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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ADAM17-SEC31A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ADAM17-SEC31A
	FusionPDB ID: 1981
	FusionGDB2.0 ID: 1981
		Hgene	Tgene
	Gene symbol	ADAM17	SEC31A
	Gene ID	6868	22872
	Gene name	ADAM metallopeptidase domain 17	SEC31 homolog A, COPII coat complex component
	Synonyms	ADAM18\|CD156B\|CSVP\|NISBD\|NISBD1\|TACE	ABP125\|ABP130\|HSPC275\|HSPC334\|NEDSOSB\|SEC31L1
	Cytomap	2p25.1	4q21.22
	Type of gene	protein-coding	protein-coding
	Description	disintegrin and metalloproteinase domain-containing protein 17ADAM metallopeptidase domain 18TNF-alpha convertaseTNF-alpha converting enzymesnake venom-like proteasetumor necrosis factor, alpha, converting enzyme	protein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog
	Modification date	20200320	20200313
	UniProtAcc	P78536	O94979
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000310823, ENST00000497134,	ENST00000436790, ENST00000264405, ENST00000311785, ENST00000326950, ENST00000348405, ENST00000355196, ENST00000395310, ENST00000432794, ENST00000443462, ENST00000448323, ENST00000500777, ENST00000505472, ENST00000505984, ENST00000508479, ENST00000508502, ENST00000509142, ENST00000513858,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 8 X 6=288	27 X 19 X 11=5643
	# samples	11	28
	** MAII score	log2(11/288*10)=-1.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(28/5643*10)=-4.33296361729939 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ADAM17 [Title/Abstract] AND SEC31A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ADAM17(9634765)-SEC31A(83765662), # samples:1
Anticipated loss of major functional domain due to fusion event.	ADAM17-SEC31A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM17-SEC31A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM17-SEC31A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM17-SEC31A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ADAM17	GO:0001666	response to hypoxia	18276953
Hgene	ADAM17	GO:0006508	proteolysis	24227843
Hgene	ADAM17	GO:0006509	membrane protein ectodomain proteolysis	9034190\|9574564\|17786981\|18676862
Hgene	ADAM17	GO:0007155	cell adhesion	14970227
Hgene	ADAM17	GO:0007173	epidermal growth factor receptor signaling pathway	12743035
Hgene	ADAM17	GO:0007220	Notch receptor processing	24226769
Hgene	ADAM17	GO:0032496	response to lipopolysaccharide	18383040
Hgene	ADAM17	GO:0033627	cell adhesion mediated by integrin	14970227
Hgene	ADAM17	GO:0043536	positive regulation of blood vessel endothelial cell migration	24813629
Hgene	ADAM17	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	18483258
Hgene	ADAM17	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis	14625290\|15691827\|17010968
Hgene	ADAM17	GO:0071403	cellular response to high density lipoprotein particle stimulus	17786981
Hgene	ADAM17	GO:1905564	positive regulation of vascular endothelial cell proliferation	24813629
Tgene	SEC31A	GO:0051592	response to calcium ion	17196169
Tgene	SEC31A	GO:0090110	cargo loading into COPII-coated vesicle	17499046\|18843296

Fusion gene breakpoints across ADAM17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEC31A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-VR-A8EU	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000348405	SEC31A	chr4	83765662	-	3671	2097	183	3257	1024
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000513858	SEC31A	chr4	83765662	-	3329	2097	183	2915	910
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000395310	SEC31A	chr4	83765662	-	3671	2097	183	3257	1024
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000443462	SEC31A	chr4	83765662	-	3625	2097	183	3212	1009
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000509142	SEC31A	chr4	83765662	-	3328	2097	183	2915	910
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000326950	SEC31A	chr4	83765662	-	3670	2097	183	3257	1024
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000432794	SEC31A	chr4	83765662	-	3709	2097	183	3296	1037
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000311785	SEC31A	chr4	83765662	-	3328	2097	183	2915	910
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000448323	SEC31A	chr4	83765662	-	3670	2097	183	3257	1024
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000505472	SEC31A	chr4	83765662	-	3660	2097	183	3257	1024
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000500777	SEC31A	chr4	83765662	-	3318	2097	183	2915	910
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000508502	SEC31A	chr4	83765662	-	3276	2097	183	3212	1009
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000355196	SEC31A	chr4	83765662	-	3321	2097	183	3257	1024
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000264405	SEC31A	chr4	83765662	-	3265	2097	183	3212	1009
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000505984	SEC31A	chr4	83765662	-	3243	2097	183	3212	1009
ENST00000310823	ADAM17	chr2	9634765	-	ENST00000508479	SEC31A	chr4	83765662	-	2922	2097	183	2228	681

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000310823	ENST00000348405	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000383799	0.99961615
ENST00000310823	ENST00000513858	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000455655	0.9995443
ENST00000310823	ENST00000395310	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000383799	0.99961615
ENST00000310823	ENST00000443462	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000397012	0.999603
ENST00000310823	ENST00000509142	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000456808	0.9995432
ENST00000310823	ENST00000326950	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000383947	0.999616
ENST00000310823	ENST00000432794	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000457206	0.99954283
ENST00000310823	ENST00000311785	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000456808	0.9995432
ENST00000310823	ENST00000448323	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000383947	0.999616
ENST00000310823	ENST00000505472	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000403834	0.9995962
ENST00000310823	ENST00000500777	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000481811	0.99951816
ENST00000310823	ENST00000508502	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000461902	0.99953806
ENST00000310823	ENST00000355196	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000444152	0.9995559
ENST00000310823	ENST00000264405	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000509304	0.9994906
ENST00000310823	ENST00000505984	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000517299	0.99948263
ENST00000310823	ENST00000508479	ADAM17	chr2	9634765	-	SEC31A	chr4	83765662	-	0.000411418	0.99958855

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1981_1981_1_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000264405_length(amino acids)=1009AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT
SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP
IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET

--------------------------------------------------------------

>1981_1981_2_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000311785_length(amino acids)=910AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD
PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK
TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV

--------------------------------------------------------------

>1981_1981_3_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000326950_length(amino acids)=1024AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------

>1981_1981_4_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000348405_length(amino acids)=1024AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------

>1981_1981_5_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000355196_length(amino acids)=1024AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------

>1981_1981_6_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000395310_length(amino acids)=1024AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------

>1981_1981_7_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000432794_length(amino acids)=1037AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTENQSIQDQAPMLEGPQN
GWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPN
IEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNI

--------------------------------------------------------------

>1981_1981_8_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000443462_length(amino acids)=1009AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT
SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP
IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET

--------------------------------------------------------------

>1981_1981_9_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000448323_length(amino acids)=1024AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------

>1981_1981_10_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000500777_length(amino acids)=910AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD
PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK
TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV

--------------------------------------------------------------

>1981_1981_11_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000505472_length(amino acids)=1024AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------

>1981_1981_12_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000505984_length(amino acids)=1009AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT
SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP
IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET

--------------------------------------------------------------

>1981_1981_13_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000508479_length(amino acids)=681AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC

--------------------------------------------------------------

>1981_1981_14_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000508502_length(amino acids)=1009AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT
SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP
IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET

--------------------------------------------------------------

>1981_1981_15_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000509142_length(amino acids)=910AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD
PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK
TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV

--------------------------------------------------------------

>1981_1981_16_ADAM17-SEC31A_ADAM17_chr2_9634765_ENST00000310823_SEC31A_chr4_83765662_ENST00000513858_length(amino acids)=910AA_BP=638
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD
PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK
TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:9634765/chr4:83765662)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ADAM17 P78536	SEC31A O94979
FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). {ECO:0000250\|UniProtKB:Q9Z0F8, ECO:0000269\|PubMed:12441351, ECO:0000269\|PubMed:20592283, ECO:0000269\|PubMed:24226769, ECO:0000269\|PubMed:24227843, ECO:0000269\|PubMed:26876177, ECO:0000269\|PubMed:28060820, ECO:0000269\|PubMed:9034191}.	FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250\|UniProtKB:Q9Z2Q1, ECO:0000269\|PubMed:10788476}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

564_602

638.0

825.0

Compositional bias

Note=Cys-rich

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

96_99

638.0

825.0

Compositional bias

Note=Poly-Val

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

223_474

638.0

825.0

Domain

Peptidase M12B

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

475_563

638.0

825.0

Domain

Disintegrin

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

182_189

638.0

825.0

Motif

Cysteine switch

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000326950

800_1091

795.0

1182.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000348405

800_1091

795.0

1182.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000500777

800_1091

795.0

1068.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000513858

800_1091

795.0

1068.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000311785

842_848

834.0

1107.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000326950

842_848

795.0

1182.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000348405

842_848

795.0

1182.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000355196

842_848

834.0

1221.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000395310

842_848

834.0

1221.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000432794

842_848

834.0

1234.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000443462

842_848

829.0

1201.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000448323

842_848

834.0

1221.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000500777

842_848

795.0

1068.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000508502

842_848

834.0

1206.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000509142

842_848

834.0

1107.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000513858

842_848

795.0

1068.0

Motif

Note=ALG-2-binding site motif-2 (ABS-2)%2C

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

731_738

638.0

825.0

Motif

SH3-binding

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

741_748

638.0

825.0

Motif

SH3-binding

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

603_671

638.0

825.0

Region

Note=Crambin-like

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

215_671

638.0

825.0

Topological domain

Extracellular

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

693_824

638.0

825.0

Topological domain

Cytoplasmic

Hgene

ADAM17

chr2:9634765

chr4:83765662

ENST00000310823

672_692

638.0

825.0

Transmembrane

Helical

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000311785

800_1091

834.0

1107.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000355196

800_1091

834.0

1221.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000395310

800_1091

834.0

1221.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000432794

800_1091

834.0

1234.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000443462

800_1091

829.0

1201.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000448323

800_1091

834.0

1221.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000508502

800_1091

834.0

1206.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000509142

800_1091

834.0

1107.0

Compositional bias

Note=Pro-rich

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000311785

120_160

834.0

1107.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000311785

166_206

834.0

1107.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000311785

209_254

834.0

1107.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000311785

258_298

834.0

1107.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000311785

301_342

834.0

1107.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000311785

4_47

834.0

1107.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000311785

68_111

834.0

1107.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000326950

120_160

795.0

1182.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000326950

166_206

795.0

1182.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000326950

209_254

795.0

1182.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000326950

258_298

795.0

1182.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000326950

301_342

795.0

1182.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000326950

4_47

795.0

1182.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000326950

68_111

795.0

1182.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000348405

120_160

795.0

1182.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000348405

166_206

795.0

1182.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000348405

209_254

795.0

1182.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000348405

258_298

795.0

1182.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000348405

301_342

795.0

1182.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000348405

4_47

795.0

1182.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000348405

68_111

795.0

1182.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000355196

120_160

834.0

1221.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000355196

166_206

834.0

1221.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000355196

209_254

834.0

1221.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000355196

258_298

834.0

1221.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000355196

301_342

834.0

1221.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000355196

4_47

834.0

1221.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000355196

68_111

834.0

1221.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000395310

120_160

834.0

1221.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000395310

166_206

834.0

1221.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000395310

209_254

834.0

1221.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000395310

258_298

834.0

1221.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000395310

301_342

834.0

1221.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000395310

4_47

834.0

1221.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000395310

68_111

834.0

1221.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000432794

120_160

834.0

1234.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000432794

166_206

834.0

1234.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000432794

209_254

834.0

1234.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000432794

258_298

834.0

1234.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000432794

301_342

834.0

1234.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000432794

4_47

834.0

1234.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000432794

68_111

834.0

1234.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000443462

120_160

829.0

1201.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000443462

166_206

829.0

1201.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000443462

209_254

829.0

1201.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000443462

258_298

829.0

1201.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000443462

301_342

829.0

1201.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000443462

4_47

829.0

1201.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000443462

68_111

829.0

1201.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000448323

120_160

834.0

1221.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000448323

166_206

834.0

1221.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000448323

209_254

834.0

1221.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000448323

258_298

834.0

1221.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000448323

301_342

834.0

1221.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000448323

4_47

834.0

1221.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000448323

68_111

834.0

1221.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000500777

120_160

795.0

1068.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000500777

166_206

795.0

1068.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000500777

209_254

795.0

1068.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000500777

258_298

795.0

1068.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000500777

301_342

795.0

1068.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000500777

4_47

795.0

1068.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000500777

68_111

795.0

1068.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000508502

120_160

834.0

1206.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000508502

166_206

834.0

1206.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000508502

209_254

834.0

1206.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000508502

258_298

834.0

1206.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000508502

301_342

834.0

1206.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000508502

4_47

834.0

1206.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000508502

68_111

834.0

1206.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000509142

120_160

834.0

1107.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000509142

166_206

834.0

1107.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000509142

209_254

834.0

1107.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000509142

258_298

834.0

1107.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000509142

301_342

834.0

1107.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000509142

4_47

834.0

1107.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000509142

68_111

834.0

1107.0

Repeat

Note=WD 2

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000513858

120_160

795.0

1068.0

Repeat

Note=WD 3

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000513858

166_206

795.0

1068.0

Repeat

Note=WD 4

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000513858

209_254

795.0

1068.0

Repeat

Note=WD 5

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000513858

258_298

795.0

1068.0

Repeat

Note=WD 6

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000513858

301_342

795.0

1068.0

Repeat

Note=WD 7

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000513858

4_47

795.0

1068.0

Repeat

Note=WD 1

Tgene

SEC31A

chr2:9634765

chr4:83765662

ENST00000513858

68_111

795.0

1068.0

Repeat

Note=WD 2

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

SEC31A

SEC13, APC, TNNT1, PFDN1, ALG2, STAM, STAM2, CUL3, CDK9, HSPA8, VCAM1, ITGA4, REL, SHMT2, MOV10, NXF1, TFG, SCYL1, C6orf211, ATP6V1C1, ENO2, FDPS, NUDT13, SEC23A, SEC23B, SEC24B, ALDH5A1, ATP6V1D, CBS, CTH, CYB5B, DHX15, HNRNPA1, HSD17B10, NAPRT, NSF, SAR1A, TBCA, TPD52L2, TRIM25, TSTA3, TCEB2, NTRK1, TMEM17, XPO1, Sec24c, TSC22D2, NOP14, SEC23IP, NOC4L, GNPDA1, CCDC88A, BRCA1, KLHL12, PEF1, PDCD6, UBC, SEC24C, SEC24D, UBE2M, PIH1D1, ARIH1, USP8, ESR2, ARF1, POLE3, TBL1XR1, IGF2BP1, DEPDC5, BAZ1A, ARL5A, BMI1, RAB5C, MTF2, MAN1A1, NCOR1, MAN2A1, SLC39A9, TRAPPC12, TRAPPC10, TSC1, GCNT2, CARM1, HNRNPD, ARFGAP2, SLC30A5, UBE2J1, TRAPPC13, VPS51, HDAC8, DCAF7, EP300, SLC33A1, VPS45, IGF2R, RAB1B, TRAPPC11, VPS53, TRAPPC5, RABGEF1, HSP90AB1, TCF3, MAN1B1, B3GNT2, IGF1R, RICTOR, SEC24A, SLC39A7, MOGS, EZH2, EED, TRAPPC2, CTBP1, TRAPPC2L, MYC, TP53, BET1, VCP, KIAA1429, PRNP, APEX1, ABCC6, PPP1CA, BIRC3, LMBR1L, TRIM28, FHL5, PLEKHA4, N, LUZP1, ORF6, ORF7a, E, ORF14, ORF7b, MYOM2, CIT, CHMP4C, KIF14, KIF23, ACACA, Rnf183, LGALS9, RIN3, B3GAT1, CAV1, EBAG9, EMD, ERGIC2, GJA1, GJD3, HSD3B7, NUP155, ZFPL1, WDR5, GORASP1, TMPRSS2, FURIN, IFITM1, OPTN,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ADAM17
SEC31A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000311785		19	26	800_1113	834.0	1107.0	PDCD6
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000355196		21	29	800_1113	834.0	1221.0	PDCD6
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000395310		19	27	800_1113	834.0	1221.0	PDCD6
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000432794		19	28	800_1113	834.0	1234.0	PDCD6
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000443462		18	26	800_1113	829.0	1201.0	PDCD6
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000448323		19	27	800_1113	834.0	1221.0	PDCD6
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000508502		19	27	800_1113	834.0	1206.0	PDCD6
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000509142		19	26	800_1113	834.0	1107.0	PDCD6
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000311785		19	26	161_471	834.0	1107.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000326950		17	25	161_471	795.0	1182.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000348405		17	25	161_471	795.0	1182.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000355196		21	29	161_471	834.0	1221.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000395310		19	27	161_471	834.0	1221.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000432794		19	28	161_471	834.0	1234.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000443462		18	26	161_471	829.0	1201.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000448323		19	27	161_471	834.0	1221.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000500777		16	23	161_471	795.0	1068.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000508502		19	27	161_471	834.0	1206.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000509142		19	26	161_471	834.0	1107.0	SEC13
Tgene	SEC31A	chr2:9634765	chr4:83765662	ENST00000513858		17	24	161_471	795.0	1068.0	SEC13

Top

Related Drugs to ADAM17-SEC31A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ADAM17-SEC31A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	SEC31A	C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human