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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DDX3X-KRT13

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DDX3X-KRT13
FusionPDB ID: 21984
FusionGDB2.0 ID: 21984
HgeneTgene
Gene symbol

DDX3X

KRT13

Gene ID

1654

3860

Gene nameDEAD-box helicase 3 X-linkedkeratin 13
SynonymsCAP-Rf|DBX|DDX14|DDX3|HLP2|MRX102CK13|K13|WSN2
Cytomap

Xp11.4

17q21.2

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DDX3XDEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linkedDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linkedDEAD box protein 3, X-chromosomalDEAD box, X isoformDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3DEAD/H box-3helicase-keratin, type I cytoskeletal 13CK-13cytokeratin 13keratin 13, type I
Modification date2020032920200313
UniProtAcc

O00571

P13646

Ensembl transtripts involved in fusion geneENST idsENST00000478993, ENST00000399959, 
ENST00000441189, ENST00000457138, 
ENST00000542215, 		ENST00000246635, 
ENST00000336861, ENST00000587544, 
ENST00000587118, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 9 X 6=43219 X 33 X 6=3762
# samples 824
** MAII scorelog2(8/432*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3762*10)=-3.97039353791468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DDX3X [Title/Abstract] AND KRT13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DDX3X(41206905)-KRT13(39661579), # samples:1
DDX3X(41206907)-KRT13(39661625), # samples:1
Anticipated loss of major functional domain due to fusion event.DDX3X-KRT13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX3X-KRT13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX3X-KRT13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX3X-KRT13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX3X-KRT13 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DDX3X-KRT13 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DDX3X-KRT13 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDX3X

GO:0009615

response to virus

18636090

HgeneDDX3X

GO:0010501

RNA secondary structure unwinding

22872150

HgeneDDX3X

GO:0010628

positive regulation of gene expression

10074132

HgeneDDX3X

GO:0030308

negative regulation of cell growth

16818630

HgeneDDX3X

GO:0031333

negative regulation of protein complex assembly

17667941

HgeneDDX3X

GO:0031954

positive regulation of protein autophosphorylation

30341167

HgeneDDX3X

GO:0032727

positive regulation of interferon-alpha production

30341167

HgeneDDX3X

GO:0032728

positive regulation of interferon-beta production

27980081

HgeneDDX3X

GO:0034063

stress granule assembly

21883093

HgeneDDX3X

GO:0034157

positive regulation of toll-like receptor 7 signaling pathway

30341167

HgeneDDX3X

GO:0034161

positive regulation of toll-like receptor 8 signaling pathway

30341167

HgeneDDX3X

GO:0035556

intracellular signal transduction

18636090

HgeneDDX3X

GO:0045727

positive regulation of translation

18596238|22872150

HgeneDDX3X

GO:0045944

positive regulation of transcription by RNA polymerase II

16818630|18636090|28128295

HgeneDDX3X

GO:0071243

cellular response to arsenic-containing substance

21883093

HgeneDDX3X

GO:0071470

cellular response to osmotic stress

21883093

HgeneDDX3X

GO:0071902

positive regulation of protein serine/threonine kinase activity

23413191

HgeneDDX3X

GO:1902523

positive regulation of protein K63-linked ubiquitination

27980081

TgeneKRT13

GO:0007010

cytoskeleton organization

21371075


check buttonFusion gene breakpoints across DDX3X (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KRT13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315362DDX3XchrX

41206905

+KRT13chr17

39661579

-
ChimerDB4Non-CancerERR315489DDX3XchrX

41206907

+KRT13chr17

39661625

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399959DDX3XchrX41206905+ENST00000336861KRT13chr1739661579-672453218552846663
ENST00000399959DDX3XchrX41206905+ENST00000246635KRT13chr1739661579-675053218552846663
ENST00000399959DDX3XchrX41206905+ENST00000587544KRT13chr1739661579-649153218552846663
ENST00000441189DDX3XchrX41206905+ENST00000336861KRT13chr1739661579-2441103891513140
ENST00000441189DDX3XchrX41206905+ENST00000246635KRT13chr1739661579-2467103891513140
ENST00000441189DDX3XchrX41206905+ENST00000587544KRT13chr1739661579-2208103891513140
ENST00000399959DDX3XchrX41206907+ENST00000336861KRT13chr1739661625-676853198552828657
ENST00000399959DDX3XchrX41206907+ENST00000246635KRT13chr1739661625-679453198552828657
ENST00000399959DDX3XchrX41206907+ENST00000587544KRT13chr1739661625-653553198552828657
ENST00000441189DDX3XchrX41206907+ENST00000336861KRT13chr1739661625-2485103619012392163
ENST00000441189DDX3XchrX41206907+ENST00000246635KRT13chr1739661625-2511103619272418163
ENST00000441189DDX3XchrX41206907+ENST00000587544KRT13chr1739661625-2252103616682159163

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399959ENST00000336861DDX3XchrX41206905+KRT13chr1739661579-0.0008840350.999116
ENST00000399959ENST00000246635DDX3XchrX41206905+KRT13chr1739661579-0.0009229970.99907696
ENST00000399959ENST00000587544DDX3XchrX41206905+KRT13chr1739661579-0.000910040.99908996
ENST00000441189ENST00000336861DDX3XchrX41206905+KRT13chr1739661579-0.0097905080.99020946
ENST00000441189ENST00000246635DDX3XchrX41206905+KRT13chr1739661579-0.0153514030.9846485
ENST00000441189ENST00000587544DDX3XchrX41206905+KRT13chr1739661579-0.0085975970.99140245
ENST00000399959ENST00000336861DDX3XchrX41206907+KRT13chr1739661625-0.0009337950.9990662
ENST00000399959ENST00000246635DDX3XchrX41206907+KRT13chr1739661625-0.0009762460.9990238
ENST00000399959ENST00000587544DDX3XchrX41206907+KRT13chr1739661625-0.0009719920.99902797
ENST00000441189ENST00000336861DDX3XchrX41206907+KRT13chr1739661625-0.008353890.9916461
ENST00000441189ENST00000246635DDX3XchrX41206907+KRT13chr1739661625-0.0091781490.99082184
ENST00000441189ENST00000587544DDX3XchrX41206907+KRT13chr1739661625-0.0076829750.9923171

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21984_21984_1_DDX3X-KRT13_DDX3X_chrX_41206905_ENST00000399959_KRT13_chr17_39661579_ENST00000246635_length(amino acids)=663AA_BP=
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGS
GSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISL
VLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVET
KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGS

--------------------------------------------------------------

>21984_21984_2_DDX3X-KRT13_DDX3X_chrX_41206905_ENST00000399959_KRT13_chr17_39661579_ENST00000336861_length(amino acids)=663AA_BP=
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGS
GSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISL
VLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVET
KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGS

--------------------------------------------------------------

>21984_21984_3_DDX3X-KRT13_DDX3X_chrX_41206905_ENST00000399959_KRT13_chr17_39661579_ENST00000587544_length(amino acids)=663AA_BP=
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGS
GSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISL
VLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVET
KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGS

--------------------------------------------------------------

>21984_21984_4_DDX3X-KRT13_DDX3X_chrX_41206905_ENST00000441189_KRT13_chr17_39661579_ENST00000246635_length(amino acids)=140AA_BP=
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGS

--------------------------------------------------------------

>21984_21984_5_DDX3X-KRT13_DDX3X_chrX_41206905_ENST00000441189_KRT13_chr17_39661579_ENST00000336861_length(amino acids)=140AA_BP=
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGS

--------------------------------------------------------------

>21984_21984_6_DDX3X-KRT13_DDX3X_chrX_41206905_ENST00000441189_KRT13_chr17_39661579_ENST00000587544_length(amino acids)=140AA_BP=
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGS

--------------------------------------------------------------

>21984_21984_7_DDX3X-KRT13_DDX3X_chrX_41206907_ENST00000399959_KRT13_chr17_39661625_ENST00000246635_length(amino acids)=657AA_BP=
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGS
GSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISL
VLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVET
KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGS

--------------------------------------------------------------

>21984_21984_8_DDX3X-KRT13_DDX3X_chrX_41206907_ENST00000399959_KRT13_chr17_39661625_ENST00000336861_length(amino acids)=657AA_BP=
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGS
GSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISL
VLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVET
KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGS

--------------------------------------------------------------

>21984_21984_9_DDX3X-KRT13_DDX3X_chrX_41206907_ENST00000399959_KRT13_chr17_39661625_ENST00000587544_length(amino acids)=657AA_BP=
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGS
GSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISL
VLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVET
KKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGS

--------------------------------------------------------------

>21984_21984_10_DDX3X-KRT13_DDX3X_chrX_41206907_ENST00000441189_KRT13_chr17_39661625_ENST00000246635_length(amino acids)=163AA_BP=8
MLRNGSTPRYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEILTATIENNRVILEIDNARLAADDFRLKA

--------------------------------------------------------------

>21984_21984_11_DDX3X-KRT13_DDX3X_chrX_41206907_ENST00000441189_KRT13_chr17_39661625_ENST00000336861_length(amino acids)=163AA_BP=8
MLRNGSTPRYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEILTATIENNRVILEIDNARLAADDFRLKA

--------------------------------------------------------------

>21984_21984_12_DDX3X-KRT13_DDX3X_chrX_41206907_ENST00000441189_KRT13_chr17_39661625_ENST00000587544_length(amino acids)=163AA_BP=8
MLRNGSTPRYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEILTATIENNRVILEIDNARLAADDFRLKA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:41206905/chr17:39661579)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX3X

O00571

KRT13

P13646

FUNCTION: Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:18628297, PubMed:17667941, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:31575075, PubMed:20127681, PubMed:21170385). Potentiate MAVS/DDX58-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:21170385, PubMed:27980081, PubMed:19913487). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKRT13chrX:41206905chr17:39661579ENST000002466350813_1020459.0Compositional biasNote=Gly-rich
TgeneKRT13chrX:41206905chr17:39661579ENST000003368610713_1020421.0Compositional biasNote=Gly-rich
TgeneKRT13chrX:41206907chr17:39661625ENST000002466350813_1020459.0Compositional biasNote=Gly-rich
TgeneKRT13chrX:41206907chr17:39661625ENST000003368610713_1020421.0Compositional biasNote=Gly-rich
TgeneKRT13chrX:41206905chr17:39661579ENST0000024663508104_4160459.0DomainIF rod
TgeneKRT13chrX:41206905chr17:39661579ENST0000033686107104_4160421.0DomainIF rod
TgeneKRT13chrX:41206907chr17:39661625ENST0000024663508104_4160459.0DomainIF rod
TgeneKRT13chrX:41206907chr17:39661625ENST0000033686107104_4160421.0DomainIF rod
TgeneKRT13chrX:41206905chr17:39661579ENST0000024663508104_1390459.0RegionNote=Coil 1A
TgeneKRT13chrX:41206905chr17:39661579ENST0000024663508140_1580459.0RegionNote=Linker 1
TgeneKRT13chrX:41206905chr17:39661579ENST0000024663508159_2500459.0RegionNote=Coil 1B
TgeneKRT13chrX:41206905chr17:39661579ENST00000246635081_1030459.0RegionNote=Head
TgeneKRT13chrX:41206905chr17:39661579ENST0000024663508251_2730459.0RegionNote=Linker 12
TgeneKRT13chrX:41206905chr17:39661579ENST0000024663508274_4120459.0RegionNote=Coil 2
TgeneKRT13chrX:41206905chr17:39661579ENST0000024663508413_4580459.0RegionNote=Tail
TgeneKRT13chrX:41206905chr17:39661579ENST0000033686107104_1390421.0RegionNote=Coil 1A
TgeneKRT13chrX:41206905chr17:39661579ENST0000033686107140_1580421.0RegionNote=Linker 1
TgeneKRT13chrX:41206905chr17:39661579ENST0000033686107159_2500421.0RegionNote=Coil 1B
TgeneKRT13chrX:41206905chr17:39661579ENST00000336861071_1030421.0RegionNote=Head
TgeneKRT13chrX:41206905chr17:39661579ENST0000033686107251_2730421.0RegionNote=Linker 12
TgeneKRT13chrX:41206905chr17:39661579ENST0000033686107274_4120421.0RegionNote=Coil 2
TgeneKRT13chrX:41206905chr17:39661579ENST0000033686107413_4580421.0RegionNote=Tail
TgeneKRT13chrX:41206907chr17:39661625ENST0000024663508104_1390459.0RegionNote=Coil 1A
TgeneKRT13chrX:41206907chr17:39661625ENST0000024663508140_1580459.0RegionNote=Linker 1
TgeneKRT13chrX:41206907chr17:39661625ENST0000024663508159_2500459.0RegionNote=Coil 1B
TgeneKRT13chrX:41206907chr17:39661625ENST00000246635081_1030459.0RegionNote=Head
TgeneKRT13chrX:41206907chr17:39661625ENST0000024663508251_2730459.0RegionNote=Linker 12
TgeneKRT13chrX:41206907chr17:39661625ENST0000024663508274_4120459.0RegionNote=Coil 2
TgeneKRT13chrX:41206907chr17:39661625ENST0000024663508413_4580459.0RegionNote=Tail
TgeneKRT13chrX:41206907chr17:39661625ENST0000033686107104_1390421.0RegionNote=Coil 1A
TgeneKRT13chrX:41206907chr17:39661625ENST0000033686107140_1580421.0RegionNote=Linker 1
TgeneKRT13chrX:41206907chr17:39661625ENST0000033686107159_2500421.0RegionNote=Coil 1B
TgeneKRT13chrX:41206907chr17:39661625ENST00000336861071_1030421.0RegionNote=Head
TgeneKRT13chrX:41206907chr17:39661625ENST0000033686107251_2730421.0RegionNote=Linker 12
TgeneKRT13chrX:41206907chr17:39661625ENST0000033686107274_4120421.0RegionNote=Coil 2
TgeneKRT13chrX:41206907chr17:39661625ENST0000033686107413_4580421.0RegionNote=Tail

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117582_6620663.0Compositional biasNote=Gly/Ser-rich
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116582_6620647.0Compositional biasNote=Gly/Ser-rich
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117582_6620663.0Compositional biasNote=Gly/Ser-rich
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116582_6620647.0Compositional biasNote=Gly/Ser-rich
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117211_4030663.0DomainHelicase ATP-binding
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117414_5750663.0DomainHelicase C-terminal
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116211_4030647.0DomainHelicase ATP-binding
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116414_5750647.0DomainHelicase C-terminal
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117211_4030663.0DomainHelicase ATP-binding
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117414_5750663.0DomainHelicase C-terminal
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116211_4030647.0DomainHelicase ATP-binding
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116414_5750647.0DomainHelicase C-terminal
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117180_2080663.0MotifNote=Q motif
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116180_2080647.0MotifNote=Q motif
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117180_2080663.0MotifNote=Q motif
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116180_2080647.0MotifNote=Q motif
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117200_2070663.0Nucleotide bindingNote=ATP
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117224_2310663.0Nucleotide bindingNote=ATP
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116200_2070647.0Nucleotide bindingNote=ATP
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116224_2310647.0Nucleotide bindingNote=ATP
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117200_2070663.0Nucleotide bindingNote=ATP
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117224_2310663.0Nucleotide bindingNote=ATP
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116200_2070647.0Nucleotide bindingNote=ATP
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116224_2310647.0Nucleotide bindingNote=ATP
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117250_2590663.0RegionNote=Involved in stimulation of ATPase activity by DNA and RNA%2C nucleic acid binding and unwinding and HIV-1 replication
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+1172_1390663.0RegionRequired for TBK1 and IKBKE-dependent IFNB1 activation
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+11788_1230663.0RegionInvolved in binding to RNA G-quadruplex
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116250_2590647.0RegionNote=Involved in stimulation of ATPase activity by DNA and RNA%2C nucleic acid binding and unwinding and HIV-1 replication
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+1162_1390647.0RegionRequired for TBK1 and IKBKE-dependent IFNB1 activation
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+11688_1230647.0RegionInvolved in binding to RNA G-quadruplex
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117250_2590663.0RegionNote=Involved in stimulation of ATPase activity by DNA and RNA%2C nucleic acid binding and unwinding and HIV-1 replication
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+1172_1390663.0RegionRequired for TBK1 and IKBKE-dependent IFNB1 activation
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+11788_1230663.0RegionInvolved in binding to RNA G-quadruplex
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116250_2590647.0RegionNote=Involved in stimulation of ATPase activity by DNA and RNA%2C nucleic acid binding and unwinding and HIV-1 replication
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+1162_1390647.0RegionRequired for TBK1 and IKBKE-dependent IFNB1 activation
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+11688_1230647.0RegionInvolved in binding to RNA G-quadruplex


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DDX3X
KRT13


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117139_1720663.0CHUK
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116139_1720647.0CHUK
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117139_1720663.0CHUK
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116139_1720647.0CHUK
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+11738_440663.0EIF4E
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+11638_440647.0EIF4E
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+11738_440663.0EIF4E
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+11638_440647.0EIF4E
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117100_6620663.0GSK3B
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116100_6620647.0GSK3B
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117100_6620663.0GSK3B
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116100_6620647.0GSK3B
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117409_6620663.0HCV core protein
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116409_6620647.0HCV core protein
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117409_6620663.0HCV core protein
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116409_6620647.0HCV core protein
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117100_1100663.0IKBKE
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116100_1100647.0IKBKE
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117100_1100663.0IKBKE
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116100_1100647.0IKBKE
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+117536_6610663.0NXF1
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+116536_6610647.0NXF1
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+117536_6610663.0NXF1
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+116536_6610647.0NXF1
HgeneDDX3XchrX:41206905chr17:39661579ENST00000399959+11781_900663.0VACV protein K7
HgeneDDX3XchrX:41206905chr17:39661579ENST00000457138+11681_900647.0VACV protein K7
HgeneDDX3XchrX:41206907chr17:39661625ENST00000399959+11781_900663.0VACV protein K7
HgeneDDX3XchrX:41206907chr17:39661625ENST00000457138+11681_900647.0VACV protein K7


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Related Drugs to DDX3X-KRT13


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DDX3X-KRT13


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource