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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CYP4B1-PLA2G1B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CYP4B1-PLA2G1B
FusionPDB ID: 21088
FusionGDB2.0 ID: 21088
HgeneTgene
Gene symbol

CYP4B1

PLA2G1B

Gene ID

1580

5319

Gene namecytochrome P450 family 4 subfamily B member 1phospholipase A2 group IB
SynonymsCYPIVB1|P-450HPPLA2|PLA2A|PPLA2
Cytomap

1p33

12q24.31

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 4B1cytochrome P450, family 4, subfamily B, polypeptide 1cytochrome P450, subfamily IVB, polypeptide 1cytochrome P450-HPmicrosomal monooxygenasephospholipase A2phosphatidylcholine 2-acylhydrolase 1Bphospholipase A2, group IB (pancreas)
Modification date2020031320200313
UniProtAcc

P13584

.
Ensembl transtripts involved in fusion geneENST idsENST00000271153, ENST00000371919, 
ENST00000371923, ENST00000452782, 
ENST00000546128, 		ENST00000549767, 
ENST00000308366, ENST00000423423, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 5 X 4=1207 X 6 X 7=294
# samples 710
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/294*10)=-1.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CYP4B1 [Title/Abstract] AND PLA2G1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CYP4B1(47282853)-PLA2G1B(120763823), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLA2G1B

GO:0002227

innate immune response in mucosa

12860195

TgenePLA2G1B

GO:0006633

fatty acid biosynthetic process

1918029

TgenePLA2G1B

GO:0008284

positive regulation of cell proliferation

1918029

TgenePLA2G1B

GO:0016042

lipid catabolic process

7060561

TgenePLA2G1B

GO:0019731

antibacterial humoral response

12860195

TgenePLA2G1B

GO:0046470

phosphatidylcholine metabolic process

7060561

TgenePLA2G1B

GO:0048146

positive regulation of fibroblast proliferation

1918029

TgenePLA2G1B

GO:0050830

defense response to Gram-positive bacterium

12860195

TgenePLA2G1B

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12860195


check buttonFusion gene breakpoints across CYP4B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLA2G1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-75-7025-01ACYP4B1chr1

47282853

+PLA2G1Bchr12

120763823

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371923CYP4B1chr147282853+ENST00000308366PLA2G1Bchr12120763823-17381243361655539
ENST00000371923CYP4B1chr147282853+ENST00000423423PLA2G1Bchr12120763823-16061243361421461
ENST00000271153CYP4B1chr147282853+ENST00000308366PLA2G1Bchr12120763823-17351240361652538
ENST00000271153CYP4B1chr147282853+ENST00000423423PLA2G1Bchr12120763823-16031240361418460
ENST00000371919CYP4B1chr147282853+ENST00000308366PLA2G1Bchr12120763823-1657116201574524
ENST00000371919CYP4B1chr147282853+ENST00000423423PLA2G1Bchr12120763823-1525116201340446
ENST00000452782CYP4B1chr147282853+ENST00000308366PLA2G1Bchr12120763823-1447952511364437
ENST00000452782CYP4B1chr147282853+ENST00000423423PLA2G1Bchr12120763823-1315952511130359

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371923ENST00000308366CYP4B1chr147282853+PLA2G1Bchr12120763823-0.0102531980.9897468
ENST00000371923ENST00000423423CYP4B1chr147282853+PLA2G1Bchr12120763823-0.0082503660.99174964
ENST00000271153ENST00000308366CYP4B1chr147282853+PLA2G1Bchr12120763823-0.0115821540.9884178
ENST00000271153ENST00000423423CYP4B1chr147282853+PLA2G1Bchr12120763823-0.0090917310.99090827
ENST00000371919ENST00000308366CYP4B1chr147282853+PLA2G1Bchr12120763823-0.0116950710.988305
ENST00000371919ENST00000423423CYP4B1chr147282853+PLA2G1Bchr12120763823-0.0096161250.99038386
ENST00000452782ENST00000308366CYP4B1chr147282853+PLA2G1Bchr12120763823-0.0045990470.99540097
ENST00000452782ENST00000423423CYP4B1chr147282853+PLA2G1Bchr12120763823-0.0062553590.9937447

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21088_21088_1_CYP4B1-PLA2G1B_CYP4B1_chr1_47282853_ENST00000271153_PLA2G1B_chr12_120763823_ENST00000308366_length(amino acids)=538AA_BP=398
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIG
FLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
FCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQD
EKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDL
GKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPV

--------------------------------------------------------------

>21088_21088_2_CYP4B1-PLA2G1B_CYP4B1_chr1_47282853_ENST00000271153_PLA2G1B_chr12_120763823_ENST00000423423_length(amino acids)=460AA_BP=398
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIG
FLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
FCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQD
EKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDL
GKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPV

--------------------------------------------------------------

>21088_21088_3_CYP4B1-PLA2G1B_CYP4B1_chr1_47282853_ENST00000371919_PLA2G1B_chr12_120763823_ENST00000308366_length(amino acids)=524AA_BP=384
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIG
FLNIYEPDYAKAVYSRGGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKC
TFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLD
FLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESF
RLYPPVPQVYRQLSKPVTFVDGRSLPAVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCY

--------------------------------------------------------------

>21088_21088_4_CYP4B1-PLA2G1B_CYP4B1_chr1_47282853_ENST00000371919_PLA2G1B_chr12_120763823_ENST00000423423_length(amino acids)=446AA_BP=384
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIG
FLNIYEPDYAKAVYSRGGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKC
TFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLD
FLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESF

--------------------------------------------------------------

>21088_21088_5_CYP4B1-PLA2G1B_CYP4B1_chr1_47282853_ENST00000371923_PLA2G1B_chr12_120763823_ENST00000308366_length(amino acids)=539AA_BP=399
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIG
FLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ
DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTP

--------------------------------------------------------------

>21088_21088_6_CYP4B1-PLA2G1B_CYP4B1_chr1_47282853_ENST00000371923_PLA2G1B_chr12_120763823_ENST00000423423_length(amino acids)=461AA_BP=399
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIG
FLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ
DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTP

--------------------------------------------------------------

>21088_21088_7_CYP4B1-PLA2G1B_CYP4B1_chr1_47282853_ENST00000452782_PLA2G1B_chr12_120763823_ENST00000308366_length(amino acids)=437AA_BP=297
MSPPADPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTL
MKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRR
HLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIK
ESFRLYPPVPQVYRQLSKPVTFVDGRSLPAVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHD

--------------------------------------------------------------

>21088_21088_8_CYP4B1-PLA2G1B_CYP4B1_chr1_47282853_ENST00000452782_PLA2G1B_chr12_120763823_ENST00000423423_length(amino acids)=359AA_BP=297
MSPPADPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTL
MKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRR
HLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:47282853/chr12:120763823)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYP4B1

P13584

.
FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CYP4B1
PLA2G1B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CYP4B1-PLA2G1B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CYP4B1-PLA2G1B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource