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Fusion Protein:CYTH3-MAD1L1 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: CYTH3-MAD1L1 | FusionPDB ID: 21162 | FusionGDB2.0 ID: 21162 | Hgene | Tgene | Gene symbol | CYTH3 | MAD1L1 | Gene ID | 9265 | 8379 |
Gene name | cytohesin 3 | mitotic arrest deficient 1 like 1 | |
Synonyms | ARNO3|GRP1|PSCD3|cytohesin-3 | MAD1|PIG9|TP53I9|TXBP181 | |
Cytomap | 7p22.1 | 7p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cytohesin-3ARF nucleotide-binding site opener 3PH, SEC7 and coiled-coil domain-containing protein 3general receptor of phosphoinositides 1pleckstrin homology, Sec7 and coiled-coil domains 3 | mitotic spindle assembly checkpoint protein MAD1MAD1 mitotic arrest deficient like 1MAD1-like protein 1mitotic arrest deficient 1-like protein 1mitotic checkpoint MAD1 protein homologmitotic-arrest deficient 1, yeast, homolog-like 1tax-binding prote | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | O43739 | Q9Y6D9 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000350796, ENST00000396741, ENST00000488964, | ENST00000486340, ENST00000265854, ENST00000399654, ENST00000402746, ENST00000406869, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 12 X 10 X 8=960 | 23 X 16 X 12=4416 |
# samples | 14 | 37 | |
** MAII score | log2(14/960*10)=-2.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(37/4416*10)=-3.57714299626186 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: CYTH3 [Title/Abstract] AND MAD1L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CYTH3(6210833)-MAD1L1(1938026), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | CYTH3-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CYTH3-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CYTH3-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CYTH3-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MAD1L1 | GO:0007094 | mitotic spindle assembly checkpoint | 18981471 |
Tgene | MAD1L1 | GO:0090235 | regulation of metaphase plate congression | 20133940 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-A8-A09Q-01A | CYTH3 | chr7 | 6210166 | - | MAD1L1 | chr7 | 1938026 | - |
ChimerDB4 | BRCA | TCGA-A8-A09Q-01A | CYTH3 | chr7 | 6210833 | - | MAD1L1 | chr7 | 1938026 | - |
ChimerDB4 | BRCA | TCGA-A8-A09Q | CYTH3 | chr7 | 6210165 | - | MAD1L1 | chr7 | 1938026 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000350796 | CYTH3 | chr7 | 6210833 | - | ENST00000402746 | MAD1L1 | chr7 | 1938026 | - | 1325 | 699 | 32 | 1048 | 338 |
ENST00000350796 | CYTH3 | chr7 | 6210833 | - | ENST00000399654 | MAD1L1 | chr7 | 1938026 | - | 1325 | 699 | 32 | 1048 | 338 |
ENST00000350796 | CYTH3 | chr7 | 6210833 | - | ENST00000406869 | MAD1L1 | chr7 | 1938026 | - | 1325 | 699 | 32 | 1048 | 338 |
ENST00000350796 | CYTH3 | chr7 | 6210833 | - | ENST00000265854 | MAD1L1 | chr7 | 1938026 | - | 1308 | 699 | 32 | 1048 | 338 |
ENST00000396741 | CYTH3 | chr7 | 6210833 | - | ENST00000402746 | MAD1L1 | chr7 | 1938026 | - | 1084 | 458 | 145 | 807 | 220 |
ENST00000396741 | CYTH3 | chr7 | 6210833 | - | ENST00000399654 | MAD1L1 | chr7 | 1938026 | - | 1084 | 458 | 145 | 807 | 220 |
ENST00000396741 | CYTH3 | chr7 | 6210833 | - | ENST00000406869 | MAD1L1 | chr7 | 1938026 | - | 1084 | 458 | 145 | 807 | 220 |
ENST00000396741 | CYTH3 | chr7 | 6210833 | - | ENST00000265854 | MAD1L1 | chr7 | 1938026 | - | 1067 | 458 | 145 | 807 | 220 |
ENST00000350796 | CYTH3 | chr7 | 6210165 | - | ENST00000402746 | MAD1L1 | chr7 | 1938026 | - | 1586 | 960 | 32 | 1309 | 425 |
ENST00000350796 | CYTH3 | chr7 | 6210165 | - | ENST00000399654 | MAD1L1 | chr7 | 1938026 | - | 1586 | 960 | 32 | 1309 | 425 |
ENST00000350796 | CYTH3 | chr7 | 6210165 | - | ENST00000406869 | MAD1L1 | chr7 | 1938026 | - | 1586 | 960 | 32 | 1309 | 425 |
ENST00000350796 | CYTH3 | chr7 | 6210165 | - | ENST00000265854 | MAD1L1 | chr7 | 1938026 | - | 1569 | 960 | 32 | 1309 | 425 |
ENST00000396741 | CYTH3 | chr7 | 6210165 | - | ENST00000402746 | MAD1L1 | chr7 | 1938026 | - | 1345 | 719 | 145 | 1068 | 307 |
ENST00000396741 | CYTH3 | chr7 | 6210165 | - | ENST00000399654 | MAD1L1 | chr7 | 1938026 | - | 1345 | 719 | 145 | 1068 | 307 |
ENST00000396741 | CYTH3 | chr7 | 6210165 | - | ENST00000406869 | MAD1L1 | chr7 | 1938026 | - | 1345 | 719 | 145 | 1068 | 307 |
ENST00000396741 | CYTH3 | chr7 | 6210165 | - | ENST00000265854 | MAD1L1 | chr7 | 1938026 | - | 1328 | 719 | 145 | 1068 | 307 |
ENST00000350796 | CYTH3 | chr7 | 6210166 | - | ENST00000402746 | MAD1L1 | chr7 | 1938026 | - | 1586 | 960 | 32 | 1309 | 425 |
ENST00000350796 | CYTH3 | chr7 | 6210166 | - | ENST00000399654 | MAD1L1 | chr7 | 1938026 | - | 1586 | 960 | 32 | 1309 | 425 |
ENST00000350796 | CYTH3 | chr7 | 6210166 | - | ENST00000406869 | MAD1L1 | chr7 | 1938026 | - | 1586 | 960 | 32 | 1309 | 425 |
ENST00000350796 | CYTH3 | chr7 | 6210166 | - | ENST00000265854 | MAD1L1 | chr7 | 1938026 | - | 1569 | 960 | 32 | 1309 | 425 |
ENST00000396741 | CYTH3 | chr7 | 6210166 | - | ENST00000402746 | MAD1L1 | chr7 | 1938026 | - | 1345 | 719 | 145 | 1068 | 307 |
ENST00000396741 | CYTH3 | chr7 | 6210166 | - | ENST00000399654 | MAD1L1 | chr7 | 1938026 | - | 1345 | 719 | 145 | 1068 | 307 |
ENST00000396741 | CYTH3 | chr7 | 6210166 | - | ENST00000406869 | MAD1L1 | chr7 | 1938026 | - | 1345 | 719 | 145 | 1068 | 307 |
ENST00000396741 | CYTH3 | chr7 | 6210166 | - | ENST00000265854 | MAD1L1 | chr7 | 1938026 | - | 1328 | 719 | 145 | 1068 | 307 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000350796 | ENST00000402746 | CYTH3 | chr7 | 6210833 | - | MAD1L1 | chr7 | 1938026 | - | 0.008943841 | 0.9910562 |
ENST00000350796 | ENST00000399654 | CYTH3 | chr7 | 6210833 | - | MAD1L1 | chr7 | 1938026 | - | 0.008943841 | 0.9910562 |
ENST00000350796 | ENST00000406869 | CYTH3 | chr7 | 6210833 | - | MAD1L1 | chr7 | 1938026 | - | 0.008943841 | 0.9910562 |
ENST00000350796 | ENST00000265854 | CYTH3 | chr7 | 6210833 | - | MAD1L1 | chr7 | 1938026 | - | 0.008764759 | 0.99123526 |
ENST00000396741 | ENST00000402746 | CYTH3 | chr7 | 6210833 | - | MAD1L1 | chr7 | 1938026 | - | 0.028059445 | 0.9719406 |
ENST00000396741 | ENST00000399654 | CYTH3 | chr7 | 6210833 | - | MAD1L1 | chr7 | 1938026 | - | 0.028059445 | 0.9719406 |
ENST00000396741 | ENST00000406869 | CYTH3 | chr7 | 6210833 | - | MAD1L1 | chr7 | 1938026 | - | 0.028059445 | 0.9719406 |
ENST00000396741 | ENST00000265854 | CYTH3 | chr7 | 6210833 | - | MAD1L1 | chr7 | 1938026 | - | 0.026165176 | 0.9738348 |
ENST00000350796 | ENST00000402746 | CYTH3 | chr7 | 6210165 | - | MAD1L1 | chr7 | 1938026 | - | 0.011766405 | 0.98823357 |
ENST00000350796 | ENST00000399654 | CYTH3 | chr7 | 6210165 | - | MAD1L1 | chr7 | 1938026 | - | 0.011766405 | 0.98823357 |
ENST00000350796 | ENST00000406869 | CYTH3 | chr7 | 6210165 | - | MAD1L1 | chr7 | 1938026 | - | 0.011766405 | 0.98823357 |
ENST00000350796 | ENST00000265854 | CYTH3 | chr7 | 6210165 | - | MAD1L1 | chr7 | 1938026 | - | 0.011513813 | 0.9884862 |
ENST00000396741 | ENST00000402746 | CYTH3 | chr7 | 6210165 | - | MAD1L1 | chr7 | 1938026 | - | 0.01861274 | 0.98138726 |
ENST00000396741 | ENST00000399654 | CYTH3 | chr7 | 6210165 | - | MAD1L1 | chr7 | 1938026 | - | 0.01861274 | 0.98138726 |
ENST00000396741 | ENST00000406869 | CYTH3 | chr7 | 6210165 | - | MAD1L1 | chr7 | 1938026 | - | 0.01861274 | 0.98138726 |
ENST00000396741 | ENST00000265854 | CYTH3 | chr7 | 6210165 | - | MAD1L1 | chr7 | 1938026 | - | 0.01778533 | 0.9822146 |
ENST00000350796 | ENST00000402746 | CYTH3 | chr7 | 6210166 | - | MAD1L1 | chr7 | 1938026 | - | 0.011766405 | 0.98823357 |
ENST00000350796 | ENST00000399654 | CYTH3 | chr7 | 6210166 | - | MAD1L1 | chr7 | 1938026 | - | 0.011766405 | 0.98823357 |
ENST00000350796 | ENST00000406869 | CYTH3 | chr7 | 6210166 | - | MAD1L1 | chr7 | 1938026 | - | 0.011766405 | 0.98823357 |
ENST00000350796 | ENST00000265854 | CYTH3 | chr7 | 6210166 | - | MAD1L1 | chr7 | 1938026 | - | 0.011513813 | 0.9884862 |
ENST00000396741 | ENST00000402746 | CYTH3 | chr7 | 6210166 | - | MAD1L1 | chr7 | 1938026 | - | 0.01861274 | 0.98138726 |
ENST00000396741 | ENST00000399654 | CYTH3 | chr7 | 6210166 | - | MAD1L1 | chr7 | 1938026 | - | 0.01861274 | 0.98138726 |
ENST00000396741 | ENST00000406869 | CYTH3 | chr7 | 6210166 | - | MAD1L1 | chr7 | 1938026 | - | 0.01861274 | 0.98138726 |
ENST00000396741 | ENST00000265854 | CYTH3 | chr7 | 6210166 | - | MAD1L1 | chr7 | 1938026 | - | 0.01778533 | 0.9822146 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >21162_21162_1_CYTH3-MAD1L1_CYTH3_chr7_6210165_ENST00000350796_MAD1L1_chr7_1938026_ENST00000265854_length(amino acids)=425AA_BP=309 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEEL LRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS -------------------------------------------------------------- >21162_21162_2_CYTH3-MAD1L1_CYTH3_chr7_6210165_ENST00000350796_MAD1L1_chr7_1938026_ENST00000399654_length(amino acids)=425AA_BP=309 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEEL LRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS -------------------------------------------------------------- >21162_21162_3_CYTH3-MAD1L1_CYTH3_chr7_6210165_ENST00000350796_MAD1L1_chr7_1938026_ENST00000402746_length(amino acids)=425AA_BP=309 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEEL LRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS -------------------------------------------------------------- >21162_21162_4_CYTH3-MAD1L1_CYTH3_chr7_6210165_ENST00000350796_MAD1L1_chr7_1938026_ENST00000406869_length(amino acids)=425AA_BP=309 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEEL LRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS -------------------------------------------------------------- >21162_21162_5_CYTH3-MAD1L1_CYTH3_chr7_6210165_ENST00000396741_MAD1L1_chr7_1938026_ENST00000265854_length(amino acids)=307AA_BP=191 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFF NPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETE -------------------------------------------------------------- >21162_21162_6_CYTH3-MAD1L1_CYTH3_chr7_6210165_ENST00000396741_MAD1L1_chr7_1938026_ENST00000399654_length(amino acids)=307AA_BP=191 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFF NPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETE -------------------------------------------------------------- >21162_21162_7_CYTH3-MAD1L1_CYTH3_chr7_6210165_ENST00000396741_MAD1L1_chr7_1938026_ENST00000402746_length(amino acids)=307AA_BP=191 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFF NPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETE -------------------------------------------------------------- >21162_21162_8_CYTH3-MAD1L1_CYTH3_chr7_6210165_ENST00000396741_MAD1L1_chr7_1938026_ENST00000406869_length(amino acids)=307AA_BP=191 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFF NPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETE -------------------------------------------------------------- >21162_21162_9_CYTH3-MAD1L1_CYTH3_chr7_6210166_ENST00000350796_MAD1L1_chr7_1938026_ENST00000265854_length(amino acids)=425AA_BP=309 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEEL LRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS -------------------------------------------------------------- >21162_21162_10_CYTH3-MAD1L1_CYTH3_chr7_6210166_ENST00000350796_MAD1L1_chr7_1938026_ENST00000399654_length(amino acids)=425AA_BP=309 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEEL LRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS -------------------------------------------------------------- >21162_21162_11_CYTH3-MAD1L1_CYTH3_chr7_6210166_ENST00000350796_MAD1L1_chr7_1938026_ENST00000402746_length(amino acids)=425AA_BP=309 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEEL LRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS -------------------------------------------------------------- >21162_21162_12_CYTH3-MAD1L1_CYTH3_chr7_6210166_ENST00000350796_MAD1L1_chr7_1938026_ENST00000406869_length(amino acids)=425AA_BP=309 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEEL LRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS -------------------------------------------------------------- >21162_21162_13_CYTH3-MAD1L1_CYTH3_chr7_6210166_ENST00000396741_MAD1L1_chr7_1938026_ENST00000265854_length(amino acids)=307AA_BP=191 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFF NPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETE -------------------------------------------------------------- >21162_21162_14_CYTH3-MAD1L1_CYTH3_chr7_6210166_ENST00000396741_MAD1L1_chr7_1938026_ENST00000399654_length(amino acids)=307AA_BP=191 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFF NPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETE -------------------------------------------------------------- >21162_21162_15_CYTH3-MAD1L1_CYTH3_chr7_6210166_ENST00000396741_MAD1L1_chr7_1938026_ENST00000402746_length(amino acids)=307AA_BP=191 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFF NPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETE -------------------------------------------------------------- >21162_21162_16_CYTH3-MAD1L1_CYTH3_chr7_6210166_ENST00000396741_MAD1L1_chr7_1938026_ENST00000406869_length(amino acids)=307AA_BP=191 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFF NPDREGWLLKLELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETE -------------------------------------------------------------- >21162_21162_17_CYTH3-MAD1L1_CYTH3_chr7_6210833_ENST00000350796_MAD1L1_chr7_1938026_ENST00000265854_length(amino acids)=338AA_BP=222 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYR -------------------------------------------------------------- >21162_21162_18_CYTH3-MAD1L1_CYTH3_chr7_6210833_ENST00000350796_MAD1L1_chr7_1938026_ENST00000399654_length(amino acids)=338AA_BP=222 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYR -------------------------------------------------------------- >21162_21162_19_CYTH3-MAD1L1_CYTH3_chr7_6210833_ENST00000350796_MAD1L1_chr7_1938026_ENST00000402746_length(amino acids)=338AA_BP=222 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYR -------------------------------------------------------------- >21162_21162_20_CYTH3-MAD1L1_CYTH3_chr7_6210833_ENST00000350796_MAD1L1_chr7_1938026_ENST00000406869_length(amino acids)=338AA_BP=222 MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNL VQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYR -------------------------------------------------------------- >21162_21162_21_CYTH3-MAD1L1_CYTH3_chr7_6210833_ENST00000396741_MAD1L1_chr7_1938026_ENST00000265854_length(amino acids)=220AA_BP=104 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLL -------------------------------------------------------------- >21162_21162_22_CYTH3-MAD1L1_CYTH3_chr7_6210833_ENST00000396741_MAD1L1_chr7_1938026_ENST00000399654_length(amino acids)=220AA_BP=104 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLL -------------------------------------------------------------- >21162_21162_23_CYTH3-MAD1L1_CYTH3_chr7_6210833_ENST00000396741_MAD1L1_chr7_1938026_ENST00000402746_length(amino acids)=220AA_BP=104 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLL -------------------------------------------------------------- >21162_21162_24_CYTH3-MAD1L1_CYTH3_chr7_6210833_ENST00000396741_MAD1L1_chr7_1938026_ENST00000406869_length(amino acids)=220AA_BP=104 MLMALPQLQTAMLAAFLWDPRDVVLTAQPGAEQCAESSQHIRILQPQFRLIRLRFWKLYIQRRVQAWQFLWSFRLPGEAQKIDRMMEAFA SRYCLCNPGVFQSTELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:6210833/chr7:1938026) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CYTH3 | MAD1L1 |
FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity). {ECO:0000250|UniProtKB:O08967, ECO:0000269|PubMed:23940353, ECO:0000269|PubMed:9707577}. | FUNCTION: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CYTH3 | chr7:6210165 | chr7:1938026 | ENST00000350796 | - | 9 | 13 | 14_61 | 274.3333333333333 | 400.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | CYTH3 | chr7:6210166 | chr7:1938026 | ENST00000350796 | - | 9 | 13 | 14_61 | 274.3333333333333 | 400.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | CYTH3 | chr7:6210833 | chr7:1938026 | ENST00000350796 | - | 7 | 13 | 14_61 | 187.33333333333334 | 400.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | CYTH3 | chr7:6210165 | chr7:1938026 | ENST00000350796 | - | 9 | 13 | 77_206 | 274.3333333333333 | 400.0 | Domain | SEC7 |
Hgene | CYTH3 | chr7:6210166 | chr7:1938026 | ENST00000350796 | - | 9 | 13 | 77_206 | 274.3333333333333 | 400.0 | Domain | SEC7 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CYTH3 | chr7:6210165 | chr7:1938026 | ENST00000350796 | - | 9 | 13 | 264_381 | 274.3333333333333 | 400.0 | Domain | PH |
Hgene | CYTH3 | chr7:6210166 | chr7:1938026 | ENST00000350796 | - | 9 | 13 | 264_381 | 274.3333333333333 | 400.0 | Domain | PH |
Hgene | CYTH3 | chr7:6210833 | chr7:1938026 | ENST00000350796 | - | 7 | 13 | 264_381 | 187.33333333333334 | 400.0 | Domain | PH |
Hgene | CYTH3 | chr7:6210833 | chr7:1938026 | ENST00000350796 | - | 7 | 13 | 77_206 | 187.33333333333334 | 400.0 | Domain | SEC7 |
Hgene | CYTH3 | chr7:6210165 | chr7:1938026 | ENST00000350796 | - | 9 | 13 | 273_281 | 274.3333333333333 | 400.0 | Region | Note=Phosphatidylinositol 3%2C4%2C5-trisphosphate binding |
Hgene | CYTH3 | chr7:6210165 | chr7:1938026 | ENST00000350796 | - | 9 | 13 | 392_400 | 274.3333333333333 | 400.0 | Region | C-terminal autoinhibitory region |
Hgene | CYTH3 | chr7:6210166 | chr7:1938026 | ENST00000350796 | - | 9 | 13 | 273_281 | 274.3333333333333 | 400.0 | Region | Note=Phosphatidylinositol 3%2C4%2C5-trisphosphate binding |
Hgene | CYTH3 | chr7:6210166 | chr7:1938026 | ENST00000350796 | - | 9 | 13 | 392_400 | 274.3333333333333 | 400.0 | Region | C-terminal autoinhibitory region |
Hgene | CYTH3 | chr7:6210833 | chr7:1938026 | ENST00000350796 | - | 7 | 13 | 273_281 | 187.33333333333334 | 400.0 | Region | Note=Phosphatidylinositol 3%2C4%2C5-trisphosphate binding |
Hgene | CYTH3 | chr7:6210833 | chr7:1938026 | ENST00000350796 | - | 7 | 13 | 392_400 | 187.33333333333334 | 400.0 | Region | C-terminal autoinhibitory region |
Tgene | MAD1L1 | chr7:6210165 | chr7:1938026 | ENST00000265854 | 15 | 18 | 46_632 | 602.3333333333334 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | MAD1L1 | chr7:6210165 | chr7:1938026 | ENST00000399654 | 16 | 19 | 46_632 | 602.3333333333334 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | MAD1L1 | chr7:6210165 | chr7:1938026 | ENST00000406869 | 16 | 19 | 46_632 | 602.3333333333334 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | MAD1L1 | chr7:6210166 | chr7:1938026 | ENST00000265854 | 15 | 18 | 46_632 | 602.3333333333334 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | MAD1L1 | chr7:6210166 | chr7:1938026 | ENST00000399654 | 16 | 19 | 46_632 | 602.3333333333334 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | MAD1L1 | chr7:6210166 | chr7:1938026 | ENST00000406869 | 16 | 19 | 46_632 | 602.3333333333334 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | MAD1L1 | chr7:6210833 | chr7:1938026 | ENST00000265854 | 15 | 18 | 46_632 | 602.3333333333334 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | MAD1L1 | chr7:6210833 | chr7:1938026 | ENST00000399654 | 16 | 19 | 46_632 | 602.3333333333334 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | MAD1L1 | chr7:6210833 | chr7:1938026 | ENST00000406869 | 16 | 19 | 46_632 | 602.3333333333334 | 719.0 | Coiled coil | Ontology_term=ECO:0000255 |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
CYTH3 | |
MAD1L1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to CYTH3-MAD1L1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to CYTH3-MAD1L1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |