| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Fusion Protein:CUL4A-F7 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CUL4A-F7 | FusionPDB ID: 20679 | FusionGDB2.0 ID: 20679 | Hgene | Tgene | Gene symbol | CUL4A | F7 | Gene ID | 8451 | 2155 |
| Gene name | cullin 4A | coagulation factor VII | |
| Synonyms | - | SPCA | |
| Cytomap | 13q34 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cullin-4ACUL-4A | coagulation factor VIIFVII coagulation proteincoagulation factor VII (serum prothrombin conversion accelerator)eptacog alfaproconvertin | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q13619 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000326335, ENST00000375440, ENST00000375441, ENST00000451881, ENST00000463426, | ENST00000473085, ENST00000346342, ENST00000375581, ENST00000541084, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 12 X 16 X 11=2112 | 4 X 4 X 4=64 |
| # samples | 19 | 5 | |
| ** MAII score | log2(19/2112*10)=-3.47453851102751 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: CUL4A [Title/Abstract] AND F7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CUL4A(113893865)-F7(113771787), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | CUL4A-F7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CUL4A-F7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CUL4A-F7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CUL4A-F7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CUL4A | GO:0016567 | protein ubiquitination | 26431207 |
| Tgene | F7 | GO:0002690 | positive regulation of leukocyte chemotaxis | 17991872 |
| Tgene | F7 | GO:0007596 | blood coagulation | 8632006|24998411 |
| Tgene | F7 | GO:0010641 | positive regulation of platelet-derived growth factor receptor signaling pathway | 17991872 |
| Tgene | F7 | GO:0016485 | protein processing | 24998411 |
| Tgene | F7 | GO:0050927 | positive regulation of positive chemotaxis | 17991872 |
| Tgene | F7 | GO:0051897 | positive regulation of protein kinase B signaling | 18612547 |
| Fusion gene breakpoints across CUL4A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across F7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-GM-A2DF-01A | CUL4A | chr13 | 113873802 | + | F7 | chr13 | 113768066 | + |
| ChimerDB4 | SARC | TCGA-KF-A41W-01A | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + |
Top |
Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000375441 | CUL4A | chr13 | 113893865 | + | ENST00000541084 | F7 | chr13 | 113771787 | + | 2085 | 1257 | 381 | 1976 | 531 |
| ENST00000375441 | CUL4A | chr13 | 113893865 | + | ENST00000346342 | F7 | chr13 | 113771787 | + | 3000 | 1257 | 381 | 1976 | 531 |
| ENST00000375441 | CUL4A | chr13 | 113893865 | + | ENST00000375581 | F7 | chr13 | 113771787 | + | 3650 | 1257 | 381 | 1976 | 531 |
| ENST00000451881 | CUL4A | chr13 | 113893865 | + | ENST00000541084 | F7 | chr13 | 113771787 | + | 1812 | 984 | 30 | 1703 | 557 |
| ENST00000451881 | CUL4A | chr13 | 113893865 | + | ENST00000346342 | F7 | chr13 | 113771787 | + | 2727 | 984 | 30 | 1703 | 557 |
| ENST00000451881 | CUL4A | chr13 | 113893865 | + | ENST00000375581 | F7 | chr13 | 113771787 | + | 3377 | 984 | 30 | 1703 | 557 |
| ENST00000326335 | CUL4A | chr13 | 113893865 | + | ENST00000541084 | F7 | chr13 | 113771787 | + | 1723 | 895 | 160 | 1614 | 484 |
| ENST00000326335 | CUL4A | chr13 | 113893865 | + | ENST00000346342 | F7 | chr13 | 113771787 | + | 2638 | 895 | 160 | 1614 | 484 |
| ENST00000326335 | CUL4A | chr13 | 113893865 | + | ENST00000375581 | F7 | chr13 | 113771787 | + | 3288 | 895 | 160 | 1614 | 484 |
| ENST00000375440 | CUL4A | chr13 | 113893865 | + | ENST00000541084 | F7 | chr13 | 113771787 | + | 1947 | 1119 | 84 | 1838 | 584 |
| ENST00000375440 | CUL4A | chr13 | 113893865 | + | ENST00000346342 | F7 | chr13 | 113771787 | + | 2862 | 1119 | 84 | 1838 | 584 |
| ENST00000375440 | CUL4A | chr13 | 113893865 | + | ENST00000375581 | F7 | chr13 | 113771787 | + | 3512 | 1119 | 84 | 1838 | 584 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000375441 | ENST00000541084 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.013801659 | 0.98619837 |
| ENST00000375441 | ENST00000346342 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.007171943 | 0.9928281 |
| ENST00000375441 | ENST00000375581 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.009475692 | 0.99052435 |
| ENST00000451881 | ENST00000541084 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.011350606 | 0.98864937 |
| ENST00000451881 | ENST00000346342 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.006319713 | 0.99368024 |
| ENST00000451881 | ENST00000375581 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.008995382 | 0.9910046 |
| ENST00000326335 | ENST00000541084 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.010450509 | 0.9895495 |
| ENST00000326335 | ENST00000346342 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.006325402 | 0.99367464 |
| ENST00000326335 | ENST00000375581 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.009141872 | 0.99085814 |
| ENST00000375440 | ENST00000541084 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.010558138 | 0.9894419 |
| ENST00000375440 | ENST00000346342 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.005648539 | 0.9943514 |
| ENST00000375440 | ENST00000375581 | CUL4A | chr13 | 113893865 | + | F7 | chr13 | 113771787 | + | 0.008074971 | 0.99192506 |
Top |
Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >20679_20679_1_CUL4A-F7_CUL4A_chr13_113893865_ENST00000326335_F7_chr13_113771787_ENST00000346342_length(amino acids)=484AA_BP=245 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTLINTIWVVSAA HCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVS GWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVG -------------------------------------------------------------- >20679_20679_2_CUL4A-F7_CUL4A_chr13_113893865_ENST00000326335_F7_chr13_113771787_ENST00000375581_length(amino acids)=484AA_BP=245 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTLINTIWVVSAA HCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVS GWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVG -------------------------------------------------------------- >20679_20679_3_CUL4A-F7_CUL4A_chr13_113893865_ENST00000326335_F7_chr13_113771787_ENST00000541084_length(amino acids)=484AA_BP=245 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTLINTIWVVSAA HCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVS GWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVG -------------------------------------------------------------- >20679_20679_4_CUL4A-F7_CUL4A_chr13_113893865_ENST00000375440_F7_chr13_113771787_ENST00000346342_length(amino acids)=584AA_BP=345 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAV ENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEE GDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTL INTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERT LAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIV -------------------------------------------------------------- >20679_20679_5_CUL4A-F7_CUL4A_chr13_113893865_ENST00000375440_F7_chr13_113771787_ENST00000375581_length(amino acids)=584AA_BP=345 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAV ENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEE GDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTL INTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERT LAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIV -------------------------------------------------------------- >20679_20679_6_CUL4A-F7_CUL4A_chr13_113893865_ENST00000375440_F7_chr13_113771787_ENST00000541084_length(amino acids)=584AA_BP=345 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAV ENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEE GDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTL INTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERT LAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIV -------------------------------------------------------------- >20679_20679_7_CUL4A-F7_CUL4A_chr13_113893865_ENST00000375441_F7_chr13_113771787_ENST00000346342_length(amino acids)=531AA_BP=292 MPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHC RQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFEL KFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMY QLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYV PGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITE -------------------------------------------------------------- >20679_20679_8_CUL4A-F7_CUL4A_chr13_113893865_ENST00000375441_F7_chr13_113771787_ENST00000375581_length(amino acids)=531AA_BP=292 MPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHC RQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFEL KFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMY QLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYV PGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITE -------------------------------------------------------------- >20679_20679_9_CUL4A-F7_CUL4A_chr13_113893865_ENST00000375441_F7_chr13_113771787_ENST00000541084_length(amino acids)=531AA_BP=292 MPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHC RQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFEL KFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMY QLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYV PGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITE -------------------------------------------------------------- >20679_20679_10_CUL4A-F7_CUL4A_chr13_113893865_ENST00000451881_F7_chr13_113771787_ENST00000346342_length(amino acids)=557AA_BP=318 MRGPGVFLPGPRPLSRDASGSDYRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQ ILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGE AVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGE HLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLG EHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMV LNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK -------------------------------------------------------------- >20679_20679_11_CUL4A-F7_CUL4A_chr13_113893865_ENST00000451881_F7_chr13_113771787_ENST00000375581_length(amino acids)=557AA_BP=318 MRGPGVFLPGPRPLSRDASGSDYRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQ ILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGE AVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGE HLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLG EHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMV LNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK -------------------------------------------------------------- >20679_20679_12_CUL4A-F7_CUL4A_chr13_113893865_ENST00000451881_F7_chr13_113771787_ENST00000541084_length(amino acids)=557AA_BP=318 MRGPGVFLPGPRPLSRDASGSDYRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQ ILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGE AVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGE HLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLG EHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMV LNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:113893865/chr13:113771787) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CUL4A | . |
| FUNCTION: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269|PubMed:14578910, ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:16537899, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:24209620, ECO:0000269|PubMed:26431207, ECO:0000269|PubMed:26711351}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | F7 | chr13:113893865 | chr13:113771787 | ENST00000346342 | 5 | 8 | 213_452 | 205.0 | 445.0 | Domain | Peptidase S1 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | F7 | chr13:113893865 | chr13:113771787 | ENST00000346342 | 5 | 8 | 106_142 | 205.0 | 445.0 | Domain | EGF-like 1%3B calcium-binding | |
| Tgene | F7 | chr13:113893865 | chr13:113771787 | ENST00000346342 | 5 | 8 | 147_188 | 205.0 | 445.0 | Domain | EGF-like 2 | |
| Tgene | F7 | chr13:113893865 | chr13:113771787 | ENST00000346342 | 5 | 8 | 61_105 | 205.0 | 445.0 | Domain | Gla | |
| Tgene | F7 | chr13:113893865 | chr13:113771787 | ENST00000375581 | 6 | 9 | 106_142 | 227.0 | 467.0 | Domain | EGF-like 1%3B calcium-binding | |
| Tgene | F7 | chr13:113893865 | chr13:113771787 | ENST00000375581 | 6 | 9 | 147_188 | 227.0 | 467.0 | Domain | EGF-like 2 | |
| Tgene | F7 | chr13:113893865 | chr13:113771787 | ENST00000375581 | 6 | 9 | 213_452 | 227.0 | 467.0 | Domain | Peptidase S1 | |
| Tgene | F7 | chr13:113893865 | chr13:113771787 | ENST00000375581 | 6 | 9 | 61_105 | 227.0 | 467.0 | Domain | Gla |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| CUL4A | |
| F7 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to CUL4A-F7 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to CUL4A-F7 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies