC000000121541	DB00643	Mebendazole	-5.91006	-6.52396

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000001543916	DB01610	Valganciclovir	Small molecule	CC(C)[C@H](N)C(=O)OCC(CO)OCN1C=NC2=C1NC(N)=NC2=O	Approved\|Investigational
ZINC000000034157	DB06707	Levonordefrin	Small molecule	C[C@H](N)[C@H](O)C1=CC(O)=C(O)C=C1	Approved
ZINC000000001735	DB00350	Minoxidil	Small molecule	NC1=CC(=NC(N)=[N+]1[O-])N1CCCCC1	Approved\|Investigational
ZINC000000004009	DB00196	Fluconazole	Small molecule	OC(CN1C=NC=N1)(CN1C=NC=N1)C1=C(F)C=C(F)C=C1	Approved\|Investigational
ZINC000000039089	DB00668	Epinephrine	Small molecule	CNC[C@H](O)C1=CC(O)=C(O)C=C1	Approved\|Vet_approved
ZINC000000057624	DB00368	Norepinephrine	Small molecule	NC[C@H](O)C1=CC(O)=C(O)C=C1	Approved
ZINC000000001644	DB06795	Mafenide	Small molecule	NCC1=CC=C(C=C1)S(N)(=O)=O	Approved\|Vet_approved
ZINC000009164421	DB09050	Ceftolozane	Small molecule	CN1C(N)=C(NC(=O)NCCN)C=[N+]1CC1=C(N2[C@H](SC1)[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)C1=NSC(N)=N1)C2=O)C([O-])=O	Approved\|Investigational
ZINC000000000905	DB00488	Altretamine	Small molecule	CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C	Approved
ZINC000000121541	DB00643	Mebendazole	Small molecule	COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C1	Approved\|Vet_approved

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000001543916	354.365	10.833	656.576	282.226	307.955	66.396	0	1129.771	6	11.9	8.359	1	0.466	2	1
ZINC000001543916	354.365	8.84	635.736	259.299	319.155	57.282	0	1114.93	6	11.9	8.318	1	0	2	1
ZINC000000034157	183.207	1.584	399.847	106.772	186.848	106.227	0	646.199	5	4.2	8.948	2	52.109	0	0
ZINC000000034157	183.207	2.284	398.836	105.841	186.106	106.889	0	643.154	5	4.2	8.781	2	52.19	0	0
ZINC000000001735	209.25	5.141	437.436	217.593	169.974	49.869	0	711.864	4	3.5	7.733	3	76.873	0	0
ZINC000000004009	306.274	6.083	510.024	58.825	109.435	270.763	71.001	891.153	1	6.75	10.029	3	82.865	0	0
ZINC000000039089	183.207	0.987	415.609	139.04	163.719	112.85	0	664.117	4	4.7	9.006	2	56.402	0	0
ZINC000000039089	183.207	1.06	412.1	135.076	165.027	111.996	0	658.643	4	4.7	9.004	2	56.186	0	0
ZINC000000057624	169.18	3.43	375.225	57.715	204.72	112.79	0	592.168	5	4.2	8.952	2	46.791	0	0
ZINC000000057624	169.18	2.409	366.478	58.999	201.357	106.122	0	584.369	5	4.2	8.77	2	47.306	0	0
ZINC000000001644	186.228	7.234	386.689	48.38	203.852	132.644	1.813	608.208	4	5.5	9.936	2	46.461	0	0
ZINC000000001644	186.228	8.543	384.513	48.79	201.796	132.114	1.813	604.747	4	5.5	9.902	2	46.8	0	0
ZINC000002568036	314.257	3.867	548.758	54.323	243.185	251.25	0	924.46	1	5	9.205	3	67.058	0	0
ZINC000002568036	314.257	4.186	547.3	54.729	241.127	251.444	0	922.097	1	5	9.191	3	67.408	0	0
ZINC000252679615	314.257	3.867	548.758	54.323	243.185	251.25	0	924.46	1	5	9.205	3	67.058	0	0
ZINC000252679615	314.257	2.557	527.996	64.383	238.233	225.38	0	905.494	1	5	9.686	3	67.506	0	0
ZINC000252679615	314.257	4.186	547.3	54.729	241.127	251.444	0	922.097	1	5	9.191	3	67.408	0	0
ZINC000252679615	314.257	2.845	525.884	65.15	235.939	224.795	0	902.055	1	5	9.671	3	67.875	0	0
ZINC000000000507	254.285	4.725	473.576	261.82	136.953	74.803	0	834.491	4	6.7	8.718	2	58.587	0	1
ZINC000000000507	254.285	4.114	523.523	284.58	146.44	92.503	0	869.505	4	6.7	8.676	2	56.598	0	1
ZINC000000000905	210.281	0.001	518.559	491.882	26.617	0.059	0	848.059	0	4.5	8.532	3	100	0	0
ZINC000000000905	210.281	1.1	508.989	484.053	23.862	1.075	0	837.012	0	4.5	8.928	3	100	0	0
ZINC000001530806	141.169	2.472	320.877	214.727	106.15	0	0	513.211	1	3	10.602	3	84.704	0	0
ZINC000000509440	286.717	3.437	510.923	24.832	130.585	284.062	71.444	859.771	2	5.2	9.187	3	89.415	0	0
ZINC000000643114	365.834	5.692	607.095	127.97	168.444	256.766	53.914	1056.126	3	8.5	8.638	3	79.023	0	0
ZINC000002539827	241.249	7.545	439.916	170.714	254.718	14.484	0	740.803	7	8.9	7.547	2	32.454	1	0
ZINC000002539827	241.249	12.27	439.143	170.157	254.778	14.208	0	741.346	7	8.9	7.688	2	32.485	1	0
ZINC000000121541	295.297	6.562	576.161	98.468	169.387	308.306	0	957.18	1	5	8.911	3	83.641	0	0
ZINC000000121541	295.297	2.873	577.033	96.773	172.83	307.43	0	959.022	0	3	8.668	3	88.187	0	0
ZINC000000121541	295.297	10.919	575.199	98.469	170.072	306.658	0	956.419	1	5	8.861	3	83.461	0	0

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000001543916	CC(C)[C@H](N)C(=O)OC[C@@H](CO)OCn1cnc2c(=O)[nH]c(N)nc21	0.066223161	0.39718523
ZINC000000034157	C[C@H](N)[C@H](O)c1ccc(O)c(O)c1	0.135079192	0.302260037
ZINC000000001735	Nc1cc(N2CCCCC2)nc(N)[n+]1[O-]	0.129740946	0.395964399
ZINC000000004009	OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F	0.170393972	0.393168163
ZINC000000039089	CNC[C@H](O)c1ccc(O)c(O)c1	0.191748276	0.25662051
ZINC000000057624	NC[C@H](O)c1ccc(O)c(O)c1	0.18714743	0.309816979
ZINC000000001644	NCc1ccc(S(N)(=O)=O)cc1	0.497774604	0.389970963
ZINC000002568036	O=C1CN(/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(=O)N1	0.204070823	0.461176527
ZINC000252679615	O=C1CN(N=Cc2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(O)=N1	0.149132109	0.500589886
ZINC000029571072	CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c1	0.025416027	0.235213823
ZINC000009164421	Cn1c(N)c(NC(=O)NCCN)c[n+]1CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)/C(=NOC(C)(C)C(=O)O)c3nsc(N)n3)[C@H]2SC1	0.028125613	0.175846017
ZINC000000000507	COc1ccc(OC)c([C@H](O)CNC(=O)CN)c1	0.229958737	0.301481614
ZINC000000000905	CN(C)c1nc(N(C)C)nc(N(C)C)n1	0.255308499	0.595290338
ZINC000001530806	CC[C@]1(C)CC(=O)NC1=O	0.092688168	0.486892767
ZINC000000509440	O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1O	0.183501241	0.419564566
ZINC000000643114	C[C@@H]1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1	0.166136479	0.17734677
ZINC000002539827	C[C@H](O)[C@H](O)[C@@H]1CNc2[nH]c(N)nc(=O)c2N1	0.037184534	0.22690944
ZINC000000121541	COC(=O)/N=c1[nH]c2ccc(C(=O)c3ccccc3)cc2[nH]1	0.209696342	0.592445172

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
CREBBP	EGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, tat, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, K8, MTDH, MEIS1, LDLR, vIRF-1, vIRF-3, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, Ctnnb1, Cebpb, EID3, POU2F3, Spi1, Nfic, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, HCVgp1, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, HHV8GK18_gp81, Ar, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, E7, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, E6, SUMO1, NFATC1, CPSF4, USP7, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25, HNRNPL, DUX4, HLF, EGLN3, FGF2, TH, FBXL19, USP14, BBC3, RBBP5, GATA3, BYRF1, TP53BP1, KIAA1429, ATF7IP, ATRX, CASP8AP2, CBX4, CHAF1A, CHD3, EIF3D, GATAD2A, HIPK3, HMGXB4, FBXO38, PIAS2, PPP1R8, PPP2R2A, PTPRF, RNF111, RPL3, RPL35, SETDB1, SP100, TOPORS, UIMC1, ZCCHC7, ZMYM2, ZNF451, ZNF106, HIPK1, PIAS1, FAF1, KISS1, ZHX1, ZMYM5, ZNFX1, WDR77, PPP1CC, BRIP1, CCAR2, HSPB1, MAPT, PNKP, PPP1CA, POLR1E, DDX3X, TSPYL2, PYCR1, TRIM24, SMG7, AFP, BRD4, KDM2B, ACSS1, ACTB, ANKS1A, ANKS1B, ANXA7, APP, BAG5, TUBB, CNTRL, CEP290, CHRDL1, CLASP2, EEF1A1, EEF2, EIF4G2, FUS, GAA, GPR161, GRIA3, GSTO2, HEXA, HIVEP1, HIVEP2, HMG20A, HUWE1, IQGAP1, KDM6B, KDM2A, CAMSAP2, EPG5, KIF5A, MAP1B, MYO1E, OGT, PAPPA, PAX6, PHLDA1, RAD50, RBM24, RBM5, RFK, RNF7, RPS20, EXOC5, SEMA3B, SEPT3, SLC1A4, SNAPC5, SNRNP200, SOS2, SPTAN1, SYT1, TIAL1, TIAM1, TP53BP2, KDM6A, VAT1L, WAS, YTHDF2, BCAT2, CDC25A, TERF2IP, TGM1, BAG2, GMEB2, HIST1H2AB, LATS1, RXRA, NEUROD1, CIITA, FOXH1, T, ERG, ETV4, FEV, FOXI1, FOXQ1, GATA2, HNF1B, KLF15, LHX3, NFIA, NFIB, PAX7, PAX8, SOX9, SP7, TAL1, TEAD1, TLX1, SNAI2,
KMT2A	PPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, tat, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, Cbx1, Set, ZNF131, ASB7, AR, CSNK2A1, OGT, BRD4, KDM5B, KDM5D, KDM6B, CKS1B, CKS2, CHD4, ESR2, AGR2, EZH2, FBXW7, SOX2, MED17, WDR82, ACTR8, GEMIN5, RUVBL1, MCM2, RTF1, MED15, MED8, MRGBP, MED14, HIST1H2BB, HIST1H2AB, KIAA1429, SP1, MYC, NR2C2, IRF2, PLEKHA4, DPY30, PTEN, NPM1, RPL13, CCT6A, TMCO1, ITGB1, ESR1, MYCN, SUPT5H, CIT, Pik3r2, FASN, LDLR, CDC27, KMT2B, SETD1A, KDM6A, KANSL2, BUB3, SETD1B, KANSL1, RERE, MCRS1, KMT2C, ZZZ3, MBIP, YEATS2, PAXIP1, KANSL3, KMT2D, BOD1L1, CSRP2BP, ZNF608, ATN1, PHF20L1, PHF20, NCOA6, TADA3, APEX1, ASF1A, CBX3, CD3EAP, CENPA, NUP50, POLR1E, TERF2IP, ZNF330, NAA40, PRKRA, SRSF4, KRR1, RPL13A, ABT1, CSNK2B, OASL, SRSF5, SRSF6, RPS9, FGFBP1, RPLP0, RPL36, KAL1, RPL3, PML, ELF1, ELF2, FEV, NHLH1, EN1, KLF12, KLF3, NFIX, NFYC, YY1, BRD3,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CREBBP
KMT2A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CREBBP	chr16:3900297	chr11:118354897	ENST00000262367		2	31	1162_1180	266.0	2443.0	ASF1A
Hgene	CREBBP	chr16:3900297	chr11:118354897	ENST00000382070		2	30	1162_1180	266.0	2405.0	ASF1A
Hgene	CREBBP	chr16:3900297	chr11:118354897	ENST00000262367		2	31	1433_1435	266.0	2443.0	histone
Hgene	CREBBP	chr16:3900297	chr11:118354897	ENST00000382070		2	30	1433_1435	266.0	2405.0	histone
Hgene	CREBBP	chr16:3900297	chr11:118354897	ENST00000262367		2	31	1124_1170	266.0	2443.0	histone
Hgene	CREBBP	chr16:3900297	chr11:118354897	ENST00000382070		2	30	1124_1170	266.0	2405.0	histone
Hgene	CREBBP	chr16:3900297	chr11:118354897	ENST00000262367		2	31	227_410	266.0	2443.0	SRCAP
Hgene	CREBBP	chr16:3900297	chr11:118354897	ENST00000382070		2	30	227_410	266.0	2405.0	SRCAP
Hgene	CREBBP	chr16:3900297	chr11:118354897	ENST00000262367		2	31	1460_1891	266.0	2443.0	TRERF1
Hgene	CREBBP	chr16:3900297	chr11:118354897	ENST00000382070		2	30	1460_1891	266.0	2405.0	TRERF1

Top

Related Drugs to CREBBP-KMT2A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CREBBP-KMT2A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
CREBBP	KMT2A	Breast Invasive Ductal Carcinoma	MyCancerGenome
CREBBP	KMT2A	Bladder Urothelial Carcinoma	MyCancerGenome
CREBBP	KMT2A	Lung Adenocarcinoma	MyCancerGenome
CREBBP	KMT2A	Acute Myeloid Leukemia	MyCancerGenome
CREBBP	KMT2A	Colon Adenocarcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CREBBP	C4551859	RUBINSTEIN-TAYBI SYNDROME 1	12	CLINGEN;GENOMICS_ENGLAND;UNIPROT
Hgene	CREBBP	C0035934	Rubinstein-Taybi Syndrome	6	CLINGEN;CTD_human
Hgene	CREBBP	C0033578	Prostatic Neoplasms	2	CTD_human
Hgene	CREBBP	C0376358	Malignant neoplasm of prostate	2	CTD_human
Hgene	CREBBP	C4511003	Acute myeloid leukemia with t(8;16)(p11;p13) translocation	2	ORPHANET
Hgene	CREBBP	C0005684	Malignant neoplasm of urinary bladder	1	CTD_human
Hgene	CREBBP	C0005695	Bladder Neoplasm	1	CTD_human
Hgene	CREBBP	C0007137	Squamous cell carcinoma	1	CTD_human
Hgene	CREBBP	C0007138	Carcinoma, Transitional Cell	1	CTD_human
Hgene	CREBBP	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
Hgene	CREBBP	C0011573	Endogenous depression	1	PSYGENET
Hgene	CREBBP	C0024301	Lymphoma, Follicular	1	CTD_human
Hgene	CREBBP	C0036920	Sezary Syndrome	1	CTD_human
Hgene	CREBBP	C0079745	Lymphoma, Large-Cell, Follicular	1	CTD_human
Hgene	CREBBP	C0079758	Lymphoma, Mixed-Cell, Follicular	1	CTD_human
Hgene	CREBBP	C0079765	Lymphoma, Small Cleaved-Cell, Follicular	1	CTD_human
Hgene	CREBBP	C0149925	Small cell carcinoma of lung	1	CTD_human
Hgene	CREBBP	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Hgene	CREBBP	C0279626	Squamous cell carcinoma of esophagus	1	CTD_human
Hgene	CREBBP	C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
Hgene	CREBBP	C1862941	Amyotrophic Lateral Sclerosis, Sporadic	1	CTD_human
Hgene	CREBBP	C1956130	Lymphoma, Follicular, Grade 1	1	CTD_human
Hgene	CREBBP	C1956131	Lymphoma, Follicular, Grade 3	1	CTD_human
Hgene	CREBBP	C1956132	Lymphoma, Follicular, Grade 2	1	CTD_human
Hgene	CREBBP	C4551993	Amyotrophic Lateral Sclerosis, Familial	1	CTD_human
Tgene	KMT2A	C2826025	Mixed phenotype acute leukemia	3	ORPHANET
Tgene	KMT2A	C0023418	leukemia	2	CTD_human
Tgene	KMT2A	C0023452	Childhood Acute Lymphoblastic Leukemia	2	CTD_human
Tgene	KMT2A	C0023453	L2 Acute Lymphoblastic Leukemia	2	CTD_human
Tgene	KMT2A	C0023466	Leukemia, Monocytic, Chronic	2	CTD_human
Tgene	KMT2A	C0023467	Leukemia, Myelocytic, Acute	2	CTD_human
Tgene	KMT2A	C0023470	Myeloid Leukemia	2	CTD_human
Tgene	KMT2A	C0026998	Acute Myeloid Leukemia, M1	2	CTD_human
Tgene	KMT2A	C1854630	Growth Deficiency and Mental Retardation with Facial Dysmorphism	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	KMT2A	C1879321	Acute Myeloid Leukemia (AML-M2)	2	CTD_human
Tgene	KMT2A	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CTD_human
Tgene	KMT2A	C0001418	Adenocarcinoma	1	CTD_human
Tgene	KMT2A	C0004403	Autosome Abnormalities	1	CTD_human
Tgene	KMT2A	C0005684	Malignant neoplasm of urinary bladder	1	CTD_human
Tgene	KMT2A	C0005695	Bladder Neoplasm	1	CTD_human
Tgene	KMT2A	C0007138	Carcinoma, Transitional Cell	1	CTD_human
Tgene	KMT2A	C0008625	Chromosome Aberrations	1	CTD_human
Tgene	KMT2A	C0023448	Lymphoid leukemia	1	CTD_human
Tgene	KMT2A	C0023465	Acute monocytic leukemia	1	CTD_human
Tgene	KMT2A	C0023479	Acute myelomonocytic leukemia	1	CTD_human
Tgene	KMT2A	C0024623	Malignant neoplasm of stomach	1	CTD_human
Tgene	KMT2A	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	KMT2A	C0036341	Schizophrenia	1	PSYGENET
Tgene	KMT2A	C0038356	Stomach Neoplasms	1	CTD_human
Tgene	KMT2A	C0149925	Small cell carcinoma of lung	1	CTD_human
Tgene	KMT2A	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Tgene	KMT2A	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Tgene	KMT2A	C0205643	Carcinoma, Cribriform	1	CTD_human
Tgene	KMT2A	C0205644	Carcinoma, Granular Cell	1	CTD_human
Tgene	KMT2A	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Tgene	KMT2A	C0270972	Cornelia De Lange Syndrome	1	ORPHANET
Tgene	KMT2A	C0280141	Acute Undifferentiated Leukemia	1	ORPHANET
Tgene	KMT2A	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	KMT2A	C0856823	Undifferentiated type acute leukemia	1	ORPHANET
Tgene	KMT2A	C1535926	Neurodevelopmental Disorders	1	CTD_human
Tgene	KMT2A	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Tgene	KMT2A	C2239176	Liver carcinoma	1	CTD_human
Tgene	KMT2A	C2930974	Acute erythroleukemia	1	CTD_human
Tgene	KMT2A	C2930975	Acute erythroleukemia - M6a subtype	1	CTD_human
Tgene	KMT2A	C2930976	Acute myeloid leukemia FAB-M6	1	CTD_human
Tgene	KMT2A	C2930977	Acute erythroleukemia - M6b subtype	1	CTD_human