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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CUX1-EHBP1L1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CUX1-EHBP1L1
FusionPDB ID: 20727
FusionGDB2.0 ID: 20727
HgeneTgene
Gene symbol

CUX1

EHBP1L1

Gene ID

1523

254102

Gene namecut like homeobox 1EH domain binding protein 1 like 1
SynonymsCASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GDDI|GOLIM6|Nbla10317|p100|p110|p200|p75-
Cytomap

7q22.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionprotein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317EH domain-binding protein 1-like protein 1tangerin
Modification date2020032020200313
UniProtAcc

P39880

Q8N3D4

Ensembl transtripts involved in fusion geneENST idsENST00000292538, ENST00000360264, 
ENST00000393824, ENST00000425244, 
ENST00000437600, ENST00000547394, 
ENST00000292535, ENST00000546411, 
ENST00000549414, ENST00000550008, 
ENST00000556210, ENST00000560541, 
ENST00000529596, ENST00000533364, 
ENST00000309295, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score32 X 26 X 13=108167 X 7 X 4=196
# samples 377
** MAII scorelog2(37/10816*10)=-4.86949797576587
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CUX1 [Title/Abstract] AND EHBP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CUX1(101459373)-EHBP1L1(65351712), # samples:2
Anticipated loss of major functional domain due to fusion event.CUX1-EHBP1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CUX1-EHBP1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CUX1-EHBP1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CUX1-EHBP1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CUX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EHBP1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-37-4132-01ACUX1chr7

101459373

-EHBP1L1chr11

65351712

+
ChimerDB4LUSCTCGA-37-4132-01ACUX1chr7

101459373

+EHBP1L1chr11

65351712

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437600CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+22424153521893513
ENST00000292538CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+191689261567513
ENST00000393824CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+191386231564513
ENST00000547394CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+191285221563513
ENST00000360264CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+191083201561513
ENST00000425244CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+190073101551513

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437600ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.0121824920.9878176
ENST00000292538ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.0206816350.9793184
ENST00000393824ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.0209892620.9790107
ENST00000547394ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.0209221490.9790779
ENST00000360264ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.0214993790.97850066
ENST00000425244ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.021472180.97852784

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>20727_20727_1_CUX1-EHBP1L1_CUX1_chr7_101459373_ENST00000292538_EHBP1L1_chr11_65351712_ENST00000309295_length(amino acids)=513AA_BP=20
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------

>20727_20727_2_CUX1-EHBP1L1_CUX1_chr7_101459373_ENST00000360264_EHBP1L1_chr11_65351712_ENST00000309295_length(amino acids)=513AA_BP=20
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------

>20727_20727_3_CUX1-EHBP1L1_CUX1_chr7_101459373_ENST00000393824_EHBP1L1_chr11_65351712_ENST00000309295_length(amino acids)=513AA_BP=20
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------

>20727_20727_4_CUX1-EHBP1L1_CUX1_chr7_101459373_ENST00000425244_EHBP1L1_chr11_65351712_ENST00000309295_length(amino acids)=513AA_BP=20
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------

>20727_20727_5_CUX1-EHBP1L1_CUX1_chr7_101459373_ENST00000437600_EHBP1L1_chr11_65351712_ENST00000309295_length(amino acids)=513AA_BP=20
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------

>20727_20727_6_CUX1-EHBP1L1_CUX1_chr7_101459373_ENST00000547394_EHBP1L1_chr11_65351712_ENST00000309295_length(amino acids)=513AA_BP=20
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:101459373/chr11:65351712)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUX1

P39880

EHBP1L1

Q8N3D4

FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.FUNCTION: May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191363_15151031.01524.0Coiled coilOntology_term=ECO:0000255
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191153_11581031.01524.0Compositional biasNote=Poly-Gly
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191247_12501031.01524.0Compositional biasNote=Poly-Gly
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191308_13111031.01524.0Compositional biasNote=Poly-Ala
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191316_13471031.01524.0Compositional biasNote=Pro-rich
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191037_11421031.01524.0DomainCalponin-homology (CH)
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191349_15011031.01524.0DomainbMERB
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191520_15231031.01524.0MotifCAAX motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+12456_40701506.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000292538+123502_55621.0679.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000292538+12367_45021.0679.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+12456_40721.01517.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000393824+122502_55621.0640.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000393824+12267_45021.0640.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+12256_40721.0633.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000437600+123502_55621.0677.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000437600+12367_45021.0677.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+12456_4070.01404.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000547394+122502_55621.0663.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000547394+12267_45021.0663.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+12356_4070.01484.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+12256_4070.01450.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+12256_4070.01348.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+1241406_143801506.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+1241406_143821.01517.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+1221406_143821.0633.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+1241406_14380.01404.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+1231406_14380.01484.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+1221406_14380.01450.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+1221406_14380.01348.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+1241117_120401506.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+1241244_130301506.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+124542_62901506.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+124934_102101506.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+1241117_120421.01517.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+1241244_130321.01517.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+124542_62921.01517.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+124934_102121.01517.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+1221117_120421.0633.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+1221244_130321.0633.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+122542_62921.0633.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+122934_102121.0633.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+1241117_12040.01404.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+1241244_13030.01404.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+124542_6290.01404.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+124934_10210.01404.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+1231117_12040.01484.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+1231244_13030.01484.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+123542_6290.01484.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+123934_10210.01484.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+1221117_12040.01450.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+1221244_13030.01450.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+122542_6290.01450.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+122934_10210.01450.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+1221117_12040.01348.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+1221244_13030.01348.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+122542_6290.01348.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+122934_10210.01348.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000292538+1231_61921.0679.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr11:65351712ENST00000292538+123641_67821.0679.0Topological domainLumenal
HgeneCUX1chr7:101459373chr11:65351712ENST00000393824+1221_61921.0640.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr11:65351712ENST00000393824+122641_67821.0640.0Topological domainLumenal
HgeneCUX1chr7:101459373chr11:65351712ENST00000437600+1231_61921.0677.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr11:65351712ENST00000437600+123641_67821.0677.0Topological domainLumenal
HgeneCUX1chr7:101459373chr11:65351712ENST00000547394+1221_61921.0663.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr11:65351712ENST00000547394+122641_67821.0663.0Topological domainLumenal
HgeneCUX1chr7:101459373chr11:65351712ENST00000292538+123620_64021.0679.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneCUX1chr7:101459373chr11:65351712ENST00000393824+122620_64021.0640.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneCUX1chr7:101459373chr11:65351712ENST00000437600+123620_64021.0677.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneCUX1chr7:101459373chr11:65351712ENST00000547394+122620_64021.0663.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneEHBP1L1chr7:101459373chr11:65351712ENST00000309295819222_2261031.01524.0Compositional biasNote=Poly-Glu
TgeneEHBP1L1chr7:101459373chr11:65351712ENST00000309295819561_8901031.01524.0Compositional biasNote=Glu-rich
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958198_1571031.01524.0DomainC2 NT-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CUX1
EHBP1L1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CUX1-EHBP1L1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CUX1-EHBP1L1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource