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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CTDSP2-COL15A1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CTDSP2-COL15A1
	FusionPDB ID: 20167
	FusionGDB2.0 ID: 20167
		Hgene	Tgene
	Gene symbol	CTDSP2	COL15A1
	Gene ID	10106	1306
	Gene name	CTD small phosphatase 2	collagen type XV alpha 1 chain
	Synonyms	OS4\|PSR2\|SCP2	-
	Cytomap	12q14.1	9q22.33
	Type of gene	protein-coding	protein-coding
	Description	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2NLI-interacting factor 2conserved gene amplified in osteosarcomanuclear LIM interactor-intera	collagen alpha-1(XV) chaincollagen XV, alpha-1 polypeptidecollagen type XV proteoglycancollagen, type XV, alpha 1endostatin-XVrestin
	Modification date	20200313	20200313
	UniProtAcc	O14595	P39059
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000398073, ENST00000548823, ENST00000547701,	ENST00000467052, ENST00000375001,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	32 X 8 X 10=2560	6 X 7 X 3=126
	# samples	37	7
	** MAII score	log2(37/2560*10)=-2.79054663437105 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CTDSP2 [Title/Abstract] AND COL15A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CTDSP2(58240155)-COL15A1(101759216), # samples:3
Anticipated loss of major functional domain due to fusion event.	CTDSP2-COL15A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CTDSP2-COL15A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CTDSP2-COL15A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CTDSP2-COL15A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CTDSP2	GO:0006470	protein dephosphorylation	12721286

Fusion gene breakpoints across CTDSP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across COL15A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-IK-7675-01A	CTDSP2	chr12	58240155	-	COL15A1	chr9	101759216	+
ChimerDB4	LGG	TCGA-IK-7675	CTDSP2	chr12	58240154	-	COL15A1	chr9	101759215	+
ChimerDB4	LGG	TCGA-IK-7675	CTDSP2	chr12	58240155	-	COL15A1	chr9	101759216	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000398073	CTDSP2	chr12	58240155	-	ENST00000375001	COL15A1	chr9	101759216	+	4632	368	185	3730	1181
ENST00000548823	CTDSP2	chr12	58240155	-	ENST00000375001	COL15A1	chr9	101759216	+	4597	333	150	3695	1181
ENST00000398073	CTDSP2	chr12	58240154	-	ENST00000375001	COL15A1	chr9	101759215	+	4632	368	185	3730	1181
ENST00000548823	CTDSP2	chr12	58240154	-	ENST00000375001	COL15A1	chr9	101759215	+	4597	333	150	3695	1181

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398073	ENST00000375001	CTDSP2	chr12	58240155	-	COL15A1	chr9	101759216	+	0.001726643	0.9982734
ENST00000548823	ENST00000375001	CTDSP2	chr12	58240155	-	COL15A1	chr9	101759216	+	0.001699261	0.99830073
ENST00000398073	ENST00000375001	CTDSP2	chr12	58240154	-	COL15A1	chr9	101759215	+	0.001726643	0.9982734
ENST00000548823	ENST00000375001	CTDSP2	chr12	58240154	-	COL15A1	chr9	101759215	+	0.001699261	0.99830073

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>20167_20167_1_CTDSP2-COL15A1_CTDSP2_chr12_58240154_ENST00000398073_COL15A1_chr9_101759215_ENST00000375001_length(amino acids)=1181AA_BP=487
MWKSESREPERAPAQAPQPSPARAPARPPAQPARARGIVRWNTAPSSPRRGGKTPWCSPSKPKEAKVEPINTPPTPSSPFEDMELSGEPV
PEGTLETTNMSIIQHSSPKQGSGEILNDTLEGVHSVDGDPITDSGSGAGAFLDIAEEKNLAATAAGLAEVPISTAGEAEASSVPTGGPTL
SMSTENPEEGVTPGPDNEERLAATAAGEAEALASMPGEVEASGVAPGELDLSMSAQSLGEEATVGPSSEDSLTTAAAATEVSLSTFEDEE
ASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESGSPPPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEK
GDAGEELPGPPEPSGPVGPTAGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRGPPGPPGPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGEP
GPPGPEGQPGVDGATGLPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKGQAGPPGVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGS
TQLLNEPKLSRPTAAIGLKGEKGDRGPKGERGMDGASIVGPPGPRGPPGHIKVLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFP
GPRGPKGDTGLPGFPGLKGEQGEKGEPGAILTEDIPLERLMGKKGEPGMHGAPGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGTKGDPG
VIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKMPVDTAHPGSPELITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLA
YLRHFLNNLKGENGDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGETVVGPQGPPGAPGLPGPPGFGRPGDPGPPGPPGPPGPP
AILGAAVALPGPPGPPGQPGLPGSRNLVTAFSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSN
PHQLLPPPNPISSANYEKPALHLAALNMPFSGDIRADFQCFKQARAAGLLSTYRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNW
DSIFSGHGGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYCEAWRTADTAVTGLASPLSTGKILDQKAYSCANRLIVLC

--------------------------------------------------------------

>20167_20167_2_CTDSP2-COL15A1_CTDSP2_chr12_58240154_ENST00000548823_COL15A1_chr9_101759215_ENST00000375001_length(amino acids)=1181AA_BP=487
MWKSESREPERAPAQAPQPSPARAPARPPAQPARARGIVRWNTAPSSPRRGGKTPWCSPSKPKEAKVEPINTPPTPSSPFEDMELSGEPV
PEGTLETTNMSIIQHSSPKQGSGEILNDTLEGVHSVDGDPITDSGSGAGAFLDIAEEKNLAATAAGLAEVPISTAGEAEASSVPTGGPTL
SMSTENPEEGVTPGPDNEERLAATAAGEAEALASMPGEVEASGVAPGELDLSMSAQSLGEEATVGPSSEDSLTTAAAATEVSLSTFEDEE
ASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESGSPPPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEK
GDAGEELPGPPEPSGPVGPTAGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRGPPGPPGPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGEP
GPPGPEGQPGVDGATGLPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKGQAGPPGVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGS
TQLLNEPKLSRPTAAIGLKGEKGDRGPKGERGMDGASIVGPPGPRGPPGHIKVLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFP
GPRGPKGDTGLPGFPGLKGEQGEKGEPGAILTEDIPLERLMGKKGEPGMHGAPGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGTKGDPG
VIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKMPVDTAHPGSPELITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLA
YLRHFLNNLKGENGDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGETVVGPQGPPGAPGLPGPPGFGRPGDPGPPGPPGPPGPP
AILGAAVALPGPPGPPGQPGLPGSRNLVTAFSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSN
PHQLLPPPNPISSANYEKPALHLAALNMPFSGDIRADFQCFKQARAAGLLSTYRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNW
DSIFSGHGGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYCEAWRTADTAVTGLASPLSTGKILDQKAYSCANRLIVLC

--------------------------------------------------------------

>20167_20167_3_CTDSP2-COL15A1_CTDSP2_chr12_58240155_ENST00000398073_COL15A1_chr9_101759216_ENST00000375001_length(amino acids)=1181AA_BP=487
MWKSESREPERAPAQAPQPSPARAPARPPAQPARARGIVRWNTAPSSPRRGGKTPWCSPSKPKEAKVEPINTPPTPSSPFEDMELSGEPV
PEGTLETTNMSIIQHSSPKQGSGEILNDTLEGVHSVDGDPITDSGSGAGAFLDIAEEKNLAATAAGLAEVPISTAGEAEASSVPTGGPTL
SMSTENPEEGVTPGPDNEERLAATAAGEAEALASMPGEVEASGVAPGELDLSMSAQSLGEEATVGPSSEDSLTTAAAATEVSLSTFEDEE
ASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESGSPPPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEK
GDAGEELPGPPEPSGPVGPTAGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRGPPGPPGPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGEP
GPPGPEGQPGVDGATGLPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKGQAGPPGVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGS
TQLLNEPKLSRPTAAIGLKGEKGDRGPKGERGMDGASIVGPPGPRGPPGHIKVLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFP
GPRGPKGDTGLPGFPGLKGEQGEKGEPGAILTEDIPLERLMGKKGEPGMHGAPGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGTKGDPG
VIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKMPVDTAHPGSPELITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLA
YLRHFLNNLKGENGDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGETVVGPQGPPGAPGLPGPPGFGRPGDPGPPGPPGPPGPP
AILGAAVALPGPPGPPGQPGLPGSRNLVTAFSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSN
PHQLLPPPNPISSANYEKPALHLAALNMPFSGDIRADFQCFKQARAAGLLSTYRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNW
DSIFSGHGGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYCEAWRTADTAVTGLASPLSTGKILDQKAYSCANRLIVLC

--------------------------------------------------------------

>20167_20167_4_CTDSP2-COL15A1_CTDSP2_chr12_58240155_ENST00000548823_COL15A1_chr9_101759216_ENST00000375001_length(amino acids)=1181AA_BP=487
MWKSESREPERAPAQAPQPSPARAPARPPAQPARARGIVRWNTAPSSPRRGGKTPWCSPSKPKEAKVEPINTPPTPSSPFEDMELSGEPV
PEGTLETTNMSIIQHSSPKQGSGEILNDTLEGVHSVDGDPITDSGSGAGAFLDIAEEKNLAATAAGLAEVPISTAGEAEASSVPTGGPTL
SMSTENPEEGVTPGPDNEERLAATAAGEAEALASMPGEVEASGVAPGELDLSMSAQSLGEEATVGPSSEDSLTTAAAATEVSLSTFEDEE
ASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESGSPPPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEK
GDAGEELPGPPEPSGPVGPTAGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRGPPGPPGPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGEP
GPPGPEGQPGVDGATGLPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKGQAGPPGVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGS
TQLLNEPKLSRPTAAIGLKGEKGDRGPKGERGMDGASIVGPPGPRGPPGHIKVLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFP
GPRGPKGDTGLPGFPGLKGEQGEKGEPGAILTEDIPLERLMGKKGEPGMHGAPGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGTKGDPG
VIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKMPVDTAHPGSPELITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLA
YLRHFLNNLKGENGDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGETVVGPQGPPGAPGLPGPPGFGRPGDPGPPGPPGPPGPP
AILGAAVALPGPPGPPGQPGLPGSRNLVTAFSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSN
PHQLLPPPNPISSANYEKPALHLAALNMPFSGDIRADFQCFKQARAAGLLSTYRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNW
DSIFSGHGGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYCEAWRTADTAVTGLASPLSTGKILDQKAYSCANRLIVLC

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:58240155/chr9:101759216)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CTDSP2 O14595	COL15A1 P39059
FUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. {ECO:0000269\|PubMed:12721286, ECO:0000269\|PubMed:15681389}.	FUNCTION: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. {ECO:0000269\|PubMed:10049780}.; FUNCTION: Restin potently inhibits angiogenesis. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

619_680

268.0

1389.0

Domain

Note=Collagen-like 1

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

681_731

268.0

1389.0

Domain

Note=Collagen-like 2

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

823_865

268.0

1389.0

Domain

Note=Collagen-like 3

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

879_927

268.0

1389.0

Domain

Note=Collagen-like 4

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

619_680

268.0

1389.0

Domain

Note=Collagen-like 1

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

681_731

268.0

1389.0

Domain

Note=Collagen-like 2

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

823_865

268.0

1389.0

Domain

Note=Collagen-like 3

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

879_927

268.0

1389.0

Domain

Note=Collagen-like 4

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

1014_1027

268.0

1389.0

Region

Note=Nonhelical region 7 (NC7)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

1028_1045

268.0

1389.0

Region

Note=Triple-helical region 7 (COL7)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

1046_1052

268.0

1389.0

Region

Note=Nonhelical region 8 (NC8)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

1053_1107

268.0

1389.0

Region

Note=Triple-helical region 8 (COL8)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

1108_1117

268.0

1389.0

Region

Note=Nonhelical region 9 (NC9)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

1118_1132

268.0

1389.0

Region

Note=Triple-helical region 9 (COL9)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

1133_1388

268.0

1389.0

Region

Note=Nonhelical region 10 (NC10)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

358_555

268.0

1389.0

Region

Note=4 X tandem repeats

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

556_573

268.0

1389.0

Region

Note=Triple-helical region 1 (COL1)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

574_618

268.0

1389.0

Region

Note=Nonhelical region 2 (NC2)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

619_732

268.0

1389.0

Region

Note=Triple-helical region 2 (COL2)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

733_763

268.0

1389.0

Region

Note=Nonhelical region 3 (NC3)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

764_798

268.0

1389.0

Region

Note=Triple-helical region 3 (COL3)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

799_822

268.0

1389.0

Region

Note=Nonhelical region 4 (NC4)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

823_867

268.0

1389.0

Region

Note=Triple-helical region 4 (COL4)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

868_878

268.0

1389.0

Region

Note=Nonhelical region 5 (NC5)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

879_949

268.0

1389.0

Region

Note=Triple-helical region 5 (COL5)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

950_983

268.0

1389.0

Region

Note=Nonhelical region 6 (NC6)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

984_1013

268.0

1389.0

Region

Note=Triple-helical region 6 (COL6)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

1014_1027

268.0

1389.0

Region

Note=Nonhelical region 7 (NC7)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

1028_1045

268.0

1389.0

Region

Note=Triple-helical region 7 (COL7)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

1046_1052

268.0

1389.0

Region

Note=Nonhelical region 8 (NC8)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

1053_1107

268.0

1389.0

Region

Note=Triple-helical region 8 (COL8)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

1108_1117

268.0

1389.0

Region

Note=Nonhelical region 9 (NC9)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

1118_1132

268.0

1389.0

Region

Note=Triple-helical region 9 (COL9)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

1133_1388

268.0

1389.0

Region

Note=Nonhelical region 10 (NC10)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

358_555

268.0

1389.0

Region

Note=4 X tandem repeats

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

556_573

268.0

1389.0

Region

Note=Triple-helical region 1 (COL1)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

574_618

268.0

1389.0

Region

Note=Nonhelical region 2 (NC2)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

619_732

268.0

1389.0

Region

Note=Triple-helical region 2 (COL2)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

733_763

268.0

1389.0

Region

Note=Nonhelical region 3 (NC3)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

764_798

268.0

1389.0

Region

Note=Triple-helical region 3 (COL3)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

799_822

268.0

1389.0

Region

Note=Nonhelical region 4 (NC4)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

823_867

268.0

1389.0

Region

Note=Triple-helical region 4 (COL4)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

868_878

268.0

1389.0

Region

Note=Nonhelical region 5 (NC5)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

879_949

268.0

1389.0

Region

Note=Triple-helical region 5 (COL5)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

950_983

268.0

1389.0

Region

Note=Nonhelical region 6 (NC6)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

984_1013

268.0

1389.0

Region

Note=Triple-helical region 6 (COL6)

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

358_408

268.0

1389.0

Repeat

Note=1

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

409_459

268.0

1389.0

Repeat

Note=2

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

460_509

268.0

1389.0

Repeat

Note=3

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

510_555

268.0

1389.0

Repeat

Note=4

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

358_408

268.0

1389.0

Repeat

Note=1

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

409_459

268.0

1389.0

Repeat

Note=2

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

460_509

268.0

1389.0

Repeat

Note=3

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

510_555

268.0

1389.0

Repeat

Note=4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CTDSP2

chr12:58240154

chr9:101759215

ENST00000398073

97_255

21.333333333333332

272.0

Domain

FCP1 homology

Hgene

CTDSP2

chr12:58240155

chr9:101759216

ENST00000398073

97_255

21.333333333333332

272.0

Domain

FCP1 homology

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

66_249

268.0

1389.0

Domain

Note=Laminin G-like

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

66_249

268.0

1389.0

Domain

Note=Laminin G-like

Tgene

COL15A1

chr12:58240154

chr9:101759215

ENST00000375001

229_555

268.0

1389.0

Region

Note=Nonhelical region 1 (NC1)

Tgene

COL15A1

chr12:58240155

chr9:101759216

ENST00000375001

229_555

268.0

1389.0

Region

Note=Nonhelical region 1 (NC1)

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1918_CTDSP2_58240155_COL15A1_101759216_ranked_0.pdb	CTDSP2	58240154	58240155	ENST00000375001	COL15A1	chr9	101759216	+	MWKSESREPERAPAQAPQPSPARAPARPPAQPARARGIVRWNTAPSSPRRGGKTPWCSPSKPKEAKVEPINTPPTPSSPFEDMELSGEPV PEGTLETTNMSIIQHSSPKQGSGEILNDTLEGVHSVDGDPITDSGSGAGAFLDIAEEKNLAATAAGLAEVPISTAGEAEASSVPTGGPTL SMSTENPEEGVTPGPDNEERLAATAAGEAEALASMPGEVEASGVAPGELDLSMSAQSLGEEATVGPSSEDSLTTAAAATEVSLSTFEDEE ASGVPTDGLAPLTATMAPERAVTSGPGDEEDLAAATTEEPLITAGGEESGSPPPDGPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEK GDAGEELPGPPEPSGPVGPTAGAEAEGSGLGWGSDVGSGSGDLVGSEQLLRGPPGPPGPPGLPGIPGKPGTDVFMGPPGSPGEDGPAGEP GPPGPEGQPGVDGATGLPGMKGEKGARGPNGSVGEKGDPGNRGLPGPPGKKGQAGPPGVMGPPGPPGPPGPPGPGCTMGLGFEDTEGSGS TQLLNEPKLSRPTAAIGLKGEKGDRGPKGERGMDGASIVGPPGPRGPPGHIKVLSNSLINITHGFMNFSDIPELVGPPGPDGLPGLPGFP GPRGPKGDTGLPGFPGLKGEQGEKGEPGAILTEDIPLERLMGKKGEPGMHGAPGPMGPKGPPGHKGEFGLPGRPGRPGLNGLKGTKGDPG VIMQGPPGLPGPPGPPGPPGAVINIKGAIFPIPVRPHCKMPVDTAHPGSPELITFHGVKGEKGSWGLPGSKGEKGDQGAQGPPGPPLDLA YLRHFLNNLKGENGDKGFKGEKGEKGDINGSFLMSGPPGLPGNPGPAGQKGETVVGPQGPPGAPGLPGPPGFGRPGDPGPPGPPGPPGPP AILGAAVALPGPPGPPGQPGLPGSRNLVTAFSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWKKLQLGELIPIPADSPPPPALSSN PHQLLPPPNPISSANYEKPALHLAALNMPFSGDIRADFQCFKQARAAGLLSTYRAFLSSHLQDLSTIVRKAERYSLPIVNLKGQVLFNNW DSIFSGHGGQFNMHIPIYSFDGRDIMTDPSWPQKVIWHGSSPHGVRLVDNYCEAWRTADTAVTGLASPLSTGKILDQKAYSCANRLIVLC	1181

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CTDSP2_pLDDT.png

COL15A1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CTDSP2
COL15A1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CTDSP2-COL15A1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CTDSP2-COL15A1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source