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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DAPK1-GRIN2D

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DAPK1-GRIN2D
FusionPDB ID: 21349
FusionGDB2.0 ID: 21349
HgeneTgene
Gene symbol

DAPK1

GRIN2D

Gene ID

1612

2906

Gene namedeath associated protein kinase 1glutamate ionotropic receptor NMDA type subunit 2D
SynonymsDAPK|ROCO3EB11|EIEE46|GluN2D|NMDAR2D|NR2D
Cytomap

9q21.33

19q13.33

Type of geneprotein-codingprotein-coding
Descriptiondeath-associated protein kinase 1DAP kinase 1glutamate receptor ionotropic, NMDA 2DN-methyl D-aspartate receptor subtype 2DN-methyl-d-aspartate receptor subunit 2Destrogen receptor binding CpG islandglutamate [NMDA] receptor subunit epsilon-4glutamate receptor, ionotropic, N-methyl D-aspartate
Modification date2020031320200313
UniProtAcc

P53355

O15399

Ensembl transtripts involved in fusion geneENST idsENST00000358077, ENST00000408954, 
ENST00000469640, ENST00000472284, 
ENST00000491893, ENST00000466188, 
ENST00000263269, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 13 X 5=9105 X 9 X 5=225
# samples 148
** MAII scorelog2(14/910*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/225*10)=-1.49185309632967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DAPK1 [Title/Abstract] AND GRIN2D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DAPK1(90296541)-GRIN2D(48922842), # samples:2
Anticipated loss of major functional domain due to fusion event.DAPK1-GRIN2D seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DAPK1-GRIN2D seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DAPK1-GRIN2D seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DAPK1-GRIN2D seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAPK1

GO:0006468

protein phosphorylation

10629061

HgeneDAPK1

GO:0017148

negative regulation of translation

18995835

HgeneDAPK1

GO:0035556

intracellular signal transduction

10629061

HgeneDAPK1

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

16132846

HgeneDAPK1

GO:0046777

protein autophosphorylation

10629061|12730201

HgeneDAPK1

GO:0071346

cellular response to interferon-gamma

18995835

TgeneGRIN2D

GO:0097553

calcium ion transmembrane import into cytosol

26875626


check buttonFusion gene breakpoints across DAPK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRIN2D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0I8-01ADAPK1chr9

90296541

-GRIN2Dchr19

48922842

+
ChimerDB4BRCATCGA-B6-A0I8-01ADAPK1chr9

90296541

+GRIN2Dchr19

48922842

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358077DAPK1chr990296541+ENST00000263269GRIN2Dchr1948922842+5551240718345561457
ENST00000472284DAPK1chr990296541+ENST00000263269GRIN2Dchr1948922842+5568242420045731457
ENST00000469640DAPK1chr990296541+ENST00000263269GRIN2Dchr1948922842+5743259937547481457
ENST00000408954DAPK1chr990296541+ENST00000263269GRIN2Dchr1948922842+5703255933547081457
ENST00000491893DAPK1chr990296541+ENST00000263269GRIN2Dchr1948922842+544122977344461457

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358077ENST00000263269DAPK1chr990296541+GRIN2Dchr1948922842+0.0037831090.99621683
ENST00000472284ENST00000263269DAPK1chr990296541+GRIN2Dchr1948922842+0.0039205270.9960795
ENST00000469640ENST00000263269DAPK1chr990296541+GRIN2Dchr1948922842+0.004290220.9957098
ENST00000408954ENST00000263269DAPK1chr990296541+GRIN2Dchr1948922842+0.0040965230.99590355
ENST00000491893ENST00000263269DAPK1chr990296541+GRIN2Dchr1948922842+0.0032441650.9967558

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21349_21349_1_DAPK1-GRIN2D_DAPK1_chr9_90296541_ENST00000358077_GRIN2D_chr19_48922842_ENST00000263269_length(amino acids)=1457AA_BP=1032
MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVI
LILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSL
QHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL
QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALH
VAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC
DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLC
LMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR
PRLSSTNSSRFPPSPLASKPTGPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDT
VSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIG
SGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLV
YWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLAD
GFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLA
FEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPY
PYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCP
RSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGD

--------------------------------------------------------------

>21349_21349_2_DAPK1-GRIN2D_DAPK1_chr9_90296541_ENST00000408954_GRIN2D_chr19_48922842_ENST00000263269_length(amino acids)=1457AA_BP=1032
MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVI
LILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSL
QHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL
QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALH
VAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC
DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLC
LMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR
PRLSSTNSSRFPPSPLASKPTGPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDT
VSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIG
SGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLV
YWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLAD
GFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLA
FEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPY
PYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCP
RSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGD

--------------------------------------------------------------

>21349_21349_3_DAPK1-GRIN2D_DAPK1_chr9_90296541_ENST00000469640_GRIN2D_chr19_48922842_ENST00000263269_length(amino acids)=1457AA_BP=1032
MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVI
LILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSL
QHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL
QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALH
VAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC
DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLC
LMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR
PRLSSTNSSRFPPSPLASKPTGPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDT
VSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIG
SGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLV
YWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLAD
GFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLA
FEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPY
PYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCP
RSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGD

--------------------------------------------------------------

>21349_21349_4_DAPK1-GRIN2D_DAPK1_chr9_90296541_ENST00000472284_GRIN2D_chr19_48922842_ENST00000263269_length(amino acids)=1457AA_BP=1032
MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVI
LILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSL
QHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL
QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALH
VAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC
DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLC
LMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR
PRLSSTNSSRFPPSPLASKPTGPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDT
VSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIG
SGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLV
YWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLAD
GFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLA
FEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPY
PYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCP
RSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGD

--------------------------------------------------------------

>21349_21349_5_DAPK1-GRIN2D_DAPK1_chr9_90296541_ENST00000491893_GRIN2D_chr19_48922842_ENST00000263269_length(amino acids)=1457AA_BP=1032
MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVI
LILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSL
QHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL
QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALH
VAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC
DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLC
LMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR
PRLSSTNSSRFPPSPLASKPTGPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDT
VSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIG
SGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLV
YWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLAD
GFHRYYGPIEPQGLGLGLGEARAAPRGAAGRPLSPPAAQPPQKPPPSYFAIVRDKEPAEPPAGAFPGFPSPPAPPAAAATAVGPPLCRLA
FEDESPPAPARWPRSDPESQPLLGPGAGGAGGTGGAGGGAPAAPPPCRAAPPPCPYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPY
PYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRSGPAAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPLPRRRARCGCP
RSHPHRPRASHRTPAAAAPHHHRHRRAAGGWDLPPPAPTSRSLEDLSSCPRAAPARRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGD

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:90296541/chr19:48922842)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAPK1

P53355

GRIN2D

O15399

FUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION: Isoform 2 cannot induce apoptosis but can induce membrane blebbing.FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750). {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:27616483, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:9489750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+202613_275741.33333333333341431.0DomainProtein kinase
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+202613_275741.33333333333341431.0DomainProtein kinase
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+202613_275741.33333333333341431.0DomainProtein kinase
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+202619_27741.33333333333341431.0Nucleotide bindingNote=ATP
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+202694_96741.33333333333341431.0Nucleotide bindingNote=ATP
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+202619_27741.33333333333341431.0Nucleotide bindingNote=ATP
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+202694_96741.33333333333341431.0Nucleotide bindingNote=ATP
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+202619_27741.33333333333341431.0Nucleotide bindingNote=ATP
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+202694_96741.33333333333341431.0Nucleotide bindingNote=ATP
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026267_334741.33333333333341431.0RegionNote=Calmodulin-binding
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026292_301741.33333333333341431.0RegionAutoinhibitory domain
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026267_334741.33333333333341431.0RegionNote=Calmodulin-binding
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026292_301741.33333333333341431.0RegionAutoinhibitory domain
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026267_334741.33333333333341431.0RegionNote=Calmodulin-binding
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026292_301741.33333333333341431.0RegionAutoinhibitory domain
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026378_407741.33333333333341431.0RepeatNote=ANK 1
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026411_440741.33333333333341431.0RepeatNote=ANK 2
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026444_473741.33333333333341431.0RepeatNote=ANK 3
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026477_506741.33333333333341431.0RepeatNote=ANK 4
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026510_539741.33333333333341431.0RepeatNote=ANK 5
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026543_572741.33333333333341431.0RepeatNote=ANK 6
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026576_605741.33333333333341431.0RepeatNote=ANK 7
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026609_638741.33333333333341431.0RepeatNote=ANK 8
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026378_407741.33333333333341431.0RepeatNote=ANK 1
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026411_440741.33333333333341431.0RepeatNote=ANK 2
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026444_473741.33333333333341431.0RepeatNote=ANK 3
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026477_506741.33333333333341431.0RepeatNote=ANK 4
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026510_539741.33333333333341431.0RepeatNote=ANK 5
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026543_572741.33333333333341431.0RepeatNote=ANK 6
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026576_605741.33333333333341431.0RepeatNote=ANK 7
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026609_638741.33333333333341431.0RepeatNote=ANK 8
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026378_407741.33333333333341431.0RepeatNote=ANK 1
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026411_440741.33333333333341431.0RepeatNote=ANK 2
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026444_473741.33333333333341431.0RepeatNote=ANK 3
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026477_506741.33333333333341431.0RepeatNote=ANK 4
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026510_539741.33333333333341431.0RepeatNote=ANK 5
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026543_572741.33333333333341431.0RepeatNote=ANK 6
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026576_605741.33333333333341431.0RepeatNote=ANK 7
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026609_638741.33333333333341431.0RepeatNote=ANK 8
TgeneGRIN2Dchr9:90296541chr19:48922842ENST000002632697131035_1040620.33333333333341337.0Compositional biasNote=Poly-Ala
TgeneGRIN2Dchr9:90296541chr19:48922842ENST000002632697131209_1213620.33333333333341337.0Compositional biasNote=Poly-Pro
TgeneGRIN2Dchr9:90296541chr19:48922842ENST000002632697131244_1247620.33333333333341337.0Compositional biasNote=Poly-Ala
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713908_916620.33333333333341337.0Compositional biasNote=Poly-Pro
TgeneGRIN2Dchr9:90296541chr19:48922842ENST000002632697131334_1336620.33333333333341337.0MotifPDZ-binding
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713631_650620.33333333333341337.0RegionPore-forming
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713717_718620.33333333333341337.0RegionGlutamate binding
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713651_657620.33333333333341337.0Topological domainCytoplasmic
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713674_844620.33333333333341337.0Topological domainExtracellular
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713865_1336620.33333333333341337.0Topological domainCytoplasmic
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713658_673620.33333333333341337.0TransmembraneHelical
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713845_864620.33333333333341337.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+20261312_1396741.33333333333341431.0DomainDeath
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026681_955741.33333333333341431.0DomainRoc
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+20261312_1396741.33333333333341431.0DomainDeath
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026681_955741.33333333333341431.0DomainRoc
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+20261312_1396741.33333333333341431.0DomainDeath
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026681_955741.33333333333341431.0DomainRoc
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+20261162_1196741.33333333333341431.0RepeatNote=ANK 10
HgeneDAPK1chr9:90296541chr19:48922842ENST00000358077+2026875_904741.33333333333341431.0RepeatNote=ANK 9
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+20261162_1196741.33333333333341431.0RepeatNote=ANK 10
HgeneDAPK1chr9:90296541chr19:48922842ENST00000408954+2026875_904741.33333333333341431.0RepeatNote=ANK 9
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+20261162_1196741.33333333333341431.0RepeatNote=ANK 10
HgeneDAPK1chr9:90296541chr19:48922842ENST00000472284+2026875_904741.33333333333341431.0RepeatNote=ANK 9
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713281_286620.33333333333341337.0Compositional biasNote=Poly-Gly
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713539_541620.33333333333341337.0RegionGlutamate binding
TgeneGRIN2Dchr9:90296541chr19:48922842ENST0000026326971328_584620.33333333333341337.0Topological domainExtracellular
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713604_630620.33333333333341337.0Topological domainCytoplasmic
TgeneGRIN2Dchr9:90296541chr19:48922842ENST00000263269713585_603620.33333333333341337.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DAPK1
GRIN2D


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DAPK1-GRIN2D


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DAPK1-GRIN2D


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource