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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CYP7B1-EPS15

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CYP7B1-EPS15
	FusionPDB ID: 21114
	FusionGDB2.0 ID: 21114
		Hgene	Tgene
	Gene symbol	CYP7B1	EPS15
	Gene ID	9420	2060
	Gene name	cytochrome P450 family 7 subfamily B member 1	epidermal growth factor receptor pathway substrate 15
	Synonyms	CBAS3\|CP7B\|SPG5A	AF-1P\|AF1P\|MLLT5
	Cytomap	8q12.3	1p32.3
	Type of gene	protein-coding	protein-coding
	Description	cytochrome P450 7B124-hydroxycholesterol 7-alpha-hydroxylase25-hydroxycholesterol 7-alpha-hydroxylase25/26-hydroxycholesterol 7-alpha-hydroxylase3-hydroxysteroid 7-alpha hydroxylasecytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), poly	epidermal growth factor receptor substrate 15ALL1 fused gene from chromosome 1protein AF-1p
	Modification date	20200313	20200313
	UniProtAcc	O75881	Q9UBC2
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000310193, ENST00000523954,	ENST00000396122, ENST00000493793, ENST00000371730, ENST00000371733,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 4=64	11 X 14 X 5=770
	# samples	5	14
	** MAII score	log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/770*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CYP7B1 [Title/Abstract] AND EPS15 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CYP7B1(65517239)-EPS15(51946986), # samples:3
Anticipated loss of major functional domain due to fusion event.	CYP7B1-EPS15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CYP7B1-EPS15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CYP7B1-EPS15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CYP7B1-EPS15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	EPS15	GO:0048268	clathrin coat assembly	12807910

Fusion gene breakpoints across CYP7B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EPS15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-AB2W-01A	CYP7B1	chr8	65517239	-	EPS15	chr1	51946986	-
ChimerDB4	SARC	TCGA-PC-A5DO-01A	CYP7B1	chr8	65517239	-	EPS15	chr1	51946986	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000310193	CYP7B1	chr8	65517239	-	ENST00000371730	EPS15	chr1	51946986	-	6100	1407	174	3662	1162
ENST00000310193	CYP7B1	chr8	65517239	-	ENST00000371733	EPS15	chr1	51946986	-	6502	1407	174	4064	1296

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000310193	ENST00000371730	CYP7B1	chr8	65517239	-	EPS15	chr1	51946986	-	7.09E-05	0.9999291
ENST00000310193	ENST00000371733	CYP7B1	chr8	65517239	-	EPS15	chr1	51946986	-	0.000172989	0.9998271

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21114_21114_1_CYP7B1-EPS15_CYP7B1_chr8_65517239_ENST00000310193_EPS15_chr1_51946986_ENST00000371730_length(amino acids)=1162AA_BP=411
MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYI
TFILDPFQYQLVIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAEL
YPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDV
LEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEAL
RLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPELSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPD
LILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLS
PVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDE
IFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNI
IGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEE
QLKEVRKKCAEEAQLARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDD
PFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGF
ADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDS

--------------------------------------------------------------

>21114_21114_2_CYP7B1-EPS15_CYP7B1_chr8_65517239_ENST00000310193_EPS15_chr1_51946986_ENST00000371733_length(amino acids)=1296AA_BP=411
MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYI
TFILDPFQYQLVIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAEL
YPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDV
LEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHLTREQLDSLICLESSIFEAL
RLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLHGDPEIFEAPELSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPD
LILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLS
PVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDE
IFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNI
IGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEE
QLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK
DLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELD
NNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNS
SITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPA
LPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:65517239/chr1:51946986)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CYP7B1 O75881	EPS15 Q9UBC2
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids (PubMed:10588945, PubMed:24491228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10588945, PubMed:24491228). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position (PubMed:10588945, PubMed:24491228). Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy steroid 7-alpha hydroxylase (PubMed:24491228). Hydroxylates oxysterols, including 25-hydroxycholesterol and (25R)-cholest-5-ene-3beta,26-diol toward 7-alpha hydroxy derivatives, which may be transported to the liver and converted to bile acids (PubMed:9802883, PubMed:10588945). Via its product 7-alpha,25-dihydroxycholesterol, a ligand for the chemotactic G protein-coupled receptor GPR183/EBI2, regulates B cell migration in germinal centers of lymphoid organs, thus guiding efficient maturation of plasma B cells and overall antigen-specific humoral immune response (By similarity). 7-alpha hydroxylates neurosteroids, including 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone) and pregnenolone, both involved in hippocampus-associated memory and learning (PubMed:24491228). Metabolizes androstanoids toward 6- or 7-alpha hydroxy derivatives (PubMed:24491228). {ECO:0000250\|UniProtKB:Q60991, ECO:0000269\|PubMed:10588945, ECO:0000269\|PubMed:24491228, ECO:0000269\|PubMed:9802883}.	FUNCTION: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:9407958}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CYP7B1

chr8:65517239

chr1:51946986

ENST00000310193

17_37

411.0

507.0

Transmembrane

Helical

Hgene

CYP7B1

chr8:65517239

chr1:51946986

ENST00000310193

289_309

411.0

507.0

Transmembrane

Helical

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

173_184

11.0

897.0

Calcium binding

Note=1

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

236_247

11.0

897.0

Calcium binding

Note=2

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

768_850

11.0

897.0

Compositional bias

Note=Pro-rich

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

128_216

11.0

897.0

Domain

EH 2

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

15_104

11.0

897.0

Domain

EH 1

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

160_195

11.0

897.0

Domain

EF-hand 1

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

223_258

11.0

897.0

Domain

EF-hand 2

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

224_314

11.0

897.0

Domain

EH 3

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

851_870

11.0

897.0

Domain

UIM 1

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

877_896

11.0

897.0

Domain

UIM 2

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

768_774

11.0

897.0

Motif

Note=SH3-binding

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

599_827

11.0

897.0

Region

Note=15 X 3 AA repeats of D-P-F

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

599_601

11.0

897.0

Repeat

Note=1

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

623_625

11.0

897.0

Repeat

Note=2

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

629_631

11.0

897.0

Repeat

Note=3

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

634_636

11.0

897.0

Repeat

Note=4

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

640_642

11.0

897.0

Repeat

Note=5

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

645_647

11.0

897.0

Repeat

Note=6

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

651_653

11.0

897.0

Repeat

Note=7

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

664_666

11.0

897.0

Repeat

Note=8

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

672_674

11.0

897.0

Repeat

Note=9

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

692_694

11.0

897.0

Repeat

Note=10

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

709_711

11.0

897.0

Repeat

Note=11

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

737_739

11.0

897.0

Repeat

Note=12

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

798_800

11.0

897.0

Repeat

Note=13

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

804_806

11.0

897.0

Repeat

Note=14

Tgene

EPS15

chr8:65517239

chr1:51946986

ENST00000371733

825_827

11.0

897.0

Repeat

Note=15

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CYP7B1_pLDDT.png

EPS15_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

EPS15

RNF11, SNAP91, AGFG1, NAGPA, STON2, HGS, AP2A2, DNM2, AP2A1, EGFR, CLINT1, EPN1, SCAMP1, STAM2, GRB2, CRK, RAB11FIP2, Synj1, REPS2, UBE2D1, UBE2D2, UBE2D3, UBE2H, UBE2E1, SLC6A3, PARK2, USP8, CD4, EPS15, OCLN, UBQLN1, UBC, NEDD4, GJA1, TGFB1, Zwint, FCHO2, ITSN1, ITSN2, ELAVL1, RAD23A, UBQLN2, EPN3, SH3BP4, AP1B1, NUMB, SPG20, TFAP2A, ABL1, AP2B1, IQGAP1, KRT85, KRT1, KRT10, KRT2, AP2M1, KRT14, KRT86, KRT5, KRT6A, KRT16, KRT9, HSPA8, KRT35, HSPA9, KRT17, KRT33B, KRT83, BMP2K, KRT34, KRT82, NONO, KRT38, KRT75, KRT79, PRDX1, KRT36, KRT32, MAP4, HSPA1L, HSPA1B, KRT37, HSPA5, KRT73, AP2S1, NECAP2, TRAF2, MCCC2, KRT4, ACTB, KRT3, VPRBP, TUBB, HIST4H4, PCCB, KRTAP9-3, NECAP1, VSIG8, CCT3, CRKL, Dab2, FN1, VCAM1, Fcho2, LAPTM5, ITGA4, OPTN, RABL6, EPHA2, CORO7, UBI4, AGFG2, SLC25A41, AURKA, SPC25, Numb, NTRK1, TMEM17, XPO1, CAPZA2, CLTB, CLTC, DBN1, FLNA, GAK, MYH9, PPP1CB, PICALM, PDLIM7, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, Actb, Flot1, Myh9, Myo1c, Tpm1, Lima1, Calml3, Myh10, Sec24c, Flnb, MAPK14, AP1G1, MYO6, SPOPL, SGIP1, FCHO1, CDH1, RUNDC3A, LSR, STAMBPL1, CCDC172, OXCT1, MTNR1A, RNF26, fcho1, HNRNPL, STK40, DYRK1A, PLK1, DVL2, MIB1, ORF7a, ESR1, TRIM56, KIF14, Rnf183, DNAJC5, DDX58, ACBD5, CLTA, VASP, NAA40, RNPS1, MACC1, SYCE1, RARRES1, POLR2J3, EPS15L1, C15orf59, ZCCHC10, SYNC, INO80E, DNAJC6, RUFY4,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CYP7B1
EPS15

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	EPS15	chr8:65517239	chr1:51946986	ENST00000371733		0	25	2_330	11.0	897.0	DAB2

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Related Drugs to CYP7B1-EPS15

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CYP7B1-EPS15

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source