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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DAND5-NFIC

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DAND5-NFIC
FusionPDB ID: 21319
FusionGDB2.0 ID: 21319
HgeneTgene
Gene symbol

DAND5

NFIC

Gene ID

199699

4782

Gene nameDAN domain BMP antagonist family member 5nuclear factor I C
SynonymsCER2|CERL2|CKTSF1B3|COCO|CRL2|DANTE|GREM3|SP1CTF|CTF5|NF-I|NFI
Cytomap

19p13.13

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionDAN domain family member 5DAN domain family member 5, BMP antagonistDAN domain family, member 5cerberus 2cerberus-like 2cerberus-like protein 2cerl-2cysteine knot superfamily 1, BMP antagonist 3gremlin-3nuclear factor 1 C-typeCCAAT-box-binding transcription factorNF-I/CNF1-CTGGCA-binding proteinnuclear factor I/C (CCAAT-binding transcription factor)
Modification date2020031320200313
UniProtAcc

Q8N907

P08651

Ensembl transtripts involved in fusion geneENST idsENST00000317060, ENST00000585548, 
ENST00000588839, ENST00000341919, 
ENST00000346156, ENST00000395111, 
ENST00000443272, ENST00000586919, 
ENST00000589123, ENST00000590282, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 3=2724 X 21 X 9=4536
# samples 327
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(27/4536*10)=-4.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DAND5 [Title/Abstract] AND NFIC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DAND5(13080798)-NFIC(3381709), # samples:35
Anticipated loss of major functional domain due to fusion event.DAND5-NFIC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DAND5-NFIC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DAND5-NFIC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DAND5-NFIC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNFIC

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

TgeneNFIC

GO:0045944

positive regulation of transcription by RNA polymerase II

1524678|19706729


check buttonFusion gene breakpoints across DAND5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NFIC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5LSDAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4CESCTCGA-Q1-A73RDAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4ESCATCGA-L5-A893DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-CS-5393DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-DB-A64UDAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-DU-7009DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-DU-7300DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-DU-7306DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-DU-8164DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-DU-A6S2DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-EZ-7264DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-F6-A8O3DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HT-7478DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HT-7480DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HT-7485DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HT-7690DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HT-7873DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HT-7875DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HT-7881DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HW-7486DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HW-7491DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HW-7495DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-HW-8322DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-QH-A65RDAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-QH-A6CZDAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-QH-A6X8DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-R8-A6MLDAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-S9-A7J1DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-S9-A7J2DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-S9-A7J3DAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-TM-A84GDAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-TM-A84HDAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-TM-A84MDAND5chr19

13080798

+NFICchr19

3381709

+
ChimerDB4LGGTCGA-TQ-A7RODAND5chr19

13080798

+NFICchr19

3381709

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585548DAND5chr1913080798+ENST00000589123NFICchr193381709+8455510962006636
ENST00000585548DAND5chr1913080798+ENST00000346156NFICchr193381709+2617510961727543
ENST00000585548DAND5chr1913080798+ENST00000395111NFICchr193381709+2226510961799567
ENST00000585548DAND5chr1913080798+ENST00000586919NFICchr193381709+1728510961727543
ENST00000585548DAND5chr1913080798+ENST00000341919NFICchr193381709+1965510961766556
ENST00000585548DAND5chr1913080798+ENST00000590282NFICchr193381709+1984510961799567
ENST00000585548DAND5chr1913080798+ENST00000443272NFICchr193381709+2145510962006636
ENST00000317060DAND5chr1913080798+ENST00000589123NFICchr193381709+8448503891999636
ENST00000317060DAND5chr1913080798+ENST00000346156NFICchr193381709+2610503891720543
ENST00000317060DAND5chr1913080798+ENST00000395111NFICchr193381709+2219503891792567
ENST00000317060DAND5chr1913080798+ENST00000586919NFICchr193381709+1721503891720544
ENST00000317060DAND5chr1913080798+ENST00000341919NFICchr193381709+1958503891759556
ENST00000317060DAND5chr1913080798+ENST00000590282NFICchr193381709+1977503891792567
ENST00000317060DAND5chr1913080798+ENST00000443272NFICchr193381709+2138503891999636

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585548ENST00000589123DAND5chr1913080798+NFICchr193381709+0.0181404860.9818595
ENST00000585548ENST00000346156DAND5chr1913080798+NFICchr193381709+0.1143295840.8856704
ENST00000585548ENST00000395111DAND5chr1913080798+NFICchr193381709+0.110359540.8896405
ENST00000585548ENST00000586919DAND5chr1913080798+NFICchr193381709+0.134011860.86598814
ENST00000585548ENST00000341919DAND5chr1913080798+NFICchr193381709+0.1157738640.8842261
ENST00000585548ENST00000590282DAND5chr1913080798+NFICchr193381709+0.1151049660.8848951
ENST00000585548ENST00000443272DAND5chr1913080798+NFICchr193381709+0.093166880.9068331
ENST00000317060ENST00000589123DAND5chr1913080798+NFICchr193381709+0.018195880.98180413
ENST00000317060ENST00000346156DAND5chr1913080798+NFICchr193381709+0.108014590.8919854
ENST00000317060ENST00000395111DAND5chr1913080798+NFICchr193381709+0.0995026160.90049744
ENST00000317060ENST00000586919DAND5chr1913080798+NFICchr193381709+0.1304240.869576
ENST00000317060ENST00000341919DAND5chr1913080798+NFICchr193381709+0.111656770.8883432
ENST00000317060ENST00000590282DAND5chr1913080798+NFICchr193381709+0.108860250.8911398
ENST00000317060ENST00000443272DAND5chr1913080798+NFICchr193381709+0.085349770.91465026

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21319_21319_1_DAND5-NFIC_DAND5_chr19_13080798_ENST00000317060_NFIC_chr19_3381709_ENST00000341919_length(amino acids)=556AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL

--------------------------------------------------------------

>21319_21319_2_DAND5-NFIC_DAND5_chr19_13080798_ENST00000317060_NFIC_chr19_3381709_ENST00000346156_length(amino acids)=543AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHL
AYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRL
SSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPPTLRPTRPLQTVP

--------------------------------------------------------------

>21319_21319_3_DAND5-NFIC_DAND5_chr19_13080798_ENST00000317060_NFIC_chr19_3381709_ENST00000395111_length(amino acids)=567AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL

--------------------------------------------------------------

>21319_21319_4_DAND5-NFIC_DAND5_chr19_13080798_ENST00000317060_NFIC_chr19_3381709_ENST00000443272_length(amino acids)=636AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL
ACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQA

--------------------------------------------------------------

>21319_21319_5_DAND5-NFIC_DAND5_chr19_13080798_ENST00000317060_NFIC_chr19_3381709_ENST00000586919_length(amino acids)=544AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHL
AYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRL
SSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPPTLRPTRPLQTVP

--------------------------------------------------------------

>21319_21319_6_DAND5-NFIC_DAND5_chr19_13080798_ENST00000317060_NFIC_chr19_3381709_ENST00000589123_length(amino acids)=636AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL
ACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQA

--------------------------------------------------------------

>21319_21319_7_DAND5-NFIC_DAND5_chr19_13080798_ENST00000317060_NFIC_chr19_3381709_ENST00000590282_length(amino acids)=567AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL

--------------------------------------------------------------

>21319_21319_8_DAND5-NFIC_DAND5_chr19_13080798_ENST00000585548_NFIC_chr19_3381709_ENST00000341919_length(amino acids)=556AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL

--------------------------------------------------------------

>21319_21319_9_DAND5-NFIC_DAND5_chr19_13080798_ENST00000585548_NFIC_chr19_3381709_ENST00000346156_length(amino acids)=543AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHL
AYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRL
SSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPPTLRPTRPLQTVP

--------------------------------------------------------------

>21319_21319_10_DAND5-NFIC_DAND5_chr19_13080798_ENST00000585548_NFIC_chr19_3381709_ENST00000395111_length(amino acids)=567AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL

--------------------------------------------------------------

>21319_21319_11_DAND5-NFIC_DAND5_chr19_13080798_ENST00000585548_NFIC_chr19_3381709_ENST00000443272_length(amino acids)=636AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL
ACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQA

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>21319_21319_12_DAND5-NFIC_DAND5_chr19_13080798_ENST00000585548_NFIC_chr19_3381709_ENST00000586919_length(amino acids)=543AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHL
AYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRL
SSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPPTLRPTRPLQTVP

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>21319_21319_13_DAND5-NFIC_DAND5_chr19_13080798_ENST00000585548_NFIC_chr19_3381709_ENST00000589123_length(amino acids)=636AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL
ACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQA

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>21319_21319_14_DAND5-NFIC_DAND5_chr19_13080798_ENST00000585548_NFIC_chr19_3381709_ENST00000590282_length(amino acids)=567AA_BP=137
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:13080798/chr19:3381709)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAND5

Q8N907

NFIC

P08651

FUNCTION: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity). {ECO:0000250}.FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNFICchr19:13080798chr19:3381709ENST00000346156091_1951.0669.0DNA bindingCTF/NF-I
TgeneNFICchr19:13080798chr19:3381709ENST000003951110101_1951.0548.3333333333334DNA bindingCTF/NF-I
TgeneNFICchr19:13080798chr19:3381709ENST00000586919081_1951.0407.0DNA bindingCTF/NF-I
TgeneNFICchr19:13080798chr19:3381709ENST000005891230111_1951.0500.0DNA bindingCTF/NF-I
TgeneNFICchr19:13080798chr19:3381709ENST0000034191909404_41210.0429.0Motif9aaTAD
TgeneNFICchr19:13080798chr19:3381709ENST0000034615609404_4121.0669.0Motif9aaTAD
TgeneNFICchr19:13080798chr19:3381709ENST00000395111010404_4121.0548.3333333333334Motif9aaTAD
TgeneNFICchr19:13080798chr19:3381709ENST00000443272011404_41210.0509.0Motif9aaTAD
TgeneNFICchr19:13080798chr19:3381709ENST0000058691908404_4121.0407.0Motif9aaTAD
TgeneNFICchr19:13080798chr19:3381709ENST00000589123011404_4121.0500.0Motif9aaTAD
TgeneNFICchr19:13080798chr19:3381709ENST00000590282010404_41210.0461.6666666666667Motif9aaTAD

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDAND5chr19:13080798chr19:3381709ENST00000317060+12101_186108.0190.0DomainNote=CTCK
TgeneNFICchr19:13080798chr19:3381709ENST00000341919091_19510.0429.0DNA bindingCTF/NF-I
TgeneNFICchr19:13080798chr19:3381709ENST000004432720111_19510.0509.0DNA bindingCTF/NF-I
TgeneNFICchr19:13080798chr19:3381709ENST000005902820101_19510.0461.6666666666667DNA bindingCTF/NF-I


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1334_DAND5_13080798_NFIC_3381709_1334_DAND5_13080798_NFIC_3381709_ranked_0.pdbDAND51308079813080798ENST00000443272NFICchr193381709+
MPLTRQQGRLLVTLSPVRTDRQADRRTDKQMLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKD
EERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIP
LESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELI
QVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGIS
SPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSL
ACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQA
636


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
DAND5_pLDDT.png
all structure
all structure
NFIC_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DAND5
NFIC


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DAND5-NFIC


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DAND5-NFIC


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource