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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABCA9-TANC2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCA9-TANC2
FusionPDB ID: 208
FusionGDB2.0 ID: 208
HgeneTgene
Gene symbol

ABCA9

TANC2

Gene ID

10350

26115

Gene nameATP binding cassette subfamily A member 9tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
SynonymsEST640918ROLSA|rols
Cytomap

17q24.2

17q23.2-q23.3

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family A member 9ATP-binding cassette A9ATP-binding cassette, sub-family A (ABC1), member 9protein TANC2putative ankyrin-repeat containing proteinrolling pebbles homolog Btetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2
Modification date2020031320200313
UniProtAcc

Q8IUA7

.
Ensembl transtripts involved in fusion geneENST idsENST00000370732, ENST00000340001, 
ENST00000453985, ENST00000482072, 
ENST00000495634, 		ENST00000389520, 
ENST00000424789, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 1=419 X 18 X 6=2052
# samples 221
** MAII scorelog2(2/4*10)=2.32192809488736log2(21/2052*10)=-3.28856949794093
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCA9 [Title/Abstract] AND TANC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCA9(66978703)-TANC2(61345109), # samples:3
Anticipated loss of major functional domain due to fusion event.ABCA9-TANC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA9-TANC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA9-TANC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA9-TANC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ABCA9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TANC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A2QS-01AABCA9chr17

66978703

-TANC2chr17

61345109

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340001ABCA9chr1766978703-ENST00000424789TANC2chr1761345109+158384932212100933293
ENST00000340001ABCA9chr1766978703-ENST00000389520TANC2chr1761345109+105254932212101233303
ENST00000453985ABCA9chr1766978703-ENST00000424789TANC2chr1761345109+1558446787298393255
ENST00000453985ABCA9chr1766978703-ENST00000389520TANC2chr1761345109+1027146787298693265

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340001ENST00000424789ABCA9chr1766978703-TANC2chr1761345109+0.0009131090.99908686
ENST00000340001ENST00000389520ABCA9chr1766978703-TANC2chr1761345109+0.0007338120.9992662
ENST00000453985ENST00000424789ABCA9chr1766978703-TANC2chr1761345109+0.0007875680.9992124
ENST00000453985ENST00000389520ABCA9chr1766978703-TANC2chr1761345109+0.0006426820.9993573

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>208_208_1_ABCA9-TANC2_ABCA9_chr17_66978703_ENST00000340001_TANC2_chr17_61345109_ENST00000389520_length(amino acids)=3303AA_BP=1568
MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQMSSMDLGRVDSFNDTNYVIAFAPESKTTQEI
MNKVASAPFLKGRTIMGWPDEKSMDELDLNYSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA
FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSW
GLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW
TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRAN
HVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS
VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGI
AILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER
CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFLKLEGKSTIDESDIGIWGQLQT
DGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT
YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDVI
SNGLLGIFNSSEHIQTDRSTFFEEHMDYEYGYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL
ILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTML
IPPFTLIGSLFIFSEISPDSMDYLGASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEED
IQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQV
ILKGSGGGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPS
VVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEP
LHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVRFAP
YRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKH
VDANRELPLTQPPSAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPH
LQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEIT
KLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYK
VVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSF
REWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRN
LYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHL
DKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETA
LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIA
LMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVT
LLKKGAKIGCQTLPSRPRGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNL
SRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQPPPPPQP
QQQLPEEAEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQGLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSP
TRQTYQSTSPALSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQE
TSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSPAVHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQSR
LVYQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLTKEDLPQRPSSAYRGGVRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLGSPDV
SHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLTPTFRPSSSIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEP
TRSRTTPFMGIIDKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPHGMLA

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>208_208_2_ABCA9-TANC2_ABCA9_chr17_66978703_ENST00000340001_TANC2_chr17_61345109_ENST00000424789_length(amino acids)=3293AA_BP=1568
MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQMSSMDLGRVDSFNDTNYVIAFAPESKTTQEI
MNKVASAPFLKGRTIMGWPDEKSMDELDLNYSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA
FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSW
GLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW
TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRAN
HVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS
VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGI
AILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER
CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFLKLEGKSTIDESDIGIWGQLQT
DGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT
YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDVI
SNGLLGIFNSSEHIQTDRSTFFEEHMDYEYGYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL
ILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTML
IPPFTLIGSLFIFSEISPDSMDYLGASESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEED
IQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQV
ILKGSGGGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPS
VVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEP
LHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVRFAP
YRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKH
VDANRELPLTQPPSAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPH
LQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEIT
KLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYK
VVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSF
REWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRN
LYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHL
DKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETA
LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIA
LMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVT
LLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDF
GMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQPPPPPQPQQQLPEEAEP
EPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQGLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSP
ALSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRP
KSPLSKMAQRPYQMPQLPVAVPQQGLRLQPAKAQIVRSNQPSPAVHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGI
VGDGRPVQHVQASLSAGAICQHGGLTKEDLPQRPSSAYRGGVRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLGSPDVSHLIRRPISV
NPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNLTPTFRPSSSIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEPTRSRTTPFMG
IIDKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPHGMLANGSRGDLLER

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>208_208_3_ABCA9-TANC2_ABCA9_chr17_66978703_ENST00000453985_TANC2_chr17_61345109_ENST00000389520_length(amino acids)=3265AA_BP=1530
MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQMSSMDLGRVDSFNDTNYVIAFAPESKTTQEI
MNKVASAPFLKGRTIMGWPDEKSMDELDLNYSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA
FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSW
GLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW
TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRAN
HVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS
VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGI
AILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER
CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFLKLEGKSTIDESDIGIWGQLQT
DGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT
YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDVI
SNGLLGIFNSSEHIQTDRSTFFEEHMDYEYGYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL
ILLLMQIMDYIFSPEEIIFIIQNLLIQVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESEIVYLALLI
PYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKN
CFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENALWPNLTVRQHLEVYAA
VKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTT
HYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAF
FKLEIATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQL
QSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPGTPEMRRRQEEAM
RRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDE
DFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQ
NNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASL
HPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLN
RQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHL
GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVF
KKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV
RQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKN
GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQTLPSRPRGPATWAMATSKPDIMIILLS
KLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAK
RSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQPPPPPQPQQQLPEEAEPEPQHEDIYSVQDIFEEEYLEQDVENVSI
GLQTEARPSQGLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQNSHYRPSPPHTSPAHQGGSYR
FSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRL
QPAKAQIVRSNQPSPAVHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLTKE
DLPQRPSSAYRGGVRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLGSPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSPS
SNSISSTSNLTPTFRPSSSIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPHLHQQNRTWAVSSVDT
VLSPTSPGNLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPHGMLANGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYR

--------------------------------------------------------------

>208_208_4_ABCA9-TANC2_ABCA9_chr17_66978703_ENST00000453985_TANC2_chr17_61345109_ENST00000424789_length(amino acids)=3255AA_BP=1530
MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQMSSMDLGRVDSFNDTNYVIAFAPESKTTQEI
MNKVASAPFLKGRTIMGWPDEKSMDELDLNYSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA
FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSW
GLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW
TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRAN
HVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS
VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGI
AILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER
CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFLKLEGKSTIDESDIGIWGQLQT
DGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT
YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDVI
SNGLLGIFNSSEHIQTDRSTFFEEHMDYEYGYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL
ILLLMQIMDYIFSPEEIIFIIQNLLIQVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESEIVYLALLI
PYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKN
CFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENALWPNLTVRQHLEVYAA
VKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTT
HYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAF
FKLEIATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMGGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQL
QSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPGTPEMRRRQEEAM
RRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDE
DFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQ
NNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASL
HPLTDEHIFQAINAGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLN
RQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHL
GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVF
KKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV
RQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKN
GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFY
KKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAAL
EDLNEAIKLCPNNREIQRLLLRVEEECRQMQQPQQPPPPPQPQQQLPEEAEPEPQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQ
GLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPPVGGQG
KEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQQGLRLQPAKAQIVRS
NQPSPAVHSSTVIPTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLTKEDLPQRPSSAY
RGGVRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLGSPDVSHLIRRPISVNPNEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSTSNL
TPTFRPSSSIQQMEIPLKPAYERSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGNL
PQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPHGMLANGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:66978703/chr17:61345109)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCA9

Q8IUA7

.
FUNCTION: Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis. {ECO:0000305|PubMed:12150964}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-37391288_15211573.33333333333331625.0DomainABC transporter 2
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-3739481_7161573.33333333333331625.0DomainABC transporter 1
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-36381288_15211541.66666666666671790.0DomainABC transporter 2
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-3638481_7161541.66666666666671790.0DomainABC transporter 1
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-37391326_13331573.33333333333331625.0Nucleotide bindingATP 2
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-3739517_5241573.33333333333331625.0Nucleotide bindingATP 1
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-36381326_13331541.66666666666671790.0Nucleotide bindingATP 2
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-3638517_5241541.66666666666671790.0Nucleotide bindingATP 1
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-37391026_10461573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-37391065_10851573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-37391108_11281573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-37391136_11561573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-37391163_11831573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-37391200_12201573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-3739221_2431573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-3739269_2891573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-3739300_3201573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-373931_511573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-3739329_3491573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-3739354_3741573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-3739398_4181573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000340001-3739864_8841573.33333333333331625.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-36381026_10461541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-36381065_10851541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-36381108_11281541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-36381136_11561541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-36381163_11831541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-36381200_12201541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-3638221_2431541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-3638269_2891541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-3638300_3201541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-363831_511541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-3638329_3491541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-3638354_3741541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-3638398_4181541.66666666666671790.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000370732-3638864_8841541.66666666666671790.0TransmembraneHelical
TgeneTANC2chr17:66978703chr17:61345109ENST000003895205261033_1062270.33333333333332001.0RepeatNote=ANK 6
TgeneTANC2chr17:66978703chr17:61345109ENST000003895205261066_1095270.33333333333332001.0RepeatNote=ANK 7
TgeneTANC2chr17:66978703chr17:61345109ENST000003895205261099_1128270.33333333333332001.0RepeatNote=ANK 8
TgeneTANC2chr17:66978703chr17:61345109ENST000003895205261132_1161270.33333333333332001.0RepeatNote=ANK 9
TgeneTANC2chr17:66978703chr17:61345109ENST000003895205261165_1194270.33333333333332001.0RepeatNote=ANK 10
TgeneTANC2chr17:66978703chr17:61345109ENST000003895205261198_1227270.33333333333332001.0RepeatNote=ANK 11
TgeneTANC2chr17:66978703chr17:61345109ENST000003895205261244_1277270.33333333333332001.0RepeatNote=TPR 1
TgeneTANC2chr17:66978703chr17:61345109ENST000003895205261291_1324270.33333333333332001.0RepeatNote=TPR 2
TgeneTANC2chr17:66978703chr17:61345109ENST000003895205261325_1358270.33333333333332001.0RepeatNote=TPR 3
TgeneTANC2chr17:66978703chr17:61345109ENST00000389520526846_878270.33333333333332001.0RepeatNote=ANK 1
TgeneTANC2chr17:66978703chr17:61345109ENST00000389520526884_913270.33333333333332001.0RepeatNote=ANK 2
TgeneTANC2chr17:66978703chr17:61345109ENST00000389520526917_946270.33333333333332001.0RepeatNote=ANK 3
TgeneTANC2chr17:66978703chr17:61345109ENST00000389520526950_979270.33333333333332001.0RepeatNote=ANK 4
TgeneTANC2chr17:66978703chr17:61345109ENST00000389520526990_1019270.33333333333332001.0RepeatNote=ANK 5
TgeneTANC2chr17:66978703chr17:61345109ENST000004247895251033_1062270.33333333333331991.0RepeatNote=ANK 6
TgeneTANC2chr17:66978703chr17:61345109ENST000004247895251066_1095270.33333333333331991.0RepeatNote=ANK 7
TgeneTANC2chr17:66978703chr17:61345109ENST000004247895251099_1128270.33333333333331991.0RepeatNote=ANK 8
TgeneTANC2chr17:66978703chr17:61345109ENST000004247895251132_1161270.33333333333331991.0RepeatNote=ANK 9
TgeneTANC2chr17:66978703chr17:61345109ENST000004247895251165_1194270.33333333333331991.0RepeatNote=ANK 10
TgeneTANC2chr17:66978703chr17:61345109ENST000004247895251198_1227270.33333333333331991.0RepeatNote=ANK 11
TgeneTANC2chr17:66978703chr17:61345109ENST000004247895251244_1277270.33333333333331991.0RepeatNote=TPR 1
TgeneTANC2chr17:66978703chr17:61345109ENST000004247895251291_1324270.33333333333331991.0RepeatNote=TPR 2
TgeneTANC2chr17:66978703chr17:61345109ENST000004247895251325_1358270.33333333333331991.0RepeatNote=TPR 3
TgeneTANC2chr17:66978703chr17:61345109ENST00000424789525846_878270.33333333333331991.0RepeatNote=ANK 1
TgeneTANC2chr17:66978703chr17:61345109ENST00000424789525884_913270.33333333333331991.0RepeatNote=ANK 2
TgeneTANC2chr17:66978703chr17:61345109ENST00000424789525917_946270.33333333333331991.0RepeatNote=ANK 3
TgeneTANC2chr17:66978703chr17:61345109ENST00000424789525950_979270.33333333333331991.0RepeatNote=ANK 4
TgeneTANC2chr17:66978703chr17:61345109ENST00000424789525990_1019270.33333333333331991.0RepeatNote=ANK 5

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-161288_15210268.0DomainABC transporter 2
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-16481_7160268.0DomainABC transporter 1
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-161326_13330268.0Nucleotide bindingATP 2
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-16517_5240268.0Nucleotide bindingATP 1
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-161026_10460268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-161065_10850268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-161108_11280268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-161136_11560268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-161163_11830268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-161200_12200268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-16221_2430268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-16269_2890268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-16300_3200268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-1631_510268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-16329_3490268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-16354_3740268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-16398_4180268.0TransmembraneHelical
HgeneABCA9chr17:66978703chr17:61345109ENST00000495634-16864_8840268.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCA9
TANC2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABCA9-TANC2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABCA9-TANC2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource