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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CYLD-HAGH

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CYLD-HAGH
	FusionPDB ID: 20992
	FusionGDB2.0 ID: 20992
		Hgene	Tgene
	Gene symbol	CYLD	HAGH
	Gene ID	1540	3029
	Gene name	CYLD lysine 63 deubiquitinase	hydroxyacylglutathione hydrolase
	Synonyms	BRSS\|CDMT\|CYLD1\|CYLDI\|EAC\|MFT\|MFT1\|SBS\|TEM\|USPL2	GLO2\|GLX2\|GLXII\|HAGH1
	Cytomap	16q12.1	16p13.3
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase CYLDcylindromatosis (turban tumor syndrome)deubiquitinating enzyme CYLDprobable ubiquitin carboxyl-terminal hydrolase CYLDubiquitin specific peptidase like 2ubiquitin thioesterase CYLDubiquitin thiolesterase CYL	hydroxyacylglutathione hydrolase, mitochondrialglyoxalase IIhydroxyacylglutathione hydroxylase
	Modification date	20200329	20200313
	UniProtAcc	Q9NQC7	Q6PII5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000311559, ENST00000398568, ENST00000427738, ENST00000540145, ENST00000564326, ENST00000566206, ENST00000568704, ENST00000569418,	ENST00000566709, ENST00000567398, ENST00000397353, ENST00000397356, ENST00000455446,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 4 X 4=96	4 X 2 X 4=32
	# samples	6	4
	** MAII score	log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CYLD [Title/Abstract] AND HAGH [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CYLD(50788335)-HAGH(1859834), # samples:1
Anticipated loss of major functional domain due to fusion event.	CYLD-HAGH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CYLD-HAGH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CYLD-HAGH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CYLD-HAGH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CYLD-HAGH seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CYLD-HAGH seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CYLD-HAGH seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CYLD	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	26997266\|27458237\|27591049
Hgene	CYLD	GO:0016579	protein deubiquitination	29291351
Hgene	CYLD	GO:0032088	negative regulation of NF-kappaB transcription factor activity	18313383
Hgene	CYLD	GO:0045087	innate immune response	26997266
Hgene	CYLD	GO:0046329	negative regulation of JNK cascade	29291351
Hgene	CYLD	GO:0050727	regulation of inflammatory response	27591049
Hgene	CYLD	GO:0060544	regulation of necroptotic process	27458237
Hgene	CYLD	GO:0070536	protein K63-linked deubiquitination	18313383\|18636086\|26997266\|27458237\|27591049\|29291351
Hgene	CYLD	GO:1901223	negative regulation of NIK/NF-kappaB signaling	18313383
Hgene	CYLD	GO:1903753	negative regulation of p38MAPK cascade	29291351
Hgene	CYLD	GO:1990108	protein linear deubiquitination	26997266\|27458237\|27591049
Tgene	HAGH	GO:0006750	glutathione biosynthetic process	8550579

Fusion gene breakpoints across CYLD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HAGH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-14-0736-02A	CYLD	chr16	50788335	+	HAGH	chr16	1859834	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000569418	CYLD	chr16	50788335	+	ENST00000455446	HAGH	chr16	1859834	-	1782	1191	278	1300	340
ENST00000540145	CYLD	chr16	50788335	+	ENST00000455446	HAGH	chr16	1859834	-	1919	1328	415	1437	340
ENST00000311559	CYLD	chr16	50788335	+	ENST00000455446	HAGH	chr16	1859834	-	1895	1304	391	1413	340
ENST00000564326	CYLD	chr16	50788335	+	ENST00000455446	HAGH	chr16	1859834	-	1698	1107	194	1216	340
ENST00000566206	CYLD	chr16	50788335	+	ENST00000455446	HAGH	chr16	1859834	-	1754	1163	250	1272	340
ENST00000398568	CYLD	chr16	50788335	+	ENST00000455446	HAGH	chr16	1859834	-	1804	1213	300	1322	340
ENST00000427738	CYLD	chr16	50788335	+	ENST00000455446	HAGH	chr16	1859834	-	1709	1118	205	1227	340
ENST00000568704	CYLD	chr16	50788335	+	ENST00000455446	HAGH	chr16	1859834	-	1654	1063	150	1172	340

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000569418	ENST00000455446	CYLD	chr16	50788335	+	HAGH	chr16	1859834	-	0.000356486	0.99964356
ENST00000540145	ENST00000455446	CYLD	chr16	50788335	+	HAGH	chr16	1859834	-	0.000215028	0.999785
ENST00000311559	ENST00000455446	CYLD	chr16	50788335	+	HAGH	chr16	1859834	-	0.000212641	0.9997874
ENST00000564326	ENST00000455446	CYLD	chr16	50788335	+	HAGH	chr16	1859834	-	0.000403401	0.99959666
ENST00000566206	ENST00000455446	CYLD	chr16	50788335	+	HAGH	chr16	1859834	-	0.000362295	0.9996377
ENST00000398568	ENST00000455446	CYLD	chr16	50788335	+	HAGH	chr16	1859834	-	0.000342777	0.9996573
ENST00000427738	ENST00000455446	CYLD	chr16	50788335	+	HAGH	chr16	1859834	-	0.000357053	0.99964297
ENST00000568704	ENST00000455446	CYLD	chr16	50788335	+	HAGH	chr16	1859834	-	0.000379031	0.9996209

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>20992_20992_1_CYLD-HAGH_CYLD_chr16_50788335_ENST00000311559_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------

>20992_20992_2_CYLD-HAGH_CYLD_chr16_50788335_ENST00000398568_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------

>20992_20992_3_CYLD-HAGH_CYLD_chr16_50788335_ENST00000427738_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------

>20992_20992_4_CYLD-HAGH_CYLD_chr16_50788335_ENST00000540145_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------

>20992_20992_5_CYLD-HAGH_CYLD_chr16_50788335_ENST00000564326_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------

>20992_20992_6_CYLD-HAGH_CYLD_chr16_50788335_ENST00000566206_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------

>20992_20992_7_CYLD-HAGH_CYLD_chr16_50788335_ENST00000568704_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------

>20992_20992_8_CYLD-HAGH_CYLD_chr16_50788335_ENST00000569418_HAGH_chr16_1859834_ENST00000455446_length(amino acids)=340AA_BP=304
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRIPSAKGKKNQIGLKILEQPHAVLFVDEKDVV
EINEKFTELLLAITNCEERFSLFKNRNRLSKGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKVGETIESGTVIFCDVLPGKESLGYFVGVDMD

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:50788335/chr16:1859834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CYLD Q9NQC7	HAGH Q6PII5
FUNCTION: Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18636086, PubMed:26670046, PubMed:27458237, PubMed:26997266, PubMed:27591049, PubMed:29291351, PubMed:18313383). Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26997266, PubMed:26670046, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). {ECO:0000250\|UniProtKB:Q80TQ2, ECO:0000269\|PubMed:12917689, ECO:0000269\|PubMed:12917690, ECO:0000269\|PubMed:12917691, ECO:0000269\|PubMed:17495026, ECO:0000269\|PubMed:18222923, ECO:0000269\|PubMed:18313383, ECO:0000269\|PubMed:18636086, ECO:0000269\|PubMed:19893491, ECO:0000269\|PubMed:20194890, ECO:0000269\|PubMed:20227366, ECO:0000269\|PubMed:26670046, ECO:0000269\|PubMed:26997266, ECO:0000269\|PubMed:27458237, ECO:0000269\|PubMed:27591049, ECO:0000269\|PubMed:29291351}.	FUNCTION: Hydrolase acting on ester bonds. {ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000311559

153_198

304.3333333333333

957.0

Domain

CAP-Gly 1

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000311559

253_286

304.3333333333333

957.0

Domain

CAP-Gly 2

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000398568

153_198

304.3333333333333

954.0

Domain

CAP-Gly 1

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000398568

253_286

304.3333333333333

954.0

Domain

CAP-Gly 2

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000427738

153_198

304.3333333333333

957.0

Domain

CAP-Gly 1

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000427738

253_286

304.3333333333333

957.0

Domain

CAP-Gly 2

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000564326

153_198

304.3333333333333

954.0

Domain

CAP-Gly 1

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000564326

253_286

304.3333333333333

954.0

Domain

CAP-Gly 2

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000569418

153_198

304.3333333333333

954.0

Domain

CAP-Gly 1

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000569418

253_286

304.3333333333333

954.0

Domain

CAP-Gly 2

Tgene

HAGH

chr16:50788335

chr16:1859834

ENST00000397353

221_223

201.0

261.0

Region

Substrate binding

Tgene

HAGH

chr16:50788335

chr16:1859834

ENST00000397353

297_300

201.0

261.0

Region

Substrate binding

Tgene

HAGH

chr16:50788335

chr16:1859834

ENST00000397356

297_300

249.0

309.0

Region

Substrate binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000311559

492_535

304.3333333333333

957.0

Domain

CAP-Gly 3

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000311559

592_950

304.3333333333333

957.0

Domain

Note=USP

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000398568

492_535

304.3333333333333

954.0

Domain

CAP-Gly 3

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000398568

592_950

304.3333333333333

954.0

Domain

Note=USP

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000427738

492_535

304.3333333333333

957.0

Domain

CAP-Gly 3

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000427738

592_950

304.3333333333333

957.0

Domain

Note=USP

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000564326

492_535

304.3333333333333

954.0

Domain

CAP-Gly 3

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000564326

592_950

304.3333333333333

954.0

Domain

Note=USP

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000569418

492_535

304.3333333333333

954.0

Domain

CAP-Gly 3

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000569418

592_950

304.3333333333333

954.0

Domain

Note=USP

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000311559

781_833

304.3333333333333

957.0

Region

B-box

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000398568

781_833

304.3333333333333

954.0

Region

B-box

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000427738

781_833

304.3333333333333

957.0

Region

B-box

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000564326

781_833

304.3333333333333

954.0

Region

B-box

Hgene

CYLD

chr16:50788335

chr16:1859834

ENST00000569418

781_833

304.3333333333333

954.0

Region

B-box

Tgene

HAGH

chr16:50788335

chr16:1859834

ENST00000397353

191_193

201.0

261.0

Region

Substrate binding

Tgene

HAGH

chr16:50788335

chr16:1859834

ENST00000397356

191_193

249.0

309.0

Region

Substrate binding

Tgene

HAGH

chr16:50788335

chr16:1859834

ENST00000397356

221_223

249.0

309.0

Region

Substrate binding

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CYLD
HAGH

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000311559	+	6	20	470_554	304.3333333333333	957.0	IKBKG/NEMO
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000398568	+	5	18	470_554	304.3333333333333	954.0	IKBKG/NEMO
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000427738	+	4	18	470_554	304.3333333333333	957.0	IKBKG/NEMO
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000564326	+	4	17	470_554	304.3333333333333	954.0	IKBKG/NEMO
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000569418	+	5	18	470_554	304.3333333333333	954.0	IKBKG/NEMO
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000311559	+	6	20	394_469	304.3333333333333	957.0	TRAF2
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000398568	+	5	18	394_469	304.3333333333333	954.0	TRAF2
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000427738	+	4	18	394_469	304.3333333333333	957.0	TRAF2
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000564326	+	4	17	394_469	304.3333333333333	954.0	TRAF2
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000569418	+	5	18	394_469	304.3333333333333	954.0	TRAF2
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000311559	+	6	20	106_593	304.3333333333333	957.0	TRIP
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000398568	+	5	18	106_593	304.3333333333333	954.0	TRIP
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000427738	+	4	18	106_593	304.3333333333333	957.0	TRIP
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000564326	+	4	17	106_593	304.3333333333333	954.0	TRIP
Hgene	CYLD	chr16:50788335	chr16:1859834	ENST00000569418	+	5	18	106_593	304.3333333333333	954.0	TRIP

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Related Drugs to CYLD-HAGH

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CYLD-HAGH

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source