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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CTIF-GRM4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CTIF-GRM4
FusionPDB ID: 20236
FusionGDB2.0 ID: 20236
HgeneTgene
Gene symbol

CTIF

GRM4

Gene ID

9811

2914

Gene namecap binding complex dependent translation initiation factorglutamate metabotropic receptor 4
SynonymsGm672|KIAA0427GPRC1D|MGLUR4|mGlu4
Cytomap

18q21.1

6p21.31

Type of geneprotein-codingprotein-coding
DescriptionCBP80/20-dependent translation initiation factormetabotropic glutamate receptor 4glutamate receptor, metabotropic 4
Modification date2020031320200313
UniProtAcc

O43310

Q14833

Ensembl transtripts involved in fusion geneENST idsENST00000256413, ENST00000382998, 
ENST00000592658, 		ENST00000455714, 
ENST00000535756, ENST00000545715, 
ENST00000609222, ENST00000374177, 
ENST00000374181, ENST00000538487, 
ENST00000544773, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 11 X 10=22007 X 7 X 6=294
# samples 239
** MAII scorelog2(23/2200*10)=-3.25779775746765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CTIF [Title/Abstract] AND GRM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CTIF(46197115)-GRM4(34059876), # samples:3
Anticipated loss of major functional domain due to fusion event.CTIF-GRM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTIF-GRM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTIF-GRM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTIF-GRM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRM4

GO:0000187

activation of MAPK activity

15102938


check buttonFusion gene breakpoints across CTIF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B0-4945-01ACTIFchr18

46197115

-GRM4chr6

34059876

-
ChimerDB4KIRCTCGA-B0-4945-01ACTIFchr18

46197115

+GRM4chr6

34059876

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256413CTIFchr1846197115+ENST00000538487GRM4chr634059876-39928022953021908
ENST00000256413CTIFchr1846197115+ENST00000374181GRM4chr634059876-39918022953021908
ENST00000256413CTIFchr1846197115+ENST00000374177GRM4chr634059876-38488022952880861
ENST00000256413CTIFchr1846197115+ENST00000544773GRM4chr634059876-34108022953021908
ENST00000382998CTIFchr1846197115+ENST00000538487GRM4chr634059876-39547642572983908
ENST00000382998CTIFchr1846197115+ENST00000374181GRM4chr634059876-39537642572983908
ENST00000382998CTIFchr1846197115+ENST00000374177GRM4chr634059876-38107642572842861
ENST00000382998CTIFchr1846197115+ENST00000544773GRM4chr634059876-33727642572983908

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256413ENST00000538487CTIFchr1846197115+GRM4chr634059876-0.0027335520.9972664
ENST00000256413ENST00000374181CTIFchr1846197115+GRM4chr634059876-0.0027184650.99728155
ENST00000256413ENST00000374177CTIFchr1846197115+GRM4chr634059876-0.0031260430.996874
ENST00000256413ENST00000544773CTIFchr1846197115+GRM4chr634059876-0.003910490.9960896
ENST00000382998ENST00000538487CTIFchr1846197115+GRM4chr634059876-0.0033904950.99660957
ENST00000382998ENST00000374181CTIFchr1846197115+GRM4chr634059876-0.0033678180.99663216
ENST00000382998ENST00000374177CTIFchr1846197115+GRM4chr634059876-0.0038208860.9961791
ENST00000382998ENST00000544773CTIFchr1846197115+GRM4chr634059876-0.0051072360.9948927

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>20236_20236_1_CTIF-GRM4_CTIF_chr18_46197115_ENST00000256413_GRM4_chr6_34059876_ENST00000374177_length(amino acids)=861AA_BP=166
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQIPQISYASTAP
DLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE
TSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRDRERIGQDSAYEQEGKVQFVID
AVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHL
RIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLP
LFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIF
EQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYA
IKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLK

--------------------------------------------------------------

>20236_20236_2_CTIF-GRM4_CTIF_chr18_46197115_ENST00000256413_GRM4_chr6_34059876_ENST00000374181_length(amino acids)=908AA_BP=166
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQIPQISYASTAP
DLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE
TSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAE
FWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVN
FSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEP
CTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIF
LCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSH
SVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADK
LYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTY

--------------------------------------------------------------

>20236_20236_3_CTIF-GRM4_CTIF_chr18_46197115_ENST00000256413_GRM4_chr6_34059876_ENST00000538487_length(amino acids)=908AA_BP=166
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQIPQISYASTAP
DLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE
TSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAE
FWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVN
FSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEP
CTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIF
LCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSH
SVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADK
LYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTY

--------------------------------------------------------------

>20236_20236_4_CTIF-GRM4_CTIF_chr18_46197115_ENST00000256413_GRM4_chr6_34059876_ENST00000544773_length(amino acids)=908AA_BP=166
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQIPQISYASTAP
DLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE
TSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAE
FWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVN
FSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEP
CTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIF
LCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSH
SVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADK
LYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTY

--------------------------------------------------------------

>20236_20236_5_CTIF-GRM4_CTIF_chr18_46197115_ENST00000382998_GRM4_chr6_34059876_ENST00000374177_length(amino acids)=861AA_BP=166
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQIPQISYASTAP
DLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE
TSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRDRERIGQDSAYEQEGKVQFVID
AVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHL
RIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLP
LFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIF
EQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYA
IKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLK

--------------------------------------------------------------

>20236_20236_6_CTIF-GRM4_CTIF_chr18_46197115_ENST00000382998_GRM4_chr6_34059876_ENST00000374181_length(amino acids)=908AA_BP=166
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQIPQISYASTAP
DLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE
TSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAE
FWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVN
FSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEP
CTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIF
LCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSH
SVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADK
LYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTY

--------------------------------------------------------------

>20236_20236_7_CTIF-GRM4_CTIF_chr18_46197115_ENST00000382998_GRM4_chr6_34059876_ENST00000538487_length(amino acids)=908AA_BP=166
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQIPQISYASTAP
DLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE
TSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAE
FWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVN
FSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEP
CTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIF
LCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSH
SVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADK
LYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTY

--------------------------------------------------------------

>20236_20236_8_CTIF-GRM4_CTIF_chr18_46197115_ENST00000382998_GRM4_chr6_34059876_ENST00000544773_length(amino acids)=908AA_BP=166
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDN
SLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQIPQISYASTAP
DLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE
TSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAE
FWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVN
FSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEP
CTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIF
LCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSH
SVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADK
LYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTY

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:46197115/chr6:34059876)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTIF

O43310

GRM4

Q14833

FUNCTION: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}.FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:7617140, ECO:0000269|PubMed:8738157, ECO:0000269|PubMed:9473604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709180_182104.0797.0RegionGlutamate binding
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010180_182173.0913.0RegionGlutamate binding
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010180_18233.0773.0RegionGlutamate binding
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010180_18240.0780.0RegionGlutamate binding
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111180_182173.0913.0RegionGlutamate binding
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010180_1824.0744.0RegionGlutamate binding
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709611_624104.0797.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709646_656104.0797.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709676_699104.0797.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709721_750104.0797.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709773_785104.0797.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709809_821104.0797.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709848_912104.0797.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010611_624173.0913.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010646_656173.0913.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010676_699173.0913.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010721_750173.0913.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010773_785173.0913.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010809_821173.0913.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010848_912173.0913.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST0000045571401033_58733.0773.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010611_62433.0773.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010646_65633.0773.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010676_69933.0773.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010721_75033.0773.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010773_78533.0773.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010809_82133.0773.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010848_91233.0773.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010611_62440.0780.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010646_65640.0780.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010676_69940.0780.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010721_75040.0780.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010773_78540.0780.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010809_82140.0780.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010848_91240.0780.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111611_624173.0913.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111646_656173.0913.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111676_699173.0913.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111721_750173.0913.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111773_785173.0913.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111809_821173.0913.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111848_912173.0913.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST0000054477301033_5874.0744.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010611_6244.0744.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010646_6564.0744.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010676_6994.0744.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010721_7504.0744.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010773_7854.0744.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010809_8214.0744.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010848_9124.0744.0Topological domainCytoplasmic
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709588_610104.0797.0TransmembraneHelical%3B Name%3D1
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709625_645104.0797.0TransmembraneHelical%3B Name%3D2
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709657_675104.0797.0TransmembraneHelical%3B Name%3D3
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709700_720104.0797.0TransmembraneHelical%3B Name%3D4
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709751_772104.0797.0TransmembraneHelical%3B Name%3D5
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709786_808104.0797.0TransmembraneHelical%3B Name%3D6
TgeneGRM4chr18:46197115chr6:34059876ENST0000037417709822_847104.0797.0TransmembraneHelical%3B Name%3D7
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010588_610173.0913.0TransmembraneHelical%3B Name%3D1
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010625_645173.0913.0TransmembraneHelical%3B Name%3D2
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010657_675173.0913.0TransmembraneHelical%3B Name%3D3
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010700_720173.0913.0TransmembraneHelical%3B Name%3D4
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010751_772173.0913.0TransmembraneHelical%3B Name%3D5
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010786_808173.0913.0TransmembraneHelical%3B Name%3D6
TgeneGRM4chr18:46197115chr6:34059876ENST00000374181010822_847173.0913.0TransmembraneHelical%3B Name%3D7
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010588_61033.0773.0TransmembraneHelical%3B Name%3D1
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010625_64533.0773.0TransmembraneHelical%3B Name%3D2
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010657_67533.0773.0TransmembraneHelical%3B Name%3D3
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010700_72033.0773.0TransmembraneHelical%3B Name%3D4
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010751_77233.0773.0TransmembraneHelical%3B Name%3D5
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010786_80833.0773.0TransmembraneHelical%3B Name%3D6
TgeneGRM4chr18:46197115chr6:34059876ENST00000455714010822_84733.0773.0TransmembraneHelical%3B Name%3D7
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010588_61040.0780.0TransmembraneHelical%3B Name%3D1
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010625_64540.0780.0TransmembraneHelical%3B Name%3D2
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010657_67540.0780.0TransmembraneHelical%3B Name%3D3
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010700_72040.0780.0TransmembraneHelical%3B Name%3D4
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010751_77240.0780.0TransmembraneHelical%3B Name%3D5
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010786_80840.0780.0TransmembraneHelical%3B Name%3D6
TgeneGRM4chr18:46197115chr6:34059876ENST00000535756010822_84740.0780.0TransmembraneHelical%3B Name%3D7
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111588_610173.0913.0TransmembraneHelical%3B Name%3D1
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111625_645173.0913.0TransmembraneHelical%3B Name%3D2
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111657_675173.0913.0TransmembraneHelical%3B Name%3D3
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111700_720173.0913.0TransmembraneHelical%3B Name%3D4
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111751_772173.0913.0TransmembraneHelical%3B Name%3D5
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111786_808173.0913.0TransmembraneHelical%3B Name%3D6
TgeneGRM4chr18:46197115chr6:34059876ENST00000538487111822_847173.0913.0TransmembraneHelical%3B Name%3D7
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010588_6104.0744.0TransmembraneHelical%3B Name%3D1
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010625_6454.0744.0TransmembraneHelical%3B Name%3D2
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010657_6754.0744.0TransmembraneHelical%3B Name%3D3
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010700_7204.0744.0TransmembraneHelical%3B Name%3D4
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010751_7724.0744.0TransmembraneHelical%3B Name%3D5
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010786_8084.0744.0TransmembraneHelical%3B Name%3D6
TgeneGRM4chr18:46197115chr6:34059876ENST00000544773010822_8474.0744.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTIFchr18:46197115chr6:34059876ENST00000256413+612376_577169.0599.0DomainNote=MIF4G
HgeneCTIFchr18:46197115chr6:34059876ENST00000382998+713376_577169.0601.0DomainNote=MIF4G
TgeneGRM4chr18:46197115chr6:34059876ENST000003741770933_587104.0797.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST0000037418101033_587173.0913.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST0000053575601033_58740.0780.0Topological domainExtracellular
TgeneGRM4chr18:46197115chr6:34059876ENST0000053848711133_587173.0913.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CTIF
GRM4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCTIFchr18:46197115chr6:34059876ENST00000256413+6121_305169.0599.0NCBP1/CBP80
HgeneCTIFchr18:46197115chr6:34059876ENST00000382998+7131_305169.0601.0NCBP1/CBP80


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Related Drugs to CTIF-GRM4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to CTIF-GRM4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource