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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DACH1-KLF12

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DACH1-KLF12
	FusionPDB ID: 21250
	FusionGDB2.0 ID: 21250
		Hgene	Tgene
	Gene symbol	DACH1	KLF12
	Gene ID	1602	11278
	Gene name	dachshund family transcription factor 1	Kruppel like factor 12
	Synonyms	DACH	AP-2rep\|AP2REP\|HSPC122
	Cytomap	13q21.33	13q22.1
	Type of gene	protein-coding	protein-coding
	Description	dachshund homolog 1dac homolog	Krueppel-like factor 12AP-2 repressorAP-2rep transcription factorKLF12 zinc finger transcriptional repressortranscriptional repressor AP-2rep
	Modification date	20200328	20200313
	UniProtAcc	Q9UI36	Q9Y4X4
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000305425, ENST00000313174, ENST00000354591, ENST00000359684,	ENST00000472022, ENST00000377669, ENST00000377666,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 7 X 4=224	13 X 13 X 6=1014
	# samples	8	16
	** MAII score	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1014*10)=-2.66391384211598 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DACH1 [Title/Abstract] AND KLF12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DACH1(72440054)-KLF12(74269808), # samples:3
Anticipated loss of major functional domain due to fusion event.	DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. DACH1-KLF12 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. DACH1-KLF12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. DACH1-KLF12 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DACH1	GO:0000122	negative regulation of transcription by RNA polymerase II	20956529
Hgene	DACH1	GO:0030336	negative regulation of cell migration	20956529
Hgene	DACH1	GO:2000279	negative regulation of DNA biosynthetic process	16980615
Tgene	KLF12	GO:0000122	negative regulation of transcription by RNA polymerase II	16615998

Fusion gene breakpoints across DACH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KLF12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-XP-A8T8-01A	DACH1	chr13	72440054	-	KLF12	chr13	74269808	-
ChimerDB4	ESCA	TCGA-XP-A8T8	DACH1	chr13	72440054	-	KLF12	chr13	74269808	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000313174	DACH1	chr13	72440054	-	ENST00000377666	KLF12	chr13	74269808	-	1550	1277	180	1337	385
ENST00000305425	DACH1	chr13	72440054	-	ENST00000377666	KLF12	chr13	74269808	-	1550	1277	180	1337	385
ENST00000354591	DACH1	chr13	72440054	-	ENST00000377666	KLF12	chr13	74269808	-	1550	1277	180	1337	385
ENST00000359684	DACH1	chr13	72440054	-	ENST00000377666	KLF12	chr13	74269808	-	1127	854	0	914	304

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000313174	ENST00000377666	DACH1	chr13	72440054	-	KLF12	chr13	74269808	-	0.017466577	0.9825334
ENST00000305425	ENST00000377666	DACH1	chr13	72440054	-	KLF12	chr13	74269808	-	0.017466577	0.9825334
ENST00000354591	ENST00000377666	DACH1	chr13	72440054	-	KLF12	chr13	74269808	-	0.017466577	0.9825334
ENST00000359684	ENST00000377666	DACH1	chr13	72440054	-	KLF12	chr13	74269808	-	0.005797009	0.99420303

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21250_21250_1_DACH1-KLF12_DACH1_chr13_72440054_ENST00000305425_KLF12_chr13_74269808_ENST00000377666_length(amino acids)=385AA_BP=365
MRDTFVRSSPERLSCSPLLRSLFITFTSFSPPSLPFSFSFSPGVVVAPLAPSPPFFPLPLPGVCGNFSSRFSSVCFPLYVTMAVPAALIP
PTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGSSGNGGGGGG
GGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNE
CKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYN

--------------------------------------------------------------

>21250_21250_2_DACH1-KLF12_DACH1_chr13_72440054_ENST00000313174_KLF12_chr13_74269808_ENST00000377666_length(amino acids)=385AA_BP=365
MRDTFVRSSPERLSCSPLLRSLFITFTSFSPPSLPFSFSFSPGVVVAPLAPSPPFFPLPLPGVCGNFSSRFSSVCFPLYVTMAVPAALIP
PTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGSSGNGGGGGG
GGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNE
CKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYN

--------------------------------------------------------------

>21250_21250_3_DACH1-KLF12_DACH1_chr13_72440054_ENST00000354591_KLF12_chr13_74269808_ENST00000377666_length(amino acids)=385AA_BP=365
MRDTFVRSSPERLSCSPLLRSLFITFTSFSPPSLPFSFSFSPGVVVAPLAPSPPFFPLPLPGVCGNFSSRFSSVCFPLYVTMAVPAALIP
PTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGSSGNGGGGGG
GGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNE
CKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYN

--------------------------------------------------------------

>21250_21250_4_DACH1-KLF12_DACH1_chr13_72440054_ENST00000359684_KLF12_chr13_74269808_ENST00000377666_length(amino acids)=304AA_BP=284
MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGS
SGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSP
VENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLIS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:72440054/chr13:74269808)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DACH1 Q9UI36	KLF12 Q9Y4X4
FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250, ECO:0000269\|PubMed:14525983}.	FUNCTION: Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000305425

114_121

284.6666666666667

709.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000305425

140_163

284.6666666666667

709.0

Compositional bias

Note=Poly-Ser

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000305425

61_68

284.6666666666667

709.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000305425

74_87

284.6666666666667

709.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000305425

90_101

284.6666666666667

709.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000313174

114_121

284.6666666666667

561.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000313174

140_163

284.6666666666667

561.0

Compositional bias

Note=Poly-Ser

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000313174

61_68

284.6666666666667

561.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000313174

74_87

284.6666666666667

561.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000313174

90_101

284.6666666666667

561.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000354591

114_121

284.6666666666667

507.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000354591

140_163

284.6666666666667

507.0

Compositional bias

Note=Poly-Ser

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000354591

61_68

284.6666666666667

507.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000354591

74_87

284.6666666666667

507.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000354591

90_101

284.6666666666667

507.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000359684

114_121

284.6666666666667

761.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000359684

140_163

284.6666666666667

761.0

Compositional bias

Note=Poly-Ser

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000359684

61_68

284.6666666666667

761.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000359684

74_87

284.6666666666667

761.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000359684

90_101

284.6666666666667

761.0

Compositional bias

Note=Poly-Gly

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000305425

189_275

284.6666666666667

709.0

Region

Note=DACHbox-N

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000313174

189_275

284.6666666666667

561.0

Region

Note=DACHbox-N

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000354591

189_275

284.6666666666667

507.0

Region

Note=DACHbox-N

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000359684

189_275

284.6666666666667

761.0

Region

Note=DACHbox-N

Tgene

KLF12

chr13:72440054

chr13:74269808

ENST00000377666

347_371

342.3333333333333

403.0

Zinc finger

C2H2-type 2

Tgene

KLF12

chr13:72440054

chr13:74269808

ENST00000377666

377_399

342.3333333333333

403.0

Zinc finger

C2H2-type 3

Tgene

KLF12

chr13:72440054

chr13:74269808

ENST00000377669

347_371

342.3333333333333

403.0

Zinc finger

C2H2-type 2

Tgene

KLF12

chr13:72440054

chr13:74269808

ENST00000377669

377_399

342.3333333333333

403.0

Zinc finger

C2H2-type 3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000305425

630_718

284.6666666666667

709.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000313174

630_718

284.6666666666667

561.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000354591

630_718

284.6666666666667

507.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000359684

630_718

284.6666666666667

761.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000305425

325_333

284.6666666666667

709.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000305425

467_470

284.6666666666667

709.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000313174

325_333

284.6666666666667

561.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000313174

467_470

284.6666666666667

561.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000354591

325_333

284.6666666666667

507.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000354591

467_470

284.6666666666667

507.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000359684

325_333

284.6666666666667

761.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000359684

467_470

284.6666666666667

761.0

Compositional bias

Note=Poly-Ala

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000305425

616_696

284.6666666666667

709.0

Region

Note=DACHbox-C

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000313174

616_696

284.6666666666667

561.0

Region

Note=DACHbox-C

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000354591

616_696

284.6666666666667

507.0

Region

Note=DACHbox-C

Hgene

DACH1

chr13:72440054

chr13:74269808

ENST00000359684

616_696

284.6666666666667

761.0

Region

Note=DACHbox-C

Tgene

KLF12

chr13:72440054

chr13:74269808

ENST00000377666

80_88

342.3333333333333

403.0

Motif

9aaTAD%3B inactive

Tgene

KLF12

chr13:72440054

chr13:74269808

ENST00000377669

80_88

342.3333333333333

403.0

Motif

9aaTAD%3B inactive

Tgene

KLF12

chr13:72440054

chr13:74269808

ENST00000377666

317_341

342.3333333333333

403.0

Zinc finger

C2H2-type 1

Tgene

KLF12

chr13:72440054

chr13:74269808

ENST00000377669

317_341

342.3333333333333

403.0

Zinc finger

C2H2-type 1

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>768_DACH1_72440054_KLF12_74269808_ranked_0.pdb	DACH1	72440054	72440054	ENST00000377666	KLF12	chr13	74269808	-	MRDTFVRSSPERLSCSPLLRSLFITFTSFSPPSLPFSFSFSPGVVVAPLAPSPPFFPLPLPGVCGNFSSRFSSVCFPLYVTMAVPAALIP PTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSIGPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGGGSGGGGGSSGNGGGGGG GGGGSNCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPSPVENTPQNNE CKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYN	385

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DACH1_pLDDT.png

KLF12_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DACH1
KLF12

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	DACH1	chr13:72440054	chr13:74269808	ENST00000305425	-	1	11	627_706	284.6666666666667	709.0	SIN3A
Hgene	DACH1	chr13:72440054	chr13:74269808	ENST00000313174	-	1	8	627_706	284.6666666666667	561.0	SIN3A
Hgene	DACH1	chr13:72440054	chr13:74269808	ENST00000354591	-	1	7	627_706	284.6666666666667	507.0	SIN3A
Hgene	DACH1	chr13:72440054	chr13:74269808	ENST00000359684	-	1	12	627_706	284.6666666666667	761.0	SIN3A
Hgene	DACH1	chr13:72440054	chr13:74269808	ENST00000305425	-	1	11	189_384	284.6666666666667	709.0	SIX6 and HDAC3
Hgene	DACH1	chr13:72440054	chr13:74269808	ENST00000313174	-	1	8	189_384	284.6666666666667	561.0	SIX6 and HDAC3
Hgene	DACH1	chr13:72440054	chr13:74269808	ENST00000354591	-	1	7	189_384	284.6666666666667	507.0	SIX6 and HDAC3
Hgene	DACH1	chr13:72440054	chr13:74269808	ENST00000359684	-	1	12	189_384	284.6666666666667	761.0	SIX6 and HDAC3

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Related Drugs to DACH1-KLF12

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DACH1-KLF12

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source