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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DCAF6-MPZL1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DCAF6-MPZL1
	FusionPDB ID: 21524
	FusionGDB2.0 ID: 21524
		Hgene	Tgene
	Gene symbol	DCAF6	MPZL1
	Gene ID	55827	9019
	Gene name	DDB1 and CUL4 associated factor 6	myelin protein zero like 1
	Synonyms	1200006M05Rik\|ARCAP\|IQWD1\|MSTP055\|NRIP\|PC326	MPZL1b\|PZR\|PZR1b\|PZRa\|PZRb
	Cytomap	1q24.2	1q24.2
	Type of gene	protein-coding	protein-coding
	Description	DDB1- and CUL4-associated factor 6IQ motif and WD repeat-containing protein 1IQ motif and WD repeats 1androgen receptor complex-associated proteinnuclear receptor interaction protein	myelin protein zero-like protein 1immunoglobulin family transmembrane proteinprotein zero related
	Modification date	20200313	20200313
	UniProtAcc	Q58WW2	O95297
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000470919, ENST00000312263, ENST00000367840, ENST00000367843, ENST00000432587,	ENST00000359523, ENST00000392121, ENST00000474859, ENST00000403379,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 10 X 8=1040	5 X 7 X 4=140
	# samples	17	9
	** MAII score	log2(17/1040*10)=-2.61297687689075 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/140*10)=-0.637429920615292 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DCAF6 [Title/Abstract] AND MPZL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DCAF6(167974031)-MPZL1(167734820), # samples:6 MPZL1(167691479)-DCAF6(167935866), # samples:2
Anticipated loss of major functional domain due to fusion event.	DCAF6-MPZL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DCAF6-MPZL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DCAF6-MPZL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DCAF6-MPZL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MPZL1-DCAF6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MPZL1-DCAF6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. DCAF6-MPZL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DCAF6-MPZL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DCAF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MPZL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0YG-01A	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+
ChimerDB4	BRCA	TCGA-A7-A26G-01A	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+
ChimerDB4	BRCA	TCGA-A7-A26G-01A	DCAF6	chr1	167974031	-	MPZL1	chr1	167734820	+
ChimerDB4	BRCA	TCGA-A7-A26G-01A	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+
ChimerDB4	BRCA	TCGA-C8-A137-01A	DCAF6	chr1	167921099	-	MPZL1	chr1	167734820	+
ChimerDB4	BRCA	TCGA-C8-A137-01A	DCAF6	chr1	167921099	+	MPZL1	chr1	167734820	+
ChimerDB4	PRAD	TCGA-G9-A9S0-01A	DCAF6	chr1	167974031	-	MPZL1	chr1	167734820	+
ChimerDB4	PRAD	TCGA-G9-A9S0-01A	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+
ChimerDB4	PRAD	TCGA-G9-A9S0	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+
ChimerDB4	PRAD	TCGA-G9-A9S0	DCAF6	chr1	167992285	+	MPZL1	chr1	167734820	+
ChimerKB4	.	.	DCAF6	chr1	168013822	+	MPZL1	chr1	168013822	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367843	DCAF6	chr1	167906246	+	ENST00000359523	MPZL1	chr1	167734820	+	5065	348	251	1066	271
ENST00000367843	DCAF6	chr1	167906246	+	ENST00000392121	MPZL1	chr1	167734820	+	3515	348	2881	3381	166
ENST00000367843	DCAF6	chr1	167906246	+	ENST00000474859	MPZL1	chr1	167734820	+	887	348	251	886	212
ENST00000432587	DCAF6	chr1	167906246	+	ENST00000359523	MPZL1	chr1	167734820	+	5027	310	213	1028	271
ENST00000432587	DCAF6	chr1	167906246	+	ENST00000392121	MPZL1	chr1	167734820	+	3477	310	2843	3343	166
ENST00000432587	DCAF6	chr1	167906246	+	ENST00000474859	MPZL1	chr1	167734820	+	849	310	213	848	211
ENST00000312263	DCAF6	chr1	167906246	+	ENST00000359523	MPZL1	chr1	167734820	+	5018	301	204	1019	271
ENST00000312263	DCAF6	chr1	167906246	+	ENST00000392121	MPZL1	chr1	167734820	+	3468	301	2834	3334	166
ENST00000312263	DCAF6	chr1	167906246	+	ENST00000474859	MPZL1	chr1	167734820	+	840	301	204	839	211
ENST00000367840	DCAF6	chr1	167906246	+	ENST00000359523	MPZL1	chr1	167734820	+	4908	191	94	909	271
ENST00000367840	DCAF6	chr1	167906246	+	ENST00000392121	MPZL1	chr1	167734820	+	3358	191	2724	3224	166
ENST00000367840	DCAF6	chr1	167906246	+	ENST00000474859	MPZL1	chr1	167734820	+	730	191	94	729	212
ENST00000367843	DCAF6	chr1	167974031	+	ENST00000359523	MPZL1	chr1	167734820	+	6346	1629	251	2347	698
ENST00000367843	DCAF6	chr1	167974031	+	ENST00000392121	MPZL1	chr1	167734820	+	4796	1629	251	1897	548
ENST00000367843	DCAF6	chr1	167974031	+	ENST00000474859	MPZL1	chr1	167734820	+	2168	1629	251	2167	639
ENST00000432587	DCAF6	chr1	167974031	+	ENST00000359523	MPZL1	chr1	167734820	+	6215	1498	213	2216	667
ENST00000432587	DCAF6	chr1	167974031	+	ENST00000392121	MPZL1	chr1	167734820	+	4665	1498	213	1766	517
ENST00000432587	DCAF6	chr1	167974031	+	ENST00000474859	MPZL1	chr1	167734820	+	2037	1498	213	2036	607
ENST00000312263	DCAF6	chr1	167974031	+	ENST00000359523	MPZL1	chr1	167734820	+	6299	1582	204	2300	698
ENST00000312263	DCAF6	chr1	167974031	+	ENST00000392121	MPZL1	chr1	167734820	+	4749	1582	204	1850	548
ENST00000312263	DCAF6	chr1	167974031	+	ENST00000474859	MPZL1	chr1	167734820	+	2121	1582	204	2120	638
ENST00000367840	DCAF6	chr1	167974031	+	ENST00000359523	MPZL1	chr1	167734820	+	6189	1472	94	2190	698
ENST00000367840	DCAF6	chr1	167974031	+	ENST00000392121	MPZL1	chr1	167734820	+	4639	1472	94	1740	548
ENST00000367840	DCAF6	chr1	167974031	+	ENST00000474859	MPZL1	chr1	167734820	+	2011	1472	94	2010	639
ENST00000367843	DCAF6	chr1	167992285	+	ENST00000359523	MPZL1	chr1	167734820	+	6406	1689	251	2407	718
ENST00000367843	DCAF6	chr1	167992285	+	ENST00000392121	MPZL1	chr1	167734820	+	4856	1689	251	1957	568
ENST00000367843	DCAF6	chr1	167992285	+	ENST00000474859	MPZL1	chr1	167734820	+	2228	1689	251	2227	659
ENST00000432587	DCAF6	chr1	167992285	+	ENST00000359523	MPZL1	chr1	167734820	+	6446	1729	213	2447	744
ENST00000432587	DCAF6	chr1	167992285	+	ENST00000392121	MPZL1	chr1	167734820	+	4896	1729	213	1997	594
ENST00000432587	DCAF6	chr1	167992285	+	ENST00000474859	MPZL1	chr1	167734820	+	2268	1729	213	2267	684
ENST00000367840	DCAF6	chr1	167992285	+	ENST00000359523	MPZL1	chr1	167734820	+	6420	1703	94	2421	775
ENST00000367840	DCAF6	chr1	167992285	+	ENST00000392121	MPZL1	chr1	167734820	+	4870	1703	94	1971	625
ENST00000367840	DCAF6	chr1	167992285	+	ENST00000474859	MPZL1	chr1	167734820	+	2242	1703	94	2241	716
ENST00000367843	DCAF6	chr1	167974030	+	ENST00000359523	MPZL1	chr1	167734819	+	6346	1629	251	2347	698
ENST00000367843	DCAF6	chr1	167974030	+	ENST00000392121	MPZL1	chr1	167734819	+	4796	1629	251	1897	548
ENST00000367843	DCAF6	chr1	167974030	+	ENST00000474859	MPZL1	chr1	167734819	+	2168	1629	251	2167	639
ENST00000432587	DCAF6	chr1	167974030	+	ENST00000359523	MPZL1	chr1	167734819	+	6215	1498	213	2216	667
ENST00000432587	DCAF6	chr1	167974030	+	ENST00000392121	MPZL1	chr1	167734819	+	4665	1498	213	1766	517
ENST00000432587	DCAF6	chr1	167974030	+	ENST00000474859	MPZL1	chr1	167734819	+	2037	1498	213	2036	607
ENST00000312263	DCAF6	chr1	167974030	+	ENST00000359523	MPZL1	chr1	167734819	+	6299	1582	204	2300	698
ENST00000312263	DCAF6	chr1	167974030	+	ENST00000392121	MPZL1	chr1	167734819	+	4749	1582	204	1850	548
ENST00000312263	DCAF6	chr1	167974030	+	ENST00000474859	MPZL1	chr1	167734819	+	2121	1582	204	2120	638
ENST00000367840	DCAF6	chr1	167974030	+	ENST00000359523	MPZL1	chr1	167734819	+	6189	1472	94	2190	698
ENST00000367840	DCAF6	chr1	167974030	+	ENST00000392121	MPZL1	chr1	167734819	+	4639	1472	94	1740	548
ENST00000367840	DCAF6	chr1	167974030	+	ENST00000474859	MPZL1	chr1	167734819	+	2011	1472	94	2010	639

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367843	ENST00000359523	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.001103546	0.9988965
ENST00000367843	ENST00000392121	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.42800024	0.5719998
ENST00000367843	ENST00000474859	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.002668802	0.99733126
ENST00000432587	ENST00000359523	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.001153566	0.9988464
ENST00000432587	ENST00000392121	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.43912235	0.5608777
ENST00000432587	ENST00000474859	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.003519881	0.99648017
ENST00000312263	ENST00000359523	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.001144528	0.9988555
ENST00000312263	ENST00000392121	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.43591115	0.5640888
ENST00000312263	ENST00000474859	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.003408417	0.99659157
ENST00000367840	ENST00000359523	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.001080868	0.9989191
ENST00000367840	ENST00000392121	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.45354277	0.54645723
ENST00000367840	ENST00000474859	DCAF6	chr1	167906246	+	MPZL1	chr1	167734820	+	0.002584164	0.9974158
ENST00000367843	ENST00000359523	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.000636425	0.9993636
ENST00000367843	ENST00000392121	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.000829611	0.9991704
ENST00000367843	ENST00000474859	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.000695456	0.99930453
ENST00000432587	ENST00000359523	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.00046611	0.9995339
ENST00000432587	ENST00000392121	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.000918521	0.9990815
ENST00000432587	ENST00000474859	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.000804311	0.99919575
ENST00000312263	ENST00000359523	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.000652796	0.99934715
ENST00000312263	ENST00000392121	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.000862499	0.9991375
ENST00000312263	ENST00000474859	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.000791676	0.9992084
ENST00000367840	ENST00000359523	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.00059595	0.9994041
ENST00000367840	ENST00000392121	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.000764741	0.9992353
ENST00000367840	ENST00000474859	DCAF6	chr1	167974031	+	MPZL1	chr1	167734820	+	0.000605775	0.9993942
ENST00000367843	ENST00000359523	DCAF6	chr1	167992285	+	MPZL1	chr1	167734820	+	0.000671701	0.9993284
ENST00000367843	ENST00000392121	DCAF6	chr1	167992285	+	MPZL1	chr1	167734820	+	0.000871923	0.99912804
ENST00000367843	ENST00000474859	DCAF6	chr1	167992285	+	MPZL1	chr1	167734820	+	0.000826544	0.99917346
ENST00000432587	ENST00000359523	DCAF6	chr1	167992285	+	MPZL1	chr1	167734820	+	0.000474708	0.9995253
ENST00000432587	ENST00000392121	DCAF6	chr1	167992285	+	MPZL1	chr1	167734820	+	0.001022881	0.9989772
ENST00000432587	ENST00000474859	DCAF6	chr1	167992285	+	MPZL1	chr1	167734820	+	0.001300563	0.9986994
ENST00000367840	ENST00000359523	DCAF6	chr1	167992285	+	MPZL1	chr1	167734820	+	0.00068645	0.9993136
ENST00000367840	ENST00000392121	DCAF6	chr1	167992285	+	MPZL1	chr1	167734820	+	0.001139551	0.9988605
ENST00000367840	ENST00000474859	DCAF6	chr1	167992285	+	MPZL1	chr1	167734820	+	0.001180584	0.9988194
ENST00000367843	ENST00000359523	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.000636425	0.9993636
ENST00000367843	ENST00000392121	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.000829611	0.9991704
ENST00000367843	ENST00000474859	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.000695456	0.99930453
ENST00000432587	ENST00000359523	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.00046611	0.9995339
ENST00000432587	ENST00000392121	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.000918521	0.9990815
ENST00000432587	ENST00000474859	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.000804311	0.99919575
ENST00000312263	ENST00000359523	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.000652796	0.99934715
ENST00000312263	ENST00000392121	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.000862499	0.9991375
ENST00000312263	ENST00000474859	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.000791676	0.9992084
ENST00000367840	ENST00000359523	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.00059595	0.9994041
ENST00000367840	ENST00000392121	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.000764741	0.9992353
ENST00000367840	ENST00000474859	DCAF6	chr1	167974030	+	MPZL1	chr1	167734819	+	0.000605775	0.9993942

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21524_21524_1_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000312263_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=271AA_BP=32
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFF
HYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLG
LTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRK

--------------------------------------------------------------

>21524_21524_2_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000312263_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=166AA_BP=
MRCRDHVLVKLVLWGPLTRMTPGGLFLPYHSLPQPDFLASCPTRHLKLCQCPGILAENPHQFSPTFPPGKGSCQHGALPGQVSLKEAAHT

--------------------------------------------------------------

>21524_21524_3_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000312263_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=211AA_BP=32
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFF
HYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLG

--------------------------------------------------------------

>21524_21524_4_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000367840_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=271AA_BP=32
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFF
HYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLG
LTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRK

--------------------------------------------------------------

>21524_21524_5_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000367840_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=166AA_BP=
MRCRDHVLVKLVLWGPLTRMTPGGLFLPYHSLPQPDFLASCPTRHLKLCQCPGILAENPHQFSPTFPPGKGSCQHGALPGQVSLKEAAHT

--------------------------------------------------------------

>21524_21524_6_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000367840_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=212AA_BP=32
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFF
HYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLG

--------------------------------------------------------------

>21524_21524_7_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000367843_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=271AA_BP=32
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFF
HYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLG
LTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRK

--------------------------------------------------------------

>21524_21524_8_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000367843_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=166AA_BP=
MRCRDHVLVKLVLWGPLTRMTPGGLFLPYHSLPQPDFLASCPTRHLKLCQCPGILAENPHQFSPTFPPGKGSCQHGALPGQVSLKEAAHT

--------------------------------------------------------------

>21524_21524_9_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000367843_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=212AA_BP=32
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFF
HYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLG

--------------------------------------------------------------

>21524_21524_10_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000432587_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=271AA_BP=32
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFF
HYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLG
LTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRK

--------------------------------------------------------------

>21524_21524_11_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000432587_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=166AA_BP=
MRCRDHVLVKLVLWGPLTRMTPGGLFLPYHSLPQPDFLASCPTRHLKLCQCPGILAENPHQFSPTFPPGKGSCQHGALPGQVSLKEAAHT

--------------------------------------------------------------

>21524_21524_12_DCAF6-MPZL1_DCAF6_chr1_167906246_ENST00000432587_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=211AA_BP=32
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFF
HYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLG

--------------------------------------------------------------

>21524_21524_13_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000312263_MPZL1_chr1_167734819_ENST00000359523_length(amino acids)=698AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_14_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000312263_MPZL1_chr1_167734819_ENST00000392121_length(amino acids)=548AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSGPVIYAQLDHSGGHHSDKINKSESV

--------------------------------------------------------------

>21524_21524_15_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000312263_MPZL1_chr1_167734819_ENST00000474859_length(amino acids)=638AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_16_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000367840_MPZL1_chr1_167734819_ENST00000359523_length(amino acids)=698AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_17_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000367840_MPZL1_chr1_167734819_ENST00000392121_length(amino acids)=548AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSGPVIYAQLDHSGGHHSDKINKSESV

--------------------------------------------------------------

>21524_21524_18_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000367840_MPZL1_chr1_167734819_ENST00000474859_length(amino acids)=639AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_19_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000367843_MPZL1_chr1_167734819_ENST00000359523_length(amino acids)=698AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_20_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000367843_MPZL1_chr1_167734819_ENST00000392121_length(amino acids)=548AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSGPVIYAQLDHSGGHHSDKINKSESV

--------------------------------------------------------------

>21524_21524_21_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000367843_MPZL1_chr1_167734819_ENST00000474859_length(amino acids)=639AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_22_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000432587_MPZL1_chr1_167734819_ENST00000359523_length(amino acids)=667AA_BP=427
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIF
YTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGC
SDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREE
LRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPD
LEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSVTAGVSALEVYTPKEIFVANGT
QGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPD
IVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPS

--------------------------------------------------------------

>21524_21524_23_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000432587_MPZL1_chr1_167734819_ENST00000392121_length(amino acids)=517AA_BP=427
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIF
YTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGC
SDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREE
LRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPD
LEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSVTAGVSALEVYTPKEIFVANGT

--------------------------------------------------------------

>21524_21524_24_DCAF6-MPZL1_DCAF6_chr1_167974030_ENST00000432587_MPZL1_chr1_167734819_ENST00000474859_length(amino acids)=607AA_BP=427
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIF
YTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGC
SDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREE
LRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPD
LEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSVTAGVSALEVYTPKEIFVANGT
QGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPD

--------------------------------------------------------------

>21524_21524_25_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000312263_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=698AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_26_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000312263_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=548AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSGPVIYAQLDHSGGHHSDKINKSESV

--------------------------------------------------------------

>21524_21524_27_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000312263_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=638AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_28_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000367840_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=698AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_29_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000367840_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=548AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSGPVIYAQLDHSGGHHSDKINKSESV

--------------------------------------------------------------

>21524_21524_30_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000367840_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=639AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_31_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000367843_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=698AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_32_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000367843_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=548AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSGPVIYAQLDHSGGHHSDKINKSESV

--------------------------------------------------------------

>21524_21524_33_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000367843_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=639AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG
DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT

--------------------------------------------------------------

>21524_21524_34_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000432587_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=667AA_BP=427
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIF
YTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGC
SDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREE
LRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPD
LEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSVTAGVSALEVYTPKEIFVANGT
QGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPD
IVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPS

--------------------------------------------------------------

>21524_21524_35_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000432587_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=517AA_BP=427
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIF
YTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGC
SDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREE
LRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPD
LEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSVTAGVSALEVYTPKEIFVANGT

--------------------------------------------------------------

>21524_21524_36_DCAF6-MPZL1_DCAF6_chr1_167974031_ENST00000432587_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=607AA_BP=427
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIF
YTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGC
SDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREE
LRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPD
LEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSVTAGVSALEVYTPKEIFVANGT
QGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPD

--------------------------------------------------------------

>21524_21524_37_DCAF6-MPZL1_DCAF6_chr1_167992285_ENST00000367840_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=775AA_BP=515
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQVTAG
VSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIEN
MQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQ

--------------------------------------------------------------

>21524_21524_38_DCAF6-MPZL1_DCAF6_chr1_167992285_ENST00000367840_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=625AA_BP=515
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQVTAG

--------------------------------------------------------------

>21524_21524_39_DCAF6-MPZL1_DCAF6_chr1_167992285_ENST00000367840_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=716AA_BP=515
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQVTAG
VSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIEN

--------------------------------------------------------------

>21524_21524_40_DCAF6-MPZL1_DCAF6_chr1_167992285_ENST00000367843_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=718AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSDSPSSVVNKQLGSMSLDEQQVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYS
QGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTL

--------------------------------------------------------------

>21524_21524_41_DCAF6-MPZL1_DCAF6_chr1_167992285_ENST00000367843_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=568AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSDSPSSVVNKQLGSMSLDEQQVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSGPVIY

--------------------------------------------------------------

>21524_21524_42_DCAF6-MPZL1_DCAF6_chr1_167992285_ENST00000367843_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=659AA_BP=458
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR
SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV
SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
SGHHTHHQSDSPSSVVNKQLGSMSLDEQQVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYS
QGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTL

--------------------------------------------------------------

>21524_21524_43_DCAF6-MPZL1_DCAF6_chr1_167992285_ENST00000432587_MPZL1_chr1_167734820_ENST00000359523_length(amino acids)=744AA_BP=484
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIF
YTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGC
SDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREE
LRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPD
LEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKK
AEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTST
TGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVV
EKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLD

--------------------------------------------------------------

>21524_21524_44_DCAF6-MPZL1_DCAF6_chr1_167992285_ENST00000432587_MPZL1_chr1_167734820_ENST00000392121_length(amino acids)=594AA_BP=484
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIF
YTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGC
SDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREE
LRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPD
LEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKK
AEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTST

--------------------------------------------------------------

>21524_21524_45_DCAF6-MPZL1_DCAF6_chr1_167992285_ENST00000432587_MPZL1_chr1_167734820_ENST00000474859_length(amino acids)=684AA_BP=484
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIF
YTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGC
SDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREE
LRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPD
LEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSEFLRGPEIALLRKRLQQLRLKK
AEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTST
TGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVV

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:167974031/chr1:167734820)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DCAF6 Q58WW2	MPZL1 O95297
FUNCTION: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269\|PubMed:15784617, ECO:0000269\|PubMed:16949367, ECO:0000269\|PubMed:16964240}.	FUNCTION: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269\|PubMed:11751924, ECO:0000269\|PubMed:12410637}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000312263

139_179

459.3333333333333

861.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000312263

189_229

459.3333333333333

861.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000312263

251_290

459.3333333333333

861.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000312263

49_88

459.3333333333333

861.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000312263

92_133

459.3333333333333

861.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367840

139_179

459.3333333333333

952.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367840

189_229

459.3333333333333

952.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367840

251_290

459.3333333333333

952.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367840

49_88

459.3333333333333

952.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367840

92_133

459.3333333333333

952.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367843

139_179

459.3333333333333

881.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367843

189_229

459.3333333333333

881.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367843

251_290

459.3333333333333

881.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367843

49_88

459.3333333333333

881.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367843

92_133

459.3333333333333

881.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000432587

139_179

428.3333333333333

921.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000432587

189_229

428.3333333333333

921.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000432587

251_290

428.3333333333333

921.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000432587

49_88

428.3333333333333

921.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000432587

92_133

428.3333333333333

921.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000312263

139_179

459.3333333333333

861.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000312263

189_229

459.3333333333333

861.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000312263

251_290

459.3333333333333

861.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000312263

49_88

459.3333333333333

861.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000312263

92_133

459.3333333333333

861.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367840

139_179

459.3333333333333

952.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367840

189_229

459.3333333333333

952.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367840

251_290

459.3333333333333

952.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367840

49_88

459.3333333333333

952.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367840

92_133

459.3333333333333

952.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367843

139_179

459.3333333333333

881.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367843

189_229

459.3333333333333

881.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367843

251_290

459.3333333333333

881.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367843

49_88

459.3333333333333

881.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367843

92_133

459.3333333333333

881.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000432587

139_179

428.3333333333333

921.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000432587

189_229

428.3333333333333

921.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000432587

251_290

428.3333333333333

921.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000432587

49_88

428.3333333333333

921.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000432587

92_133

428.3333333333333

921.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367840

139_179

536.3333333333334

952.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367840

189_229

536.3333333333334

952.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367840

251_290

536.3333333333334

952.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367840

49_88

536.3333333333334

952.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367840

92_133

536.3333333333334

952.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367843

139_179

479.3333333333333

881.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367843

189_229

479.3333333333333

881.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367843

251_290

479.3333333333333

881.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367843

49_88

479.3333333333333

881.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367843

92_133

479.3333333333333

881.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000432587

139_179

505.3333333333333

921.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000432587

189_229

505.3333333333333

921.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000432587

251_290

505.3333333333333

921.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000432587

49_88

505.3333333333333

921.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000432587

92_133

505.3333333333333

921.0

Repeat

Note=WD 2

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000359523

36_146

30.333333333333332

270.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000392121

36_146

30.333333333333332

120.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000474859

36_146

30.333333333333332

210.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000359523

36_146

30.333333333333332

270.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000392121

36_146

30.333333333333332

120.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000474859

36_146

30.333333333333332

210.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000359523

36_146

30.333333333333332

270.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000392121

36_146

30.333333333333332

120.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000474859

36_146

30.333333333333332

210.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000359523

36_146

30.333333333333332

270.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000392121

36_146

30.333333333333332

120.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000474859

36_146

30.333333333333332

210.0

Domain

Note=Ig-like V-type

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000359523

239_244

30.333333333333332

270.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000359523

261_266

30.333333333333332

270.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000392121

239_244

30.333333333333332

120.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000392121

261_266

30.333333333333332

120.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000474859

239_244

30.333333333333332

210.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000474859

261_266

30.333333333333332

210.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000359523

239_244

30.333333333333332

270.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000359523

261_266

30.333333333333332

270.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000392121

239_244

30.333333333333332

120.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000392121

261_266

30.333333333333332

120.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000474859

239_244

30.333333333333332

210.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000474859

261_266

30.333333333333332

210.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000359523

239_244

30.333333333333332

270.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000359523

261_266

30.333333333333332

270.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000392121

239_244

30.333333333333332

120.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000392121

261_266

30.333333333333332

120.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000474859

239_244

30.333333333333332

210.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000474859

261_266

30.333333333333332

210.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000359523

239_244

30.333333333333332

270.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000359523

261_266

30.333333333333332

270.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000392121

239_244

30.333333333333332

120.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000392121

261_266

30.333333333333332

120.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000474859

239_244

30.333333333333332

210.0

Motif

Note=ITIM motif 1

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000474859

261_266

30.333333333333332

210.0

Motif

Note=ITIM motif 2

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000359523

184_269

30.333333333333332

270.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000359523

36_162

30.333333333333332

270.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000392121

184_269

30.333333333333332

120.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000392121

36_162

30.333333333333332

120.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000474859

184_269

30.333333333333332

210.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000474859

36_162

30.333333333333332

210.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000359523

184_269

30.333333333333332

270.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000359523

36_162

30.333333333333332

270.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000392121

184_269

30.333333333333332

120.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000392121

36_162

30.333333333333332

120.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000474859

184_269

30.333333333333332

210.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000474859

36_162

30.333333333333332

210.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000359523

184_269

30.333333333333332

270.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000359523

36_162

30.333333333333332

270.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000392121

184_269

30.333333333333332

120.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000392121

36_162

30.333333333333332

120.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000474859

184_269

30.333333333333332

210.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000474859

36_162

30.333333333333332

210.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000359523

184_269

30.333333333333332

270.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000359523

36_162

30.333333333333332

270.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000392121

184_269

30.333333333333332

120.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000392121

36_162

30.333333333333332

120.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000474859

184_269

30.333333333333332

210.0

Topological domain

Cytoplasmic

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000474859

36_162

30.333333333333332

210.0

Topological domain

Extracellular

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000359523

163_183

30.333333333333332

270.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000392121

163_183

30.333333333333332

120.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167906246

chr1:167734820

ENST00000474859

163_183

30.333333333333332

210.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000359523

163_183

30.333333333333332

270.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000392121

163_183

30.333333333333332

120.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167974030

chr1:167734819

ENST00000474859

163_183

30.333333333333332

210.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000359523

163_183

30.333333333333332

270.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000392121

163_183

30.333333333333332

120.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167974031

chr1:167734820

ENST00000474859

163_183

30.333333333333332

210.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000359523

163_183

30.333333333333332

270.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000392121

163_183

30.333333333333332

120.0

Transmembrane

Helical

Tgene

MPZL1

chr1:167992285

chr1:167734820

ENST00000474859

163_183

30.333333333333332

210.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000312263

676_705

32.333333333333336

861.0

Domain

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367840

676_705

32.333333333333336

952.0

Domain

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367843

676_705

32.333333333333336

881.0

Domain

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000432587

676_705

32.333333333333336

921.0

Domain

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000312263

676_705

459.3333333333333

861.0

Domain

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367840

676_705

459.3333333333333

952.0

Domain

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367843

676_705

459.3333333333333

881.0

Domain

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000432587

676_705

428.3333333333333

921.0

Domain

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000312263

676_705

459.3333333333333

861.0

Domain

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367840

676_705

459.3333333333333

952.0

Domain

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367843

676_705

459.3333333333333

881.0

Domain

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000432587

676_705

428.3333333333333

921.0

Domain

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000312263

676_705

861.0

Domain

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367840

676_705

536.3333333333334

952.0

Domain

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367843

676_705

479.3333333333333

881.0

Domain

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000432587

676_705

505.3333333333333

921.0

Domain

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000312263

139_179

32.333333333333336

861.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000312263

189_229

32.333333333333336

861.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000312263

251_290

32.333333333333336

861.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000312263

49_88

32.333333333333336

861.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000312263

718_756

32.333333333333336

861.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000312263

759_798

32.333333333333336

861.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000312263

92_133

32.333333333333336

861.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367840

139_179

32.333333333333336

952.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367840

189_229

32.333333333333336

952.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367840

251_290

32.333333333333336

952.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367840

49_88

32.333333333333336

952.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367840

718_756

32.333333333333336

952.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367840

759_798

32.333333333333336

952.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367840

92_133

32.333333333333336

952.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367843

139_179

32.333333333333336

881.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367843

189_229

32.333333333333336

881.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367843

251_290

32.333333333333336

881.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367843

49_88

32.333333333333336

881.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367843

718_756

32.333333333333336

881.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367843

759_798

32.333333333333336

881.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000367843

92_133

32.333333333333336

881.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000432587

139_179

32.333333333333336

921.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000432587

189_229

32.333333333333336

921.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000432587

251_290

32.333333333333336

921.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000432587

49_88

32.333333333333336

921.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000432587

718_756

32.333333333333336

921.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000432587

759_798

32.333333333333336

921.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167906246

chr1:167734820

ENST00000432587

92_133

32.333333333333336

921.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000312263

718_756

459.3333333333333

861.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000312263

759_798

459.3333333333333

861.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367840

718_756

459.3333333333333

952.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367840

759_798

459.3333333333333

952.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367843

718_756

459.3333333333333

881.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000367843

759_798

459.3333333333333

881.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000432587

718_756

428.3333333333333

921.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167974030

chr1:167734819

ENST00000432587

759_798

428.3333333333333

921.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000312263

718_756

459.3333333333333

861.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000312263

759_798

459.3333333333333

861.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367840

718_756

459.3333333333333

952.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367840

759_798

459.3333333333333

952.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367843

718_756

459.3333333333333

881.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000367843

759_798

459.3333333333333

881.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000432587

718_756

428.3333333333333

921.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167974031

chr1:167734820

ENST00000432587

759_798

428.3333333333333

921.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000312263

139_179

861.0

Repeat

Note=WD 3

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000312263

189_229

861.0

Repeat

Note=WD 4

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000312263

251_290

861.0

Repeat

Note=WD 5

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000312263

49_88

861.0

Repeat

Note=WD 1

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000312263

718_756

861.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000312263

759_798

861.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000312263

92_133

861.0

Repeat

Note=WD 2

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367840

718_756

536.3333333333334

952.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367840

759_798

536.3333333333334

952.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367843

718_756

479.3333333333333

881.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000367843

759_798

479.3333333333333

881.0

Repeat

Note=WD 7

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000432587

718_756

505.3333333333333

921.0

Repeat

Note=WD 6

Hgene

DCAF6

chr1:167992285

chr1:167734820

ENST00000432587

759_798

505.3333333333333

921.0

Repeat

Note=WD 7

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1432_DCAF6_167974031_MPZL1_167734820_ranked_0.pdb	DCAF6	167974030	167974031	ENST00000474859	MPZL1	chr1	167734820	+	MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIR SGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILV SYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA SGHHTHHQSVTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAG DLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYT	698

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DCAF6_pLDDT.png

MPZL1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DCAF6
MPZL1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to DCAF6-MPZL1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to DCAF6-MPZL1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source