UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:CSMD3-ADCY8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CSMD3-ADCY8
FusionPDB ID: 19777
FusionGDB2.0 ID: 19777
HgeneTgene
Gene symbol

CSMD3

ADCY8

Gene ID

114788

114

Gene nameCUB and Sushi multiple domains 3adenylate cyclase 8
Synonyms-AC8|ADCY3|HBAC1
Cytomap

8q23.3

8q24.22

Type of geneprotein-codingprotein-coding
DescriptionCUB and sushi domain-containing protein 3CUB and sushi multiple domains protein 3adenylate cyclase type 8ATP pyrophosphate-lyase 8HEL-S-172mPadenylate cyclase 8 (brain)adenylate cyclase type VIIIadenylyl cyclase 8adenylyl cyclase-8, brainca(2+)/calmodulin-activated adenylyl cyclaseepididymis secretory sperm binding protein Li
Modification date2020031320200313
UniProtAcc

Q7Z407

P40145

Ensembl transtripts involved in fusion geneENST idsENST00000297405, ENST00000352409, 
ENST00000455883, ENST00000343508, 
ENST00000519485, 		ENST00000286355, 
ENST00000377928, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 7 X 3=1473 X 3 X 3=27
# samples 73
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CSMD3 [Title/Abstract] AND ADCY8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CSMD3(114290821)-ADCY8(131964244), # samples:2
Anticipated loss of major functional domain due to fusion event.CSMD3-ADCY8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CSMD3-ADCY8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CSMD3-ADCY8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CSMD3-ADCY8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CSMD3-ADCY8 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CSMD3-ADCY8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CSMD3-ADCY8 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CSMD3-ADCY8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CSMD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADCY8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3M1-01ACSMD3chr8

114290821

-ADCY8chr8

131964244

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343508CSMD3chr8114290821-ENST00000286355ADCY8chr8131964244-33005655263210894
ENST00000343508CSMD3chr8114290821-ENST00000377928ADCY8chr8131964244-28185655262817764

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343508ENST00000286355CSMD3chr8114290821-ADCY8chr8131964244-0.0008752010.9991248
ENST00000343508ENST00000377928CSMD3chr8114290821-ADCY8chr8131964244-0.0019320390.99806803

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19777_19777_1_CSMD3-ADCY8_CSMD3_chr8_114290821_ENST00000343508_ADCY8_chr8_131964244_ENST00000286355_length(amino acids)=894AA_BP=13
MQLVLMDLRYITKERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFD
RLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIA
NKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPEL
PFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLV
CAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWC
DFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGT
KEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFAS
IPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEI
NKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKT

--------------------------------------------------------------

>19777_19777_2_CSMD3-ADCY8_CSMD3_chr8_114290821_ENST00000343508_ADCY8_chr8_131964244_ENST00000377928_length(amino acids)=764AA_BP=13
MQLVLMDLRYITKERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFD
RLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIA
NKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPEL
PFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYFVFTGVLAMVTCA
VFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEIN
EMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQ
DIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLA
SRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQ

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:114290821/chr8:131964244)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSMD3

Q7Z407

ADCY8

P40145

FUNCTION: Involved in dendrite development. {ECO:0000250|UniProtKB:Q80T79}.FUNCTION: Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. {ECO:0000250|UniProtKB:P40146}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-37165_173171.333333333333343708.0DomainCUB 1
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-36965_173171.333333333333343638.0DomainCUB 1
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-36965_173171.333333333333343539.0DomainCUB 1
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711_42171.333333333333343708.0Topological domainCytoplasmic
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721_42131.333333333333343668.0Topological domainCytoplasmic
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691_42171.333333333333343638.0Topological domainCytoplasmic
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691_42171.333333333333343539.0Topological domainCytoplasmic
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-37143_63171.333333333333343708.0TransmembraneHelical
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-47243_63131.333333333333343668.0TransmembraneHelical
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-36943_63171.333333333333343638.0TransmembraneHelical
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-36943_63171.333333333333343539.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST000002863551181109_1111370.01252.0Nucleotide bindingATP
TgeneADCY8chr8:114290821chr8:131964244ENST000002863551181116_1120370.01252.0Nucleotide bindingATP
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118419_424370.01252.0Nucleotide bindingATP
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118461_463370.01252.0Nucleotide bindingATP
TgeneADCY8chr8:114290821chr8:131964244ENST000002863551181200_1215370.01252.0RegionRequired for both calcium stimulation and maintenance of autoinhibition
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118915_1251370.01252.0Topological domainCytoplasmic
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118716_736370.01252.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118738_758370.01252.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118787_807370.01252.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118831_851370.01252.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118861_881370.01252.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118894_914370.01252.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711008_1065171.333333333333343708.0DomainSushi 5
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711067_1177171.333333333333343708.0DomainCUB 6
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711180_1239171.333333333333343708.0DomainSushi 6
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711241_1349171.333333333333343708.0DomainCUB 7
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711352_1412171.333333333333343708.0DomainSushi 7
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711414_1523171.333333333333343708.0DomainCUB 8
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711526_1586171.333333333333343708.0DomainSushi 8
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711588_1696171.333333333333343708.0DomainCUB 9
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711699_1760171.333333333333343708.0DomainSushi 9
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711762_1870171.333333333333343708.0DomainCUB 10
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-371176_237171.333333333333343708.0DomainSushi 1
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711876_1937171.333333333333343708.0DomainSushi 10
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3711939_2047171.333333333333343708.0DomainCUB 11
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712050_2109171.333333333333343708.0DomainSushi 11
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712111_2219171.333333333333343708.0DomainCUB 12
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712222_2281171.333333333333343708.0DomainSushi 12
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712283_2394171.333333333333343708.0DomainCUB 13
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712393_2454171.333333333333343708.0DomainSushi 13
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-371241_345171.333333333333343708.0DomainCUB 2
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712456_2567171.333333333333343708.0DomainCUB 14
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712567_2629171.333333333333343708.0DomainSushi 14
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712630_2691171.333333333333343708.0DomainSushi 15
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712757_2814171.333333333333343708.0DomainSushi 17
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712815_2872171.333333333333343708.0DomainSushi 18
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712873_2930171.333333333333343708.0DomainSushi 19
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712931_2992171.333333333333343708.0DomainSushi 20
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3712993_3050171.333333333333343708.0DomainSushi 21
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3713054_3111171.333333333333343708.0DomainSushi 22
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3713112_3170171.333333333333343708.0DomainSushi 23
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3713171_3230171.333333333333343708.0DomainSushi 24
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3713231_3288171.333333333333343708.0DomainSushi 25
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3713289_3346171.333333333333343708.0DomainSushi 26
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3713350_3408171.333333333333343708.0DomainSushi 27
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3713409_3468171.333333333333343708.0DomainSushi 28
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-371484_545171.333333333333343708.0DomainSushi 2
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-371548_659171.333333333333343708.0DomainCUB 3
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-371662_719171.333333333333343708.0DomainSushi 3
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-371721_829171.333333333333343708.0DomainCUB 4
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-371832_893171.333333333333343708.0DomainSushi 4
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-371895_1003171.333333333333343708.0DomainCUB 5
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721008_1065131.333333333333343668.0DomainSushi 5
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721067_1177131.333333333333343668.0DomainCUB 6
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721180_1239131.333333333333343668.0DomainSushi 6
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721241_1349131.333333333333343668.0DomainCUB 7
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721352_1412131.333333333333343668.0DomainSushi 7
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721414_1523131.333333333333343668.0DomainCUB 8
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721526_1586131.333333333333343668.0DomainSushi 8
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721588_1696131.333333333333343668.0DomainCUB 9
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721699_1760131.333333333333343668.0DomainSushi 9
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721762_1870131.333333333333343668.0DomainCUB 10
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-472176_237131.333333333333343668.0DomainSushi 1
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721876_1937131.333333333333343668.0DomainSushi 10
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4721939_2047131.333333333333343668.0DomainCUB 11
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722050_2109131.333333333333343668.0DomainSushi 11
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722111_2219131.333333333333343668.0DomainCUB 12
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722222_2281131.333333333333343668.0DomainSushi 12
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722283_2394131.333333333333343668.0DomainCUB 13
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722393_2454131.333333333333343668.0DomainSushi 13
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-472241_345131.333333333333343668.0DomainCUB 2
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722456_2567131.333333333333343668.0DomainCUB 14
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722567_2629131.333333333333343668.0DomainSushi 14
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722630_2691131.333333333333343668.0DomainSushi 15
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722757_2814131.333333333333343668.0DomainSushi 17
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722815_2872131.333333333333343668.0DomainSushi 18
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722873_2930131.333333333333343668.0DomainSushi 19
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722931_2992131.333333333333343668.0DomainSushi 20
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4722993_3050131.333333333333343668.0DomainSushi 21
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4723054_3111131.333333333333343668.0DomainSushi 22
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4723112_3170131.333333333333343668.0DomainSushi 23
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4723171_3230131.333333333333343668.0DomainSushi 24
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4723231_3288131.333333333333343668.0DomainSushi 25
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4723289_3346131.333333333333343668.0DomainSushi 26
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4723350_3408131.333333333333343668.0DomainSushi 27
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4723409_3468131.333333333333343668.0DomainSushi 28
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-472484_545131.333333333333343668.0DomainSushi 2
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-472548_659131.333333333333343668.0DomainCUB 3
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-47265_173131.333333333333343668.0DomainCUB 1
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-472662_719131.333333333333343668.0DomainSushi 3
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-472721_829131.333333333333343668.0DomainCUB 4
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-472832_893131.333333333333343668.0DomainSushi 4
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-472895_1003131.333333333333343668.0DomainCUB 5
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691008_1065171.333333333333343638.0DomainSushi 5
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691067_1177171.333333333333343638.0DomainCUB 6
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691180_1239171.333333333333343638.0DomainSushi 6
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691241_1349171.333333333333343638.0DomainCUB 7
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691352_1412171.333333333333343638.0DomainSushi 7
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691414_1523171.333333333333343638.0DomainCUB 8
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691526_1586171.333333333333343638.0DomainSushi 8
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691588_1696171.333333333333343638.0DomainCUB 9
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691699_1760171.333333333333343638.0DomainSushi 9
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691762_1870171.333333333333343638.0DomainCUB 10
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-369176_237171.333333333333343638.0DomainSushi 1
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691876_1937171.333333333333343638.0DomainSushi 10
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3691939_2047171.333333333333343638.0DomainCUB 11
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692050_2109171.333333333333343638.0DomainSushi 11
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692111_2219171.333333333333343638.0DomainCUB 12
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692222_2281171.333333333333343638.0DomainSushi 12
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692283_2394171.333333333333343638.0DomainCUB 13
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692393_2454171.333333333333343638.0DomainSushi 13
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-369241_345171.333333333333343638.0DomainCUB 2
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692456_2567171.333333333333343638.0DomainCUB 14
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692567_2629171.333333333333343638.0DomainSushi 14
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692630_2691171.333333333333343638.0DomainSushi 15
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692757_2814171.333333333333343638.0DomainSushi 17
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692815_2872171.333333333333343638.0DomainSushi 18
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692873_2930171.333333333333343638.0DomainSushi 19
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692931_2992171.333333333333343638.0DomainSushi 20
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3692993_3050171.333333333333343638.0DomainSushi 21
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3693054_3111171.333333333333343638.0DomainSushi 22
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3693112_3170171.333333333333343638.0DomainSushi 23
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3693171_3230171.333333333333343638.0DomainSushi 24
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3693231_3288171.333333333333343638.0DomainSushi 25
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3693289_3346171.333333333333343638.0DomainSushi 26
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3693350_3408171.333333333333343638.0DomainSushi 27
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3693409_3468171.333333333333343638.0DomainSushi 28
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-369484_545171.333333333333343638.0DomainSushi 2
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-369548_659171.333333333333343638.0DomainCUB 3
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-369662_719171.333333333333343638.0DomainSushi 3
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-369721_829171.333333333333343638.0DomainCUB 4
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-369832_893171.333333333333343638.0DomainSushi 4
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-369895_1003171.333333333333343638.0DomainCUB 5
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691008_1065171.333333333333343539.0DomainSushi 5
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691067_1177171.333333333333343539.0DomainCUB 6
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691180_1239171.333333333333343539.0DomainSushi 6
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691241_1349171.333333333333343539.0DomainCUB 7
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691352_1412171.333333333333343539.0DomainSushi 7
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691414_1523171.333333333333343539.0DomainCUB 8
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691526_1586171.333333333333343539.0DomainSushi 8
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691588_1696171.333333333333343539.0DomainCUB 9
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691699_1760171.333333333333343539.0DomainSushi 9
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691762_1870171.333333333333343539.0DomainCUB 10
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-369176_237171.333333333333343539.0DomainSushi 1
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691876_1937171.333333333333343539.0DomainSushi 10
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3691939_2047171.333333333333343539.0DomainCUB 11
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692050_2109171.333333333333343539.0DomainSushi 11
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692111_2219171.333333333333343539.0DomainCUB 12
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692222_2281171.333333333333343539.0DomainSushi 12
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692283_2394171.333333333333343539.0DomainCUB 13
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692393_2454171.333333333333343539.0DomainSushi 13
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-369241_345171.333333333333343539.0DomainCUB 2
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692456_2567171.333333333333343539.0DomainCUB 14
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692567_2629171.333333333333343539.0DomainSushi 14
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692630_2691171.333333333333343539.0DomainSushi 15
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692757_2814171.333333333333343539.0DomainSushi 17
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692815_2872171.333333333333343539.0DomainSushi 18
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692873_2930171.333333333333343539.0DomainSushi 19
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692931_2992171.333333333333343539.0DomainSushi 20
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3692993_3050171.333333333333343539.0DomainSushi 21
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3693054_3111171.333333333333343539.0DomainSushi 22
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3693112_3170171.333333333333343539.0DomainSushi 23
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3693171_3230171.333333333333343539.0DomainSushi 24
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3693231_3288171.333333333333343539.0DomainSushi 25
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3693289_3346171.333333333333343539.0DomainSushi 26
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3693350_3408171.333333333333343539.0DomainSushi 27
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3693409_3468171.333333333333343539.0DomainSushi 28
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-369484_545171.333333333333343539.0DomainSushi 2
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-369548_659171.333333333333343539.0DomainCUB 3
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-369662_719171.333333333333343539.0DomainSushi 3
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-369721_829171.333333333333343539.0DomainCUB 4
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-369832_893171.333333333333343539.0DomainSushi 4
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-369895_1003171.333333333333343539.0DomainCUB 5
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3713652_3707171.333333333333343708.0Topological domainCytoplasmic
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-37164_3630171.333333333333343708.0Topological domainExtracellular
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4723652_3707131.333333333333343668.0Topological domainCytoplasmic
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-47264_3630131.333333333333343668.0Topological domainExtracellular
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3693652_3707171.333333333333343638.0Topological domainCytoplasmic
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-36964_3630171.333333333333343638.0Topological domainExtracellular
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3693652_3707171.333333333333343539.0Topological domainCytoplasmic
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-36964_3630171.333333333333343539.0Topological domainExtracellular
HgeneCSMD3chr8:114290821chr8:131964244ENST00000297405-3713631_3651171.333333333333343708.0TransmembraneHelical
HgeneCSMD3chr8:114290821chr8:131964244ENST00000343508-4723631_3651131.333333333333343668.0TransmembraneHelical
HgeneCSMD3chr8:114290821chr8:131964244ENST00000352409-3693631_3651171.333333333333343638.0TransmembraneHelical
HgeneCSMD3chr8:114290821chr8:131964244ENST00000455883-3693631_3651171.333333333333343539.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118342_715370.01252.0Topological domainCytoplasmic
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118183_203370.01252.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118212_232370.01252.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118247_267370.01252.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118274_294370.01252.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118296_316370.01252.0TransmembraneHelical
TgeneADCY8chr8:114290821chr8:131964244ENST00000286355118321_341370.01252.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CSMD3
ADCY8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to CSMD3-ADCY8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to CSMD3-ADCY8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource