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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DDX10-NUP98

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DDX10-NUP98
FusionPDB ID: 21881
FusionGDB2.0 ID: 21881
HgeneTgene
Gene symbol

DDX10

NUP98

Gene ID

1662

4928

Gene nameDEAD-box helicase 10nucleoporin 98 and 96 precursor
SynonymsDbp4|HRH-J8ADIR2|NUP196|NUP96|Nup98-96
Cytomap

11q22.3

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DDX10DDX10-NUP98 fusion protein type 2DEAD (Asp-Glu-Ala-Asp) box polypeptide 10DEAD box protein 10DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)nuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 96nucleoporin 98kDnucleoporin 98kDa
Modification date2020031320200313
UniProtAcc

Q13206

P52948

Ensembl transtripts involved in fusion geneENST idsENST00000322536, ENST00000526794, 
ENST00000534221, 		ENST00000488828, 
ENST00000324932, ENST00000355260, 
ENST00000359171, ENST00000397004, 
ENST00000397007, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 14 X 6=117617 X 18 X 10=3060
# samples 1718
** MAII scorelog2(17/1176*10)=-2.79028140869866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/3060*10)=-4.08746284125034
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DDX10 [Title/Abstract] AND NUP98 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DDX10(108549162)-NUP98(3756556), # samples:1
DDX10(108550288)-NUP98(3746454), # samples:1
NUP98(3765871)-DDX10(108550096), # samples:1
NUP98(3765739)-DDX10(108550096), # samples:1
NUP98(3752621)-DDX10(108559663), # samples:1
Anticipated loss of major functional domain due to fusion event.DDX10-NUP98 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX10-NUP98 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX10-NUP98 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX10-NUP98 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NUP98-DDX10 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NUP98-DDX10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NUP98-DDX10 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
NUP98-DDX10 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NUP98-DDX10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DDX10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUP98 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..DDX10chr11

108054372

+NUP98chr11

3702968

-
ChimerKB3..DDX10chr11

108055498

+NUP98chr11

3702968

-
ChiTaRS5.0N/AAB001342DDX10chr11

108549162

+NUP98chr11

3756556

-
ChiTaRS5.0N/AAB001343DDX10chr11

108550288

+NUP98chr11

3746454

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000322536DDX10chr11108549162+ENST00000324932NUP98chr113756556-59317874847811577
ENST00000322536DDX10chr11108549162+ENST00000359171NUP98chr113756556-57287874842951415
ENST00000322536DDX10chr11108549162+ENST00000355260NUP98chr113756556-49207874845591503
ENST00000322536DDX10chr11108549162+ENST00000397004NUP98chr113756556-3132787482141697
ENST00000322536DDX10chr11108549162+ENST00000397007NUP98chr113756556-2850787482141697
ENST00000526794DDX10chr11108549162+ENST00000324932NUP98chr113756556-5834690246841560
ENST00000526794DDX10chr11108549162+ENST00000359171NUP98chr113756556-5631690241981398
ENST00000526794DDX10chr11108549162+ENST00000355260NUP98chr113756556-4823690244621486
ENST00000526794DDX10chr11108549162+ENST00000397004NUP98chr113756556-303569022044680
ENST00000526794DDX10chr11108549162+ENST00000397007NUP98chr113756556-275369022044680
ENST00000322536DDX10chr11108550288+ENST00000324932NUP98chr113746454-57999774846491533
ENST00000322536DDX10chr11108550288+ENST00000359171NUP98chr113746454-55969774841631371
ENST00000322536DDX10chr11108550288+ENST00000355260NUP98chr113746454-47889774844271459
ENST00000322536DDX10chr11108550288+ENST00000397004NUP98chr113746454-3000977482009653
ENST00000322536DDX10chr11108550288+ENST00000397007NUP98chr113746454-2718977482009653
ENST00000526794DDX10chr11108550288+ENST00000324932NUP98chr113746454-5702880245521516
ENST00000526794DDX10chr11108550288+ENST00000359171NUP98chr113746454-5499880240661354
ENST00000526794DDX10chr11108550288+ENST00000355260NUP98chr113746454-4691880243301442
ENST00000526794DDX10chr11108550288+ENST00000397004NUP98chr113746454-290388021912636
ENST00000526794DDX10chr11108550288+ENST00000397007NUP98chr113746454-262188021912636

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000322536ENST00000324932DDX10chr11108549162+NUP98chr113756556-0.0007648530.99923515
ENST00000322536ENST00000359171DDX10chr11108549162+NUP98chr113756556-0.0004010050.99959904
ENST00000322536ENST00000355260DDX10chr11108549162+NUP98chr113756556-0.0014950.998505
ENST00000322536ENST00000397004DDX10chr11108549162+NUP98chr113756556-0.0012366280.99876344
ENST00000322536ENST00000397007DDX10chr11108549162+NUP98chr113756556-0.0016678860.9983321
ENST00000526794ENST00000324932DDX10chr11108549162+NUP98chr113756556-0.0007814940.99921846
ENST00000526794ENST00000359171DDX10chr11108549162+NUP98chr113756556-0.0004176970.99958235
ENST00000526794ENST00000355260DDX10chr11108549162+NUP98chr113756556-0.0015605670.9984395
ENST00000526794ENST00000397004DDX10chr11108549162+NUP98chr113756556-0.0014112680.99858874
ENST00000526794ENST00000397007DDX10chr11108549162+NUP98chr113756556-0.0019487920.99805117
ENST00000322536ENST00000324932DDX10chr11108550288+NUP98chr113746454-0.0006239790.999376
ENST00000322536ENST00000359171DDX10chr11108550288+NUP98chr113746454-0.0003300290.99967
ENST00000322536ENST00000355260DDX10chr11108550288+NUP98chr113746454-0.0011934870.9988065
ENST00000322536ENST00000397004DDX10chr11108550288+NUP98chr113746454-0.0009259570.999074
ENST00000322536ENST00000397007DDX10chr11108550288+NUP98chr113746454-0.0011906750.99880934
ENST00000526794ENST00000324932DDX10chr11108550288+NUP98chr113746454-0.0006348940.99936515
ENST00000526794ENST00000359171DDX10chr11108550288+NUP98chr113746454-0.0003422120.99965775
ENST00000526794ENST00000355260DDX10chr11108550288+NUP98chr113746454-0.0012750490.9987249
ENST00000526794ENST00000397004DDX10chr11108550288+NUP98chr113746454-0.0010501910.9989498
ENST00000526794ENST00000397007DDX10chr11108550288+NUP98chr113746454-0.0013921410.99860793

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21881_21881_1_DDX10-NUP98_DDX10_chr11_108549162_ENST00000322536_NUP98_chr11_3756556_ENST00000324932_length(amino acids)=1577AA_BP=246
MSHAGSVSLALGVSCLGLIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKI
NVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTREL
AYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLALTDPNASAAQQAVLQQHINSLTY
SPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKL
VLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVA
LNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGD
VNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPET
GSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLD
TMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG
RSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHV
DELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEE
EVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQL
SEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYS
DRHYDLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEGLWEWAIFVLLHIDNSGIREKAVRELLTRHC
QLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERS
SLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSD

--------------------------------------------------------------

>21881_21881_2_DDX10-NUP98_DDX10_chr11_108549162_ENST00000322536_NUP98_chr11_3756556_ENST00000355260_length(amino acids)=1503AA_BP=246
MSHAGSVSLALGVSCLGLIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKI
NVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTREL
AYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLALTDPNASAAQQAVLQQHINSLTY
SPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKL
VLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVA
LNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGD
VNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPET
GSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLD
TMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG
RSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHV
DELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEE
EVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQL
SEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYS
DSIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENY
DYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANL

--------------------------------------------------------------

>21881_21881_3_DDX10-NUP98_DDX10_chr11_108549162_ENST00000322536_NUP98_chr11_3756556_ENST00000359171_length(amino acids)=1415AA_BP=246
MSHAGSVSLALGVSCLGLIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKI
NVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTREL
AYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLALTDPNASAAQQAVLQQHINSLTY
SPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKL
VLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVA
LNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGD
VNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPET
GSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLD
TMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG
RSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHV
DELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEE
EVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQL
SEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYS
DSIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENY

--------------------------------------------------------------

>21881_21881_4_DDX10-NUP98_DDX10_chr11_108549162_ENST00000322536_NUP98_chr11_3756556_ENST00000397004_length(amino acids)=697AA_BP=246
MSHAGSVSLALGVSCLGLIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKI
NVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTREL
AYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLALTDPNASAAQQAVLQQHINSLTY
SPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKL
VLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVA
LNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGD
VNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPET

--------------------------------------------------------------

>21881_21881_5_DDX10-NUP98_DDX10_chr11_108549162_ENST00000322536_NUP98_chr11_3756556_ENST00000397007_length(amino acids)=697AA_BP=246
MSHAGSVSLALGVSCLGLIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKI
NVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTREL
AYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLALTDPNASAAQQAVLQQHINSLTY
SPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKL
VLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVA
LNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGD
VNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPET

--------------------------------------------------------------

>21881_21881_6_DDX10-NUP98_DDX10_chr11_108549162_ENST00000526794_NUP98_chr11_3756556_ENST00000324932_length(amino acids)=1560AA_BP=229
LIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKT
LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDF
SAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSDPK
KKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRD
SENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEE
TSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRK
EVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQD
SDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSAS
THIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQE
CRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSG
EQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIH
DYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSY
LTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRS
LAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDRHYDLNQLLEPRSITA
DPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEGLWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWAKETFLTQ
KLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYI
RVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAPHI

--------------------------------------------------------------

>21881_21881_7_DDX10-NUP98_DDX10_chr11_108549162_ENST00000526794_NUP98_chr11_3756556_ENST00000355260_length(amino acids)=1486AA_BP=229
LIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKT
LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDF
SAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSDPK
KKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRD
SENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEE
TSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRK
EVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQD
SDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSAS
THIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQE
CRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSG
EQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIH
DYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSY
LTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRS
LAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVRELLTRHCQ
LLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSS
LIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDS

--------------------------------------------------------------

>21881_21881_8_DDX10-NUP98_DDX10_chr11_108549162_ENST00000526794_NUP98_chr11_3756556_ENST00000359171_length(amino acids)=1398AA_BP=229
LIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKT
LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDF
SAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSDPK
KKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRD
SENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEE
TSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRK
EVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQD
SDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSAS
THIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQE
CRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSG
EQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIH
DYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSY
LTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRS
LAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVRELLTRHCQ
LLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSS

--------------------------------------------------------------

>21881_21881_9_DDX10-NUP98_DDX10_chr11_108549162_ENST00000526794_NUP98_chr11_3756556_ENST00000397004_length(amino acids)=680AA_BP=229
LIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKT
LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDF
SAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSDPK
KKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRD
SENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEE
TSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRK
EVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQD

--------------------------------------------------------------

>21881_21881_10_DDX10-NUP98_DDX10_chr11_108549162_ENST00000526794_NUP98_chr11_3756556_ENST00000397007_length(amino acids)=680AA_BP=229
LIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKT
LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDF
SAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSDPK
KKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNRD
SENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEE
TSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRK
EVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQD

--------------------------------------------------------------

>21881_21881_11_DDX10-NUP98_DDX10_chr11_108550288_ENST00000322536_NUP98_chr11_3746454_ENST00000324932_length(amino acids)=1533AA_BP=308
MSHAGSVSLALGVSCLGLIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKI
NVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTREL
AYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENL
PKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYRKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDEN
HQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGI
ILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLD
GVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQ
TTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEED
VDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSV
FTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPV
AVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWT
LCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQ
FVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQ
NTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDRHYDLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSAQC
EGVLQASYAGQLESEGLWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEA
LCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVT
SLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAPHIGRLPMPEDYAMDELRSLTQSYLRELAV

--------------------------------------------------------------

>21881_21881_12_DDX10-NUP98_DDX10_chr11_108550288_ENST00000322536_NUP98_chr11_3746454_ENST00000355260_length(amino acids)=1459AA_BP=308
MSHAGSVSLALGVSCLGLIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKI
NVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTREL
AYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENL
PKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYRKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDEN
HQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGI
ILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLD
GVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQ
TTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEED
VDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSV
FTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPV
AVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWT
LCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQ
FVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQ
NTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHE
AKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQ
VDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAPHIGRLPMPEDYAM

--------------------------------------------------------------

>21881_21881_13_DDX10-NUP98_DDX10_chr11_108550288_ENST00000322536_NUP98_chr11_3746454_ENST00000359171_length(amino acids)=1371AA_BP=308
MSHAGSVSLALGVSCLGLIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKI
NVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTREL
AYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENL
PKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYRKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDEN
HQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGI
ILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLD
GVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQ
TTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEED
VDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSV
FTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPV
AVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWT
LCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQ
FVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQ
NTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHE
AKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQ

--------------------------------------------------------------

>21881_21881_14_DDX10-NUP98_DDX10_chr11_108550288_ENST00000322536_NUP98_chr11_3746454_ENST00000397004_length(amino acids)=653AA_BP=308
MSHAGSVSLALGVSCLGLIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKI
NVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTREL
AYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENL
PKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYRKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDEN
HQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGI
ILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLD
GVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQ

--------------------------------------------------------------

>21881_21881_15_DDX10-NUP98_DDX10_chr11_108550288_ENST00000322536_NUP98_chr11_3746454_ENST00000397007_length(amino acids)=653AA_BP=308
MSHAGSVSLALGVSCLGLIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKI
NVNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTREL
AYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENL
PKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYRKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDEN
HQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGI
ILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLD
GVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQ

--------------------------------------------------------------

>21881_21881_16_DDX10-NUP98_DDX10_chr11_108550288_ENST00000526794_NUP98_chr11_3746454_ENST00000324932_length(amino acids)=1516AA_BP=291
LIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKT
LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDF
SAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSV
KDLARLSLKNPEYVWVHEKAKYRKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTN
PIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLA
KITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPD
RLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ
SQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKAD
TSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGT
RRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKL
SLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLN
EPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVD
WHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYL
EGSGCVIAEEQNSQTPLRDVCFHLLKLYSDRHYDLNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEGL
WEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLII
RHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDR

--------------------------------------------------------------

>21881_21881_17_DDX10-NUP98_DDX10_chr11_108550288_ENST00000526794_NUP98_chr11_3746454_ENST00000355260_length(amino acids)=1442AA_BP=291
LIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKT
LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDF
SAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSV
KDLARLSLKNPEYVWVHEKAKYRKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTN
PIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLA
KITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPD
RLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ
SQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKAD
TSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGT
RRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKL
SLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLN
EPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVD
WHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYL
EGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEAL
CLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTS
LCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAPHIGRLPMPEDYAMDELRSLTQSYLRELAVG

--------------------------------------------------------------

>21881_21881_18_DDX10-NUP98_DDX10_chr11_108550288_ENST00000526794_NUP98_chr11_3746454_ENST00000359171_length(amino acids)=1354AA_BP=291
LIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKT
LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDF
SAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSV
KDLARLSLKNPEYVWVHEKAKYRKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTN
PIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLA
KITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPD
RLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ
SQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVSASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKAD
TSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGT
RRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKL
SLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLN
EPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVFSYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVD
WHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWKRSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYL
EGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVRELLTRHCQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEAL
CLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLRHIQQIALFCVEWIAQVMTWSS

--------------------------------------------------------------

>21881_21881_19_DDX10-NUP98_DDX10_chr11_108550288_ENST00000526794_NUP98_chr11_3746454_ENST00000397004_length(amino acids)=636AA_BP=291
LIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKT
LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDF
SAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSV
KDLARLSLKNPEYVWVHEKAKYRKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTN
PIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLA
KITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPD
RLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ

--------------------------------------------------------------

>21881_21881_20_DDX10-NUP98_DDX10_chr11_108550288_ENST00000526794_NUP98_chr11_3746454_ENST00000397007_length(amino acids)=636AA_BP=291
LIRAVAAAAAMGKTANSPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKINVNEITRFSDFPLSKKT
LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDF
SAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSV
KDLARLSLKNPEYVWVHEKAKYRKSIKKLVLKNLNNSNLFSPVNRDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTN
PIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLA
KITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPD
RLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:108549162/chr11:3756556)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX10

Q13206

NUP98

P52948

FUNCTION: Putative ATP-dependent RNA helicase.FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change ASN-74-ASP is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX10chr11:108550288chr11:3746454ENST00000322536+618100_274282.6666666666667876.0DomainHelicase ATP-binding
HgeneDDX10chr11:108549162chr11:3756556ENST00000322536+51869_97219.33333333333334876.0MotifNote=Q motif
HgeneDDX10chr11:108550288chr11:3746454ENST00000322536+618222_225282.6666666666667876.0MotifNote=DEAD box
HgeneDDX10chr11:108550288chr11:3746454ENST00000322536+61869_97282.6666666666667876.0MotifNote=Q motif
HgeneDDX10chr11:108549162chr11:3756556ENST00000322536+518113_120219.33333333333334876.0Nucleotide bindingNote=ATP
HgeneDDX10chr11:108549162chr11:3756556ENST00000322536+51889_91219.33333333333334876.0Nucleotide bindingNote=ATP
HgeneDDX10chr11:108550288chr11:3746454ENST00000322536+618113_120282.6666666666667876.0Nucleotide bindingNote=ATP
HgeneDDX10chr11:108550288chr11:3746454ENST00000322536+61889_91282.6666666666667876.0Nucleotide bindingNote=ATP
TgeneNUP98chr11:108549162chr11:3756556ENST000003249321133890_894469.33333333333331801.0Compositional biasNote=Poly-Glu
TgeneNUP98chr11:108549162chr11:3756556ENST000003552601132890_894469.33333333333331727.0Compositional biasNote=Poly-Glu
TgeneNUP98chr11:108549162chr11:3756556ENST000003970041120890_894469.3333333333333921.0Compositional biasNote=Poly-Glu
TgeneNUP98chr11:108549162chr11:3756556ENST000003970071120890_894486.3333333333333938.0Compositional biasNote=Poly-Glu
TgeneNUP98chr11:108550288chr11:3746454ENST000003249321333890_894576.66666666666661801.0Compositional biasNote=Poly-Glu
TgeneNUP98chr11:108550288chr11:3746454ENST000003552601332890_894576.66666666666661727.0Compositional biasNote=Poly-Glu
TgeneNUP98chr11:108550288chr11:3746454ENST000003970041320890_894576.6666666666666921.0Compositional biasNote=Poly-Glu
TgeneNUP98chr11:108550288chr11:3746454ENST000003970071320890_894593.6666666666666938.0Compositional biasNote=Poly-Glu
TgeneNUP98chr11:108549162chr11:3756556ENST000003249321133738_880469.33333333333331801.0DomainPeptidase S59
TgeneNUP98chr11:108549162chr11:3756556ENST000003552601132738_880469.33333333333331727.0DomainPeptidase S59
TgeneNUP98chr11:108549162chr11:3756556ENST000003970041120738_880469.3333333333333921.0DomainPeptidase S59
TgeneNUP98chr11:108549162chr11:3756556ENST000003970071120738_880486.3333333333333938.0DomainPeptidase S59
TgeneNUP98chr11:108550288chr11:3746454ENST000003249321333738_880576.66666666666661801.0DomainPeptidase S59
TgeneNUP98chr11:108550288chr11:3746454ENST000003552601332738_880576.66666666666661727.0DomainPeptidase S59
TgeneNUP98chr11:108550288chr11:3746454ENST000003970041320738_880576.6666666666666921.0DomainPeptidase S59
TgeneNUP98chr11:108550288chr11:3746454ENST000003970071320738_880593.6666666666666938.0DomainPeptidase S59

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX10chr11:108549162chr11:3756556ENST00000322536+518100_274219.33333333333334876.0DomainHelicase ATP-binding
HgeneDDX10chr11:108549162chr11:3756556ENST00000322536+518287_448219.33333333333334876.0DomainHelicase C-terminal
HgeneDDX10chr11:108550288chr11:3746454ENST00000322536+618287_448282.6666666666667876.0DomainHelicase C-terminal
HgeneDDX10chr11:108549162chr11:3756556ENST00000322536+518222_225219.33333333333334876.0MotifNote=DEAD box
TgeneNUP98chr11:108549162chr11:3756556ENST0000032493211337_480469.33333333333331801.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr11:108549162chr11:3756556ENST0000035526011327_480469.33333333333331727.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr11:108549162chr11:3756556ENST0000039700411207_480469.3333333333333921.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr11:108549162chr11:3756556ENST0000039700711207_480486.3333333333333938.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr11:108550288chr11:3746454ENST0000032493213337_480576.66666666666661801.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr11:108550288chr11:3746454ENST0000035526013327_480576.66666666666661727.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr11:108550288chr11:3746454ENST0000039700413207_480576.6666666666666921.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr11:108550288chr11:3746454ENST0000039700713207_480593.6666666666666938.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr11:108549162chr11:3756556ENST0000032493211331_156469.33333333333331801.0RegionNote=FG repeats 1
TgeneNUP98chr11:108549162chr11:3756556ENST000003249321133214_480469.33333333333331801.0RegionNote=FG repeats 2
TgeneNUP98chr11:108549162chr11:3756556ENST0000035526011321_156469.33333333333331727.0RegionNote=FG repeats 1
TgeneNUP98chr11:108549162chr11:3756556ENST000003552601132214_480469.33333333333331727.0RegionNote=FG repeats 2
TgeneNUP98chr11:108549162chr11:3756556ENST0000039700411201_156469.3333333333333921.0RegionNote=FG repeats 1
TgeneNUP98chr11:108549162chr11:3756556ENST000003970041120214_480469.3333333333333921.0RegionNote=FG repeats 2
TgeneNUP98chr11:108549162chr11:3756556ENST0000039700711201_156486.3333333333333938.0RegionNote=FG repeats 1
TgeneNUP98chr11:108549162chr11:3756556ENST000003970071120214_480486.3333333333333938.0RegionNote=FG repeats 2
TgeneNUP98chr11:108550288chr11:3746454ENST0000032493213331_156576.66666666666661801.0RegionNote=FG repeats 1
TgeneNUP98chr11:108550288chr11:3746454ENST000003249321333214_480576.66666666666661801.0RegionNote=FG repeats 2
TgeneNUP98chr11:108550288chr11:3746454ENST0000035526013321_156576.66666666666661727.0RegionNote=FG repeats 1
TgeneNUP98chr11:108550288chr11:3746454ENST000003552601332214_480576.66666666666661727.0RegionNote=FG repeats 2
TgeneNUP98chr11:108550288chr11:3746454ENST0000039700413201_156576.6666666666666921.0RegionNote=FG repeats 1
TgeneNUP98chr11:108550288chr11:3746454ENST000003970041320214_480576.6666666666666921.0RegionNote=FG repeats 2
TgeneNUP98chr11:108550288chr11:3746454ENST0000039700713201_156593.6666666666666938.0RegionNote=FG repeats 1
TgeneNUP98chr11:108550288chr11:3746454ENST000003970071320214_480593.6666666666666938.0RegionNote=FG repeats 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NUP98MOB1A, PARP11, QRICH2, TPR, NUP88, CREBBP, EP300, NUP133, Rae1, KPNB1, RAE1, TNPO2, CRM1, KAP104, NXF1, TNPO1, USP7, NPM1, PTTG1, APC, HDAC1, tat, NUP82, NUP159, Nup188, Nup98, Nup107, Nup214, SIRT7, NUP107, RAPGEF3, rev, NUMA1, ECT2, CSNK2A1, HNRNPUL1, LMNA, HDAC8, HDAC11, FBXO6, ARFGEF2, CDC73, PAF1, CDC37, CUL7, OBSL1, EED, MAPK8, COMTD1, SEC13, PNKD, NUP43, CLEC11A, RNF166, UNK, NUP54, NUP85, SEH1L, XPO5, KRAS, IFI16, NUP160, NUP35, B9D2, UBE2I, NUPL1, NUP153, PIM2, NUDT21, NCBP2, CHMP4B, GTF2H5, Ranbp2, Ube2i, Ssna1, Rcc1, Xpo1, Kifc1, Nup155, FOXI2, FOXL1, FOXQ1, FAF1, C11orf30, DUSP13, SPAST, FAM136A, UXS1, CD70, VASN, TRIM25, G3BP1, ORF10, CDC27, ANAPC4, ANAPC10, MAD2L1, CDC20, FZR1, PIN1, CTNNB1, TGFB1, NKX2-1, ESR2, NUP155, EZH2, DCPS, CDK9, DYNLT1, TOMM20, KIAA1429, DISC1, NR2C2, AGRN, HIST1H4A, PTPMT1, ORF6, BIRC3, LMBR1L, FAM105A, PLEKHA4, TTC9, HIST1H2BH, HIST3H3, M, nsp16, nsp4, nsp6, ORF7b, GLE1, NEK4, CIT, KIF14, KIF20A, PRC1, ARHGEF19, MYO9A, PTPN1, SEC61B, NFX1, HULC, NUPR1, BRD4, LGALS9, DYRK1A, NUP37, DDX58, CKAP4, DERL1, EMD, HSD17B11, HSD3B7, LMNB1, LRRC59, METTL7A, NUP50, REEP5, SEC62, SSR1, STIM1, SYNE3, TMPO, WDR5, NAA40, OCIAD1, CADPS, TACSTD2, RGPD1, TPST2, CD40, SLFN11, FBXO32, RCHY1, SIRT6, ETV6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DDX10
NUP98all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DDX10-NUP98


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DDX10-NUP98


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUP98C0002871Anemia1CTD_human
TgeneNUP98C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneNUP98C0024312Lymphopenia1CTD_human
TgeneNUP98C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneNUP98C0027947Neutropenia1CTD_human
TgeneNUP98C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneNUP98C2930974Acute erythroleukemia1CTD_human
TgeneNUP98C2930975Acute erythroleukemia - M6a subtype1CTD_human
TgeneNUP98C2930976Acute myeloid leukemia FAB-M61CTD_human
TgeneNUP98C2930977Acute erythroleukemia - M6b subtype1CTD_human