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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CTSC-GRM5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CTSC-GRM5
FusionPDB ID: 20482
FusionGDB2.0 ID: 20482
HgeneTgene
Gene symbol

CTSC

GRM5

Gene ID

1075

2915

Gene namecathepsin Cglutamate metabotropic receptor 5
SynonymsCPPI|DPP-I|DPP1|DPPI|HMS|JP|JPD|PALS|PDON1|PLSGPRC1E|MGLUR5|PPP1R86|mGlu5
Cytomap

11q14.2

11q14.2-q14.3

Type of geneprotein-codingprotein-coding
Descriptiondipeptidyl peptidase 1cathepsin Jdipeptidyl transferasedipeptidyl-peptidase Imetabotropic glutamate receptor 5glutamate receptor, metabotropic 5protein phosphatase 1, regulatory subunit 86
Modification date2020031320200329
UniProtAcc

P53634

P41594

Ensembl transtripts involved in fusion geneENST idsENST00000227266, ENST00000524463, 
ENST00000529974, ENST00000393301, 
ENST00000393294, ENST00000393297, 
ENST00000305432, ENST00000305447, 
ENST00000418177, ENST00000455756, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 11 X 7=6937 X 5 X 4=140
# samples 147
** MAII scorelog2(14/693*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CTSC [Title/Abstract] AND GRM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CTSC(88068105)-GRM5(88242672), # samples:1
Anticipated loss of major functional domain due to fusion event.CTSC-GRM5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTSC-GRM5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CTSC-GRM5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTSC-GRM5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CTSC-GRM5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CTSC-GRM5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CTSC-GRM5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTSC

GO:0006508

proteolysis

8811434


check buttonFusion gene breakpoints across CTSC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRM5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-7660-01ACTSCchr11

88068105

-GRM5chr11

88242672

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000227266CTSCchr1188068105-ENST00000455756GRM5chr1188242672-53624334041345313
ENST00000227266CTSCchr1188068105-ENST00000418177GRM5chr1188242672-53624334041345313
ENST00000524463CTSCchr1188068105-ENST00000455756GRM5chr1188242672-53364073781319313
ENST00000524463CTSCchr1188068105-ENST00000418177GRM5chr1188242672-53364073781319313
ENST00000529974CTSCchr1188068105-ENST00000455756GRM5chr1188242672-53083793501291313
ENST00000529974CTSCchr1188068105-ENST00000418177GRM5chr1188242672-53083793501291313

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000227266ENST00000455756CTSCchr1188068105-GRM5chr1188242672-0.002022840.9979772
ENST00000227266ENST00000418177CTSCchr1188068105-GRM5chr1188242672-0.002022840.9979772
ENST00000524463ENST00000455756CTSCchr1188068105-GRM5chr1188242672-0.0020627510.9979373
ENST00000524463ENST00000418177CTSCchr1188068105-GRM5chr1188242672-0.0020627510.9979373
ENST00000529974ENST00000455756CTSCchr1188068105-GRM5chr1188242672-0.002032670.9979673
ENST00000529974ENST00000418177CTSCchr1188068105-GRM5chr1188242672-0.002032670.9979673

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>20482_20482_1_CTSC-GRM5_CTSC_chr11_88068105_ENST00000227266_GRM5_chr11_88242672_ENST00000418177_length(amino acids)=313AA_BP=8
MTTSGLPFLSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGG
PESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMM
LSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPF

--------------------------------------------------------------

>20482_20482_2_CTSC-GRM5_CTSC_chr11_88068105_ENST00000227266_GRM5_chr11_88242672_ENST00000455756_length(amino acids)=313AA_BP=8
MTTSGLPFLSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGG
PESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMM
LSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPF

--------------------------------------------------------------

>20482_20482_3_CTSC-GRM5_CTSC_chr11_88068105_ENST00000524463_GRM5_chr11_88242672_ENST00000418177_length(amino acids)=313AA_BP=8
MTTSGLPFLSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGG
PESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMM
LSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPF

--------------------------------------------------------------

>20482_20482_4_CTSC-GRM5_CTSC_chr11_88068105_ENST00000524463_GRM5_chr11_88242672_ENST00000455756_length(amino acids)=313AA_BP=8
MTTSGLPFLSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGG
PESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMM
LSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPF

--------------------------------------------------------------

>20482_20482_5_CTSC-GRM5_CTSC_chr11_88068105_ENST00000529974_GRM5_chr11_88242672_ENST00000418177_length(amino acids)=313AA_BP=8
MTTSGLPFLSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGG
PESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMM
LSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPF

--------------------------------------------------------------

>20482_20482_6_CTSC-GRM5_CTSC_chr11_88068105_ENST00000529974_GRM5_chr11_88242672_ENST00000455756_length(amino acids)=313AA_BP=8
MTTSGLPFLSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGG
PESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMM
LSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:88068105/chr11:88242672)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTSC

P53634

GRM5

P41594

FUNCTION: Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. {ECO:0000269|PubMed:1586157}.FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269|PubMed:25042998, ECO:0000269|PubMed:7908515}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709173_1750.0943.0RegionNote=Glutamate binding
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709805_8090.0943.0RegionNote=Allosteric effector binding
TgeneGRM5chr11:88068105chr11:88242672ENST000003932970922_5800.0943.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709604_6130.0943.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709637_6440.0943.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709668_6930.0943.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709715_7370.0943.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709760_7720.0943.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709796_7980.0943.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709821_12120.0943.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709581_6030.0943.0TransmembraneNote=Helical%3B Name%3D1
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709614_6360.0943.0TransmembraneNote=Helical%3B Name%3D2
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709645_6670.0943.0TransmembraneNote=Helical%3B Name%3D3
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709694_7140.0943.0TransmembraneNote=Helical%3B Name%3D4
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709738_7590.0943.0TransmembraneNote=Helical%3B Name%3D5
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709773_7950.0943.0TransmembraneNote=Helical%3B Name%3D6
TgeneGRM5chr11:88068105chr11:88242672ENST0000039329709799_8200.0943.0TransmembraneNote=Helical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268173_175876.66666666666661181.0RegionNote=Glutamate binding
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268805_809876.66666666666661181.0RegionNote=Allosteric effector binding
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779173_175908.66666666666661213.0RegionNote=Glutamate binding
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779805_809908.66666666666661213.0RegionNote=Allosteric effector binding
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810173_175908.66666666666661213.0RegionNote=Glutamate binding
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810805_809908.66666666666661213.0RegionNote=Allosteric effector binding
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679173_175876.66666666666661181.0RegionNote=Glutamate binding
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679805_809876.66666666666661181.0RegionNote=Allosteric effector binding
TgeneGRM5chr11:88068105chr11:88242672ENST000003054326822_580876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268604_613876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268637_644876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268668_693876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268715_737876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268760_772876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268796_798876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268821_1212876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST000003054477922_580908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779604_613908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779637_644908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779668_693908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779715_737908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779760_772908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779796_798908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779821_1212908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000041817781022_580908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810604_613908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810637_644908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810668_693908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810715_737908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810760_772908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810796_798908.66666666666661213.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810821_1212908.66666666666661213.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST000004557567922_580876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679604_613876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679637_644876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679668_693876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679715_737876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679760_772876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679796_798876.66666666666661181.0Topological domainExtracellular
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679821_1212876.66666666666661181.0Topological domainCytoplasmic
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268581_603876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D1
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268614_636876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D2
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268645_667876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D3
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268694_714876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D4
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268738_759876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D5
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268773_795876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D6
TgeneGRM5chr11:88068105chr11:88242672ENST0000030543268799_820876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D7
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779581_603908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D1
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779614_636908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D2
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779645_667908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D3
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779694_714908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D4
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779738_759908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D5
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779773_795908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D6
TgeneGRM5chr11:88068105chr11:88242672ENST0000030544779799_820908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D7
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810581_603908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D1
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810614_636908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D2
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810645_667908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D3
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810694_714908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D4
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810738_759908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D5
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810773_795908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D6
TgeneGRM5chr11:88068105chr11:88242672ENST00000418177810799_820908.66666666666661213.0TransmembraneNote=Helical%3B Name%3D7
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679581_603876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D1
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679614_636876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D2
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679645_667876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D3
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679694_714876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D4
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679738_759876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D5
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679773_795876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D6
TgeneGRM5chr11:88068105chr11:88242672ENST0000045575679799_820876.66666666666661181.0TransmembraneNote=Helical%3B Name%3D7


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CTSC
GRM5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CTSC-GRM5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CTSC-GRM5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource