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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DCTN2-DDX23

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DCTN2-DDX23
	FusionPDB ID: 21679
	FusionGDB2.0 ID: 21679
		Hgene	Tgene
	Gene symbol	DCTN2	DDX23
	Gene ID	10540	9416
	Gene name	dynactin subunit 2	DEAD-box helicase 23
	Synonyms	DCTN50\|DYNAMITIN\|HEL-S-77\|RBP50	PRPF28\|SNRNP100\|U5-100K\|U5-100KD\|prp28
	Cytomap	12q13.3	12q13.12
	Type of gene	protein-coding	protein-coding
	Description	dynactin subunit 250 kDa dynein-associated polypeptidedynactin 2 (p50)dynactin complex 50 kDa subunitepididymis secretory protein Li 77epididymis secretory sperm binding proteinp50 dynamitin	probable ATP-dependent RNA helicase DDX23100 kDa U5 snRNP-specific proteinDEAD (Asp-Glu-Ala-Asp) box polypeptide 23DEAD box protein 23PRP28 homolog, yeastPRP28p homologU5 snRNP 100 kD protein
	Modification date	20200313	20200313
	UniProtAcc	Q13561	Q9BUQ8
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000434715, ENST00000543672, ENST00000548249, ENST00000537439, ENST00000551400,	ENST00000553182, ENST00000308025,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 9 X 6=810	6 X 6 X 4=144
	# samples	16	7
	** MAII score	log2(16/810*10)=-2.33985000288462 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DCTN2 [Title/Abstract] AND DDX23 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DCTN2(57939811)-DDX23(49230049), # samples:3
Anticipated loss of major functional domain due to fusion event.	DCTN2-DDX23 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DCTN2-DDX23 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DCTN2-DDX23 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DCTN2-DDX23 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DCTN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DDX23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-6175-01A	DCTN2	chr12	57939810	-	DDX23	chr12	49230048	-
ChimerDB4	LUSC	TCGA-85-6175-01A	DCTN2	chr12	57939811	-	DDX23	chr12	49230049	-
ChimerDB4	LUSC	TCGA-85-6175	DCTN2	chr12	57939810	-	DDX23	chr12	49230049	-
ChimerDB4	LUSC	TCGA-85-6175	DCTN2	chr12	57939811	-	DDX23	chr12	49230049	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000548249	DCTN2	chr12	57939811	-	ENST00000308025	DDX23	chr12	49230049	-	2305	373	37	1599	520
ENST00000434715	DCTN2	chr12	57939811	-	ENST00000308025	DDX23	chr12	49230049	-	2115	183	78	1409	443
ENST00000543672	DCTN2	chr12	57939811	-	ENST00000308025	DDX23	chr12	49230049	-	2183	251	146	1477	443
ENST00000548249	DCTN2	chr12	57939810	-	ENST00000308025	DDX23	chr12	49230049	-	2305	373	37	1599	520
ENST00000434715	DCTN2	chr12	57939810	-	ENST00000308025	DDX23	chr12	49230049	-	2115	183	78	1409	443
ENST00000543672	DCTN2	chr12	57939810	-	ENST00000308025	DDX23	chr12	49230049	-	2183	251	146	1477	443
ENST00000548249	DCTN2	chr12	57939810	-	ENST00000308025	DDX23	chr12	49230048	-	2305	373	37	1599	520
ENST00000434715	DCTN2	chr12	57939810	-	ENST00000308025	DDX23	chr12	49230048	-	2115	183	78	1409	443
ENST00000543672	DCTN2	chr12	57939810	-	ENST00000308025	DDX23	chr12	49230048	-	2183	251	146	1477	443

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000548249	ENST00000308025	DCTN2	chr12	57939811	-	DDX23	chr12	49230049	-	0.002442674	0.9975573
ENST00000434715	ENST00000308025	DCTN2	chr12	57939811	-	DDX23	chr12	49230049	-	0.00238039	0.99761957
ENST00000543672	ENST00000308025	DCTN2	chr12	57939811	-	DDX23	chr12	49230049	-	0.002556063	0.9974439
ENST00000548249	ENST00000308025	DCTN2	chr12	57939810	-	DDX23	chr12	49230049	-	0.002442674	0.9975573
ENST00000434715	ENST00000308025	DCTN2	chr12	57939810	-	DDX23	chr12	49230049	-	0.00238039	0.99761957
ENST00000543672	ENST00000308025	DCTN2	chr12	57939810	-	DDX23	chr12	49230049	-	0.002556063	0.9974439
ENST00000548249	ENST00000308025	DCTN2	chr12	57939810	-	DDX23	chr12	49230048	-	0.002442674	0.9975573
ENST00000434715	ENST00000308025	DCTN2	chr12	57939810	-	DDX23	chr12	49230048	-	0.00238039	0.99761957
ENST00000543672	ENST00000308025	DCTN2	chr12	57939810	-	DDX23	chr12	49230048	-	0.002556063	0.9974439

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21679_21679_1_DCTN2-DDX23_DCTN2_chr12_57939810_ENST00000434715_DDX23_chr12_49230048_ENST00000308025_length(amino acids)=443AA_BP=35
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQ
GPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDM
GFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMS
ESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVV

--------------------------------------------------------------

>21679_21679_2_DCTN2-DDX23_DCTN2_chr12_57939810_ENST00000434715_DDX23_chr12_49230049_ENST00000308025_length(amino acids)=443AA_BP=35
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQ
GPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDM
GFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMS
ESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVV

--------------------------------------------------------------

>21679_21679_3_DCTN2-DDX23_DCTN2_chr12_57939810_ENST00000543672_DDX23_chr12_49230048_ENST00000308025_length(amino acids)=443AA_BP=35
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQ
GPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDM
GFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMS
ESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVV

--------------------------------------------------------------

>21679_21679_4_DCTN2-DDX23_DCTN2_chr12_57939810_ENST00000543672_DDX23_chr12_49230049_ENST00000308025_length(amino acids)=443AA_BP=35
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQ
GPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDM
GFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMS
ESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVV

--------------------------------------------------------------

>21679_21679_5_DCTN2-DDX23_DCTN2_chr12_57939810_ENST00000548249_DDX23_chr12_49230048_ENST00000308025_length(amino acids)=520AA_BP=112
MASFSPIPASPGVWQQGCSRDFCFTLLLCYCCRETSCSSAAPFAAALARDPNPASPLPEHRPRLHRGPGPPARLAAAMADPKYADLPGIA
RNEPDVYETSDLPEDDQAEFDAEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL
AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHM
PVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE
QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIH

--------------------------------------------------------------

>21679_21679_6_DCTN2-DDX23_DCTN2_chr12_57939810_ENST00000548249_DDX23_chr12_49230049_ENST00000308025_length(amino acids)=520AA_BP=112
MASFSPIPASPGVWQQGCSRDFCFTLLLCYCCRETSCSSAAPFAAALARDPNPASPLPEHRPRLHRGPGPPARLAAAMADPKYADLPGIA
RNEPDVYETSDLPEDDQAEFDAEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL
AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHM
PVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE
QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIH

--------------------------------------------------------------

>21679_21679_7_DCTN2-DDX23_DCTN2_chr12_57939811_ENST00000434715_DDX23_chr12_49230049_ENST00000308025_length(amino acids)=443AA_BP=35
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQ
GPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDM
GFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMS
ESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVV

--------------------------------------------------------------

>21679_21679_8_DCTN2-DDX23_DCTN2_chr12_57939811_ENST00000543672_DDX23_chr12_49230049_ENST00000308025_length(amino acids)=443AA_BP=35
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQ
GPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDM
GFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMS
ESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVV

--------------------------------------------------------------

>21679_21679_9_DCTN2-DDX23_DCTN2_chr12_57939811_ENST00000548249_DDX23_chr12_49230049_ENST00000308025_length(amino acids)=520AA_BP=112
MASFSPIPASPGVWQQGCSRDFCFTLLLCYCCRETSCSSAAPFAAALARDPNPASPLPEHRPRLHRGPGPPARLAAAMADPKYADLPGIA
RNEPDVYETSDLPEDDQAEFDAEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL
AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHM
PVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE
QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIH

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:57939811/chr12:49230049)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DCTN2 Q13561	DDX23 Q9BUQ8
FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.	FUNCTION: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). {ECO:0000269\|PubMed:18425142, ECO:0000269\|PubMed:28076779}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DDX23

chr12:57939810

chr12:49230048

ENST00000308025

422_627

412.0

821.0

Domain

Helicase ATP-binding

Tgene

DDX23

chr12:57939810

chr12:49230048

ENST00000308025

651_799

412.0

821.0

Domain

Helicase C-terminal

Tgene

DDX23

chr12:57939810

chr12:49230049

ENST00000308025

422_627

412.0

821.0

Domain

Helicase ATP-binding

Tgene

DDX23

chr12:57939810

chr12:49230049

ENST00000308025

651_799

412.0

821.0

Domain

Helicase C-terminal

Tgene

DDX23

chr12:57939811

chr12:49230049

ENST00000308025

422_627

412.0

821.0

Domain

Helicase ATP-binding

Tgene

DDX23

chr12:57939811

chr12:49230049

ENST00000308025

651_799

412.0

821.0

Domain

Helicase C-terminal

Tgene

DDX23

chr12:57939810

chr12:49230048

ENST00000308025

549_552

412.0

821.0

Motif

DEAD box

Tgene

DDX23

chr12:57939810

chr12:49230049

ENST00000308025

549_552

412.0

821.0

Motif

DEAD box

Tgene

DDX23

chr12:57939811

chr12:49230049

ENST00000308025

549_552

412.0

821.0

Motif

DEAD box

Tgene

DDX23

chr12:57939810

chr12:49230048

ENST00000308025

435_442

412.0

821.0

Nucleotide binding

ATP

Tgene

DDX23

chr12:57939810

chr12:49230049

ENST00000308025

435_442

412.0

821.0

Nucleotide binding

ATP

Tgene

DDX23

chr12:57939811

chr12:49230049

ENST00000308025

435_442

412.0

821.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DCTN2

chr12:57939810

chr12:49230048

ENST00000434715

214_244

35.0

407.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230048

ENST00000434715

379_399

35.0

407.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230048

ENST00000434715

99_132

35.0

407.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230048

ENST00000548249

214_244

35.0

402.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230048

ENST00000548249

379_399

35.0

402.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230048

ENST00000548249

99_132

35.0

402.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230049

ENST00000434715

214_244

35.0

407.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230049

ENST00000434715

379_399

35.0

407.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230049

ENST00000434715

99_132

35.0

407.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230049

ENST00000548249

214_244

35.0

402.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230049

ENST00000548249

379_399

35.0

402.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939810

chr12:49230049

ENST00000548249

99_132

35.0

402.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939811

chr12:49230049

ENST00000434715

214_244

35.0

407.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939811

chr12:49230049

ENST00000434715

379_399

35.0

407.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939811

chr12:49230049

ENST00000434715

99_132

35.0

407.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939811

chr12:49230049

ENST00000548249

214_244

35.0

402.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939811

chr12:49230049

ENST00000548249

379_399

35.0

402.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DCTN2

chr12:57939811

chr12:49230049

ENST00000548249

99_132

35.0

402.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DDX23

chr12:57939810

chr12:49230048

ENST00000308025

128_240

412.0

821.0

Compositional bias

Glu-rich

Tgene

DDX23

chr12:57939810

chr12:49230048

ENST00000308025

20_122

412.0

821.0

Compositional bias

Arg/Ser-rich (RS domain)

Tgene

DDX23

chr12:57939810

chr12:49230049

ENST00000308025

128_240

412.0

821.0

Compositional bias

Glu-rich

Tgene

DDX23

chr12:57939810

chr12:49230049

ENST00000308025

20_122

412.0

821.0

Compositional bias

Arg/Ser-rich (RS domain)

Tgene

DDX23

chr12:57939811

chr12:49230049

ENST00000308025

128_240

412.0

821.0

Compositional bias

Glu-rich

Tgene

DDX23

chr12:57939811

chr12:49230049

ENST00000308025

20_122

412.0

821.0

Compositional bias

Arg/Ser-rich (RS domain)

Tgene

DDX23

chr12:57939810

chr12:49230048

ENST00000308025

391_419

412.0

821.0

Motif

Q motif

Tgene

DDX23

chr12:57939810

chr12:49230049

ENST00000308025

391_419

412.0

821.0

Motif

Q motif

Tgene

DDX23

chr12:57939811

chr12:49230049

ENST00000308025

391_419

412.0

821.0

Motif

Q motif

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1110_DCTN2_57939811_DDX23_49230049_1110_DCTN2_57939811_DDX23_49230049_ranked_0.pdb	DCTN2	57939810	57939811	ENST00000308025	DDX23	chr12	49230049	-	MASFSPIPASPGVWQQGCSRDFCFTLLLCYCCRETSCSSAAPFAAALARDPNPASPLPEHRPRLHRGPGPPARLAAAMADPKYADLPGIA RNEPDVYETSDLPEDDQAEFDAEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHM PVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILE QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIH	520

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DCTN2_pLDDT.png

DDX23_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DCTN2
DDX23

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to DCTN2-DDX23

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DCTN2-DDX23

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source